Reduction of organic nitrates catalysed by xanthine oxidoreductase under anaerobic conditions

Biochimica et Biophysica Acta - General Subjects

Volumn 1527, Issue 1-2, 2001, Pages 81-87

  Doel, J J ^a   Godber, B L J ^a   Eisenthal, R ^a   Harrison, R ^a  

^a University of Bath   (United Kingdom)

Author keywords

Glyceryl trinitrate; Nitric oxide; Xanthine dehydrogenase; Xanthine oxidase

Indexed keywords

FLAVINE ADENINE NUCLEOTIDE; GLYCERYL TRINITRATE; ISOSORBIDE DINITRATE; ISOSORBIDE MONONITRATE; NITRIC OXIDE; ORGANIC NITRATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; URATE; XANTHINE OXIDASE;

ANALYTIC METHOD; ARTICLE; CATALYSIS; ENZYME INACTIVATION; IN VIVO STUDY; PRIORITY JOURNAL; REACTION ANALYSIS; REDUCTION; STOICHIOMETRY;

ANAEROBIOSIS; ANIMALS; CATALYSIS; CATTLE; FLAVIN-ADENINE DINUCLEOTIDE; MOLYBDENUM; NITRATES; NITRITES; OXIDATION-REDUCTION; XANTHINE; XANTHINE DEHYDROGENASE; XANTHINE OXIDASE;

EID: 0035797084     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4165(01)00148-9     Document Type: Article

References (47)

1. Organic nitrate esters: Clinical use and mechanisms of actions
2. Biochemical mechanism of organic nitrate action
3. The nitrovasodilators: New ideas about old drugs
4. Nitrate therapy for stable angina pectoris
5. The biotransformation of nitroglycerin
6. The metabolic pathway in the degradation of glyceryl trinitrate
7. Requirement of thiols for activation of coronary arterial guanylate cyclase by glycerol trinitrate and sodium nitrite: Possible involvement of S-nitrosothiols
8. Biochemical and pharmacological interactions between nitroglycerin and thiols
9. Differential formation of dinitrate metabolites from glyceryl trinitrate in subcellular fractions of rabbit liver
10. Metabolism of nitroglycerin by smooth muscle cells. Involvement of glutathione and glutathione-S-transferase
11. 2 formation
12. Conversion of glyceryl trinitrite to nitric oxide in tolerant and non-tolerant smooth muscle and endothelial cells
13. Nitric oxide formation during microsomal hepatic denitration of glyceryl trinitrate: Involvement of cytochrome P450
14. Cytochrome P-450 mediates biotransformation of organic nitrates
15. Cytochrome P-450 mediates bioactivation of organic nitrates
16. Investigation of aortic CYP3A bioactivation of nitroglycerin in vivo
17. Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions
18. Milk xanthine dehydrogenase: The first one hundred years
19. The mononuclear molybdenum enzymes
20. Oxygen-derived free radicals in post-ischemic tissue injury
21. Reduction of nitrite to nitric oxide catalysed by xanthine oxidoreductase
22. On the mechanism of inactivation of xanthine oxidase by allopurinol and other pyrazolo[3,4-d]pyrimidines
23. Cellular constituents. The chemistry of xanthine oxidase. Part III. Estimations of the cofactors and the catalytic functions of enzyme fractions from cows' milk
24. The preparation and properties of deflavo xanthine oxidase
25. Evidence for the inorganic nature of the cyanolyzable sulfur of molybdenum hydroxylases
26. The extinction coefficients of the reduced band of pyridine nucleosides
27. Bemerkungen zu der abhandlung der HH. Weselsky und Benedikt 'ueber einige azoverbindungen'
28. Ueber die einwirkung von salpetrigsaureanhydrid auf glycerin
29. Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase
30. The determination of enzyme inhibitor constants
31. A simple graphical method for determining the inhibition constants of mixed, uncompetitive and non-competitive inhibitors
32. NADH oxidase activity of human xanthine oxidoreductase. Generation of superoxide anion
33. Reduction of organic nitrites to nitric oxide catalyzed by xanthine oxidase: Possible role in metabolism of nitrovasodilators
34. Differences in protein structure of xanthine dehydrogenase and xanthine oxidase revealed by reconstitution with flavin active site probes
35. 2-dependent types of rat liver xanthine dehydrogenase shown by an active site probe study
36. Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion
37. Identification of the subcellular site for nitroglycerin metabolism to nitric oxide in bovine coronary smooth muscle
38. Conversion of nitroglycerin to nitric oxide in microsomes of the bovine coronary artery smooth muscle is not primarily mediated by glutathione-S-transferases
39. Localization of xanthine oxidase in mammary gland epithelium and capillary endothelium
40. Xanthine oxidoreductase is asymmetrically localised on the outer surface of human endothelial and epithelial cells in culture
41. Phenomenon of nitrate tolerance
42. Tolerance: An historical overview
43. Nitrate tolerance is specific for nitric acid esters and its recovery requires an intact protein synthesis
44. Nitric oxide inhibits vascular bioactivation of glyceryl trinitrate: A novel mechanism to explain preferential venodilation of organic nitrates
45. Possible involvement of nitroglycerin converting step in nitroglycerin tolerance