Novel synthesis of O6-alkylguanine containing oligodeoxyribonucleotides as substrates for the human DNA repair protein, O6-methylguanine DNA methyltransferase (MGMT)

Nucleic Acids Research

Volumn 34, Issue 6, 2006, Pages 1884-1891

  Shibata, Takayuki ^a   Glynn, Nicola ^b   McMurry, T Brian H ^c   McElhinney, R Stanley ^c   Margison, Geoffrey P ^b   Williams, David M ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 THIO 2' DEOXYGUANOSINE; 9 (2' DEOXYRIBOFURANOSYL) N2 [(DIMETHYLAMINO)METHYLIDENE] 2 AMINO 6 METHYLSULFONYLPURINE; 9 (5' O DIMETHOXYTRITYL 2' DEOXYRIBOFURANOSYL) N2 [(DIMETHYLAMINO)METHYLIDENE] 2 AMINO 6 METHYLSULFONYLPURINE; 9 (5' O DIMETHOXYTRITYL 2' DEOXYRIBOFURANOSYL) N2 [(DIMETHYLAMINO)METHYLIDENE] 2 AMINO 6 METHYLSULFONYLPURINE 3' (2 CYANOETHYL N,N DIISOPROPYL)PHOSPHORAMIDITE; 9 [3',5' BIS(TERT BUTYLDIMETHYLSILYL) 2' DEOXYRIBOFURANOSYL] 2 AMINO 6 METHYLSULFANYLPURINE; 9 [3',5' BIS(TERT BUTYLDIMETHYLSILYL) 2' DEOXYRIBOFURANOSYL] 2 AMINO 6 METHYLSULFONYLPURINE; 9 [3',5' O BIS(TERT BUTYLDIMETHYLSILYL) 2' DEOCYRIBOFURANOSYL] N2 [(DIMETHYLAMINO)METHYLIDENE] 2 AMINO 6 METHYLSULFONYLPURINE; ALKYLATING AGENT; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METHYLTRANSFERASE INHIBITOR; OLIGODEOXYRIBONUCLEOTIDE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PURINE DERIVATIVE; UNCLASSIFIED DRUG; DRUG DERIVATIVE; GUANINE; O(6) (4 BROMOTHENYL)GUANINE; O(6)-(4-BROMOTHENYL)GUANINE; ORGANOPHOSPHORUS COMPOUND; PHOSPHORAMIDOUS ACID;

ARTICLE; CANCER RESISTANCE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INACTIVATION; HUMAN; IC 50; PRIORITY JOURNAL; PROTEIN FUNCTION; STRUCTURE ANALYSIS; CHEMISTRY; METABOLISM; SYNTHESIS;

GUANINE; HUMANS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; OLIGODEOXYRIBONUCLEOTIDES; ORGANOPHOSPHORUS COMPOUNDS;

EID: 33645835907     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkl117     Document Type: Article

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