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Volumn 176, Issue 8, 2006, Pages 4902-4913

Novel immunostimulatory agent based on CpG oligodeoxynucleotide linked to the nontoxic B subunit of cholera toxin

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CHOLERA TOXIN B SUBUNIT; CPG OLIGODEOXYNUCLEOTIDE; CPG OLIGODEOXYNUCLEOTIDE CHOLERA TOXIN B SUBUNIT; CYTOKINE; GANGLIOSIDE GM1; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G; IMMUNOLOGICAL ADJUVANT; IMMUNOSTIMULATING AGENT; MYELOID DIFFERENTIATION FACTOR 88; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; TETANUS TOXOID; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

EID: 33645790032     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.8.4902     Document Type: Article
Times cited : (30)

References (30)
  • 1
    • 0033779762 scopus 로고    scopus 로고
    • The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides
    • Weiner, G. J. 2000. The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides. J. Leukocyte Biol. 68: 455-463.
    • (2000) J. Leukocyte Biol. , vol.68 , pp. 455-463
    • Weiner, G.J.1
  • 2
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg, A. M. 2002. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20: 709-760.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 3
    • 3042725534 scopus 로고    scopus 로고
    • CpG DNA as potent inducer of mucosal immunity: Implications for immunoprophylaxis and immunotherapy of mucosal infections
    • Harandi, A. M., and J. Holmgren. 2004. CpG DNA as potent inducer of mucosal immunity: implications for immunoprophylaxis and immunotherapy of mucosal infections. Curr. Opin. Invest. Drugs 5: 141-145.
    • (2004) Curr. Opin. Invest. Drugs , vol.5 , pp. 141-145
    • Harandi, A.M.1    Holmgren, J.2
  • 4
    • 0027672189 scopus 로고
    • Stimulation of in vitro proliferation of murine lymphocytes by synthetic oligodeoxynucleotides
    • Pisetsky, D. S., and C. Reich. 1993. Stimulation of in vitro proliferation of murine lymphocytes by synthetic oligodeoxynucleotides. Mol. Biol. Rep. 18: 217-221.
    • (1993) Mol. Biol. Rep. , vol.18 , pp. 217-221
    • Pisetsky, D.S.1    Reich, C.2
  • 5
    • 0036226045 scopus 로고    scopus 로고
    • Activation of the immune system by bacterial CpG-DNA
    • Hacker, G., V. Redecke, and H. Hacker. 2002. Activation of the immune system by bacterial CpG-DNA. Immunology 105: 245-251.
    • (2002) Immunology , vol.105 , pp. 245-251
    • Hacker, G.1    Redecke, V.2    Hacker, H.3
  • 6
    • 0029984358 scopus 로고    scopus 로고
    • CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon γ
    • Klinman, D. M., A. K. Yi, S. L. Beaucage, J. Conover, and A. M. Krieg. 1996. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon γ. Proc. Natl. Acad. Sci. USA 93: 2879-2883.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2879-2883
    • Klinman, D.M.1    Yi, A.K.2    Beaucage, S.L.3    Conover, J.4    Krieg, A.M.5
  • 7
    • 0034650517 scopus 로고    scopus 로고
    • Mechanism and function of a newly identified CpG DNA motif in human primary B cells
    • Hartmann, G., and A. M. Krieg. 2000. Mechanism and function of a newly identified CpG DNA motif in human primary B cells. J. Immunol. 164: 1617-1624.
    • (2000) J. Immunol. , vol.164 , pp. 1617-1624
    • Hartmann, G.1    Krieg, A.M.2
  • 9
    • 0034295582 scopus 로고    scopus 로고
    • Intranasal immunization of mice with CpG DNA induces strong systemic and mucosal responses that are influenced by other mucosal adjuvants and antigen distribution
    • McCluskie, M. J., R. D. Weeratna, and H. L. Davis. 2000. Intranasal immunization of mice with CpG DNA induces strong systemic and mucosal responses that are influenced by other mucosal adjuvants and antigen distribution. Mol. Med. 6: 867-877.
    • (2000) Mol. Med. , vol.6 , pp. 867-877
    • McCluskie, M.J.1    Weeratna, R.D.2    Davis, H.L.3
  • 10
    • 0842326199 scopus 로고    scopus 로고
    • Transcutaneous immunization with combined cholera toxin and CpG adjuvant protects against Chlamydia muridarum genital tract infection
    • Berry, L. J., D. K. Hickey, K. A. Skelding, S. Bao, A. M. Rendina, P. M. Hansbro, C. M. Gockel, and K. W. Beagley. 2004. Transcutaneous immunization with combined cholera toxin and CpG adjuvant protects against Chlamydia muridarum genital tract infection. Infect. Immun. 72: 1019-1028.
    • (2004) Infect. Immun. , vol.72 , pp. 1019-1028
    • Berry, L.J.1    Hickey, D.K.2    Skelding, K.A.3    Bao, S.4    Rendina, A.M.5    Hansbro, P.M.6    Gockel, C.M.7    Beagley, K.W.8
  • 11
    • 0032209286 scopus 로고    scopus 로고
    • CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice
    • McCluskie, M., and H. L. Davis. 1998. CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice. J. Immunol. 161: 4463-4466.
    • (1998) J. Immunol. , vol.161 , pp. 4463-4466
    • McCluskie, M.1    Davis, H.L.2
  • 12
    • 0019448149 scopus 로고
    • Actions of cholera toxin and the prevention and treatment of cholera
    • Holmgren, J. 1981. Actions of cholera toxin and the prevention and treatment of cholera. Nature 292: 413-417.
    • (1981) Nature , vol.292 , pp. 413-417
    • Holmgren, J.1
  • 13
    • 1942487871 scopus 로고    scopus 로고
    • Cholera toxin: A paradigm for multi-functional engagement of cellular mechanisms
    • de Haan, L., and T. R. Hirst. 2004. Cholera toxin: a paradigm for multi-functional engagement of cellular mechanisms. Mol. Membrane Biol. 21: 77-92.
    • (2004) Mol. Membrane Biol. , vol.21 , pp. 77-92
    • De Haan, L.1    Hirst, T.R.2
  • 14
    • 0038330428 scopus 로고    scopus 로고
    • Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA
    • Holmgren, J., A. M. Harandi, and C. Czerkinsky. 2003. Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA. Expert Rev. Vaccines 2: 205-217.
    • (2003) Expert Rev. Vaccines , vol.2 , pp. 205-217
    • Holmgren, J.1    Harandi, A.M.2    Czerkinsky, C.3
  • 15
    • 0018721005 scopus 로고
    • Evaluation of a gangliossde immunosorbent assay for detection of Escherichia coli heat-labile enterotoxin
    • Back, E., A. M. Svennerholm, J. Holmgren, and R. Mollby. 1979. Evaluation of a gangliossde immunosorbent assay for detection of Escherichia coli heat-labile enterotoxin. J. Clin. Microbiol. 10: 791-795.
    • (1979) J. Clin. Microbiol. , vol.10 , pp. 791-795
    • Back, E.1    Svennerholm, A.M.2    Holmgren, J.3    Mollby, R.4
  • 16
    • 0034699340 scopus 로고    scopus 로고
    • Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88
    • Schnare, M., A. C. Holt, K. Takeda, S. Akira, and R. Medzhitov. 2000. Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Curr. Biol. 10: 1139-1142.
    • (2000) Curr. Biol. , vol.10 , pp. 1139-1142
    • Schnare, M.1    Holt, A.C.2    Takeda, K.3    Akira, S.4    Medzhitov, R.5
  • 18
    • 0032732168 scopus 로고    scopus 로고
    • Antagonism of immunostimulatory CpG-oligodeoxynucleotides by 4-aminoquinolines and other weak bases: Mechanistic studies
    • Manzel, L., L. Strekowsk, P. M. Ismail, J. C. Smith, and D. E. Macfarlane. 1999. Antagonism of immunostimulatory CpG-oligodeoxynucleotides by 4-aminoquinolines and other weak bases: mechanistic studies. J. Pharmacol. Exp. Ther. 291: 1337-1347.
    • (1999) J. Pharmacol. Exp. Ther. , vol.291 , pp. 1337-1347
    • Manzel, L.1    Strekowsk, L.2    Ismail, P.M.3    Smith, J.C.4    Macfarlane, D.E.5
  • 19
    • 0031936182 scopus 로고    scopus 로고
    • Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds
    • Macfarlane, D. E., and L. Manzel. 1998. Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds. J. Immunol. 160: 1122-1131.
    • (1998) J. Immunol. , vol.160 , pp. 1122-1131
    • Macfarlane, D.E.1    Manzel, L.2
  • 20
    • 0037099629 scopus 로고    scopus 로고
    • Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation
    • Ishii, K. J., F. Takeshita, I. Gursel, M. Gursel, J. Conover, A. Nussenzweig, and D. M. Klinman. 2002. Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation. J. Exp. Med. 196: 269-274.
    • (2002) J. Exp. Med. , vol.196 , pp. 269-274
    • Ishii, K.J.1    Takeshita, F.2    Gursel, I.3    Gursel, M.4    Conover, J.5    Nussenzweig, A.6    Klinman, D.M.7
  • 23
    • 33645768593 scopus 로고    scopus 로고
    • Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways
    • Yasuda, K., P. Yu, C. J. Kirschning, B. Schlatter, F. Schmitz, A. Heit, S. Bauer, H. Hochrein, and H. Wagner. 2005. Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways. J. Immunol. 164: 1617-1624.
    • (2005) J. Immunol. , vol.164 , pp. 1617-1624
    • Yasuda, K.1    Yu, P.2    Kirschning, C.J.3    Schlatter, B.4    Schmitz, F.5    Heit, A.6    Bauer, S.7    Hochrein, H.8    Wagner, H.9
  • 26
    • 17844380477 scopus 로고    scopus 로고
    • Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
    • Honda, K., Y. Ohba, H. Yanai, H. Negishi, T. Mizutani, A. Takaoka, C. Taya, and T. Taniguchi. 2005. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434: 1035-1040.
    • (2005) Nature , vol.434 , pp. 1035-1040
    • Honda, K.1    Ohba, Y.2    Yanai, H.3    Negishi, H.4    Mizutani, T.5    Takaoka, A.6    Taya, C.7    Taniguchi, T.8
  • 27
    • 4043065769 scopus 로고    scopus 로고
    • Necessity of oligonucleotide aggregation for Toll-like receptor 9 activation
    • Wu, C. C., J. Lee, E. Raz, M. Corr, and D. A. Carson. 2004. Necessity of oligonucleotide aggregation for Toll-like receptor 9 activation. J. Biol Chem. 279: 33071-33078.
    • (2004) J. Biol Chem. , vol.279 , pp. 33071-33078
    • Wu, C.C.1    Lee, J.2    Raz, E.3    Corr, M.4    Carson, D.A.5
  • 29
    • 15444378922 scopus 로고    scopus 로고
    • Protective CD8 T cell immunity triggered by CpG-protein conjugates competes with the efficacy of live vaccines
    • Heit, A., F. Schmitz, M. O'Keeffe, C. Staib, D. H. Busch, H. Wagner, and K. M. Huster. 2005. Protective CD8 T cell immunity triggered by CpG-protein conjugates competes with the efficacy of live vaccines. J. Immunol. 174: 4373-4380.
    • (2005) J. Immunol. , vol.174 , pp. 4373-4380
    • Heit, A.1    Schmitz, F.2    O'Keeffe, M.3    Staib, C.4    Busch, D.H.5    Wagner, H.6    Huster, K.M.7
  • 30
    • 0035399836 scopus 로고    scopus 로고
    • Novel roles of CpG oligodeoxynucleotides as a leader for the sampling and presentation of CpG-tagged antigen by dendritic cells
    • Shirota, H., K. Sano, N. Hirasawa, T. Terui, K. Ohuchi, T. Hattori, K. Shirato, and G. Tamura. 2001. Novel roles of CpG oligodeoxynucleotides as a leader for the sampling and presentation of CpG-tagged antigen by dendritic cells. J. Immunol. 167: 66-74.
    • (2001) J. Immunol. , vol.167 , pp. 66-74
    • Shirota, H.1    Sano, K.2    Hirasawa, N.3    Terui, T.4    Ohuchi, K.5    Hattori, T.6    Shirato, K.7    Tamura, G.8


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