Antitrypanosomal activity of 5′-deoxy-5′-(iodomethylene) adenosine and related 6-N-cyclopropyladenosine analogues

Journal of Medicinal Chemistry

Volumn 49, Issue 6, 2006, Pages 2096-2102

  Rapp, Magdalena ^a,e   Haubrich, Trisha A ^b   Perrault, Jacques ^b   Mackey, Zachary B ^c   McKerrow, James H ^c   Chiang, Peter K ^c,d   Wnuk, Stanislaw F ^a  

^a FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^b SAN DIEGO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Pharmadyn Inc   (United States)

^e ADAM MICKIEWICZ UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

5' CYANOMETHYLENE; 5' DEOXY 5' (IODOMETHYLENE)ADENOSINE; 5' DIBROMOMETHYLENE; 6 N CYCLOPROPYL 2',3' DI O ISOPROPYLIDENEADENOSINE 5' ALDEHYDE; 6 N CYCLOPROPYL 5' DEOXY 5' (IODOMETHYLENE)ADENOSINE; 6 N CYCLOPROPYL 9 (BETA DEXTRO RIBOPENTODIALDO 1,4 FURANOSYL)ADENINE OXIME; 6 N CYCLOPROPYL 9 [5,6 DIDEOXY 6 CYANO BETA DEXTRO RIBOHEX 5 ENOFURANOSYL]ADENINE; 6 N CYCLOPROPYL 9 [5,6 DIDEOXY 6 FLUORO BETA DEXTRO RIBOHEX 5 ENOFURANOSYL]ADENINE; 6 N CYCLOPROPYL 9 [5,6 DIDEOXY 6 IODO BETA DEXTRO RIBOHEX 5 ENOFURANOSYL]ADENINE; 6 N CYCLOPROPYLADENOSINE DERIVATIVE; ADENINE DERIVATIVE; ALDEHYDE DERIVATIVE; ANTITRYPANOSOMAL AGENT; HYDROLASE; HYDROXYLAMINE; OXIME DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; SULFONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ANTITRYPANOSOMAL ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; BROMINATION; CONTROLLED STUDY; DEPROTECTION REACTION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; NONHUMAN; REACTION ANALYSIS; TRYPANOSOMA BRUCEI;

ACETYLENE; ADENOSYLHOMOCYSTEINASE; ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CERCOPITHECUS AETHIOPS; CYCLOPROPANES; DEOXYADENOSINES; HUMANS; OXIMES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

EID: 33645389725     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0511379     Document Type: Article

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