Dichloroacetate stimulates glycogen accumulation in primary hepatocytes through an insulin-independent mechanism

Toxicological Sciences

Volumn 68, Issue 2, 2002, Pages 508-515

  Lingohr, Melissa K ^a,b   Bull, Richard J ^a,b,c   Kato Weinstein, Junko ^a,b   Thrall, Brian D ^b  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^c WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Dichloroacetate; Glycogen; Hepatocyte; Insulin; Insulin receptor; PI3K; PKB Akt

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; DICHLOROACETIC ACID; GLUCAGON; GLYCOGEN; INSULIN; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN; PROTEIN KINASE B; RAPAMYCIN; S6 KINASE; WORTMANNIN; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; ANDROSTANE DERIVATIVE; CHROMONE DERIVATIVE; ENZYME INHIBITOR; MORPHOLINE DERIVATIVE; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; CELL ISOLATION; CELL LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; GLYCOGEN SYNTHESIS; GLYCOGENOLYSIS; HORMONAL REGULATION; IN VIVO STUDY; LIVER CELL; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; DRUG INTERACTION; METABOLISM; MOUSE STRAIN; PHYSIOLOGY;

ANIMALIA; MURINAE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; CELLS, CULTURED; CHROMONES; DICHLOROACETATE; DRUG INTERACTIONS; ENZYME INHIBITORS; GLYCOGEN; HEPATOCYTES; INSULIN; MICE; MICE, INBRED STRAINS; MORPHOLINES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN;

EID: 0036667374     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/68.2.508     Document Type: Article

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