Synthesis of a potent 5′-methylthioadenosine/S-adenosylhomocysteine (MTAN) inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 10, 2006, Pages 2662-2665

  Kamath, Vivekanand P ^a   Zhang, Jainwen ^a   Morris Jr , Philip E ^a   Babu, Y Sudhakar ^a  

^a BIOCRYST PHARMACEUTICALS INC   (United States)

Author keywords

PNP; Purine pathway

Indexed keywords

2 AMINO 4 [5 (4 AMINO 5H PYRROLO[3,2 D]PYRIMIDIN 7 YL) 3,4 DIHYDROXYPYRROLIDIN 2 YLMETHYLSULFANYL]BUTYRIC ACID; 5' METHYLTHIOADENOSINE; 5' METHYLTHIOADENOSINE NUCLEOSIDASE INHIBITOR; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BUTYRIC ACID DERIVATIVE; ENZYME INHIBITOR; PYRIMIDINE DERIVATIVE; S ADENOSYLHOMOCYSTEINE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL CELL; BACTERIAL INFECTION; BACTERIAL STRAIN; CELL TYPE; DRUG POTENCY; DRUG SYNTHESIS; MOLECULAR EVOLUTION;

BUTYRIC ACIDS; DEOXYADENOSINES; S-ADENOSYLHOMOCYSTEINE; SPECTROPHOTOMETRY, ULTRAVIOLET; THIONUCLEOSIDES;

BACTERIA (MICROORGANISMS);

EID: 33645851017     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.02.029     Document Type: Article

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