Conformational and spacial preferences for substrates of PepT1

Chemical Communications

Volumn , Issue 42, 2005, Pages 5352-5354

  Bailey, Patrick D ^a   Boyd, C A Richard ^b   Collier, Ian D ^c   George, John G ^c   Kellett, George L ^d   Meredith, David ^b   Morgan, Keith M ^c   Pettecrew, Rachel ^a   Price, Richard A ^a   Pritchard, Robin G ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c HERIOT WATT UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF YORK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE DERIVATIVE; PEPTIDE TRANSPORTER 1;

ARTICLE; MOLECULAR PROBE; PROTEIN ANALYSIS; PROTEIN CONFORMATION; SPACE;

EID: 27944447221     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/b510697d     Document Type: Article

References (14)

1. H. Daniel, Annu. Rev. Physiol., 2004, 66, 361.
2. T. Terada and K. Inui, Curr. Drug Metab., 2004, 5, 85.
3. D. Meredith and C. A. R. Boyd, Cell Mol. Life Sci., 2000, 57, 754.
4. D. M. Matthews in Protein Absorption: Development and Present State of the Subject, Wiley-Liss, New York, 1991.
5. V. Ganapathy, M. Brandsch and F. H. Leibach in Physiology of the Gastro-intestinal Tract, ed. L. R. Johnson, Raven Press, New York, 1994, 3rd edn, pp. 1773-1794.
6. By analysis of data from refs. 1-3.
7. P. D. Bailey, C. A. R. Boyd, J. R. Bronk, I. D. Collier, D. Meredith, K. M. Morgan and C. S. Temple, Angew. Chem., Int. Ed., 2000, 39, 506.
8. Alternative methods explored were: (a) cyclization of a homoserine derivative via the bromide, based on work by: N. M. Howarth and L. P. G. Wakelin, J. Org. Chem., 1997, 62, 5441;
9. (b) cyclization of 2,4-diaminobutyric acid, based on work byR. Pellegata, M. Pinza and G. Pifferi, Synthesis, 1978, 614; both approaches were, successful, but the method described in this paper was found to give the most reliable yields.
10. R. M. Freidlinger, D. S. Perlow and D. F. Veber, J. Org. Chem., 1982, 47, 104.
11. -1, max./min. transmission: 0.996/0.978), the structure was solved by direct methods using SHELXS-97
12. ((a) G. M. Sheldrick, SHELXS97: Program for crystal structure solution, University of Göttingen, Germany, 1997), refinement method full-matrix least squares on F using SHELXL-97;
13. -3. CCDC 278679.
14. See http://dx.doi.org/10.1039/ b510697d for crystallographic data in CIF or other electronic format.