Role of conserved prolines in the structure and function of the Na +/dicarboxylate cotransporter 1, NaDC1

Biochemistry

Volumn 45, Issue 13, 2006, Pages 4231-4239

  Joshi, Aditya D ^a   Pajor, Ana M ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BIOLOGICAL MEMBRANES; MUTAGENS; ORGANIC ACIDS; PROTEINS; SODIUM COMPOUNDS;

CONSERVED PROLINES; DICARBOXYLATE COTRANSPORTER 1, NADC1; LOW-AFFINITY TRANSPORTERS; TRANSMEMBRANE HELICES;

AMINO ACIDS;

ALANINE; CARRIER PROTEIN; CITRIC ACID; GLYCINE; MUTANT PROTEIN; PROLINE; SODIUM DICARBOXYLATE COTRANSPORTER 1; SUCCINIC ACID; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CITRIC ACID CYCLE; HUMAN; HUMAN CELL; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; RABBIT; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; DICARBOXYLIC ACID TRANSPORTERS; DIMETHYL SULFOXIDE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLYCEROL; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROLINE; PROTEIN STRUCTURE, SECONDARY; RABBITS; SEQUENCE ALIGNMENT; SUCCINIC ACID;

ORYCTOLAGUS CUNICULUS;

EID: 33645541874     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi052064y     Document Type: Article

References (35)

1. Pajor, A. M. (2000) Molecular properties of sodium/dicarboxylate cotransporters, J. Membr. Biol. 175, 1-8.
2. Girard, J. P., Baekkevold, E. S., Feliu, J., Brandtzaeg, P., and Amalric, F. (1999) Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules, Proc. Natl. Acad. Sci. U.S.A. 96, 12772-12777.
3. 2- cotransport, Proc. Natl. Acad. Sci. U.S.A. 90, 8073-8077.
4. Pajor, A. M. (1999) Citrate transport by the kidney and intestine, Semin. Nephrol. 19, 195-200.
5. Rogina, B., Reenan, R. A., Nilsen, S. P., and Helfand, S. L. (2000) Extended life-span conferred by cotransporter gene mutations in Drosophila, Science 290, 2137-2140.
6. +-dicarboxylate cotransporter using aritifusion protein antibodies, Am. J. Physiol. 271, C1808-C1816.
7. +/dicarboxylate cotransporter: The N-terminus and hydrophilic loop 4 are located intracellularly, Biochim. Biophys. Acta 1511, 80-89.
8. +/sulfate cotransporters is located in the carboxy-terminal portion of the protein, Biochim. Biophys. Acta 1370, 98-106.
9. Woolfson, D. N., and Williams, D. H. (1990) The influence of proline residues on α-helical structure, FEBS Lett. 277, 185-188.
10. Shelden, M. C., Loughlin, P., Tierney, M. L., and Howitt, S. M. (2001) Proline residues in two tightly coupled helices of the sulphate transporter, SHST1, are important for sulphate transport, Biochem. J. 356, 589-594.
11. Lu, H., Marti, T., and Booth, P. J. (2001) Proline residues in transmembrane α helices affect the folding of bacteriorhodopsin, J. Mol. Biol. 308, 437-446.
12. Sansom, M. S. (1992) Proline residues in transmembrane helices of channel and transport proteins: A molecular modelling study, Protein Eng. 5, 53-60.
13. Brandl, C. J., and Deber, C. M. (1986) Hypothesis about the function of membrane-buried proline residues in transport proteins, Proc. Natl. Acad. Sci. U.S.A. 83, 917-921.
14. Sansom, M. S., and Weinstein, H. (2000) Hinges, swivels and switches: The role of prolines in signalling via transmembrane α-helices, Trends Pharmacol. Sci. 21, 445-451.
15. +/dicarboxylate cotransporter, Biochemistry 38, 6151-6156.
16. +/dicarboxylate co-transporter, J. Biol. Chem. 280, 18728-18735.
17. Pajor, A. M. (1995) Sequence and functional characterization of a renal sodium/dicarboxylate cotransporter, J. Biol. Chem. 270, 5779-5785.
18. +/dicarboxylate cotransporter, J. Biol. Chem. 276, 29961-29968.
19. King, S. C. (2004) The "transport specificity ratio": A structure-function tool to search the protein fold for loci that control transition state stability in membrane transport catalysis, BMC Biochem. 5, 16.
20. King, S. C., and Brown-Istvan, L. (2003) Use of the transport specificity ratio and cysteine-scanning mutagenesis to detect multiple substrate specificity determinants in the consensus amphipathic region of the Escherichia coli GABA (γ-aminobutyric acid) transporter encoded by gabP, Biochem. J. 376, 633-644.
21. Li, H., and Pajor, A. M. (2003) Mutagenesis of the N-glycosylation site of hNaSi-1 reduces transport activity, Am. J. Physiol. Cell Physiol. 285, C1188-C1196.
22. +/dicarboxylate cotransporter, NaDC-1, Biochem. J. 331, 257-264.
23. Tamarappoo, B. K., and Verkman, A. S. (1998) Defective aquaporin-2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperones, J. Clin. Invest. 101, 2257-2267.
24. Barlow, D. J., and Thornton, J. M. (1988) Helix geometry in proteins, J. Mol. Biol. 201, 601-619.
25. Cordes, F. S., Bright, J. N., and Sansom, M. S. (2002) Proline-induced distortions of transmembrane helices, J. Mol. Biol. 323, 951-960.
26. Richardson, J. S., and Richardson, D. C. (1988) Amino acid preferences for specific locations at the ends of α helices, Science 240, 1648-1652.
27. Sankararamakrishnan, R., and Vishveshwara, S. (1990) Conformational studies on peptides with proline in the right-handed α-helical region, Biopolymers 30, 287-298.
28. Labro, A. J., Raes, A. L., Bellens, I., Ottschytsch, N., and Snyders, D. J. (2003) Gating of Shaker-type, channels requires the flexibility of S6 caused by prolines, J. Biol. Chem. 278, 50724-50731.
29. Lin, Z., Itokawa, M., and Uhl, G. R. (2000) Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression, FASEB J. 14, 715-728.
30. Paczkowski, F. A., and Bryan-Lluka, L. J. (2004) Role of proline residues in the expression and function of the human noradrenaline transporter, J. Neurochem. 88, 203-211.
31. + exchanger isoform 1, Biochem. J. 379, 31-38.
32. Abramson, J., Smirnova, I., Kasho, V., Verner, G., Kaback, H. R., and Iwata, S. (2003) Structure and mechanism of the lactose permease of Escherichia coli, Science 301, 610-615,
33. Sato, S., Ward, C. L., Krouse, M. E., Wine, J. J., and Kopito, R. R. (1996) Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation, J. Biol. Chem. 271, 635-638.
34. de Jong, J. C., Willems, P. H., Goossens, M., Vandewalle, A., van den Heuvel, L. P., Knoers, N. V., and Bindels, R. J. (2004) Effects of chemical chaperones on partially retarded NaCl cotransporter mutants associated with Gitelman's syndrome in a mouse cortical collecting duct cell line, Nephrol., Dial., Transplant. 19, 1069-1076.
35. Pajor, A. M., and Sun, N. N. (2000) Molecular cloning, chromosomal organization, and functional characterization of a sodium-dicarboxylate cotransporter from mouse kidney, Am. J. Physiol. Renal. Physiol. 279, F482-F490.