Use of human antigen presenting cell gene array profiling to examine the effect of human T-cell leukemia virus type 1 Tax on primary human dendritic cells

Journal of NeuroVirology

Volumn 12, Issue 1, 2006, Pages 47-59

  Ahuja, Jaya ^a   Kampani, Karan ^a   Datta, Suman ^a   Wigdahl, Brian ^a   Flaig, Katherine E ^a   Jain, Pooja ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Dendritic cells; HTLV 1; HTLV 1 Tax; Microarray

Indexed keywords

CELL ADHESION MOLECULE; CELL PROTEIN; CHEMOKINE; CYTOKINE; TAX PROTEIN; TOLL LIKE RECEPTOR;

ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; CELL ACTIVATION; CENTRAL NERVOUS SYSTEM INFECTION; DENDRITIC CELL; DNA FINGERPRINTING; GENE EXPRESSION REGULATION; GENETIC CODE; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS; LYMPHOCYTE FUNCTION; MICROARRAY ANALYSIS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T CELL LEUKEMIA; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

ANTIGEN-PRESENTING CELLS; DENDRITIC CELLS; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, VIRAL; GENE PRODUCTS, TAX; HTLV-I INFECTIONS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 33645787800     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/13550280600614981     Document Type: Article

References (67)

1. Alefantis, T and Mostoller, K and Jain, P and Harhaj, E and Grant, C and Wigdahl, B. (2005a) Secretion of the human T cell leukemia virus type 1 (HTLV-1) transactivator protein Tax J Biol Chem, 280, pp. 17353-17362. [PUBMED] [INFOTRIEVE] [CSA]
2. Alefantis, T and Jain, P and Ahuja, J and Mostoller, K and Wigdahl, B. (2005b) HTLV-1 Tax nucleocytoplasmic shuttling, interaction with the secretory pathway, extracellular signaling, and implications for neurologic disease J Biomed Sci, 12, pp. 961-974. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
3. Alexopoulou, L and Holt, A and Medzhitov, R and Flavell, R. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by toll-like receptor 3 Nature, 413, pp. 732-738. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
4. Ali, A and Patterson, S and Cruickshank, K and Rudge, P and Daldleish, A and Knight, S. (1993) Dendritic cells infected in vitro with human T cell leukaemia/lymphoma virus type-1 (HTLV-1); enhanced lymphocytic proliferation and tropical spastic paraparesis Clin Exp Immunol, 94, pp. 32-37. [PUBMED] [INFOTRIEVE] [CSA]
5. Azimi, N and Mariner, J and Jacobson, S and Waldmann, T. (2000) How does interleukin 15 contribute to the pathogenesis of HTLV type 1-associated myelopathy/tropical spastic paraparesis? AIDS Res Hum Retroviruses, 16, pp. 1717-1722. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
6. Azran, I and Schavinsky-Khrapunsky, Y and Aboud, M. (2004) Role of Tax protein in human T-cell leukemia virus type-1 leukemogenicity Retrovirology, 1, pp. 20. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
7. Banchereau, J and Steinman, R. (1998) Dendritic cells and the control of immunity Nature, 392, pp. 245-252. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
8. Biddison, W and Kubota, R and Kawanishi, T and Taub, D and Cruikshank, W and Center, D and Connor, E and Utz, U and Jacobson, S. (1997) Human T cell leukemia virus type 1 (HTLV-1)-specific CD8+ CTL clones from patients with HTLV associated neurologic disease secrete proinflammatory cytokines, chemokines, and matrix metalloproteinase J Immunol, 159, pp. 2018-2025. [PUBMED] [INFOTRIEVE] [CSA]
9. Bonjardim, C. (2005) Interferons (IFNs) are key cytokines in both innate and adaptive immune responses-and viruses counteract IFN action Microbes and Infection, 7, pp. 569-578. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
10. Bowie, A and Haga, I. (2005) The role of toll-like receptors in the host response to virus Mol Immunol, 42, pp. 859-867. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
11. Brady, J. (1992) Extracellular Tax1 protein stimulates NF-κB and expression of NF-κB-responsive Ig kappa and TNF beta genes in lymphoid cells AIDS Res Hum Retroviruses, 8, pp. 724-727. [PUBMED] [INFOTRIEVE] [CSA]
12. Cartier Rovirosa, L and Ramirez, E. (2005) Presence of HTLV-1 Tax protein in cerebrospinal fluid from HAM/TSP patients Arch Virol, 150, pp. 743-753. [CROSSREF] [CSA]
13. Cowan, E and Alexander, R and Daniel, S and Kashanchi, F and Brady, J. (1997) Induction of tumor necrosis factor alpha in human neuronal cells by extracellular human T-cell lymphotropic virus type 1 Tax1 J Virol, 71, pp. 6982-6989. [PUBMED] [INFOTRIEVE] [CSA]
14. de, L and Feunte, C and Deng, L and Santiago, F and Arce, L and Wang, L and Kashanchi, F. (2000) Gene expression array of HTLV type 1-infected T cells: Up-regulation of transcription factors and cell cycle genes AIDS Res Hum Retroviruses, 16, pp. 1695-1700. [CROSSREF] [CSA]
15. de, l and Fuente, H and Mittelbrunn, M and Sanchez-Martin, L and Vicente-Manzanares, M and Lamana, A and Pardi, R and Cabanas, C and Sanchez-Madrid, F. (2005) Synaptic clusters of MHC class II molecules induced on DCs by adhesion molecule-meidated initial T cell scanning Mol Biol Cell, 16, pp. 3314-3322. [CROSSREF] [CSA]
16. Dhib-Jalbut, S and Hoffman, P and Yamabe, T and Sun, D and Xia, J and Eisenberg, H and Bergey, G and Ruscetti, F. (1994) Extracellular human T-cell lymphotropic virus type 1 Tax protein induces cytokine production in adult human microglial cells Annals of Neurology, 36, pp. 787-790. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
17. Dodon, M and Li, Z and Hamaia, S and Gazzolo, L. (2004) Tax protein of human T-cell leukemia virus type 1 induces interleukin 17 gene expression in T cells J Gen Virol, 85, pp. 1921-1932. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
18. Elovaara, I and Koenig, S and Brewah, A and Woods, R and Lehky, T and Jacobson, S. (1993) High human T cell lymphotropic virus type 1 (HTLV-1)-specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-1-associated neurological disease J Exp Med, 177, pp. 1567-1573. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
19. Fanales-Belasio, E and Moretti, S and Nappi, F and Barillari, G and Micheletti, F and Cafaro, A and Ensoli, B. (2002) Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses J Immunol, 168, pp. 197-206. [PUBMED] [INFOTRIEVE] [CSA]
20. Figdor, C and van Kyook, Y and Adema, G. (2002) C-type lectin receptors on dendritic cells and langerhans cells Nat Rev Immunol, 2, pp. 77-84. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
21. Fung, M and Chu, Y and Wallace, A and McGuire, K. (2005) IL-2- and STAT5-regulated cytokine gene expression in cells expressing the Tax protein of HTLV-1 Oncogene, 24, pp. 4624-4633. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
22. Gately, M and Renzetti, L and Magram, J and Stern, A and Adorini, L and Gubler, U and Presky, D. (1998) The interleukin-12/ interleukin-12-receptor system: Role in normal and pathologic immune responses Annu Rev Immunol, 16, pp. 495-521. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
23. Harhaj, E and Harhaj, N and Grant, C and Mostoller, K and Alefantis, T and Sun, S and Wigdahl, B. (2005) Human T cell leukemia virus type 1 Tax activates CD40 gene expression via the NF-kappa B pathway Virology, 333, pp. 145-158. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
24. Hemmi, H and Takeuchi, O and Kawai, T and Kaisho, T and Sato, S and Sanjo, H and Matsumoto, M and Hoshino, K and Wagner, H and Takeda, K. (2000) A toll-like receptor recognizes bacterial DNA Nature, 408, pp. 740-745. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
25. Izmailova, E and Bertley, F and Huang, Q and Makori, N and Miller, C and Young, R and Aldovini, A. (2003) HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages Nat Med, 9, pp. 191-197. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
26. Jacobson, S and McFarlin, D and Robinson, S and Voskuhl, R and Martin, R and Brewah, A and Newell, A and Koenig, S. (1992) HTLV-1-specific cytotoxic T lymphocytes in the cerebrospinal fluid of patients with HTLV-1-associated neurological disease Ann Neurol, 32, pp. 651-657. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
27. Jeang, K. (2001) Functional activities of the human T-cell leukemia virus type 1 Tax oncoprotein: Cellular signaling through NF-kappa B Cytokine Growth Factor Rev, 12, pp. 207-217. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
28. Kannagi, M and Shida, H and Igarashi, H and Kuruma, K and Murai, H and Aono, Y and Maruyama, I and Osame, M and Hattori, T and Inoko, H et al. (1992) Target epitope in the Tax protein of human T-cell leukemia virus type 1 recognized by class I major histocompatibility complex-restricted cytotoxic T cells J Virol, 66, pp. 2928-2933. [PUBMED] [INFOTRIEVE] [CSA]
29. Kanno, T and Brown, K and Siebenlist, U. (1995) Evidence in support of a role for human T-cell leukemia virus type 1 Tax in activating NF-kappa B via stimulation of signaling pathways J Biol Chem, 270, pp. 11745-11748. [PUBMED] [INFOTRIEVE] [CSA]
30. Kanno, T and Franzoso, G and Siebenlist, U. (1994) Human T-cell leukemia virus type 1 Tax-protein-mediated activation of NF-kappa B from p100 (NF-kappa B2)-inhibited cytoplasmic reservoirs Proc Natl Acad Sci USA, 91, pp. 12634-12638. [PUBMED] [INFOTRIEVE] [CSA]
31. Koenig, S and Woods, R and Brewah, Y and Newell, A and Jones, G and Boone, E and Adelsberger, J and Baseler, M and Robinson, S and Jacobson, S. (1993) Characterization of MHC class I restricted cytotoxic T cell responses to Tax in HTLV-1 infected patients with neurologic disease J Immunol, 151, pp. 3874-3883. [PUBMED] [INFOTRIEVE] [CSA]
32. Levin, M and Min Lee, S and Kalume, F and Morcos, Y and Curtis, F and Hasty, K and Callaway, J and Zunt, J and Desiderio, D and Stuart, J. (2002) Autoimmunity due to molecular mimicry as a cause of neurological disease Nat Med, 8, pp. 509-513. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
33. Levin, M and Jacobson, S. (1997) HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A chronic progressive neurologic disease associated with immunologically mediated damage to the central nervous system J Neurovirol, 3, pp. 126-140. [PUBMED] [INFOTRIEVE] [CSA]
34. Lindholm, P and Marriott, S and Gitlin, S and Bohan, C and Brady, J. (1990) Induction of nuclear NF-kappa B DNA binding activity after exposure of lymphoid cells to soluble Tax1 protein New Biol, 2, pp. 1034-1043. [PUBMED] [INFOTRIEVE] [CSA]
35. Lindholm, P and Reid, R and Brady, J. (1992) Extracellular Taxβ1 protein stimulates tumor necrosis factor-β and immunoglobulin kappa light chain expression in lymphoid cells J Virol, 66, pp. 1294-1302. [PUBMED] [INFOTRIEVE] [CSA]
36. Macatonia, S and Cruickshank, J and Rudge, P and Knight, S. (1992) Dendritic cells from patients with tropical spastic paraparesis are infected with HTLV-1 and stimulate autologous lymphocyte proliferation AIDS Res Hum Retroviruses, 8, pp. 1699-1706. [PUBMED] [INFOTRIEVE] [CSA]
37. Makino, M and Shimokubo, S and Wakamatsu, S and Izumo, S and Baba, M. (1999) The role of human T-lymphotropic virus type 1 (HTLV-1) infected dendritic cells in the development of HTLV-1-associated myelopathy/ tropical spastic paraparesis J Virol, 73, pp. 4575-4581. [PUBMED] [INFOTRIEVE] [CSA]
38. Makino, M and Utsunomiya, A and Maeda, Y and Shimokubo, S and Izumo, S and Baba, M. (2001) Association of CD40 ligand expression on HTLV-I-infected T cells and maturation of dendritic cells Scand J Immunol, 54, pp. 574-81. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
39. Marriott, S and Trinh, D and Brady, J. (1991) Soluble HTLV-1 Tax1 protein stimulates proliferation of human peripheral blood lymphocytes New Biol, 3, pp. 678-686. [PUBMED] [INFOTRIEVE] [CSA]
40. Marriott, S and Trinh, D and Brady, J. (1992) Activation of interleukin-2 receptor alpha expression by extracellular HTLV-1 Tax1 protein: A potential role in HTLV-1 pathogenesis Oncogene, 7, pp. 1749-1755. [PUBMED] [INFOTRIEVE] [CSA]
41. Mellman, I and Steinman, R. (2001) Dendritic cells: Specialized and regulated antigen processing machines Cell, 106, pp. 255-258. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
42. Miyagishi, R and Kikuchi, S and Fukazawa, T and Tashiro, K. (1995) Macrophage inflammatory protein-1 alpha in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological diseases J Neurol Sci, 129, pp. 223-227. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
43. Mori, N and Yamada, Y and Tomonaga, M and Ikeda, S and Yamamoto, N. (1998) Interleukin-15 stimulate the proliferation of peripheral blood leukemic cells from adult T cell leukemia patients Eur J Hematol, 61, pp. 278-279. [CSA]
44. Mori, N and Krensky, A and Ohshima, K and Tomita, M and Matsuda, T and Ohta, T and Yamada, Y and Tomonaga, M and Ikeda, S and Yamamoto, N. (2004) Elevated expression of CCL5/RANTES in adult T-cell leukemia cells: Possible transactivation of the CCL5 gene by human T-cell leukemia virus type 1 Tax Int J Cancer, 111, pp. 548-557. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
45. Mostoller, K and Norbury, C and Jain, P and Wigdahl, B. (2004) Human T cell leukemia virus type 1 Tax induces the expression of dendritic cell markers associated with maturation and activation J Neurovirol, 10, pp. 358-371. [PUBMED] [INFOTRIEVE] [CSA]
46. Mueller, C and Rissoan, M and Salinas, B and Ait-Yahia, S and Ravel, O and Bridon, J and Briere, F and Lebecque, S and Liu, Y. (1997) Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells J Exp Med, 186, pp. 655-663. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
47. Nagai, M and Yamano, Y and Brennan, M and Mora, C and Jacobson, S. (2001) Increased HTLV-1 proviral load and preferential expansion of HTLV-1 Tax-specific CD8+ T cells in cerebrospinal fluid from patients with HAM/TSP Ann Neurol, 50, pp. 807-812. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
48. Ng, P and Iha, H and Iwanaga, Y and Bittner, M and Chen, Y and Jiang, Y and Gooden, G and Trent, J and Meltzer, O and Jeang, K and Zeichner, S. (2001) Genome-wide expression changes induced by HTLV-1 Tax: Evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-κB activation Oncogene, 20, pp. 4484-4496. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
49. Osame, M. (2002) Pathological mechanisms of human T-cell lymphotropic virus type 1-associated myelopathy (HAM/TSP) J Neurovirol, 8, pp. 359-364. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
50. Pashenkov, M and Soderstromb, M and Link, H. (2003) Secondary lymphoid organ chemokines are elevated in the cerebrospinal fluid during central nervous system inflammation J Neuroimmunol, 135, pp. 154 - 160. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
51. Poltorak, A and He, X and Smirnova, I and Liu, M and Huffel, C and Du, X and (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in TLR4 gene Science, 282, pp. 2085-2088. [PUBMED] [INFOTRIEVE] [CSA]
52. Pulendran, B and Smith, J and Caspary, G and Brasel, K and Pettit, D and Maraskovsky, E and Maliszewski, C. (1999) Distinct dendritic cell subsets differentially regulate the class of immune response in vivo Proc Natl Acad Sci USA, 96, pp. 1036-1041. [PUBMED] [INFOTRIEVE] [CSA]
53. Richter, G and Hayden-Ledbetter, M and Irgang, M and Ledbetter, J and Westermann, J and Korner, I and Daemen, K and Clark, E and Aicher, A and Pezzutto, A. (2001) Tumor necrosis factor-α regulates the expression of inducible costimulator receptor ligand on CD34+ progenitor cells during differentiation into antigen presenting cells J Biol Chem, 276, pp. 45686-45693. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
54. Sallusto, F and Schaerli, P and Loetscher, P and Schaniel, C and Lenig, D and Mackay, C and Qin, S and Lanzavecchia, A. (1998) Rapid and coordinated switch in chemokines receptor expression during dendritic cell maturation Eur J Immunol, 28, pp. 760-2769. [CROSSREF] [CSA]
55. Samuel, C. (2001) Antiviral actions of interferons Clin Microbiol Rev, 14, pp. 778-809. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
56. Sharief, M and Thompson, E. (1992) In vivo relationship of tumor necrosis factor-α to blood-brain barrier damage in patients with multiple sclerosis J Neuroimmunol, 38, pp. 27-33. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
57. Smith, K. (1984) Interleukin 2 Annu Rev Immunol, 2, pp. 319-333. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
58. Sztein, M and Steeg, P and Johnson, H and Oppenheim, J. (1984) Regulation of human peripheral blood monocyte DR antigen expression in vitro by lymphokines and recombinant interferons J Clin Invest, 73, pp. 556-565. [PUBMED] [INFOTRIEVE] [CSA]
59. Takeda, K and Kaisho, T and Akira, S. (2003) Toll-like receptors Annu Rev Immunol, 21, pp. 335-376. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
60. Trincheri, G and Gerosa, F. (1996) Immunoregulation by interleukin-12 J Leukoc Biol, 59, pp. 505-511. [CSA]
61. Uchiyama, T. (1997) Human T cell leukemia virus type 1 (HTLV-1) and human diseases Annu Rev Immunol, 15, pp. 15 - 37. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
62. Umehara, F and Izumo, S and Nakagawa, M and Ronquillo, A and Takahashi, K and Matsumuro, K and Sato, E and Osame, M. (1993) Immunocytochemical analysis of the cellular infiltrate in the spinal cord lesions in HTLV-1-associated myelopathy J Neuropathol Exp Neurol, 52, pp. 424-430. [PUBMED] [INFOTRIEVE] [CSA]
63. Underhill, D and Ozinsky, A. (2002) Toll-like receptors: Key mediators of microbe detection Curr Opin Immunol, 14, pp. 103-110. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
64. Venkatanarayanan, S and May, C. (1999) Human T-cell lymphotropic virus type-I Tax gene induces secretion of human macrophage inflammatory protein-1α Biochem Biophys Res Comm, 262, pp. 429-432. [CROSSREF] [CSA]
65. Watanabe, H and Nakamura, T and Nagasato, K. (1995) Exaggerated messenger RNA expression of inflammatory cytokines in human T-cell lymphotropic virus type 1-associated myelopathy Arch Neurol, 52, pp. 276-280. [PUBMED] [INFOTRIEVE] [CSA]
66. Yamano, Y and Nagai, M and Brennan, M and Mora, C and Soldan, S and Tomaru, U and Takenouchi, N and Izumo, S and Osame, M and Jacobson, S. (2002) Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8+ T cells, and disease severity in HTLV-1-associated myelopathy (HAM/TSP) Blood, 99, pp. 88-94. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
67. Zhang, X and Siquan, S and Hwang, I and Tough, D and Waldmann, T. (1999) Invovlement of IL-15 in the pathogenesis of human T lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis: Implications for therapy with a monoclonal antibody directed to the IL-2/15R beta receptor J Immunol, 163, pp. 4064-4072. [CSA]