Mechanochemical solid-state polymerization. IX. Theoretical analysis of rate of drug release from powdered polymeric prodrugs in a heterogeneous system

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 12, 1998, Pages 1918-1923

  Kondo, Shin Ichi ^a   Hosaka, Shouichi ^a   Hatakeyama, Isao ^a   Kuzuya, Masayuki ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Drug release; Heterogeneous system; Mechanochemical polymerization; Polymeric prodrug; Rate equation

Indexed keywords

POLYMER; PRODRUG;

ARTICLE; CONTROLLED DRUG RELEASE; DIFFUSION; DRUG RELEASE; HYDROLYSIS; POLYMERIZATION;

EID: 0032446094     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.1918     Document Type: Article

References (3)

1. Sinkula A. A., "Design of Prodrugs", ed. by Bundgaard H., Elsevier Science Publishers, Amsterdam, The Netherlands, 1985, pp. 157-176.
2. Pierre T. S., Chiellini E., J. Bioact. Compat. Polym., 1, 467-497 (1986).
3. Roos C. F., Matsumoto S., Takakura Y., Hashida M., Sezaki H., Int. J. Pharm., 22, 75-87 (1984).