Comments on article "applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: An example with trichloroethylene" by Clewell and Andersen

Critical Reviews in Toxicology

Volumn 36, Issue 3, 2006, Pages 291-294

  Caldwell, Jane C ^a   Evans, Marina V ^a   Marcus, Allan H ^a   Scott, Cheryl Siegel ^a   Chiu, Weihsueh A ^a   Okino, Miles S ^a   Preuss, Peter W ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Cancer; Mode of Action; Pharmacokinetics; Risk Assessment; Trichloroethylene

Indexed keywords

DRUG METABOLITE; HALOGENATED HYDROCARBON; TRICHLOROETHYLENE; VINYL CHLORIDE;

CANCER RISK; CARCINOGENIC ACTIVITY; DOSE RESPONSE; GOVERNMENT; HEALTH HAZARD; HUMAN; INFORMATION; NONHUMAN; QUANTITATIVE ANALYSIS; REVIEW; RISK ASSESSMENT; SCIENTIFIC LITERATURE; SCIENTIST; TOXICITY;

ANIMALS; CARCINOGENICITY TESTS; ENVIRONMENTAL POLLUTANTS; GUIDELINES; HUMANS; MODELS, BIOLOGICAL; RISK ASSESSMENT; TRICHLOROETHYLENE; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

EID: 33645731704     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.1080/10408440600599240     Document Type: Review

References (33)

1. Anttila, A., Pukkala, E., Sallmen, M., Hernberg, S., Hemminki, K. (1995). Cancer incidence among Finnish workers exposed to halogenated hydrocarbons. J. Environ. Occup. Med. 37:797-806.
2. Axelson, O., Selden, A., Andersson, K., and Hogstedt, C. (1994). Updated and expanded Swedish cohort study on trichloroethylene and cancer risk. J. Occup. Med. 36:556-562.
3. Bannasch, P., Nehrbass, D., and Kopp-Schneider, A. (2001). Significance of hepatic preneoplasia for cancer chemoprevention. IARC Sci Publ. 154:223-240.
4. Blair, A., Hartge, P., Stewart, P.A., McAdams, M., and . Lubin, J. (1999) Mortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: Extended follow up. Occup. Environ. Med. 55:161-171.
5. Bull, R.J., Orner, G.A., Cheng, R.S., Stillwell, L., Stauber, A.J., Sasser, L.B., Lingohr, M.K., and Thrall, B.D. (2002). Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene. Toxicol. Appl. Pharmacol. 182(1):55-65.
6. Bull, R.J., Sasser, L.B., and Lei, X.C. (2004). Interaction in the tumor promoting activity of carbon tetrachloride, trichloroacetate, and dichloroacetate in the liver of male B6c3F1 mice. Toxicology 199 (2-3):169-83.
7. Clewell, H. J., and Andersen, M. E., (2004). Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: An example with trichloroethylene. Crit. Rev. Toxicol. 34(5):385-445.
8. Clewell, H. J., Gentry, P. R., Gearhart, M., Allen, B. C., and Andersen, M. E. (1995). Considering pharmacokinetic and mechanistic information in cancer risk assessments for environmental contaminants: Examples with vinyl chloride and trichloroethylene. Chemosphere 31(1):2561-2578.
9. Clewell, H.J. III, Gentry, P.R., Covington, T.R., and Gearhart, J.M. (2000). Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment. Environ. Health Perspect. 108(suppl, 2):283-305.
10. Fisher, J.W. (2000). Physiologically based pharmacokinetic models for trichloroethylene and its oxidative metabolites. Environ. Health Perspect. 108(suppl. 2):265-273
11. Ge, R., Yang, S., Kramer, P.M., Tao, L., and Pereira, M.A. (2001). The effect of dichloroacetic acid and trichloroacetic acid on DNA methylation and cell proliferation in B6C3F1 mice. J. Biochem. Mol. Toxicol. 15(2):100-106.
12. Ge, R., Tao, L., Kramer, P.M., Cunningham, M.L., and Pereira, M.A. (2002). Effect of peroxisome proliferators on the methylation and protein level of the c-myc protooncogene in B6C3F1 mice liver. J. Biochem. Mol. Toxicol. 16(1):41-47.
13. International Agency for Research on Cancer. (1995). Dry cleaning, some solvents used in dry cleaning and other industrial chemicals. Scand. J. Work Enivron. Health 21:310-312.
14. Kato-Weinstein, J., Stauber, A.J, Orner, G.A., Thrall, B.D., and Bull, R.J. (2001). Differential effects of dihalogenated and trihalogenated acetates in the liver of B6C3F1 mice. J. Appl. Toxicol. 21(2):81-89.
15. Lewandowski, T. A., and Rhomberg, L.R. (2005). A proposed methodology for selecting a trichloroethylene inhalation unit risk value for use in risk assessment. Regul. Toxicol. Pharmacol. 41(1):39-54. Epub 2004 Dec 10.
16. Lingohr, M.K., Bull, R.J., Kato-Weinstein, J., and Thrall, B.D. (2002). Dichloroacetate stimulates glycogen accumulation in primary hepatocytes through an insulin-independent mechanism. Toxicol. Sci. 68(2):508-515.
17. Lingohr, M.K., Thrall, B.D., and Bull, R.J. (2001). Effects of dichloroacetate (DCA) on serum insulin levels and insulin-controlled signaling proteins in livers of male B6C3F1 mice. Toxicol. Sci. 59(1):178-184.
18. National Academy of Sciences Board on Environmental Studies and Toxicology. (2005). Assessing the human health risks of trichloroethylene: Key scientific issues. Washington, DC: National Academy of Sciences; 2005 URL: http://www4.nas.edu/cp.nsf/Projects+_by+_PIN/BEST-K-03-06-A?OpenDocument
19. Pereira, M.A., Kramer, P.M., Conran, P.B., and Tao, L. (2001). Effect of chloroform on dichloroacetic acid and trichloroacetic acid-induced hypomethylation and expression of the c-myc gene and on their promotion of liver and kidney tumors in mice. Carcinogenesis 22(9):1511-1519.
20. Pereira, M.A., Wang, W., Kramer, P.M., and Tao, L. (2004). Prevention by methionine of dichloroacetic acid-induced liver cancer and DNA hypomethylation in mice. Toxicol. Sci. 77(2):243-248. Epub 2003 Dec 02.
21. Raaschou-Nielsen, O., Hansen J., McLaughlin, J.K., Kolstad, H., Christensen J.M., Tarone, R.E., and Olsen J.H. (2003). Cancer Risk among workers at Danish companies using trichloroethylene: A cohort study. Am. J. Epidemiol. 158:1182-1192.
22. Rhomberg, L.R. (2000). Dose-response analyses of the carcinogenic effects of trichloroethylene in experimental animals. Environ. Health Perspect. 108(suppl. 2):343-358.
23. Schultz, I.R., Merdink, J.L., Gonzalez-Leon, A., and Bull, R.J. (2002). Dichloroacetate toxicokinetics and disruption of tyrosine catabolism in B6C3F1 mice: Dose-response relationships and age as a modifying factor. Toxicology 173(3):229-247.
24. Simmons, J.E., Boyes, W.K., Bushnell, P.J., Raymer, J.H., Limsakun, T., McDonald, A., Sey, Y.M., and Evans, M.V. (2002). A physiologically based pharmacokinetic model for trichloroethylene in the male Long-Evans rat. Toxicol. Sci. 69:3-15.
25. Spiritas, R., Steward, P.A., Lee, J.S., Marano, D.E., Forbes, C.D., Grauman, D.J., Pettigrew, H.M., Blair, A., Hoover, R.N., and Cohen, J.L. (1991). Retrospective cohort mortality study of workers at an aircraft maintenance facility. I. Epidemiological results. Br. J. Ind. Med. 48:531-537.
26. Tao, L., Li, Y., Kramer, P.M., Wang, W., and Pereira, M.A. (2004). Hypomethylation of DNA and the insulin-like growth factor-II gene in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors. Toxicology 196(1-2):127-136.
27. U.S. Environmental Protection Agency. (1985). Health assessment document for trichloroethylene: EPA/600/8-82/006F. Office of Health and Environmental Assessment, Washington, DC.
28. U.S. Environmental Protection Agency. (1987). Addendum to the health assessment document for trichloroethylene: Updated carcinogenicity assessment for trichloroethylene. External Review Draft EPA/600/8-82/006FA. Washington, DC: U.S. Environmental Protection Agency, Office of Health and Environmental Assessment.
29. U.S. Environmental Protection Agency. (2001). Trichloroethylene health risk assessment: Synthesis and characterization. U.S. Environmental Protection Agency, Office of Research and Development. EPA/600/P-01/002A, August. External Review Draft.
30. U.S. Environmental Protection Agency Science Advisory Board (2002). Trichloroethylene health risk assessment: Synthesis and characterization. An EPA Science Advisory Board Report. EPA-SAB-EHC-03-002. Washington, DC: U.S. Environmental Protection Agency. http://www.epa.gov/sab/pdf/ehc03002.pdf
31. U.S. Environmental Protection Agency. (2004). Symposium on new scientific research related to the health effects of trichloroethylene. Washington, DC: US Environmental Protection Agency Office of Research and Development. http://cfpub.epa.gov/ncea/cfm/recorddisplay.cfm?deid=75934
32. U.S. Environmental Protection Agency. (2005a). Trichloroethylene (TCE) health risk assessment: Overview. Washington, DC: U.S. Environmental Protection Agency, Office of Research and Development. http://cfpub.epa.gov/ncea/cfm/ recordisplay.cfm?deid=119268.
33. U.S. Environmental Protection Agency. (2005b). Trichloroethylene (TCE) issue papers. Washington, DC: U.S. Environmental Protection Agency Office of Research and Development. http://cfpub.epa.gov/ncea/cfm/recorddisplay.cfm?deid= 117502.