Rapid peptide-based screening on the substrate specificity of severe acute respiratory syndrome (SARS) coronavirus 3C-like protease by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Protein Science

Volumn 15, Issue 4, 2006, Pages 699-709

  Chu, Ling Hon Matthew ^a   Choy, Wai Yan ^a   Tsai, Sau Na ^a   Rao, Zihe ^b   Ngai, Sai Ming ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b TSINGHUA UNIVERSITY   (China)

Author keywords

MALDI TOF; Mass spectrometry; Protease; SARS CoV; Substrate specificity; Synthetic peptide

Indexed keywords

PROTEINASE INHIBITOR; SARS COV 3CL PROTEASE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; AMINO ACID SYNTHESIS; ARTICLE; BINDING AFFINITY; CORONAVIRUS; DNA FLANKING REGION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; ENZYME SPECIFICITY; HIGH THROUGHPUT SCREENING; HYDROPHOBICITY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; SEVERE ACUTE RESPIRATORY SYNDROME;

AMINO ACID SUBSTITUTION; AMINO ACIDS; CYSTEINE ENDOPEPTIDASES; GLUTAMINE; PEPTIDES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY; VIRAL PROTEINS;

CORONAVIRUS; SARS CORONAVIRUS;

EID: 33645522999     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.052007306     Document Type: Article

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