Genes encoding bile acid, phospholipid and anion transporters are expressed in a human fetal cardiomyocyte culture

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 113, Issue 5, 2006, Pages 552-558

  Gorelik, J ^a   Patel, P ^a   Ng'andwe, C ^a   Vodyanoy, I ^b   Diakonov, I ^a   Lab, M ^c   Korchev, Y ^a   Williamson, C ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b National Office   (United States)

^c NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Bile; Cardiomyocyte culture; Expression; Fetus; Transporter

Indexed keywords

ALPHA ACTININ; ANION TRANSPORTER; BILE ACID; CARRIER PROTEIN; MESSENGER RNA; MONOCLONAL ANTIBODY; MYOSIN HEAVY CHAIN; ORGANIC ANION TRANSPORTER; PHOSPHOLIPID; TAUROCHOLIC ACID; TERATOGENIC AGENT; TOXIC SUBSTANCE; UNCLASSIFIED DRUG;

ARTICLE; BILE; CELL CULTURE; CHOLESTASIS; CONTROLLED STUDY; FETUS; FETUS DEATH; FETUS HEART; GENE EXPRESSION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; LIVER; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BILE ACIDS AND SALTS; FEMALE; FETAL HEART; HUMANS; IMMUNOHISTOCHEMISTRY; MYOCYTES, CARDIAC; ORGANIC ANION TRANSPORTERS; PHOSPHOLIPIDS; POLYMERASE CHAIN REACTION; PREGNANCY; RNA, MESSENGER;

EID: 33645989795     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.2006.00918.x     Document Type: Article

References (33)

1. Williamson C Gorelik J Eaton BM Lab M de Swiet M Korchev Y. The bile acid taurocholate impairs rat cardiomyocyte function: a proposed mechanism for intra-uterine fetal death in obstetric cholestasis. Clin Sci (Lond) 2001 100 363 9.
2. Gorelik J Harding SE Shevchuk AI Koralage D Lab M de Swiet M et al. Taurocholate induces changes in rat cardiomyocyte contraction and calcium dynamics. Clin Sci (Lond) 2002 103 191 200.
3. Schuetz EG Strom S Yasuda K Lecureur V Assem M Brimer C et al. Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. J Biol Chem 2001 276 39411 18.
4. Denson LA Sturm E Echevarria W Zimmerman TL Makishima M Mangelsdorf DJ et al. The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp. Gastroenterology 2001 121 140 7.
5. Lew JL Zhao A Yu J Huang L De Pedro N Pelaez F et al. The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion. J Biol Chem 2004 279 8856 61.
6. Strautnieks SS Bull LN Knisely AS Kocoshis SA Dahl N Arnell H et al. A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis. Nat Genet 1998 20 233 8.
7. de Vree JM Jacquemin E Sturm E Cresteil D Bosma PJ Aten J et al. Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis. Proc Natl Acad Sci U S A 1998 95 282 7.
8. Bull LN van Eijk MJ Pawlikowska L DeYoung JA Juijn JA Liao M et al. A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis. Nat Genet 1998 18 219 24.
9. Dixon PH Weerasekera N Linton KJ Donaldson O Chambers J Egginton E et al. Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking. Hum Mol Genet 2000 9 1209 17.
10. Jacquemin E de Vree JM Cresteil D Sokal EM Sturm E Dumont M et al. The wide spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to cirrhosis of adulthood. Gastroenterology 2001 120 1448 58.
11. Mullenbach R Linton KJ Wiltshire S Weerasekera N Chambers J Elias E et al. ABCB4 gene sequence variation in women with intrahepatic cholestasis of pregnancy. J Med Genet 2003 40 e70.
12. Gorelik J Shevchuk AI Diakonov I de Swiet M Lab M Korchev Y et al. Dexamethasone and ursodeoxycholic acid protect against the arrhythmogenic effect of taurocholate in an in vitro study of rat cardiomyocytes. BJOG 2003 110 467 74.
13. Beuers U Bilzer M Chittattu A Kullak-Ublick GA Keppler D Paumgartner G et al. Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. Hepatology 2001 33 1206 16.
14. Hew KW Keller KA. Postnatal anatomical and functional development of the heart: a species comparison. Birth Defects Res B Dev Reprod Toxicol 2003 68 309 20.
15. Goldman BI Wurzel J. Effects of subcultivation and culture medium on differentiation of human fetal cardiac myocytes. In Vitro Cell Dev Biol 1992 28A 109 19.
16. Goldman B Mach A Wurzel J. Epidermal growth factor promotes a cardiomyoblastic phenotype in human fetal cardiac myocytes. Exp Cell Res 1996 228 237 45.
17. Miranda ME Tseng CE Rashbaum W Ochs RL Casiano CA Di Donato F et al. Accessibility of SSA/Ro and SSB/La antigens to maternal autoantibodies in apoptotic human fetal cardiac myocytes. J Immunol 1998 161 5061 9.
18. Colombo C Zuliani G Ronchi M Breidenstein J Setchell KD. Biliary bile acid composition of the human fetus in early gestation. Pediatr Res 1987 21 197 200.
19. Courillon F Gerhardt MF Myara A Daffos F Forestier F Trivin F. Serum C24 bile acids in the developing human fetus. Biol Neonate 1998 73 76 88.
20. Colombo C Roda A Roda E Buscaglia M dell'Agnola CA Filippetti P et al. Correlation between fetal and maternal serum bile acid concentrations. Pediatr Res 1985 19 227 31.
21. Setchell KD Dumaswala R Colombo C Ronchi M. Hepatic bile acid metabolism during early development revealed from the analysis of human fetal gallbladder bile. J Biol Chem 1988 263 16637 44.
22. Sjovall K Sjovall J. Serum bile acid levels in pregnancy with pruritus (bile acids and steroids 158). Clin Chim Acta 1966 13 207 11.
23. Heikkinen J Maentausta O Ylostalo P Janne O. Changes in serum bile acid concentrations during normal pregnancy, in patients with intrahepatic cholestasis of pregnancy and in pregnant women with itching. Br J Obstet Gynaecol 1981 88 240 5.
24. Laatikainen T Hesso A. Determination of serum bile acids by glass capillary gas-liquid chromatography. Clin Chim Acta 1975 64 63 8.
25. Smit JJ Schinkel AH Mol CA Majoor D Mooi WJ Jongsma AP et al. Tissue distribution of the human MDR3 P-glycoprotein. Lab Invest 1994 71 638 49.
26. van Helvoort A Smith AJ Sprong H Fritzsche I Schinkel AH Borst P et al. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell 1996 87 507 17.
27. Harris MJ Arias IM. FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body. Biochim Biophys Acta 2003 1633 127 31.
28. Ujhazy P Ortiz D Misra S Li S Moseley J Jones H et al. Familial intrahepatic cholestasis 1: studies of localization and function. Hepatology 2001 34 768 75.
29. Tamai I Nezu J Uchino H Sai Y Oku A Shimane M et al. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun 2000 273 251 60.
30. Kullak-Ublick GA Glasa J Boker C Oswald M Grutzner U Hagenbuch B et al. Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas. Gastroenterology 1997 113 1295 305.
31. Abe T Kakyo M Tokui T Nakagomi R Nishio T Nakai D et al. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem 1999 274 17159 63.
32. Adachi H Suzuki T Abe M Asano N Mizutamari H Tanemoto M et al. Molecular characterization of human and rat organic anion transporter OATP-D. Am J Physiol Renal Physiol 2003 285 F1188 97.
33. Fujiwara K Adachi H Nishio T Unno M Tokui T Okabe M et al. Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology 2001 142 2005 12.