Presence of HTLV-I Tax protein in cerebrospinal fluid from HAM/TSP patients

Archives of Virology

Volumn 150, Issue 4, 2005, Pages 743-753

  Cartier, L ^a   Ramirez, E ^b,c  

^a UNIVERSITY OF CHILE   (Chile)

^b INSTITUTO DE SALUD PÚBLICA DE CHILE   (Chile)

^c UNIVERSITY OF CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; TAX PROTEIN; VIRUS ANTIGEN;

ADULT; AGED; ARTICLE; CEREBROSPINAL FLUID; CHILE; CREUTZFELDT JAKOB DISEASE; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; MALE; MIDDLE AGED; PATHOPHYSIOLOGY; REFERENCE VALUE; SPASTIC PARAPLEGIA; VIROLOGY;

ADULT; AGED; ANTIBODIES, MONOCLONAL; ANTIGENS, VIRAL; CHILE; CREUTZFELDT-JAKOB SYNDROME; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE PRODUCTS, TAX; HUMANS; MALE; MIDDLE AGED; PARAPARESIS, TROPICAL SPASTIC; REFERENCE VALUES;

HTLV; HTLV I; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN T CELL LYMPHOTROPIC VIRUS TYPE I; HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 17644410811     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00705-004-0443-3     Document Type: Article

References (43)

1. Araujo A de Q, Alfonso CR, Shor D, Andrada-Serpa MJ (1993) Spastic paraparesis of obscure origin: a case-control study of HTLV-I positive and negative patients from Rio de Janeiro, Brazil. J Neurol Sci 116: 165-169
2. Azron I, Schavinsky-Khrapunsky Y, Aboud M (2004) Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity. Retrovitrology 1: 20
3. Beham WM, Maia H (1974) Strümpell's familiar spastic paraplegia: genetic and neuropathology. J Neurol Neurosurg Psychiatry 37: 8-20
4. Breuer AC, Lynn MR, Atkinson MB, Chou SM, Wilbourn AJ, Marks KE, Culver JE, Fleegler EJ (1987) Fast axonal transport in amyotrophic lateral sclerosis: an intraaxonal organelle traffic analysis. Neurology 37: 738-748
5. Cabrera ME, Labra S, Meneses P, Matutes E, Cartier L, Ford A, Greaves M (1999) Adult-T cell leukemia/lymphoma in Chile, clinicopathological and molecular study of 26 patients. Rev Med Chile 127: 935-944
6. Cartier L, Mora C, Araya F, Castillo JL, Verdugo R (1989) HTLV-I Positive spastic paraparesis in a temperate zone. Lancet 1: 556-560
7. Cartier L, Araya F, Castillo JL, Ruiz F, Gormaz A, Tajima K (1992) Progressive spastic paraparesis associated to human T-cell leukemia virus type I (HTLV-I). Inter Med 31: 1257-1261
8. Cartier L, Castillo JL, Cea JG, Villagra R (1995) Chronic dacryosialadenitis in HTLV-I associated myelopathy. J Neurol Neurosurg Psychiatry 58: 244-246
9. Cartier L, Cea JG, Vergara C, Araya F, Born P (1997) Clinical and neuropathological study of six patients with spastic paraparesis associated with HTLV-I: an axomielinic degeneratión of the central nervous system. J neuropathol Exp Neurol 56: 403-413
10. Castillo JL, Cea JG, Verdugo RJ, Cartier L (1999) Sensory dysfunction in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP): a comprehensive neurophysiological study. Eur Neurol 42: 17-22
11. Coleman MP, Perry VH (2002) Axon pathology in neurological disease: a neglected therapeutic target. Trends Neurosci 25: 532-537
12. Feng J, Misu T, Fujihara K, Saito H, Takahashi T, Kohnosu T, Shiga Y, Takeda A, Sato S, Takase S, Itoyama Y (2003) Interferon-alpha significantly reduces cerebrospinal fluid CD4 cell subsets in HAM/TSP. J Neuroimmunol 141: 170-173
13. Fu D-X, Kuo Y, Liu B, Jeang K, Giam C (2003) Human T-lymphotropic virus type I Tax Activates I-κB kinase by inhibiting I-κB kinase-associated serine/threonine protein phosphatase 2A. J Biol Chem 278: 1487-1493
14. Gallo D, Penning LM, Hanson CV (1991) Detection and differentiation of antibodies to human T-cell lymphotropic virus types I and II by immunofluorescence method. J Clin Microbiol 29: 2345-2347
15. Gessain A, Barin F, Vernant JC, Gout O, Calender A, de The G (1985) Antibodies to human T lymphotropic virus type I in patients with Tropical Spastic Paraparesis. Lancet 2: 407-410
16. Jacobson S (1996) Cellular immune responses to HTLV-I immunopathogenic role in HTLV-I-associated neurologic disease. J AIDS Hum Retrovirol 13: S100-S106
17. Kira J, Nakamura M, Sawada T, Koyanagi Y, Ohori N, Itoyama Y, Yamamoto N, Sakaki Y, Goto I (1992) Antibody titers to HTLV-I-p40tax protein and gag-env hybrid protein in HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with increased HTLV-I proviral DNA load. J Neurol Sci 107: 98-104
18. Koya Y, Ohashi T, Kato H, Hanabuchi S, Tsukahara T, Takemura F, Etoh K, Matsuoka M, Fujii M, Kannagi M (1999) Establishment of a seronegative HTLV-I carrier state in rats inoculated with a HTLV-I-immortalizad T-cell line preferentially expressing Tax. J Virol 73: 6436-6443
19. Kubota R, Umehara F, Izumo S, Ijichi S, Matsumuro K, Yashiki S, Fujiyoshi T, Sonoda S, Osame M (1994) HTLV-I proviral DNA amount correlates with infiltrating CD4+ lymphocytes in the spinal cord from patients with HTLV-I-associated myelopathy. J Neuroimmunol 53: 23-29
20. Kubota R, Soldan SS, Martin R, Jacobson S (2002) Selected cytotoxic T lymphocytes with high specificity for HTLV-I in cerebrospinal fluid from a HAM/TSP patient. J Neurovirol 8: 53-57
21. Haller K, Wu Y, Derow E, Schmitt I, Jeang KT, Grassmann R (2002) Physical interaction of human T-cell leukaemia virus type 1 tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein. Mol Cell Biol 22: 3327-3338
22. Lee B, Tanaka Y, Tozawa H (1989) Monoclonal antibody defining tax protein of human T-cell leukemia virus type-I. Tohoku J Exp Med 157: 1-11
23. Lee JR, Shin H, Ko J, Choi J, Lee H, Kim E (2003) Characterization of the movement of the kinesin motor KIF1A in living cultured neurons. J Biol Chem 278: 2624-2629
24. Levin M, Min Lee S, Kalume F, Morcos Y, Curtis F, Hasty K, Callaway J, Zunt J, Desiderio D, Stuart J (2002) Autoimmunity due to molecular mimicry as a cause of neurological disease. Nat Med 8: 509-513
25. Liberski PP, Buczynski J, Yanagihara R, Mora C, Gibbs CJ, Gajdusek C, Cartier L, Verdugo R, Araya F, Castillo L (1999) Ultrastructural pathology of a Chilean case of tropical spastic paraparesis/human T-cell lymphotropic type I-associated myelopathy (TSP/HAM). Ultrastruct Pathol 23: 157-162
26. Marriott S, Trinh D, Brady J (1992) Activation of interleukin-2 receptor alpha expression by extracellular HTLV-I Tax1 protein: a potential role in HTLV-I pathogenesis. Oncogene 7: 1749-1755
27. Matsuoka E, Takenouchi N, Hashimoto K, Kashio N, Moritoyo T, Higuchi I, Isashiki Y, Sato E, Osame M, Izumo S (1998) Perivascular T cells are infected with HTLV-I in the spinla cord lesions with HTLV-I-associated myelopathy/tropical spastic paraparesis: double staining of immunohistochemistry and polymerase chain reaction in situ hybridization. Acta Neuropathol 96: 340-346
28. Moritoyo T, Izumo S, Moritoyo H, Tanaka Y, Koyomatsu Y, Nagai M, Usuku K, Sorimachi M, Osame M (1999) Detection of human T-lymphotropic virus type I p40tax protein in cerebrospinal fluid cells from patients with human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. J Neurovirol 5: 241-248
29. Nagai M, Yamano Y, Brennan MB, Mora CA, Jacobson S (2001) Increased HTLV-I proviral load and preferential expansion of HTLV-I Tax-specific CD8+ T cells in cerebrospinal fluid from patients with HAM/TSP. Ann Neurol 50: 807-812
30. Nakagawa M, Izumo S, Ijichi S, Kubota H, Arimura K, Kawabata M, Osame M (1995) HTLV-I associated myelopathy: analysis of 213 patients based on clinical features and laboratory findings. J Neurovirol 1: 50-61
31. Osame M, Usuku K, Izumo S, Ijichi N, Amitani H, Igata A, Matsumoto M, Tara M (1986) HTLV-I associated myelopathy, a new clinical entity. Lancet 1: 1031-1032
32. Osame M, Matsumoto M, Usuku K, Izumo S, Ijichi N, Amitani H, Tara M, Igata A (1987) Chronic progressive myelopathy associated with elevated antibodies to human T-lymphotropic virus type I and adult T-cell leukemialike cells. Ann Neurol 21: 117-122
33. Parker CE, Daenke S, Nightingale S, Bangham CR (1992) Activated, HTLV-I-specific cytotoxic T-lymphocytes are found in healthy seropositive as well as in patients with tropical spastic paraparesis. Virology 188: 628-636
34. Ramirez E, Cartier L, Rios M, Fernández J (1998) Defective human T cell lymphotropic virus type I (HTLV-I) Provirus in 10 Chilean seronegative patients with tropical spastic paraparesis or HTLV-I associated myelopathy. J Clin Microbiol 36: 1811-1813
35. Ramirez E, Fernandez J, Cartier L, Villota C, Rios M (2003) Defective HTLV-I provirus in seronegative tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM) patients. Virus Res 91: 231-239
36. Reid E (2003) Science in motion: common molecular pathological themes emerge in the hereditary spastic paraplegias. J Med Genet 40: 81-86
37. Schachter D, Cartier L, Borzutzky A (2003) Osteoporosis in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). Bone 33: 192-196
38. Takenouchi N, Yamano Y, Usuku K, Osame M, Izumo S (2003) Usefulness of proviral load measurement for monitoring of disease activity in individual patients with human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. J Neurovirol 9: 29-35
39. Umehara F, Izumo S, Nakagawa M, Ronquillo AT, Takahashi K, Matsumoro K, Sato E, Osame M (1993) Immunocytochemical analysis of the cellular infiltrate in the spinal cord lessions in HTLV-I associated myelopathy. J Neuropath Exp Neurol 52: 424-430
40. Umehara F, Izumo S, Ronquillo AT, Matsumuro K, Sato E, Osame M (1994) Cytokine expression in the spinal cord lesions in HTLV-I-associated myelopathy. J Neuropathol Exp Neurol 53: 72-77
41. Wilson K, Centern D, Cruikshank W, Zhang Y (2003) Binding of HTLV-I tax oncoprotein to the precursor of interleukin-16, a T cell PDZ domain-containing protein. Virology 306: 60-67
42. Wodarz D, Nowak MA, Bangham CR (1999) The dynamics of HTLV-I and the CTL response. Immunol Today 20: 220-227
43. Zucker-Franklin D, Pancake BA, Lalezari P, Khorshidi M (2000) Transmission of human T-cell lymphotropic virus type 1 tax to rabbits by tax-only-positive human cells. Clin Diagn Lab Immunol 7: 274-278