A physiologically based pharmacokinetic model for trichloroethylene in the male Long-Evans rat

Toxicological Sciences

Volumn 69, Issue 1, 2002, Pages 3-15

  Simmons, J E ^a,d   Boyes, W K ^a   Bushnell, P J ^a   Raymer, J H ^b   Limsakun, T ^c,e   McDonald, A ^a   Sey, Y M ^a   Evans, M V ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b RTI INTERNATIONAL   (United States)

^c UNIVERSITY OF GEORGIA   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^e GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

Long Evans rat; Physiologically based pharmacokinetic model; Trichloroethylene; Vmaxc

Indexed keywords

TRICHLOROETHYLENE;

AIRFLOW; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; BLOOD LEVEL; BODY FAT; BRAIN LEVEL; BRAIN SIZE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EXPERIMENTAL MODEL; EXPOSURE; INHALATION; LIVER LEVEL; LIVER WEIGHT; LUNG VENTILATION; MALE; NEUROLOGIC DISEASE; NONHUMAN; OUTCOMES RESEARCH; PARTITION COEFFICIENT; RAT; RAT STRAIN; REGRESSION ANALYSIS; SENSITIVITY ANALYSIS; SIMULATION; TIME; TISSUE PERFUSION; TOXICOKINETICS; VAPOR;

ADIPOSE TISSUE; AGING; ANIMALS; ATMOSPHERE EXPOSURE CHAMBERS; BODY WEIGHT; BRAIN; CHEMISTRY, PHYSICAL; ENVIRONMENTAL POLLUTANTS; LIVER; MALE; MODELS, BIOLOGICAL; NERVOUS SYSTEM; ORGAN SIZE; RATS; RATS, INBRED F344; RATS, LONG-EVANS; SOLUBILITY; SPECIES SPECIFICITY; TISSUE DISTRIBUTION; TRICHLOROETHYLENE;

ANIMALIA; RODENTIA;

EID: 0036738662     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/69.1.3     Document Type: Article

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