DOCK2 is required in T cell precursors for development of Vα14 NK T cells

Journal of Immunology

Volumn 176, Issue 8, 2006, Pages 4640-4645

  Kunisaki, Yuya ^a   Tanaka, Yoshihiko ^a   Sanui, Terukazu ^a   Inayoshi, Ayumi ^a,b   Noda, Mayuko ^a,b   Nakayama, Toshinori ^c   Harada, Michishige ^d   Taniguchi, Masaru ^d   Sasazuki, Takehiko ^e   Fukui, Yoshinori ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c CHIBA UNIVERSITY   (Japan)

^d RIKEN Center for Integrative Medical Sciences   (Japan)

^e NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA GALACTOSYLCERAMIDE; ASPARTATE AMINOTRANSFERASE; CD1D ANTIGEN; CONCANAVALIN A; CYTOKINE; DOCK2 PROTEIN; GAMMA INTERFERON; INTERLEUKIN 4; PROTEIN; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BONE MARROW; CHIMERA; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOREGULATION; LIVER; LIVER FUNCTION TEST; LYMPHOCYTE MIGRATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; SPLEEN CELL; T LYMPHOCYTE SUBPOPULATION; THYMUS; TOXIC HEPATITIS;

EID: 33645753732     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.8.4640     Document Type: Article

References (45)

1. - thymocytes by class I molecules expressed by hematopoietic cells. J. Exp. Med. 178: 901-908.
2. + thymocytes. J. Exp. Med. 180: 395-399.
3. + thymocytes selected by MHC class I molecules. Science 263: 1774-1778.
4. + T lymphocytes. Science 268: 863-865.
5. + cells in the liver of mice. J. Exp. Med. 180: 699-704.
6. + T cells by CD1-expressing cortical thymocytes. J. Exp. Med. 182: 2091-2096.
7. + cells. J. Immunol. 164: 2412-2418.
8. Gapin, L., J. L. Matsuda, C. D. Surh, and M. Kronenberg. 2001. NKT cells derive from double-positive thymocytes that are positively selected by CD1d. Nat. Immunol. 2: 971-978.
9. - single-positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor Vβ family. Proc. Natl. Acad. Sci. USA 89: 6506-6510.
10. - T cells in mice and humans. J. Exp. Med. 180: 1097-1106.
11. Kawano, T., J. Cui, Y. Koezuka, I. Toura, Y. Kaneko, K. Motoki, H. Ueno, R. Nakagawa, H. Sato, E. Kondo, et al. 1997. CD Id-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides. Science 278: 1626-1629.
12. Kronenberg, M., and L. Gapin. 2002. The unconventional lifestyle of NKT cells. Nat. Rev. Immunol. 2: 557-568.
13. Benlagha, K., T. Kyin, A. Beavis, L. Teyton, and A. Bendelac. 2002. A thymic precursor to the NK T cell lineage. Science 296: 553-555.
14. + CD1d-dependent precursor stage. J. Exp. Med. 195: 835-844.
15. Honey, K., K. Benlagha, C. Beers, K. Forbush, L. Teyton, M. J. Kleijmeer, A. Y. Rudensky, and A. Bendelac. 2002. Thymocyte expression of cathepsin L is essential for NKT cell development. Nat. Immunol. 3: 1069-1074.
16. Elewaut, D., A. P. Lawton, N. A. Nagarajan, E. Maverakis, A. Khurana, S. Höning, C. A. Benedict, E. Sercarz, O. Bakke, M. Kronenberg, and T. I. Prigozy. 2003. The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Vα14i NKT cells. J. Exp. Med. 198: 1133-1146.
17. Zhou, D., C. Cantu III, Y. Sagiv, N. Schrantz, A. B. Kulkarni, X. Qi, D. J. Mahuran, C. R. Morales, G. A. Grabowski, K. Benlagha, et al. 2004. Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins. Science 303: 523-527.
18. + cell development. J. Immunol. 159: 5931-5935.
19. Matsuda, J. L., L. Gapin, S. Sidobre, W. C. Kieper, J. T. Tan, R. Ceredig, C. D. Surh, and M. Kronenberg. 2002. Homeostasis of Vα14i NKT cells. Nat. Immunol. 3: 966-974.
20. Sivakumar, V., K. J. L. Hammond, N. Howells, K. Pfeffer, and F. Weih. 2003. Differential requirement for Rel/nuclear factor κB family members in natural killer T cell development. J. Exp. Med. 197: 1613-1621.
21. Elewaut, D., R. B. Shaikh, K. J. L. Hammond, H. D. Winter, A. J. Leishman, S. Sidobre, O. Turovskaya, T. I. Prigozy, L. Ma, T. A. Banks, et al. 2003. NIK-dependent RelB activation defines a unique signaling pathway for the development of Vα14i NKT cells. J. Exp. Med. 197: 1623-1633.
22. Gadue, P., N. Morton, and P. L. Stein. 1999. The Src family tyrosine kinase Fyn regulates natural killer T cell development. J. Exp. Med. 190: 1189-1196.
23. Eberl, G., B. Lowin-Kropf, and H. R. MacDonald. 1999. Cutting edge: NKT cell development is selectively impaired in Fyn-deficient mice. J. Immunol. 163: 4091-4094.
24. Gadue, P., L. Yin, S. Jain, and P. L. Stein. 2004. Restoration of NK T cell development in fyn-mutant mice by a TCR reveals a requirement for Fyn during early NK T cell ontogeny. J. Immunol. 172: 6093-6100.
25. Dao, T., D. Guo, A. Ploss, A. Stolzer, C. Saylor, T. E. Boursalian, J. S. Im, and D. B. Sant' Angelo. 2004. Development of CD1d-restricted NKT cells in the mouse thymus. Eur. J. Immunol. 34: 3542-3552.
26. Pasquier, B., L. Yin, M.-C. Fondanèche, F. Relouzat, C. Bloch-Queyrat, N. Lambert, A. Fischer, G. de Saint-Basile, and S. Latour. 2005. Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product. J. Exp. Med. 201: 695-701.
27. Chung, B., A. Aoukaty, J. Dutz, C. Terhorst, and R. Tan. 2005. Cutting edge: signaling lymphocytic activation molecule-associated protein controls NKT cell functions. J. Immunol. 174: 3153-3157.
28. + regulatory and natural killer-like T cells on signals leading to NF-κB activation. Proc. Natl. Acad. Sci. USA 101: 4566-4571.
29. Reif, K., and J. G. Cyster. 2002. The CDM protein DOCK2 in lymphocyte migration. Trends Cell Biol. 12: 368-373.
30. Fukui, Y., O. Hashimoto, T. Sanui, T. Oono, H. Koga, M. Abe, A. Inayoshi, M. Noda, M. Oike, T. Shirai, and T. Sasazuki. 2001. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature 412: 826-831.
31. Sanui, T., A. Inayoshi, M. Noda, E. Iwata, M. Oike, T. Sasazuki, and Y. Fukui. 2003. DOCK2 is essential for antigen-induced translocation of TCR and lipid rafts, but not PKC-θ and LFA-1, in T cells. Immunity 19: 119-129.
32. Nishihara, H., S. Kobayashi, Y. Hashimoto, F., Ohba, N. Mochizuki, T. Kurata, K. Nagashima, and M. Matsuda. 1999. Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins. Biochem. Biophys. Acta 1452: 179-187.
33. Mendiratta, S. K., W. D. Martin, S. Hong, A. Boesteanu, S. Joyce, and L. van Kaer. 1997. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6: 469-477.
34. Matsuda, J. L., O. V. Naidenko, L. Gapin, T. Nakayama, M. Taniguchi, C.-R. Wang, Y. Koezuka, and M. Kronenberg. 2000. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J. Exp. Med. 192: 741-753.
35. Eberl, G., R. Lees, S. T. Smiley, M. Taniguchi, M. J. Grusby, and H. R. MacDonald. 1999. Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells. J. Immunol. 162: 6410-6419.
36. Kaneko, Y., M. Harada, T. Kawano, M. Yamashita, Y. Shibata, F. Gejyo, T. Nakayama, and M. Taniguchi. 2000. Augmentation of Vα14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of Concanavalin A-induced hepatitis. J. Exp. Med. 191: 105-114.
37. Takeda, K., Y. Hayakawa, L. van Kaer, H. Matsuda, H. Yagita, and K. Okumura. 2000. Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc. Natl. Acad. Sci. USA 97: 5498-5503.
38. Jiang, H., F. Pan, L. M. Erickson, M.-S. Jang, T. Sanui, Y. Kunisaki, T. Sasazuki, M. Kobayashi, and Y. Fukui. 2005. Deletion of DOCK2, a regulator of the actin cytoskeleton in lymphocytes, suppresses cardiac allograft rejection. J. Exp. Med. 202: 1121-1130.
39. Nombera-Arrieta, C., R. A. Lacalle, M. C. Montoya, Y. Kunisaki, D. Megías, M. Marqués, A. C. Carrera, S. Mañes, Y. Fukui, C. Martínez-A, and J. V. Stein. 2004. Differential requirements for DOCK2 and phosphoinositide-3-kinase γ during T and B lymphocyte homing. Immunity 21: 429-441.
40. Matsuda, J. L., and L. Gapin. 2005. Developmental program of mouse Vα14i NKT cells. Curr. Opin. Immunol. 17: 122-130.
41. Sayos, J., C. Wu, M. Morra, N. Wang, X. Zhang, D. Allen, S. van Schaik, L. Notarangelo, R. Geha, M. G. Roncarolo, et al. 1998. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature 395: 462-469.
42. Latour, S., R. Roncagalli, R. Chen, M. Bakinowski, X. Shi, P. L. Schwartzberg, D. Davidson, and A. Veillette. 2003. Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation. Nat. Cell Biol. 5: 149-153.
43. Chan, B., A. Lanyi, H. K. Song, J. Griesbach, M. Simarro-Grande, F. Poy, D. Howie, J. Sumegi, C. Terhorst, and M. J. Eck. 2003. SAP couples Fyn to SLAM immune receptors. Nat. Cell Biol. 5: 155-160.
44. Cannons, J. L., L. J. Yu, B. Hill, L. A. Mijares, D. Dombroski, K. E. Nichols, A. Antonellis, G. A. Koretzky, K. Gardner, and P. L. Schwartzberg. 2004. SAP regulates Th2 differentiation and PKC-θ-mediated activation of NF-κB1. Immunity 21: 693-706.
45. Zhou, D., J. Mattner, C. Cantu III, N. Schrantz, N. Yin, Y. Gao, Y. Sagiv, K. Hudspeth, Y.-P. Wu, T. Yamashita, et al. 2004. Lysosomal glycosphingolipid recognition by NKT cells. Science 306: 1786-1789.