How does interleukin 15 contribute to the pathogenesis of HTLV type 1-associated myelopathy/tropical spastic paraparesis?

AIDS Research and Human Retroviruses

Volumn 16, Issue 16, 2000, Pages 1717-1722

  Azimi, N ^a   Mariner, J ^a   Jacobson, S ^b   Waldmann, T A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN RECEPTOR; TRANSCRIPTION FACTOR;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; PATHOGENESIS; PRIORITY JOURNAL; SPASTIC PARAPLEGIA; SPINAL CORD DISEASE; T LYMPHOCYTE;

GENE PRODUCTS, TAX; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; INTERLEUKIN-15; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; PARAPARESIS, TROPICAL SPASTIC; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; TRANS-ACTIVATION (GENETICS); UP-REGULATION;

EID: 0034329360     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/08892220050193209     Document Type: Article

References (24)

1. Detection and isolation Of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T cell lymphoma
2. A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells
3. Structure of HTLV-I
4. Biology of HTLV-I: Host cell interactions
5. Adult T-cell leukemia: Clinical and hematologic features of 16 cases
6. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis
7. HTLV-1 associated myelopathy, a new clinical entity
8. Human T lymphotropic virus, type-I myelopathy: An immunopathologically mediated chronic progressive disease of the central nervous system
9. Review of WHO Kagoshima meeting and diagnostic guidelines for HAM/TSP
10. HTLV-I proviral DNA amount correlates with infiltrating CD4+ lymphocytes in the spinal cord from patients with HTLV-I-associated myelopathy
11. Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-1 pX in patients with HTLV-I-associated neurological disease
12. Pathogenesis of diseases induced by human lymphotropic virus type I infection
13. Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins
14. Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I
15. A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells
16. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
17. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular patheogens
18. Interleukin-2, interleukin-15, and their receptors
19. Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: Pathogenic implications and a rationale for immunotherapy
20. Humanized antibodies against the alpha-chain of the IL-2 receptor and against the beta-chain shared by the IL-2 and IL-15 receptors in a monkey uveitis model of autoimmune diseases
21. Involvement of IL-45 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: Implications for therapy with a monoclonal antibody directed to the IL-2/15R beta receptor
22. Potent and selective stimulation of memory-phenotype CD8 + T cells in vivo by IL-15
23. HTLV-I-specific cytotoxic T lymphocytes in the cerebrospinal fluid of patients with HTLV-I-associated neurological disease
24. Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-kappa B site