Development and characterization of a hybrid bioartificial liver using primary hepatocytes entrapped in a basement membrane matrix

Digestive Diseases and Sciences

Volumn 46, Issue 5, 2001, Pages 1046-1056

  Nagaki, Masahito ^a   Miki, Keisaburo ^b   Kim, Yang Il ^c   Ishiyama, Haruo ^b   Hirahara, Ichiro ^b   Takahashi, Hiroaki ^b   Sugiyama, Akihiko ^a   Muto, Yasutoshi ^a   Moriwaki, Hisataka ^a  

^a GIFU UNIVERSITY   (Japan)

^b Terumo R and D Center   (Japan)

^c Kyungpook National University School of Medicine   (South Korea)

Author keywords

Bioartificial liver; Differentiation; Extracellular matrix; Fulminant hepatic failure

Indexed keywords

ALBUMIN; AMMONIA; BICARBONATE; COLLAGEN; LACTIC ACID;

ANIMAL CELL; ARTICLE; ARTIFICIAL LIVER; BICARBONATE BLOOD LEVEL; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SUBSTRATE; EXTRACELLULAR MATRIX; HEMODYNAMICS; LIVER CELL; LIVER FAILURE; LIVER PERFUSION; NONHUMAN; PORTOCAVAL SHUNT; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY;

AMMONIA; ANIMALS; BASEMENT MEMBRANE; CELLS, CULTURED; COLLAGEN; CULTURE MEDIA; GELS; HEPATOCYTES; LACTATES; LACTOSE; LIVER FAILURE, ACUTE; LIVER, ARTIFICIAL; MALE; POLYSTYRENES; RATS; RATS, WISTAR; SWINE;

EID: 0035039454     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010714112675     Document Type: Article

References (37)

1. Medical progress: Acute liver failure
2. Fulminant hepatic failure: Summary of a workshop
3. Acute liver failure
4. Transplantation of the liver in adults and children with fulminant hepatic failure
5. New directions in acute liver failure
6. A hybrid bioartificial liver composed of multiplated hepatocyte monolayers
7. An improved model of acetaminophen-induced fulminant hepatic failure in dogs
8. Development of a bioartificial liver: Properties and function of a hollow-fiber module inoculated with liver cells
9. Development of a hybrid bioartificial liver
10. Gel-entrapment bioartificial liver therapy in galactosamine hepatitis
11. Pilot-controlled trial of the extracorporeal liver assist device in acute liver failure
12. Clinical experience with a bioartificial liver in the treatment of severe liver failure
13. Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver
14. Formation of multicellular spheroids composed of adult rat hepatocytes in dishes with positively charged surfaces and under other nonadherent environments
15. Receptor-mediated formation of multilayer aggregates of primary cultures adult rat hepatocytes on lactose-substitude polystyrene
16. Hepatocytes in collagen sandwich: Evidence for transcriptional and translational regulation
17. Regulation of hepatic genes and liver transcription factors in rat hepatocytes by extracellular matrix
18. Basement membrane complexes with biological activity
19. Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix
20. Role of extracellular matrix in regulating fenestrations of sinusoidal endothelial cells isolated from normal rat liver
21. Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes
22. Preparation of isolated rat liver cells
23. Effects of intraperitoneal transplantation of microcarrierattached hepatocytes on D-galactosamine-induced acute liver failure in rats
24. Controlled synthesis of HBs Ag in a differentiated human liver carcinoma-derived cell line
25. Growth of human hepatoma cell lines with differentiated functions in chemically defined medium
26. Establishment of a continuously growing cell line from primary carcinoma of the liver
27. Fluorometric quantification of DNA in cells and tissue
28. Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver
29. Hepatic glutaminase expression: Relationship to kidney-type glutaminase and to the urea cycle
30. Channeling of ammonia from glutaminase to carbamoyl-phosphate synthetase in liver mitochondria
31. Hepatocyte function and extracellular matrix geometry: Long-term culture in a sandwich configuration
32. Hepatic tissue engineering: Development of critical technologies
33. Hepatocytes in collagen sandwich: Evidence for transcriptional and translational regulation
34. A novel full-scale flat membrane bioreactor utilizing porcine hepatocytes: Cell viability and tissue-specific functions
35. Extracorporeal plasma perfusion of cultured hepatocytes: Effect of intermittent perfusion on hepatocyte function and morphology
36. Functional activity, of isolated pig hepatocytes attached to different extracellular matrix substrates. Implication for application of pig hepatocytes in a bioartificial liver
37. The hepatix extracorporeal liver assist device: Initial clinical experience