Exogenous nitric oxide centrally enhances pulmonary reactivity in the normal and hypertensive rat

Clinical and Experimental Pharmacology and Physiology

Volumn 32, Issue 11, 2005, Pages 952-959

  Schwenke, Daryl O ^a   Pearson, James T ^a   Tsuchimochi, Hirotsugu ^a   Mori, Hidezo ^a   Shirai, Mikiyasu ^b  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b HIROSHIMA INTERNATIONAL UNIVERSITY   (Japan)

Author keywords

Chronic hypoxia; Nitric oxide; Pulmonary vasoconstriction; Sympathetic nervous system

Indexed keywords

LINSIDOMINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONOR; PENTOBARBITAL;

ADRENERGIC SYSTEM; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; BLOOD VESSEL TONE; CEREBROSPINAL FLUID; CONTROLLED STUDY; HEART OUTPUT MEASUREMENT; HEART RATE; HYPOXIA; LUNG ARTERY PRESSURE; LUNG FUNCTION; LUNG VASOCONSTRICTION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PULMONARY HYPERTENSION; RAT; RAT STRAIN;

ANIMALS; ANOXIA; BLOOD PRESSURE; CARDIAC OUTPUT; CENTRAL NERVOUS SYSTEM; HEART RATE; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; INJECTIONS, INTRAVENTRICULAR; MALE; MOLSIDOMINE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; PULMONARY CIRCULATION; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; VASCULAR RESISTANCE; VASOCONSTRICTION;

EID: 33645721521     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2005.4290.x     Document Type: Article

References (53)

1. Archer S Rich S. Primary pulmonary hypertension: A vascular biology and translational research 'work in progress'. Circulation 2000 102 : 2781 91.
2. + channels in pulmonary hypertension. Vasc. Pharmacol. 2002 38 : 25 33.
3. Barbera JA Peinado VI Santos S. Pulmonary hypertension in COPD: Old and new concepts. Monaldi Arch. Chest Dis. 2000 55 : 445 9.
4. Voelkel NF Tuder RM. Hypoxia-induced pulmonary vascular remodeling: A model for what human disease? J. Clin. Invest. 2000 106 : 733 8.
5. Fike CD Kaplowitz MR Thomas CJ Nelin LD. Chronic hypoxia decreases nitric oxide production and endothelial nitric oxide synthase in newborn pig lungs. Am. J. Physiol. 1998 274 : L517 26.
6. Huang KL Wu CP Kang BH Lin YC. Chronic hypoxia attenuates nitric oxide-dependent hemodynamic responses to acute hypoxia. J. Biomed. Sci. 2002 9 : 206 12.
7. Cornwell TL Arnold E Boerth NJ Lincoln TM. Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP. Am. J. Physiol. 1994 267 : C1405 13.
8. Le Cras TD McMurtry IF. Nitric oxide production in the hypoxic lung. Am. J. Physiol. Lung Cell. Mol. Physiol. 2001 280 : L575 82.
9. Sato J Nair K Hiddinga J et al. eNOS gene transfer to vascular smooth muscle cells inhibits cell proliferation via upregulation of p27 and p21 and not apoptosis. Cardiovasc. Res. 2000 47 : 697 706.
10. Palmer RM Rees DD Ashton DS Moncada S. l-Arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem. Biophys. Res. Commun. 1988 153 : 1251 6.
11. Fagan KA Fouty BW Tyler RC et al. The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia. J. Clin. Invest. 1999 103 : 291 9.
12. Steudel W Ichinose F Huang PL et al. Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene. Circ. Res. 1997 81 : 34 41.
13. Steudel W Scherrer-Crosbie M Bloch KD et al. Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3. J. Clin. Invest. 1998 101 : 2468-77.
14. Ozaki M Kawashima S Yamashita T et al. Reduced hypoxic pulmonary vascular remodeling by nitric oxide from the endothelium. Hypertension 2001 37 : 322 7.
15. B receptor-mediated NO synthesis in hypertensive rat lungs. Am. J. Physiol. 1999 276 : L571 81.
16. Xue C Rengasamy A Le Cras TD Koberna PA Dailey GC Johns RA. Distribution of NOS in normoxic vs. Hypoxic rat lung: Upregulation of NOS by chronic hypoxia. Am. J. Physiol. 1994 267 : L667 78.
17. Shirai M Pearson JT Shimouchi A et al. Changes in functional and histological distributions of nitric oxide synthase caused by chronic hypoxia in rat small pulmonary arteries. Br. J. Pharmacol. 2003 139 : 899 910.
18. Le Cras TD Xue C Rengasamy A Johns RA. Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung. Am. J. Physiol. 1996 270 : L164 70.
19. Matsumura K Tsuchihashi T Kagiyama S Abe I Fujishima M. Role of nitric oxide in the nucleus of the solitary tract of rats. Brain Res. 1998 798 : 232 8.
20. Zanzinger J Czachurski J Seller H. Inhibition of basal and reflex-mediated sympathetic activity in the RVLM by nitric oxide. Am. J. Physiol. 1995 268 : R958 62.
21. Ohta A Takagi H Matsui T Hamai Y Iida S Esumi H. Localization of nitric oxide synthase-immunoreactive neurons in the solitary nucleus and ventrolateral medulla oblongata of the rat: Their relation to catecholaminergic neurons. Neurosci. Lett. 1993 158 : 33 5.
22. Garthwaite J Boulton CL. Nitric oxide signaling in the central nervous system. Annu. Rev. Physiol. 1995 57 : 683 706.
23. Patel KP Li YF Hirooka Y. Role of nitric oxide in central sympathetic outflow. Exp. Biol. Med. 2001 226 : 814 24.
24. Hironaga K Hirooka Y Matsuo I et al. Role of endogenous nitric oxide in the brain stem on the rapid adaptation of baroreflex. Hypertension 1998 31 : 27 31.
25. Nishimura M Takahashi H Nanbu A Sakamoto M Yoshimura M. Cardiovascular regulation by l-arginine in the brain of rats: Role of the brain renin-angiotensin system and nitric oxide. Am. J. Hypertens. 1997 10 : 389 96.
26. Clini E Ambrosino N. Nitric oxide and pulmonary circulation. Med. Sci. Monit. 2002 8 : RA178 82.
27. Weissmann N Nollen M Gerigk B et al. Downregulation of hypoxic vasoconstriction by chronic hypoxia in rabbits: Effects of nitric oxide. Am. J. Physiol. Heart Circ. Physiol. 2003 284 : H931 8.
28. Paxinos G Watson C. The Brain in Stereotaxic Coordinates, 4th edn. Academic Press, San Diego, CA. 1998.
29. Ao Q Huang L Zhu P Xiong M Wang D. Inhibition of expression of hypoxia-inducible factor-1alpha mRNA by nitric oxide in hypoxic pulmonary hypertension rats. J. Huazhong Univ. Sci. Technol. Med. Sci. 2004 24 : 5 8.
30. Hampl V Archer SL Nelson DP Weir EK. Chronic EDRF inhibition and hypoxia: Effects on pulmonary circulation and systemic blood pressure. J. Appl. Physiol. 1993 75 : 1748 57.
31. Coney AM Bishay M Marshall JM. Influence of endogenous nitric oxide on sympathetic vasoconstriction in normoxia, acute and chronic systemic hypoxia in the rat. J. Physiol. 2004 555 : 793 804.
32. Adnot S Raffestin B Eddahibi S Braquet P Chabrie PE. Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia. J. Clin. Invest. 1991 87 : 155 62.
33. Bansinath M Arbabha B Turndorf H Garg UC. Chronic administration of a nitric oxide synthase inhibitor N-nitro-l-arginine, and drug-induced increase in cerebellar cyclic GMP in vivo. Neurochem. Res. 1993 18 : 1063 6.
34. Nurminen ML Ylikorkala A Vapaatalo H. Central inhibition of nitric oxide synthesis increases blood pressure and heart rate in anesthetized rats. Methods Fundam. Exp. Clin. Pharmacol. 1997 19 : 35 41.
35. Fletcher EC. Invited review: Physiological consequences of intermittent hypoxia: Systemic blood pressure. J. Appl. Physiol. 2001 90 : 1600 5.
36. Harada S Tokunaga S Momohara M et al. Inhibition of nitric oxide formation in the nucleus tractus solitarius increases renal sympathetic nerve activity in rabbits. Circ. Res. 1993 72 : 511 16.
37. Zanzinger J Czachurski J Seller H. Nitric oxide in the ventrolateral medulla regulates sympathetic responses to systemic hypoxia in pigs. Am. J. Physiol. 1998 275 : R33 9.
38. Hampl V Herget J. Role of nitric oxide in the pathogenesis of chronic pulmonary hypertension. Physiol. Rev. 2000 80 : 1337 72.
39. Choi KC Jung M Lee JU Kim SW Kim NH Kang YJ. Attenuated central pressor response to nitric oxide synthesis inhibition in chronic renal failure rats. Korean J. Intern. Med. 1997 12 : 58 61.
40. Togashi H Sakuma I Yoshioka M et al. A central nervous system action of nitric oxide in blood pressure regulation. J. Pharmacol. Exp. Ther. 1992 262 : 343 7.
41. Shirai M Shindo T Shimouchi A Ninomiya I. Diameter and flow velocity changes of feline small pulmonary vessels in response to sympathetic nerve stimulation. Pflügers Arch. 1994 429 : 267 73.
42. Shirai M Matsukawa K Nishiura N Kawaguchi AT Ninomiya I. Changes in efferent pulmonary sympathetic nerve activity during systemic hypoxia in anesthetized cats. Am. J. Physiol. 1995 269 : R1404 9.
43. Matsumura K Abe I Tsuchihashi T Fujishima M. Central nitric oxide attenuates the baroreceptor reflex in conscious rabbits. Am. J. Physiol. 1998 274 : R1142 9.
44. Nurminen ML Vapaatalo H. Effect of intracerebroventricular and intravenous administration of nitric oxide donors on blood pressure and heart rate in anaesthetized rats. Br. J. Pharmacol. 1996 119 : 1422 6.
45. Stopper H Moller M Bommel HM Schmidt HH. Cytotoxic versus genotoxic effects of nitric oxide (NO). Toxicol. Lett. 1999 106 : 59 67.
46. Megson IL Webb DJ. Nitric oxide donor drugs: Current status and future trends. Expert Opin. Investig. Drugs 2002 11 : 587 601.
47. Gao L Wang W Li YL et al. Superoxide mediates sympathoexcitation in heart failure: Roles of angiotensin II and NAD(P)H oxidase. Circ. Res. 2004 95 : 937 44.
48. Shapoval LN Sagach VF Pobegailo LS. Nitric oxide influences ventrolateral medullary mechanisms of vasomotor control in the cat. Neurosci. Lett. 1991 132 : 47 50.
49. Shirai M Shindo T Ninomiya I. β-Adrenergic mechanisms attenuated hypoxic pulmonary vasoconstriction during systemic hypoxia in cats. Am. J. Physiol. 1994 266 : H1777 85.
50. Kontos HA Lower RR. Role of beta-adrenergic receptors in the circulatory response to hypoxia. Am. J. Physiol. 1969 217 : 756 63.
51. Chiong MA Hatcher JD. The sympathoadrenergic system in the cardiovascular responsess to hypoxia in the dog. Can. J. Physiol. Pharmacol. 1972 50 : 674 83.
52. Birnkrant DJ Davis PB Ernsberger P. Visualization of high- and low-affinity beta-adrenergic receptors in rat lung: Upregulation by chronic hypoxia. Am. J. Physiol. 1993 265 : L389 94.
53. Winter RJ Dickinson KE Rudd RM Sever PS. Tissue specific modulation of beta-adrenoceptor number in rats with chronic hypoxia with an attenuated response to down-regulation by salbutamol. Clin. Sci. 1986 70 : 159 65.