Synthesis of a Potent Transition-State Inhibitor of 5′-Deoxy-5′ -methylthioadenosine Phosphorylase

Journal of Medicinal Chemistry

Volumn 47, Issue 6, 2004, Pages 1322-1324

  Kamath, Vivekanand P ^a   Ananth, Sandya ^a   Bantia, Shanta ^a   Morris Jr , Philip E ^a  

^a BIOCRYST PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 AMINO 5H PYRROLO[3,2 D]PYRIMIDIN 7 YL) 5 METHYLSULFANYLMETHYLPYRROLIDINE 3,4 DIOL; 5' METHYLTHIOADENOSINE PHOSPHORYLASE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CLINICAL PATHWAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; PURINE SYNTHESIS; RADIOCHEMISTRY;

ADENOSINE; ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL LINE, TUMOR; HUMANS; PURINE-NUCLEOSIDE PHOSPHORYLASE; PYRROLIDINES;

EID: 1542298120     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030455+     Document Type: Article

References (23)

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23. During the revision of the manuscript, the authors became aware of an accelerated Web edition manuscript that described several potent inhibitors of MTAP. The manuscript described several inhibitors with picomolar activity as well as the compound described in this manuscript. Singh, V.; Shi, W.; Evans, G. B.; Tyler, P. C.; Furneaux, R. H.; Almo, S. C.; Schramm, V. L. Picomolar Transition State Analogue Inhibitors of Human 5′-Methylthioadenosine Phosphorylase and X-ray Structure with MT-Immucillin-A. Biochemistry, in press.