The human homologue of rat NG2, a chondroitin sulfate proteoglycan, is not expressed on the cell surface of normal hematopoietic cells but is expressed by acute myeloid leukemia blasts from poor-prognosis patients with abnormalities of chromosome band 11q23

Blood

Volumn 87, Issue 3, 1996, Pages 1123-1133

  Smith, Franklin O ^a   Rauch, Charles ^b   Williams, Douglas E ^b   March, Carl J ^b   Arthur, Diane ^b   Hilden, Joanne ^b   Lampkin, Beatrice C ^b   Buckley, Jonathan D ^b   Buckley, Connie V ^b   Woods, William G ^b   Dinndorf, Patricia A ^b   Sorensen, Poul ^b   Kersey, John ^b   Hammond, Denman ^b   Bernstein, Irwin D ^b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; PROTEOCHONDROITIN SULFATE;

ACUTE GRANULOCYTIC LEUKEMIA; AMINO ACID SEQUENCE; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ARTICLE; BLAST CELL; CHILD; CHROMOSOME 11Q; CHROMOSOME ABERRATION; GENE LOCUS; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROGNOSIS;

ACTUARIAL ANALYSIS; ACUTE DISEASE; ADOLESCENT; AMINO ACID SEQUENCE; ANEUPLOIDY; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS; ANTIGENS, NEOPLASM; BONE MARROW; CELL LINE, TRANSFORMED; CHILD; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 11; DNA-BINDING PROTEINS; FEMALE; HELA CELLS; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKEMIA, MONOCYTIC, ACUTE; LEUKEMIA, MYELOID; LEUKEMIA, MYELOMONOCYTIC, ACUTE; MALE; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MYELOID-LYMPHOID LEUKEMIA PROTEIN; PROGNOSIS; PROTEOGLYCANS; PROTO-ONCOGENES; RATS; SURVIVAL RATE; TRANSCRIPTION FACTORS; TREATMENT OUTCOME; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; TUMOR STEM CELLS;

EID: 0030020460     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.3.1123.bloodjournal8731123     Document Type: Article

References (63)

1. Terstappen LWM, Safford M, Konemann S, Loken MR, Zurlutter K, Buchner T, Hiddemann W, Wormann B: Flow cytometric characterization of acute myeloid leukemia. Part II. Phenotypic heterogeneity at diagnosis. Leukemia 5.757, 1991
2. Dinndorf PA, Buckley JD, Nesbit ME, Lampkin BC, Piomelli S, Feig SA, Kersey JH, Hammond GD, Bernstein ID: Expression of myeloid differentiation antigens in acute nonlymphocytic leukemia: Increased concentration of CD33 antigen predicts poor outcome. Med Pediatr Oncol 20:192, 1992
3. Smith FO, Lampkin BC, Versteeg C, Flowers D, Dinndorf P, Buckley JD, Woods W, Hammond D, Bernstein ID: Expression of lymphoid-associated cell surface antigens by childhood acute myeloid leukemia lacks prognostic significance. Blood 79:2415, 1992
4. Dinndorf PA, Benjamin D, Ridgway D, Bernstein ID: Immunodiagnosis of childhood ALL with monoclonal antibodies to myeloid and lymphoid associated antigens. Leuk Res 9:449, 1985
5. Tsuruo T, Sugimoto Y, Hamada H, Roninson I, Okurura M, Adachi K, Morishima Y, Ohno R: Detection of multidrug resistance markers, P-glycoprotein and mdr-1 mRNA, in human leukemia cells. Jpn J Cancer Res 78:1415, 1987
6. Holmes J, Jacobs A, Carter G, Janowska-Wieczorek A, Padua RA: Multidrug resistance in haematopoietic cell lines, myelodysplastic syndromes and acute myeloblastic leukaemia. Br J Haematol 72:40, 1989
7. Smith FO, Broudy VC, Zsebo KM, Lampkin BC, Buckley CV, Buckley JD, Opie T, Woods WG, Hammond GD, Bernstein ID: The cell surface expression of c-kit receptors by childhood acute myeloid leukemia blasts is not of prognostic value: A report from the Childrens Cancer Group. Blood 84:847, 1994
8. Stelzer GT, Shults KE, Loken MR: CD45 gating for routine flow cytometric analysis of human bone marrow specimens. Ann NY Acad Sci 677:265, 1993
9. Borowitz MJ, Guenther KL, Shults KE, Stelzer GT: Immunophenotyping of acute leukemia by flow cytometric analysis. Am J Clin Pathol 100:534, 1993
10. Reading CL, Estey EH, Huh YO, Claxton DF, Sanchez G, Terstappen LWM, O'Brien MC, Baron S, Deisseroth AB: Expression of unusual immunophenotype combinations in acute myelogenous leukemia. Blood 81:3083, 1993
11. Campana D, Coustan-Smith E, Janossy G: The immunologic detection of minimal residual disease in acute leukemia. Blood 76:163, 1990
12. Harper JR, Reisfeld RA: Cell-associated proteoglycans in human malignant melanoma, in Wnght TN, Mecham RP (eds): Biology of Proteoglycans. Orlando, FL, Academic, 1987, p 345
13. Morgan AC, Galloway DR, Reisfeld RA. Production and characterization of monoclonal antibody to a melanoma specific glycoprotein. Hybridoma 1:27, 1981
14. Bumol TF, Reisfeld RA: Unique glycoprotein-proteoglycan complex defined by monoclonal antibody on human melanoma cells. Proc Natl Acad Sci USA 79:1245, 1982
15. Bumol TF, Walker LE, Reisfeld RA: Biosynthetic studies of proteoglycans in human melanoma cells with a monoclonal antibody to a core glycoprotein of chondroitin sulfate proteoglycans. J Biol Chem 259:12733, 1984
16. Djabah M, Selleri L, Parry P, Bower M, Young BD, Evans GA: A trithorax-like gene is interrupted by chromosome band 11q23 translocations in acute leukemias. Nature Genet 2:113, 1992
17. Gu Y, Nakamura T, Alder H, Prasad R, Canaani O, Cimino G, Croce CM, Canaani E: The t(4; 11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 71:701, 1992
18. Tkachuk DC, Kohler S, Cleary ML: Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 71:691, 1992
19. Thirman MJ, Gill HJ, Burnett RC, Mbangkollo D, McCabe NR, Kobayashi H, Ziemin-van Der Poel S, Kaneko Y, Morgan R, Sandberg AA, Chaganti RSK, Larson RA, Le Beau MM, Diaz MO, Rowley JD: Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. N Engl J Med 329:909, 1993
20. Singer JW, Charbord P, Keating A, Nemunaitis J, Raugi G, Wright TN, Lopez JA, Roth GJ, Dow LW, Fialkow PJ: Simian virus 40-transformed adherent cells from human long-term marrow cultures: Cloned cell lines produce cells with stromal and hematopoietic characteristics. Blood 70:464, 1987
21. Bernstein ID, Andrews RG, Cohen SF, McMaster BE: Normal and malignant human myelocytic and monocytic cells identified by monoclonal antibodies. J Immunol 128:876, 1982
22. Andrews RG, Singer JW, Bernstein ID: Monoclonal antibody 12-8 recognizes a 115-kd molecule present on both unipotent and multipotent hematopoietic colony-forming cells and their precursors. Blood 67:842, 1986
23. Hubbard AL, Cohn ZA: The enzymatic iodination of the red cell membrane. J Cell Biol 55:390, 1972
24. Pesando JM, Ritz J, Lazarus H, Tomaselli KJ, Schlossman SF: Fate of a common acute lymphoblastic leukemia antigen during modulation by monoclonal antibody. J Immunol 126 540, 1981
25. Axen R, Porath J, Ernbach S: Chemical coupling of peptides and proteins to polysaccharides by means of cyanogen halides. Nature 241:1302, 1967
26. Laemmli UK: Cleavage of structural proteins during the assembly of the head of the bacteriophage T-4. Nature 227:680, 1970
27. Rosenfeld J, Capdevielle J, Guillemot JC, Ferrara P: In-gel digestion of proteins for internal sequence analysis after one-or two-dimensional gel electrophoresis. Anal Biochem 203:173, 1992
28. Wells RJ, Woods WG, Buckley JD, Odom LF, Benjamin D, Bernstein I, Betcher D, Feig S, Kim T, Ruymann F, Smithson W, Srivastava A, Tannous R, Buckley CM, Shitt JK, Wolff L, Lampkin BC: Treatment of newly diagnosed children and adolescents with acute myeloid leukemia: A Childrens Cancer Group study. J Clin Oncol 12:2367, 1994
29. Chen C-S, Sorensen PHB, Domer PH, Reaman GH, Korsmeyer SJ, Heerma NA, Hammond GD, Kersey JH: Molecular rearrangements on chromosome band 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome. Blood 81:2386, 1993
30. Nishiyama A, Dahlin KL, Prince JT, Johnstone SR, Stallcup WB: The primary structure of NG2, a novel membrane-spanning proteoglycan. J Cell Biol 114:359, 1991
31. Yamagata M, Suzuki S, Akiyama K, Yamada KM, Kimata K: Regulation of cell-substrate adhesion by proteoglycans immobilized on extracellular substrates. J Biol Chem 264:8012, 1989
32. Stamenovic I, Amiot M, Pesando JM, Seed B: A lymphocyte molecule implicated in lymph node homing of the cartilage link protein family. Cell 56:1057, 1989
33. Rapraeger A, Jalkanen M, Bernfield M: Cell surface proteoglycan associates with the cytoskeleton at the basolateral cell surface of the mouse mammary epithelial cells. J Cell Biol 103:2683, 1986
34. Perris R, Johansson S: Amphibian neural crest cell migration on purified extracellular matrix components: A chondroitin sulfate proteoglycan inhibits locomotion on fibronectin substrates. J Cell Biol 105:2511, 1987
35. Yamaguchi Y, Ruoslahti E: Expression of human proteoglycan in Chinese hamster ovary cells inhibits cell proliferation. Nature 336:244, 1988
36. Oakley RA, Tosney KW. Peanut agglutinin and chondroitin-6-sulfate are molecular markers for tissues that act as barriers to axon advance in the avian embryo. Dev Biol 147:187, 1991
37. Snow DM, Lemmons V, Carrino DA, Caplan AI, Silver J: Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro. Exp Neurol 109:111, 1990
38. Friedlander DR, Milev P, Karthikeyan L, Margolis RK, Margolis RU: The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecule Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth. J Cell Biol 125:669, 1994
39. Stallcup WB, Beasley L, Levine J: Cell-surface molecules that characterize different stages in the development of cerebellar interneurons. Cold Spring Harbor Symp Quant Biol 48:761, 1983
40. Woods WG, Kobrinsky N, Buckley JD, Neudorf S, Sanders J, Miller L, Barnard D, Benjamin D, DeSwarte J, Kalousek D, Shina D, Hammond DG, Lange B: Intensively-timed induction therapy followed by autologous or allogeneic bone marrow transplantation for children with acute myeloid leukemia (AML) or myelodysplastic syndrome. J Clin Oncol 11:1448, 1993
41. Lampkin BC, Woods W, Strauss R, Feig S, Higgins G, Bernstein ID, D'Angio G, Chard R, Bleyer A, Hammond D: Current status of the biology and treatment of acute nonlymphocytic leukemia in children (report from the ANLL Strategy Group of the Childrens Cancer Study Group). Blood 61:215, 1983
42. Woods WG, Nesbut ME, Buckley J, Lampkin BC, McCredie S, Kim TH, Piomelli S, Kersey JH, Feig S, Bernstein I, Hammond D: Correlation of chromosome abnormalities with patient characteristics, histologic subtype and induction success in children with acute nonlymphocytic leukemia. J Clin Oncol 3:1, 1985
43. Chessells JM, O'Callaghan U, Hardisty RM: Acute myeloid leukemia I. Childhood: Clinical features and prognosis. Br J Haematol 63.555, 1986
44. Grier HE, Gelber RD, Camitta BM, Delorey MJ. Link MP, Price KN, Leavitt PR, Weinstein HJ. Prognostic factors in childhood acute myelogenous leukemia. J Clin Oncol 5:1026, 1987
45. Steuber CP, Krischer JC, Ravindranath Y, Civin C, Ragab A, Vietti T: Prognostic factors and treatment outcome in children with acute myeloid leukemia (AML): The POG experience, in Gale RP (ed): Acute Myelogenous Leukemia, Progress and Controversies. New York, NY, Wiley-Liss, 1990, p 193
46. Ravindranath Y, Abella E, Frischer J, Wiley J, Inoue S, Harris M, Chauvenet A, Alvarado CS, Dobowy R, Ritchey AK, Land V, Steuber CP, Weinstein H: Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: Experience on Pediatric Oncology Group AML Study 8498. Blood 80:2210, 1992
47. Hurwitz CA. Schell JJ, Pui CH, Crist WM, Behm F, Mirro J: Adverse prognostic features in 251 children treated for acute myelogenous leukemia. Med Ped Oncol 21:1, 1993
48. Griffin JD, Ritz J, Nadler LM, Schlossman SF: Expression of myeloid differentiation antigens on normal and malignant myeloid cells. J Clin Invest 68:932, 1981
49. Ball ED, Fanger MW: The expression of mycloid-specific antigens on myeloid leukemia cells: Correlations with leukemia subclasses and implications for normal myeloid differentiation. Blood 61:456, 1983
50. Sato T, Shichishima T, Kimura H, Uchida T, Kariyone S, Ohto H, Meada H: Immunocytochemical detection of normal and abnormal megakaryocytes using monoclonal antibody to glycoprotein IIb-IIIa (TP80): The quantitative assay in normal and in leukemic patients. Scand J Haematol 36:415, 1986
51. Brenton-Gorious J, Villeval JK, Keiffer N, Mitjavila MT, Guichard J, Vainchenker W: Limits of phenotypic markers for the diagnosis of megakaryoblastic leukemia. Blood Cells 15:259, 1989
52. Edwards PA: Monoclonal antibodies that bind to the human erythrocyte-membrane glycoproteins glycophorin A and band 3. Biochem Soc Trans 8:334, 1980
53. Villeval JL, Cramer P, Lemoine F, Henri A, Bettaib A, Bernaudin F, Beuzard Y, Berger R, Flandrin G, Breton-Gorius J, Vainchenker W: Phenotype of early erythroblastic leukemias. Blood 68:1167, 1986
54. Drexler HG: Classification of acute myeloid leukemias - A comparison of FAB and immunophenotyping. Leukemia 1:697, 1987
55. Hurwitz CA, Raimondi SC, Head D, Krance R, Mirro J, Kalwinsky DK, Ayers GD, Behm FG: Distinctive immunophenotypic features of t(8;21)(q22;q22) acute myeloblastic leukemia in children. Blood 80:3182, 1992
56. Sorensen PHB, Chen C-S, Smith FO, Arthur DC, Domer PH, Bernstein ID, Korsmeyer SJ, Hammond GH, Kersey JH: Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes. J Clin Invest 93:429, 1994
57. Gu Y, Alder H, Nakamura T, Schichman SA, Prasad R, Canaani O, Croce CM, Canaani E: Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved inacute leukemia. Cancer Res 54:2327, 1994
58. Cimino G, Lo Coco F, Biondi A, Elia L, Luciano A, Croce CM, Masera G, Mandelli F, Canaani E: ALL-1 gene at chromosome band 11q23 is consistently altered in acute leukemia of early infancy Blood 82:544, 1993
59. Hunger SSP, Tkachuk DC, Amylon MD, Link MP, Carroll AJ, Welborn IL, Willman CL, Cleary M: HRX involvement in de novo and secondary leukemias with diverse chromosome band 11q23 abnormalities. Blood 81:3197, 1993
60. Morgan GI, Cotter F, Katz FE, Ridge SA, Domer P, Korsmeyer S, Wiedemann LM: Breakpoints at 11q23 in infant leukemias with the t(11;19)(q23;p13) are clustered. Blood 80:2172, 1992
61. Nakamura T, Alder H, Gu Y, Prasad O, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC, Croce CM, Canaani E: Genes on chromosomes 4, 9, 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. Proc Natl Acad Sci USA 90:4631, 1993
62. Huret JL, Brizard A, Slater R, Charrin C, Bertheas MF, Guilhot F, Hahlen K, Kroes W, van Leeuwen E, Schoot EV, Beishuizen A, Tanzer J, Hagemeijer A: Cytogenetic heterogeneity in t(11:19) acute leukemia: Clinical, hematological and cytogenetic analyses of 48 patients - Updated published cases and 16 new observations. Leukemia 7:152, 1993
63. Nishiyama A, Dahlin KJ, Stallcup WB: The expression of NG2 proteoglycan in the developing rat limb. Development 111:933, 1991