Novel drug release profiles from micellar solutions of PLA-PEO-PLA triblock copolymers

Journal of Controlled Release

Volumn 112, Issue 1, 2006, Pages 64-71

  Agrawal, Sarvesh K ^a   Sanabria DeLong, Naomi ^b   Coburn, Jeannine M ^a   Tew, Gregory N ^b   Bhatia, Surita R ^a  

^a University of Massachusetts   (United States)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Controlled release; Micelles; Polyethylene oxide; Polylactic acid; Triblock

Indexed keywords

CONTROLLED RELEASE; POLYETHYLENE OXIDE; POLYLACTIC ACID; TRIBLOCKS;

BLOCK COPOLYMERS; HYDROPHOBICITY; MICELLES; MOLECULAR WEIGHT; PHARMACOKINETICS; REACTION KINETICS; SOLUTIONS;

DRUG PRODUCTS;

COPOLYMER; DRUG CARRIER; MACROGOL; POLY(LACTIDE CO ETHYLENE OXIDE CO LACTIDE); POLYETHYLENE; POLYLACTIDE; SULINDAC; TETRACAINE; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE STUDY; CRYSTALLIZATION; MICELLE; MOLECULAR INTERACTION; MOLECULAR WEIGHT; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE PREPARATION; TIME;

CRYSTALLIZATION; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; KINETICS; MICELLES; MODELS, BIOLOGICAL; MOLECULAR WEIGHT; PHARMACEUTICAL PREPARATIONS; POLYESTERS; POLYETHYLENE GLYCOLS; POLYMERS; SOLUBILITY; SULINDAC; TETRACAINE;

EID: 33645783017     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.12.024     Document Type: Article

References (36)

1. Kataoka K., Yokoyama M., Kwon G.S., Okano T., and Sakurai Y. Block copolymer micelles as vehicles for drug delivery. J. Control. Release 24 (1993) 119-132
2. Lunt J. Large-scale production, properties and commercial applications of polylactic acid polymers. Polym. Degrad. Stab. 59 (1998) 145-152
3. Langer R. New methods of drug delivery. Science 249 (1990) 1527-1533
4. Gref R., Minamitake Y., Peracchia M.T., Trubetskoy V., Torchilin V., and Langer R. Biodegradable long circulating nanospheres. Science 263 (1994) 1600-1603
5. Hershfield M.S., Buckley R.H., Greenberg M.L., Melton A.L., Schiff R., Hatem C., Kurtzberg J., Markert M.L., Kobayashi R.H., Kobayashi A.L., and Abuchowski A. Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase. N. Engl. J. Med. 316 (1987) 589-596
6. Kricheldorf H.R., and Meierhaack J. Polylactones. 22. ABA triblock copolymers of l-lactide and poly(ethylene glycol). Makromol. Chem. 194 (1993) 715-725
7. Kubies D., Rypacek F., Kovarova J., and Lednicky F. Microdomain structure in polylactide-block-poly (ethylene oxide) copolymer films. Biomaterials 21 (2000) 529-536
8. Kissel T., Li Y.X., and Unger F. ABA-triblock copolymers from biodegradable polyester A-blocks and hydrophilic poly(ethylene oxide) B-blocks as a candidate for in situ forming hydrogel delivery systems for proteins. Adv. Drug Deliv. Rev. 54 (2002) 99-134
9. Li S.M., Rashkov I., Espartero J.L., Manolova N., and Vert M. Synthesis, characterization, and hydrolytic degradation of PLA/PEO/PLA triblock copolymers with long poly (l-lactic acid) blocks. Macromolecules 129 (1996) 57-62
10. Liu L., Li C., Li X., Yuan Z., An Y., and He B. Biodegradable polylactide/poly(ethylene glycol)/polylactide, triblock copolymer micelles as anticancer drug carriers. J. Appl. Polym. Sci. 80 (2001) 1976-1982
11. Li Y.X., and Kissel T. Synthesis and properties of biodegradable ABA triblock copolymers consisting of poly (l-lactic acid) or poly(l-lactic-co-glycolic acid) A-blocks attached to central poly(oxyethylene) B-blocks. J. Control. Release 27 (1993) 247-257
12. Li Y.X., Volland C., and Kissel T. In-vitro degradation and bovine serum-albumin release of the ABA triblock copolymers consisting of poly(L(+)lactic acid), or poly(L(+)lactic acid-co-glycolic acid) A-blocks attached to central polyoxyethylene B-blocks. J. Control. Release 32 (1994) 121-128
13. Saito N., Okada T., Horiuchi H., Murakami N., Takahashi J., Nawata M., Ota H., Nozaki K., and Takaoka K. A biodegradable polymer as a cytokine delivery system for inducing bone formation. Nat. Biotechnol. 19 (2001) 332-335
14. Molina I., Li S.M., Martinez M.B., and Vert M. Protein release from physically crosslinked hydrogels of the PLA/PEO/PLA triblock copolymer-type. Biomaterials 22 (2001) 363-369
15. Jeong B., Bae Y.H., Lee D.S., and Kim S.W. Biodegradable block copolymers as injectable drug-delivery systems. Nature 388 (1997) 860-862
16. Yasugi K., Nagasaki Y., Kato M., and Kataoka K. Preparation and characterization of polymer micelles from poly (ethylene glycol)-poly (d, l-lactide) block copolymers as potential drug carriers. J. Control. Release 62 (1999) 89-100
17. Chen X.H., McCarthy S.P., and Gross R.A. Synthesis and characterization of L-lactide-ethylene oxide multiblock copolymers. Macromolecules 30 (1997) 4295-4301
18. Liu L., Li C.X., Liu X.H., and He B.L. Micellar formation in aqueous milieu from biodegradable triblock copolymer polylactide/poly(ethylene glycol)/polylactide. Polym. J. 31 (1999) 845-850
19. Choi S.K., and Kim D. Drug-releasing behavior of MPEG/PLA block copolymer micelles and solid particles controlled by component block length. J. Appl. Polym. Sci. 83 (2002) 435-445
20. Jeong B., Kibbey M.R., Birnbaum J.C., Won Y.Y., and Gutowska A. Thermogelling biodegradable polymers with hydrophilic backbones: PEG-g-PLGA. Macromolecules 33 (2000) 8317-8322
21. Semenov A.N., Joanny J.F., and Khokhlov A.R. Associating polymers: equilibrium and linear viscoelasticity. Macromolecules 28 (1995) 1066-1075
22. Aamer K.A., Sardinha H., Bhatia S.R., and Tew G.N. Rheological studies of PLLA-PEO-PLLA triblock copolymer hydrogels. Biomaterials 25 (2004) 1087-1093
23. Agrawal S.K., Chin K.S., Sanabria-DeLong N., Aamer K.A., Sardinha H., Tew G.N., Roberts S.C., and Bhatia S.R. Rheology and biocompatibility of poly(lactide)-poly(ethylene oxide)-poly(lactide) hydrogels. Mater. Res. Soc. Symp. Proc. 844 (2005) Y9.8.1-Y9.8.6
24. Tew G.N., Sanabria-DeLong N., Agrawal S.K., and Bhatia S.R. New properties from PLA-PEO-PLA hydrogels. Soft Matter 1 4 (2005) 253-258
25. Tew G.N., Sanabria-DeLong N., Agrawal S.K., and Bhatia S.R. New properties from PLA-PEO-PLA hydrogels. Soft Matter 1 (2005) 253-258
26. Sanabria-DeLong N., Agrawal S.K., Bhatia S.R., and Tew G.N. Controlling hydrogel properties by crystallization of hydrophobic domains. Macromolecules 39 (2006) 1308-1310
27. Grouls R.J.E., Ackerman E.W., Korsten H.H.M., Hellebrekers L.J., and Breimer D.D. Partition coefficients (n-octanol/water) of N-butyl-p-aminobenzoate and other local anesthetics measured by reversed-phase high pressure liquid chromatography. J. Chromatogr. B, Biomed. Sci. Appl. 694 (1997) 421-425
28. Caron G., Gaillard P., Carrupt P., and Testa B. Lipophilicity behavior of model and medicinal compounds containing a sulfide, sulfoxide or sulfone moiety. Helv. Chim. Acta 80 (1997) 449-462
29. Landgraf W., Li N.H., and Benson J.R. Polymeric microcarrier exhibiting zero order release. Drug Deliv. Technol. 3 1 (2003)
30. Ramirez L., Pastoriza P., and Herrero-Vanrell R. Biodegradable poly(dl-lactic-co-glycolic acid) microspheres containing tetracaine hydrochloride. In-vitro release profile. J. Microencapsul 16 (1999) 105-115
31. Zhang X., Jackson J.K., and Burt H.M. Development of amphiphilic diblock copolymers as micellar carriers of taxol. Int. J. Pharm. 132 (1996) 195-206
32. Tros de Ilarduya M.C., Martin C., Goni M.M., and Martinez-Oharriz M.C. Solubilization and interaction of sulindac with polyvinylpyrrolidone K30 in solid state and in aqueous solution. Drug Dev. Ind. Pharm. 24 (1998) 295-300
33. Li Y., and Kwon S. Methotrexate esters of poly(ethylene oxide)block-poly(2-hydroxyethyl-l-aspartamide). Part I: effects of the level of methotrexate conjugation on the stability of micelles and on drug release. Pharm. Res. 17 (2000) 607-611
34. Li Y., Ikeda S., Nakashima K., and Nakamura H. Nanoaggregate formation of poly (ethylene oxide)-b-polymethacrylate copolymer induced by cationic anesthetics binding. Colloid Polym. Sci. 281 (2003) 562-568
35. Kondo S., Hosaka S., Hatakeyama I., and Kuzuya M. Mechanochemical solid-sate polymerization. IX. Theoretical analysis of drug release from powdered polymeric drugs in heterogeneous systems. Chem. Pharm. Bull. 46 (1998) 1918-1923
36. D'Souza A.J.M., and Topp E.M. Release from polymeric prodrugs. J. Pharm. Sci. 93 (2004) 1962-1979