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Volumn 163, Issue 7, 1999, Pages 4064-4072

Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: Implications for therapy with a monoclonal antibody directed to the IL-2/15Rβ receptor

Author keywords

[No Author keywords available]

Indexed keywords

BLOCKING ANTIBODY; CYTOKINE; GROWTH FACTOR; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 2 RECEPTOR; MESSENGER RNA; MONOCLONAL ANTIBODY;

EID: 0033214401     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (82)

References (55)
  • 1
    • 0019254359 scopus 로고
    • Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma
    • Poiesz, B. J., F. W. Ruscetti, A. F. Gazdar, P. A. Bunn, J. D. Minna, and R. C. Gallo. 1980. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc. Natl. Acad. Sci. USA 77:7415.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 7415
    • Poiesz, B.J.1    Ruscetti, F.W.2    Gazdar, A.F.3    Bunn, P.A.4    Minna, J.D.5    Gallo, R.C.6
  • 2
    • 0021995980 scopus 로고
    • Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis
    • Gessain, A., F. Barin, J. C. Vernant, O. Gout, L. Maurs, A. Calender, and G. de The. 1985. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 24:407.
    • (1985) Lancet , vol.24 , pp. 407
    • Gessain, A.1    Barin, F.2    Vernant, J.C.3    Gout, O.4    Maurs, L.5    Calender, A.6    De The, G.7
  • 8
    • 0027322991 scopus 로고
    • Immunohistochemical characteristics of polymyositis in patients with HTLV-1-associated myelopathy and HTLV-1 carriers
    • Higuchi, I., E. S. Montemayor, S. Izumo, M. Inose, and M. Osame. 1993. Immunohistochemical characteristics of polymyositis in patients with HTLV-1-associated myelopathy and HTLV-1 carriers. Muscle Nerve 16:472.
    • (1993) Muscle Nerve , vol.16 , pp. 472
    • Higuchi, I.1    Montemayor, E.S.2    Izumo, S.3    Inose, M.4    Osame, M.5
  • 9
    • 0023051070 scopus 로고
    • The second pX product p27 chi-III of HTLV-I is required for gag gene expression
    • Inoue, J., M. Seiki, and M. Yoshida. 1986. The second pX product p27 chi-III of HTLV-I is required for gag gene expression. FEBS Lett. 209:187.
    • (1986) FEBS Lett. , vol.209 , pp. 187
    • Inoue, J.1    Seiki, M.2    Yoshida, M.3
  • 10
    • 0000431701 scopus 로고
    • Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by trans-activator (tax) gene product of human T cell leukemia virus type I
    • Siekevitz, M. F., M. B. Feinberg, N. Holbrook, F. Wong-Staal, and W. C. Greene. 1987. Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by trans-activator (tax) gene product of human T cell leukemia virus type I. Proc. Natl. Acad. Sci. USA 84:5389.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 5389
    • Siekevitz, M.F.1    Feinberg, M.B.2    Holbrook, N.3    Wong-Staal, F.4    Greene, W.C.5
  • 11
    • 0023649621 scopus 로고
    • Regulation of the human interleukin 2 receptor α chain promoter: Activation of a nonfunctional promoter by the transactivator gene of HTLV-I
    • Cross, S. L., M. B. Feinberg, J. B. Wolf, N. J. Holbrook, F. Wong-Staal, and W. J. Leonard. 1987. Regulation of the human interleukin 2 receptor α chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I. Cell 49:47.
    • (1987) Cell , vol.49 , pp. 47
    • Cross, S.L.1    Feinberg, M.B.2    Wolf, J.B.3    Holbrook, N.J.4    Wong-Staal, F.5    Leonard, W.J.6
  • 12
    • 0029075383 scopus 로고
    • Human T lymphotropic virus, type-I myelopathy: An immunopathologically mediated chronic progressive disease of the central nervous system
    • Jacobson, S. 1995. Human T lymphotropic virus, type-I myelopathy: an immunopathologically mediated chronic progressive disease of the central nervous system. Curr. Opin. Neurol. 8:179.
    • (1995) Curr. Opin. Neurol. , vol.8 , pp. 179
    • Jacobson, S.1
  • 13
    • 0026489198 scopus 로고
    • HTLV-I-speciftc cytotoxic T lymphocytes in the cerebrospinal fluid of patients with HTLV-I-associated neurological disease
    • Jacobson, S., D. E. McFarlin, S. Robinson, R. Voskuhl, R. Martin, A. Brewah, A. J. Newell, and S. Koenig. 1992. HTLV-I-speciftc cytotoxic T lymphocytes in the cerebrospinal fluid of patients with HTLV-I-associated neurological disease. Ann. Neurol. 32:651.
    • (1992) Ann. Neurol. , vol.32 , pp. 651
    • Jacobson, S.1    McFarlin, D.E.2    Robinson, S.3    Voskuhl, R.4    Martin, R.5    Brewah, A.6    Newell, A.J.7    Koenig, S.8
  • 14
    • 0025119797 scopus 로고
    • + cytotoxic T lymphocytes specific for HTLV-1 pX in patients with HTLV-1-associated neurological disease
    • + cytotoxic T lymphocytes specific for HTLV-1 pX in patients with HTLV-1-associated neurological disease. Nature 348:245.
    • (1993) Nature , vol.348 , pp. 245
    • Jacobson, S.1    Shida, H.2    McFarlin, D.E.3    Fauci, A.S.4    Koenig, S.5
  • 18
    • 0023939709 scopus 로고
    • Spontaneous proliferation of peripheral blood lymphocytes increased in patients with HTLV-1 associated myelopathy
    • Itoyama, Y., S. Minato, J. Kira, I. Goto, H. Sato, K. Ikochi, and N. Yamamoto. 1988. Spontaneous proliferation of peripheral blood lymphocytes increased in patients with HTLV-1 associated myelopathy. Neurology 38:816.
    • (1988) Neurology , vol.38 , pp. 816
    • Itoyama, Y.1    Minato, S.2    Kira, J.3    Goto, I.4    Sato, H.5    Ikochi, K.6    Yamamoto, N.7
  • 19
    • 0025286634 scopus 로고
    • Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: Pathogenic implications and a rationale for immunotherapy
    • Tendler, C. L., S. J. Greenberg, W. A. Blattner, A. Manns, E. Murphy, T. Fleisher, B. Hanchard, O. Morgan, J. D. Burton, D. L. Nelson, and T. A. Waldmann. 1990. Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy. Proc. Natl. Acad. Sci. USA 87:5218.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 5218
    • Tendler, C.L.1    Greenberg, S.J.2    Blattner, W.A.3    Manns, A.4    Murphy, E.5    Fleisher, T.6    Hanchard, B.7    Morgan, O.8    Burton, J.D.9    Nelson, D.L.10    Waldmann, T.A.11
  • 20
    • 0032478333 scopus 로고    scopus 로고
    • Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-κB site
    • Azimi, N., K. Brown, R. N. Bamford, Y. Tagaya, U. Sibenlist, and T. A. Waldmann. 1998. Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-κB site. Proc. Natl. Acad. Sci. USA 95:2452.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2452
    • Azimi, N.1    Brown, K.2    Bamford, R.N.3    Tagaya, Y.4    Sibenlist, U.5    Waldmann, T.A.6
  • 21
    • 0026577201 scopus 로고
    • The interleukin 2 receptor (IL-2R): The IL-2R α subunit alters the function of the IL-2R β subunit to enhance IL-2 binding and signaling by mechanisms that do not require binding of IL-2 to IL-2R α subunit
    • Grant, A. J., E. Roessler, G. Ju, M. Tsudo, K. Sugamara, and T. A. Waldmann. 1992. The interleukin 2 receptor (IL-2R): the IL-2R α subunit alters the function of the IL-2R β subunit to enhance IL-2 binding and signaling by mechanisms that do not require binding of IL-2 to IL-2R α subunit. Proc. Natl. Acad. Sci. USA 89:2156.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 2156
    • Grant, A.J.1    Roessler, E.2    Ju, G.3    Tsudo, M.4    Sugamara, K.5    Waldmann, T.A.6
  • 23
    • 0028363377 scopus 로고
    • The interleukin (IL) 2 receptor β chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells
    • Bamford, R. N., A. J. Grant, J. D. Burton, C. Peters, G. Kurys, C. K. Goldman, J. Brennan, E. Roessler, and T. A. Waldmann. 1994. The interleukin (IL) 2 receptor β chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc. Natl. Acad. Sci. USA 91:4940.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4940
    • Bamford, R.N.1    Grant, A.J.2    Burton, J.D.3    Peters, C.4    Kurys, G.5    Goldman, C.K.6    Brennan, J.7    Roessler, E.8    Waldmann, T.A.9
  • 24
    • 0019421207 scopus 로고
    • A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells: Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells
    • Uchiyama, T., S. Border, and T. A. Waldmann. 1981. A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells: production of anti-Tac monoclonal antibody and distribution of Tac (+) cells. J. Immunol. 126:1393.
    • (1981) J. Immunol. , vol.126 , pp. 1393
    • Uchiyama, T.1    Border, S.2    Waldmann, T.A.3
  • 25
    • 3042932317 scopus 로고
    • Characterization of the interleukin 2 receptor β chain using three distinct monoclonal antibodies
    • Tsudo, M., F. Kitamura, and M. Miyasaka. 1989. Characterization of the interleukin 2 receptor β chain using three distinct monoclonal antibodies. Proc. Natl. Acad. Sci. USA 86:1982.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 1982
    • Tsudo, M.1    Kitamura, F.2    Miyasaka, M.3
  • 26
    • 0030008255 scopus 로고    scopus 로고
    • Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotropic virus type I R region/ IL-15 fusion message that lacks many upstream AUGs that normally attenuate IL-15 mRNA translation
    • Bamford, R. N., A. P. Battiata, J. D. Burton, H. Sharma, and T. A. Waldmann. 1996. Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotropic virus type I R region/ IL-15 fusion message that lacks many upstream AUGs that normally attenuate IL-15 mRNA translation. Proc. Natl. Acad. Sci. USA 93:2897.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2897
    • Bamford, R.N.1    Battiata, A.P.2    Burton, J.D.3    Sharma, H.4    Waldmann, T.A.5
  • 27
    • 0025814988 scopus 로고
    • Cytokine induction in HTLV-1 associated myelopathy and adult T-cell leukemia: Alternate molecular mechanisms underlying retroviral pathogenesis
    • Tendler, C. L., S. J. Greenberg, J. D. Burton, D. Danielpour, S. J. Kim, W. A. Blattner, A. Manns, and T. A. Waldmann. 1991. Cytokine induction in HTLV-1 associated myelopathy and adult T-cell leukemia: alternate molecular mechanisms underlying retroviral pathogenesis. J. Cell. Biochem. 46:302.
    • (1991) J. Cell. Biochem. , vol.46 , pp. 302
    • Tendler, C.L.1    Greenberg, S.J.2    Burton, J.D.3    Danielpour, D.4    Kim, S.J.5    Blattner, W.A.6    Manns, A.7    Waldmann, T.A.8
  • 28
    • 0000259748 scopus 로고
    • Detection of human T lymphotropic virus type I (HTLV-I) tax RNA in the central nervous system of HTLV-I associated myelopathy/tropical spastic paraparesis by in situ hybridization
    • Lehky, T. J., C. H. Fox, S. Koenig, M. C. Levin, N. Flerlage, S. Izumo, E. Sato, C. S. Raine, M. Osame, and S. Jacobson. 1995. Detection of human T lymphotropic virus type I (HTLV-I) tax RNA in the central nervous system of HTLV-I associated myelopathy/tropical spastic paraparesis by in situ hybridization. Ann. Neurol. 37:246.
    • (1995) Ann. Neurol. , vol.37 , pp. 246
    • Lehky, T.J.1    Fox, C.H.2    Koenig, S.3    Levin, M.C.4    Flerlage, N.5    Izumo, S.6    Sato, E.7    Raine, C.S.8    Osame, M.9    Jacobson, S.10
  • 29
    • 0002523272 scopus 로고    scopus 로고
    • Biology of HTLV-I: Host cell interactions
    • P. Hollsberg and D. A. Hafler, eds. John Wiley & Sons Ltd, London
    • Brady, J. N. 1996. Biology of HTLV-I: host cell interactions. In Human T-Cell Lymphotropic Virus Type I. P. Hollsberg and D. A. Hafler, eds. John Wiley & Sons Ltd, London, p. 79.
    • (1996) Human T-Cell Lymphotropic Virus Type I , pp. 79
    • Brady, J.N.1
  • 30
    • 0027425122 scopus 로고
    • Dendritic cell infected in vitro with human T cell leukemia/ lymphoma virus type-I (HTLV-I): Enhanced lymphocytic proliferation and tropical spastic paraparesis
    • Ali, A., S. Patterson, K. Cruickshank, P. Rudge, A. G. Dalgleish, and S. C. Knight. 1993. Dendritic cell infected in vitro with human T cell leukemia/ lymphoma virus type-I (HTLV-I): enhanced lymphocytic proliferation and tropical spastic paraparesis. Clin. Exp. Immunol. 94:32.
    • (1993) Clin. Exp. Immunol. , vol.94 , pp. 32
    • Ali, A.1    Patterson, S.2    Cruickshank, K.3    Rudge, P.4    Dalgleish, A.G.5    Knight, S.C.6
  • 31
    • 0026700303 scopus 로고
    • Dendritic cells from pateints with tropical spastic paraparesis are infected with HTLV-I and stimulate autologous lymphocyte proliferation
    • Macatonia, S., J. K. Cruickshank, P. Rudge, and S. C. Knight. 1992. Dendritic cells from pateints with tropical spastic paraparesis are infected with HTLV-I and stimulate autologous lymphocyte proliferation. AIDS Res. Hum. Retroviruses 8:1699.
    • (1992) AIDS Res. Hum. Retroviruses , vol.8 , pp. 1699
    • Macatonia, S.1    Cruickshank, J.K.2    Rudge, P.3    Knight, S.C.4
  • 32
    • 0347467251 scopus 로고
    • Infection of human endothelial cells by human T-lymphotropic virus type I
    • Ho, D. D., T. R. Rota, and M. S. Hirsch. 1984. Infection of human endothelial cells by human T-lymphotropic virus type I. Proc. Natl. Acad. Sci USA 81:7588.
    • (1984) Proc. Natl. Acad. Sci USA , vol.81 , pp. 7588
    • Ho, D.D.1    Rota, T.R.2    Hirsch, M.S.3
  • 33
    • 0021277547 scopus 로고
    • Isolation of HTLV-I derived from japanese adult T cell leukemia patients in human diploid fibroblast strain IMR90 and the biological characters of the infected cells
    • Yoshikura, H., J. Nishida, M. Yoshida, Y. Kitamura, F. Takaku, and S. Ikeda. 1984. Isolation of HTLV-I derived from Japanese adult T cell leukemia patients in human diploid fibroblast strain IMR90 and the biological characters of the infected cells. Int. J. Cancer 33:745.
    • (1984) Int. J. Cancer , vol.33 , pp. 745
    • Yoshikura, H.1    Nishida, J.2    Yoshida, M.3    Kitamura, Y.4    Takaku, F.5    Ikeda, S.6
  • 34
    • 0042404900 scopus 로고    scopus 로고
    • Interleukin 15 gene expression in human astrocytes and microglia in culture
    • Lee, Y. B., J-I. Satoh, D. G. Walker, and U. K. Seung. 1996. Interleukin 15 gene expression in human astrocytes and microglia in culture. NeuroReport 7:1062.
    • (1996) Neuroreport , vol.7 , pp. 1062
    • Lee, Y.B.1    Satoh, J.-I.2    Walker, D.G.3    Seung, U.K.4
  • 36
    • 0030032290 scopus 로고    scopus 로고
    • Induction and regulation of IL-15 expression in murine macrophages
    • Doherty, T. M., A. S. Seder, and A. Sher. 1996. Induction and regulation of IL-15 expression in murine macrophages. J. Immunol. 156:735.
    • (1996) J. Immunol. , vol.156 , pp. 735
    • Doherty, T.M.1    Seder, A.S.2    Sher, A.3
  • 39
    • 0026467822 scopus 로고
    • Cytokine gene regulation: Regulatory cis-elements and DNA binding factors involved in the interferon system
    • Tanaka, N., and T. Taniguchi. 1992. Cytokine gene regulation: regulatory cis-elements and DNA binding factors involved in the interferon system. Adv. Immunol. 52:263.
    • (1992) Adv. Immunol. , vol.52 , pp. 263
    • Tanaka, N.1    Taniguchi, T.2
  • 40
    • 85008136689 scopus 로고
    • Pathogenesis of diseases induced by human lymphotropic virus type I infection
    • Hollsberg, P., and D. A. Hafler. 1993. Pathogenesis of diseases induced by human lymphotropic virus type I infection. N. Engl. J. Med. 328:1173.
    • (1993) N. Engl. J. Med. , vol.328 , pp. 1173
    • Hollsberg, P.1    Hafler, D.A.2
  • 41
    • 0027450404 scopus 로고
    • Detection of tumor necrosis factor-α-positive cells in cerebrospinal fluid of patients with HTLV-I-associated myelopathy
    • Nakamura, S., M. Nagano, M. Yoshiola, S. Shimazaki, and J. Onodera. 1993. Detection of tumor necrosis factor-α-positive cells in cerebrospinal fluid of patients with HTLV-I-associated myelopathy. J. Neuroimmunol. 42:127.
    • (1993) J. Neuroimmunol. , vol.42 , pp. 127
    • Nakamura, S.1    Nagano, M.2    Yoshiola, M.3    Shimazaki, S.4    Onodera, J.5
  • 42
    • 0027468192 scopus 로고
    • Cerebrospinal fluid interferon-gamma is increased in HTLV-1-associated myelopathy
    • Kuroda, Y., and M. Matsui. 1993. Cerebrospinal fluid interferon-gamma is increased in HTLV-1-associated myelopathy. J. Neuroimmunol. 42:223.
    • (1993) J. Neuroimmunol. , vol.42 , pp. 223
    • Kuroda, Y.1    Matsui, M.2
  • 43
    • 0030695442 scopus 로고    scopus 로고
    • Preassembly of interleukine 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: A fluoroescence resonance energy transfer study
    • Damjanovich, S., L. Bene, J. Matko, A. Alileche, C. K. Goldman, S. Sharrow, and T. A. Waldmann. 1997. Preassembly of interleukine 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: a fluoroescence resonance energy transfer study. Proc. Natl. Acad. Sci. USA 94:13134.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 13134
    • Damjanovich, S.1    Bene, L.2    Matko, J.3    Alileche, A.4    Goldman, C.K.5    Sharrow, S.6    Waldmann, T.A.7
  • 44
    • 0029550589 scopus 로고    scopus 로고
    • Interleukin-2 as a neuroregulatory cytokine
    • Hanisch, U. K., and R. Quirion. 1996. Interleukin-2 as a neuroregulatory cytokine. Brain Res. Rev. 21:246.
    • (1996) Brain Res. Rev. , vol.21 , pp. 246
    • Hanisch, U.K.1    Quirion, R.2
  • 45
    • 0030691759 scopus 로고    scopus 로고
    • Mouse brain microglia express interleukin-15 and its multimeric receptor complex functionally coupled to Janus kinase activity
    • Hanisch, U. K., S. A. Lyons, M. Prinz, C. Nolte, J. R. Weber, H. Kettenmann, and F. Kirchoff. 1997. Mouse brain microglia express interleukin-15 and its multimeric receptor complex functionally coupled to Janus kinase activity. J. Biol. Chem. 272:28853.
    • (1997) J. Biol. Chem. , vol.272 , pp. 28853
    • Hanisch, U.K.1    Lyons, S.A.2    Prinz, M.3    Nolte, C.4    Weber, J.R.5    Kettenmann, H.6    Kirchoff, F.7
  • 46
    • 0030714613 scopus 로고    scopus 로고
    • Interleukin 15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing γδ T cell receptor in mice
    • Inagaki-Ohara, K., H. Nishimura, A. Mitani, and Y. Yoshikai. 1997. Interleukin 15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing γδ T cell receptor in mice. Eur. J. Immunol. 27:2885.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2885
    • Inagaki-Ohara, K.1    Nishimura, H.2    Mitani, A.3    Yoshikai, Y.4
  • 48
    • 0029788297 scopus 로고    scopus 로고
    • Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotentail T/natural killer progenitor cells
    • Leclercq, G., V. Debaker, M. D. Smedt, and J. Plum. 1996. Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotentail T/natural killer progenitor cells. J. Exp. Med. 184:325.
    • (1996) J. Exp. Med. , vol.184 , pp. 325
    • Leclercq, G.1    Debaker, V.2    Smedt, M.D.3    Plum, J.4
  • 49
    • 0028963909 scopus 로고
    • Chemoattraction of human blood T lymphocytes by interleukin 15
    • Wilkinson, P. C., and F. Y. Liew. 1995. Chemoattraction of human blood T lymphocytes by interleukin 15. J. Exp. Med. 181:1255.
    • (1995) J. Exp. Med. , vol.181 , pp. 1255
    • Wilkinson, P.C.1    Liew, F.Y.2
  • 52
    • 0031573086 scopus 로고    scopus 로고
    • Enhancement of natural killer cell cytotoxicity by the human herpesvirus-7 via IL-15 induction
    • Atedzoe, B. N., A. Ahmad, and J. Menezes. 1997. Enhancement of natural killer cell cytotoxicity by the human herpesvirus-7 via IL-15 induction. J. Immunol. 159:4966.
    • (1997) J. Immunol. , vol.159 , pp. 4966
    • Atedzoe, B.N.1    Ahmad, A.2    Menezes, J.3
  • 53
    • 0029936476 scopus 로고    scopus 로고
    • Human Herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15
    • Flamand, L., I. Stefanescu, and J. Menezes. 1996. Human Herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15. J. Clin. Invest. 97:1373.
    • (1996) J. Clin. Invest. , vol.97 , pp. 1373
    • Flamand, L.1    Stefanescu, I.2    Menezes, J.3
  • 55
    • 0031770389 scopus 로고    scopus 로고
    • Reduction in HTLV-1 proviral load and spontaneous lymphoproliferation in HAM/TSP patients treated with humanized Anti-Tac (anti-IL-2Rα)
    • Lehky, T. L., M. C. Levin, R. Kubota, R. Bamford, A. N. Flerage, S. Soldan, T. P. Leist, A. Xavier, J. D. White, M. Brown, et al. 1998. Reduction in HTLV-1 proviral load and spontaneous lymphoproliferation in HAM/TSP patients treated with humanized Anti-Tac (anti-IL-2Rα). Ann. Neurol. 44:942.
    • (1998) Ann. Neurol. , vol.44 , pp. 942
    • Lehky, T.L.1    Levin, M.C.2    Kubota, R.3    Bamford, R.4    Flerage, A.N.5    Soldan, S.6    Leist, T.P.7    Xavier, A.8    White, J.D.9    Brown, M.10


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