Hepatocyte nuclear factor-4α and -1 small interfering RNA inhibits hepatocyte differentiation induced by extracellular matrix

Hepatology Research

Volumn 35, Issue 1, 2006, Pages 3-9

  Kimata, Takayuki ^a   Nagaki, Masahito ^a   Tsukada, Yoshihiko ^a   Ogiso, Tomio ^a   Moriwaki, Hisataka ^a  

^a GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Collagen; Engelbreth Holm Swarm; RNA interference; Transcription factor

Indexed keywords

ACTIN; ALBUMIN; APOLIPOPROTEIN; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MESSENGER RNA; NUCLEAR FACTOR I; PREALBUMIN; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; BASEMENT MEMBRANE; CELL CULTURE; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; CYTOSKELETON; EXTRACELLULAR MATRIX; GEL; GENE EXPRESSION; GENE EXPRESSION REGULATION; INHIBITION KINETICS; LIVER CELL; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; RAT; UPREGULATION;

EID: 33645953685     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hepres.2006.01.011     Document Type: Article

References (23)

1. Iredale J.P., and Arthur M.J. Hepatocyte-matrix interactions. Gut 35 (1994) 729-732
2. Nagaki M., Shidoji Y., Yamada Y., et al. Regulation of hepatic genes and liver transcription factors in rat hepatocytes by extracellular matrix. Biochem Biophys Res Commun 210 (1995) 38-43
3. Kuo C.J., Conley P.B., Chen L., et al. A transcriptional hierarchy involved in mammalian cell-type specification. Nature 355 (1992) 457-461
4. Cereghini S. Liver-enriched transcription factors and hepatocyte differentiation. FASEB J 10 (1996) 267-282
5. Hayhurst G.P., Lee Y.H., Lambert G., et al. Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol 21 (2001) 1393-1403
6. Sladek F.M., Zhong W.M., Lai E., et al. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev 4 (1990) 2353-2365
7. Duncan S.A., Manova K., Chen W.S., et al. Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proc Natl Acad Sci USA 91 (1994) 7598-7602
8. Oda H., Nozawa K., Hitomi Y., et al. Laminin-rich extracellular matrix maintains high level of hepatocyte nuclear factor 4 in rat hepatocyte culture. Biochem Biophys Res Commun 212 (1995) 800-805
9. Sánchez A., Álvarez A.M., Pagen R., et al. Fibronectin regulates morphology, cell organization and gene expression of rat fetal hepatocytes in primary culture. J Hepatol 32 (2000) 242-250
10. Naiki T., Nagaki M., Shidoji Y., et al. Functional activity of human hepatoma cells transfected with adenovirus-mediated hepatocyte nuclear factor(HNF)-4 gene. Cell Transplant 13 (2004) 393-403
11. Naiki T., Nagaki M., Asano T., et al. Adenovirus-mediated hepatocyte nuclear factor-4alpha overexpression maintains liver phenotype in cultured rat hepatocytes. Biochem Biophys Res Commun 335 (2005) 496-500
12. Hannon G.J. RNA interference. Nature 418 (2002) 244-251
13. Bernstein E., Caudy A.A., Hammond S.M., et al. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409 (2001) 363-366
14. Hammond S.M., Bernstein E., Beach D., et al. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404 (2000) 293-296
15. Elbashir S.M., Harborth J., Lendeckel W., et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411 (2001) 494-498
16. Caplen N.J., Parrish S., Imani F., et al. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc Natl Acad Sci USA 98 (2001) 9742-9747
17. Nagaki M., Miki K., Kim Y.I., et al. Development and characterization of a hybrid bioartificial liver using primary hepatocytes entrapped in a basement membrane matrix. Dig Dis Sci 46 (2001) 1046-1056
18. Nagaki M., Sugiyama A., Naiki T., et al. Control of cyclins, cyclin-dependent kinase inhibitors, p21 and p27, and cell cycle progression in rat hepatocytes by extracellular matrix. J Hepatol 32 (2000) 488-496
19. Chen W.S., Manova K., Weinstein D.C., et al. Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev 8 (1994) 2466-2477
20. Odom D.T., Zizsperger N., Gordon D.B., et al. Control of pancreas and liver gene expression by HNF transcription factors. Science 303 (2004) 1378-1381
21. Ben-Ze'ev A., Robinson G.S., Bucher N.L., et al. Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes. Proc Natl Acad Sci USA 85 (1998) 2161-2165
22. Hughes D.A. Control of signal transduction and morphogenesis by Ras. Semin Cell Biol 6 (1995) 89-94
23. 3. Curr Top Microbiol Immunol 282 (2004) 117-163