메뉴 건너뛰기




Volumn 7, Issue 4, 2006, Pages 344-348

New targets in and potential treatments for cholesterol gallstone disease

Author keywords

muricholic acid; 6 ethyl chenodeoxycholic acid; Bile acid conjugates; Bile acid transporters; C57L gallstone susceptible mice; Farnesoid X receptor (FXR); FXR mice; Gallstone disease; GW 4064

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; 6ALPHA ETHYL CHENODEOXYCHOLIC ACID; ABC TRANSPORTER; ARACHIDYL AMINO CHOLANOIC ACID; BETA MURICHOLIC ACID; BILE ACID; CHENODEOXYCHOLIC ACID; CHOLESTEROL; FARNESOID X RECEPTOR; FATTY ACID; INT 747; MUCIN; SC 435; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID;

EID: 33645810414     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (9)

References (27)
  • 1
    • 25144518617 scopus 로고    scopus 로고
    • Gallstones - Approach to medical management
    • October 15
    • Konikoff FM: Gallstones - approach to medical management. MedGenMed Gastroenterology (2003):October 15. http://www.medscape.com/viewarticle/460309
    • (2003) MedGenMed Gastroenterology
    • Konikoff, F.M.1
  • 2
    • 33645829218 scopus 로고    scopus 로고
    • The biliary system
    • March 10
    • Shaffer EA: The biliary system. Gastroenterology Resource Centre. (2006):March 10. http://gastroresource.com/gitextbook/en/chapter13/13-1-pr.htm
    • (2006) Gastroenterology Resource Centre
    • Shaffer, E.A.1
  • 6
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinai CJ, Tohkin M, Miyata M, Ward JM, Lambert G, Gonzalez FJ: Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell (2000) 102(6):731-744.
    • (2000) Cell , vol.102 , Issue.6 , pp. 731-744
    • Sinai, C.J.1    Tohkin, M.2    Miyata, M.3    Ward, J.M.4    Lambert, G.5    Gonzalez, F.J.6
  • 7
    • 11144318237 scopus 로고    scopus 로고
    • Prevention of cholesterol gallstone disease by FXR agonist in a mouse model
    • Moschetta A, Bookout AL, Mangelsdorf DJ: Prevention of cholesterol gallstone disease by FXR agonist in a mouse model. Nat Med (2004) 12(12):1352-1358.
    • (2004) Nat Med , vol.12 , Issue.12 , pp. 1352-1358
    • Moschetta, A.1    Bookout, A.L.2    Mangelsdorf, D.J.3
  • 9
    • 0036845139 scopus 로고    scopus 로고
    • Effect of β-muricholic acid on the prevention and dissolution of cholesterol gallstones in C57L/J mice
    • Wang DQ, Tazuma S: Effect of β-muricholic acid on the prevention and dissolution of cholesterol gallstones in C57L/J mice. J Lipid Res (2002) 43(11):1960-1968.
    • (2002) J Lipid Res , vol.43 , Issue.11 , pp. 1960-1968
    • Wang, D.Q.1    Tazuma, S.2
  • 11
    • 4143056853 scopus 로고    scopus 로고
    • Bile acid derivatives as ligands of the farnesold X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid
    • Pellicciari R, Constantino G, Camaioni E, Sadeghpour BM, Entrena A, Wilson TM, Fiorucci S, Clerici C, Gioiello A: Bile acid derivatives as ligands of the farnesold X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid. J Med Chem (2004) 47(18):4559-4569.
    • (2004) J Med Chem , vol.47 , Issue.18 , pp. 4559-4569
    • Pellicciari, R.1    Constantino, G.2    Camaioni, E.3    Sadeghpour, B.M.4    Entrena, A.5    Wilson, T.M.6    Fiorucci, S.7    Clerici, C.8    Gioiello, A.9
  • 13
    • 77958028757 scopus 로고    scopus 로고
    • Fatty acid bile acid conjugates (FABACs) - New molecules for the prevention of cholesterol crystallisation in bile
    • Gilat T, Somjen GJ, Mazur Y, Leikin-Frenkel A, Rosenberg R, Halpern Z, Konikoff F: Fatty acid bile acid conjugates (FABACs) - new molecules for the prevention of cholesterol crystallisation in bile. Gut (2001) 48(1):75-79.
    • (2001) Gut , vol.48 , Issue.1 , pp. 75-79
    • Gilat, T.1    Somjen, G.J.2    Mazur, Y.3    Leikin-Frenkel, A.4    Rosenberg, R.5    Halpern, Z.6    Konikoff, F.7
  • 14
    • 0035200386 scopus 로고    scopus 로고
    • Arachidyl amido cholanoic acid (Aramchol) is a cholesterol solubilizer and prevents the formation of cholesterol gallstones in inbred mice
    • Gilat T, Leiken-Frenkel A, Goldiner L, Laufer H, Halpern Z, Konikoff FM: Arachidyl amido cholanoic acid (Aramchol) is a cholesterol solubilizer and prevents the formation of cholesterol gallstones in inbred mice. Lipids (2001) 36(10):1135-1140.
    • (2001) Lipids , vol.36 , Issue.10 , pp. 1135-1140
    • Gilat, T.1    Leiken-Frenkel, A.2    Goldiner, L.3    Laufer, H.4    Halpern, Z.5    Konikoff, F.M.6
  • 15
    • 0036783669 scopus 로고    scopus 로고
    • 1-[4-4[4R,5R)-3,3-dibutyl-7-(dimethylamino)- 2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin- 5-yl]phenoxyl]butyl]-4-aza-1-azonia-bicyclo[2.2.2]octane methanesulfonate (SC-435), an ileal apical sodium-codependent bile acid transporter inhibitor alters hapatic cholesterol metabolism and lowers plasma low-density lipoprotein-cholesterol concentrations in guinea pigs
    • West KL, Ramjiganesh T, Roy S, Keller BT, Fernandez ML: 1-[4-4[4R,5R)-3,3-dibutyl-7-(dimethylamino) -2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin- 5-yl]phenoxyl]butyl]-4-aza-1-azonia-bicyclo[2.2.2]octane methanesulfonate (SC-435), an ileal apical sodium-codependent bile acid transporter inhibitor alters hapatic cholesterol metabolism and lowers plasma low-density lipoprotein-cholesterol concentrations in guinea pigs. J Pharmacol Exp Ther (2002) 303(1):293-299.
    • (2002) J Pharmacol Exp Ther , vol.303 , Issue.1 , pp. 293-299
    • West, K.L.1    Ramjiganesh, T.2    Roy, S.3    Keller, B.T.4    Fernandez, M.L.5
  • 16
    • 3042662820 scopus 로고    scopus 로고
    • Inhibition of ileal bile acid transport lowers plasma cholesterol levels by inactivating hepatic farnesoid X receptor and stimulating cholesterol 7α-hydoxylase
    • Li H, Xu G, Shang Q, Pan L, Shefer S, Batta AK, Bollineni J, Tint GS, Keller BT, Salen G: Inhibition of ileal bile acid transport lowers plasma cholesterol levels by inactivating hepatic farnesoid X receptor and stimulating cholesterol 7α-hydoxylase. Metabolism (2004) 53(7):927-932.
    • (2004) Metabolism , vol.53 , Issue.7 , pp. 927-932
    • Li, H.1    Xu, G.2    Shang, Q.3    Pan, L.4    Shefer, S.5    Batta, A.K.6    Bollineni, J.7    Tint, G.S.8    Keller, B.T.9    Salen, G.10
  • 20
    • 0141674797 scopus 로고    scopus 로고
    • ABC transporter regulation by bile acids: Where PXR maets FXR
    • Kullak-Ublick GA: ABC transporter regulation by bile acids: Where PXR maets FXR. J Hepatol (2003) 39(4):628-630.
    • (2003) J Hepatol , vol.39 , Issue.4 , pp. 628-630
    • Kullak-Ublick, G.A.1
  • 21
    • 0344196943 scopus 로고    scopus 로고
    • Hepatic canalicular membrane transport of bile salt in C57L/J and AKR/J mice: Implications for cholesterol gallstone formation
    • Hoda F, Green RM: Hepatic canalicular membrane transport of bile salt in C57L/J and AKR/J mice: Implications for cholesterol gallstone formation. J Membr Biol (2003) 196(1):9-14.
    • (2003) J Membr Biol , vol.196 , Issue.1 , pp. 9-14
    • Hoda, F.1    Green, R.M.2
  • 23
    • 0033984873 scopus 로고    scopus 로고
    • Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver
    • Stieger B, Fattinger K, Madon J, Kullak-Ublick GA, Meier PJ: Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. Gastroenterology (2000) 118(2):422-430.
    • (2000) Gastroenterology , vol.118 , Issue.2 , pp. 422-430
    • Stieger, B.1    Fattinger, K.2    Madon, J.3    Kullak-Ublick, G.A.4    Meier, P.J.5
  • 24
    • 24944483081 scopus 로고    scopus 로고
    • Bile acid transport in sister of P-glycoprotein (ABCB11) knockout mice
    • Lam P, Wang R, Ling V: Bile acid transport in sister of P-glycoprotein (ABCB11) knockout mice. Biochemistry (2005) 44(37):12598-12605.
    • (2005) Biochemistry , vol.44 , Issue.37 , pp. 12598-12605
    • Lam, P.1    Wang, R.2    Ling, V.3
  • 26
    • 1542723749 scopus 로고    scopus 로고
    • Targeted disruption of the murine mucin gene 1 decreases susceptibility to chotesterol gallstone formation
    • Wang HH, Afdhal NH, Gendler SJ, Wang DQ-H: Targeted disruption of the murine mucin gene 1 decreases susceptibility to chotesterol gallstone formation. J Lipid Res (2004) 45(3):438-447.
    • (2004) J Lipid Res , vol.45 , Issue.3 , pp. 438-447
    • Wang, H.H.1    Afdhal, N.H.2    Gendler, S.J.3    Wang, D.Q.-H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.