Partition coefficients (n-octanol/water) of N-butyl-p-aminobenzoate and other local anesthetics measured by reversed-phase high-performance liquid chromatography

Journal of Chromatography B: Biomedical Applications

Volumn 694, Issue 2, 1997, Pages 421-425

  Grouls, R J E ^a   Ackerman, E W ^a   Korsten, H H M ^a   Hellebrekers, L J ^b   Breimer, D D ^c  

^a CATHARINA HOSPITAL   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c Clinical Pharmacology   (Netherlands)

Author keywords

Benzocaine; Bupivacaine; Etidocaine; Lidocaine; Mepivacaine; Methyl p aminobenzoate; N Butyl p aminobenzoate; Oxubuprocaine; Partition coefficient; Procaine; Tetracaine

Indexed keywords

4 AMINOBENZOIC ACID METHYL ESTER; 4 BUTYLAMINOBENZOIC ACID; BENZOCAINE; BUPIVACAINE; ETIDOCAINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; MEPIVACAINE; OXYBUPROCAINE; PRILOCAINE; PROCAINE; TETRACAINE; UNCLASSIFIED DRUG;

ARTICLE; CALIBRATION; IN VITRO STUDY; PARTITION COEFFICIENT; PH; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TECHNIQUE;

1-OCTANOL; ANESTHETICS, LOCAL; BENZOCAINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGEN-ION CONCENTRATION; OCTANOLS; SOLUBILITY; WATER;

EID: 0030797341     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(97)00207-7     Document Type: Article

References (31)

1. Shulman M. Reg. Anesth. 12:1987;1.
2. Korsten H.H.M., Ackerman E.W., Grouls R.J.E., van Zundert A.A.J., Boon W.F., Bal F., Crommelin M.A., Ribot J.G., Hoefsloot F., Slooff J.L. Anesthesiology. 75:1991;950.
3. Korsten H.H.M., Hellebrekers L.J., Grouls R.J.E., Ackerman E.W., van Zundert A.A.J., van Herpen H., Gruys E. Anesthesiology. 739:1990;491.
4. von Buchi J., Perlia X., Strassle A. Arzneim.-Forsch. 16:1966;1657.
5. Yalkowsky S.H., Flyn G.L., Slunick T.G. J. Pharm. Sci. 61:1972;852.
6. Glyn G.L., Yalkowsky S.H. J. Pharm. Sci. 61:1972;838.
7. B.G. Ciovino, H. Vasallo, Local Anesthetics: Mechanisms of Action and Clinical Use, Grune and Stratton, New York, 1976.
8. Wildsmith J.A.W., Brown D.T., Paul D., Johnson S. Br. J. Anaesth. 63:1989;444.
9. Wildsmith J.A.W., Gissen A.J., Takman B., Covino B.G. Br. J. Anaest. 59:1987;379.
10. Butterworth J.F., Strichartz G.R. Anesthesiology. 72:1990;711.
11. Mackay D. Environ. Sci. Technol. 13:1979;1218.
12. Yalkowski S.H., Valvani S.C., Roseman T.J. J. Pharm. Sci. 72:1983;866.
13. Strichartz G.R., Sanchez V., Arthur R., Chafetz R., Martin D. Anesth. Analg. 71:1990;158.
14. G.R. Strichartz, Handbook of Experimental Pharmacology, Vol. 81: Local Anesthetics, Springer, Berlin, 1987.
15. Lambert W.J. J. Chromatogr. 656:1993;469.
16. Dorsey J.G., Khaledi M.G. J. Chromatogr. 656:1993;485.
17. OECD Guideline for Testing of Chemicals, 117, Partition Coefficients (n-octanol/water), HPLC Method, OECD, Paris, 1989.
18. Tripsa M., Sahini V.E., Nae C., Vasilescu V. Gen. Physiol. Biophys. 5:1986;371.
19. Valko K., Slegel P. J. Chromatogr. 631:1993;49.
20. Minick D.J., Brent D.A., Frenz J. J. Chromatogr. 461:1989;177.
21. Kaliszan R. CRC Crit. Rev. Anal. Chem. 16:1986;323.
22. Patel H.B., King D.N., Jefferies T.M. J. Chromatogr. 355:1991;21.
23. Miyake K., Mizuno N., Terada H. Chem. Pharm. Bull. 34:1986;4787.
24. Yamagami C., Ogura T., Takao N. J. Chromatogr. 514:1990;123.
25. Schoenmakers P.J., Billiet H.A.H., Tyssen R., de Galan L. J. Chromatogr. 149:1978;519.
26. Gullner G., Cserhati T., Bordas B., Valko K. J. Liq. Chromatogr. 12:1989;957.
27. Valko K. J. Liq. Chromatogr. 7:1984;1405.
28. McCall J.M. J. Med. Chem. 18:1975;549.
29. De Biasi V., Lough W.J., Evans M.B. J. Chromatogr. 353:1986;279.
30. Kaliszan R., Blain R.W., Hartwick R.A. Chromatographia. 15:1988;5.
31. Ascah T.C., Feibush B. J. Chromatogr. 506:1990;357.