메뉴 건너뛰기




Volumn 21, Issue 4, 2006, Pages 986-993

Increased sperm DNA damage in patients with varicocele: Relationship with seminal oxidative stress

Author keywords

Apoptosis; DNA damage; Oxidative stress; Spermatozoa; Varicocele

Indexed keywords

CELL NUCLEUS DNA; DNA FRAGMENT; REACTIVE OXYGEN METABOLITE;

EID: 33645292883     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dei429     Document Type: Article
Times cited : (246)

References (90)
  • 1
    • 0041522560 scopus 로고    scopus 로고
    • Role of sperm chromatin abnormalities and DNA, damage in male infertility
    • Agarwal A and Said TM (2003) Role of sperm chromatin abnormalities and DNA, damage in male infertility. Hum Reprod Update 9,331-345.
    • (2003) Hum Reprod Update , vol.9 , pp. 331-345
    • Agarwal, A.1    Said, T.M.2
  • 2
    • 0037382663 scopus 로고    scopus 로고
    • Role of reactive oxygen species in the pathophysiology of human reproduction
    • Agarwal A, Saleh RA and Bedaiwy MA (2003) Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil Steril 79,829-843.
    • (2003) Fertil Steril , vol.79 , pp. 829-843
    • Agarwal, A.1    Saleh, R.A.2    Bedaiwy, M.A.3
  • 4
    • 0034091122 scopus 로고    scopus 로고
    • Analysis of DNA fragmentation, plasma membrane translocation of phosphatidylserine and oxidative stress in human spermatozoa
    • Barroso G, Morshedi M and Oehninger S (2000) Analysis of DNA fragmentation, plasma membrane translocation of phosphatidylserine and oxidative stress in human spermatozoa. Hum Reprod 15,1338-1344.
    • (2000) Hum Reprod , vol.15 , pp. 1338-1344
    • Barroso, G.1    Morshedi, M.2    Oehninger, S.3
  • 5
    • 3242886115 scopus 로고    scopus 로고
    • DNA damage responses to oxidative stress
    • Barzilai A and Yamamoto K (2004) DNA damage responses to oxidative stress. DNA Repair (Amst) 3,1109-1115.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1109-1115
    • Barzilai, A.1    Yamamoto, K.2
  • 6
    • 0027562849 scopus 로고
    • Varicocele in childhood and adolescence and other testicular anomalies: An epidemiological study
    • Belloli G, D'Agostino S, Pesce C and Fantuz E (1993) [Varicocele in childhood and adolescence and other testicular anomalies: An epidemiological study]. Pediatr Med Chir 15,159-162.
    • (1993) Pediatr Med Chir , vol.15 , pp. 159-162
    • Belloli, G.1    D'Agostino, S.2    Pesce, C.3    Fantuz, E.4
  • 7
    • 0038060337 scopus 로고    scopus 로고
    • Sperm DNA fragmentation decreases the pregnancy rate in an assisted reproductive technique
    • Benchaib M, Braun V, Lornage J, Hadj S, Salle B, Lejeune H and Guerin JF (2003) Sperm DNA fragmentation decreases the pregnancy rate in an assisted reproductive technique. Hum Reprod 18,1023-1028.
    • (2003) Hum Reprod , vol.18 , pp. 1023-1028
    • Benchaib, M.1    Braun, V.2    Lornage, J.3    Hadj, S.4    Salle, B.5    Lejeune, H.6    Guerin, J.F.7
  • 8
    • 0035140480 scopus 로고    scopus 로고
    • Varicocele and male infertility: Part I. Preface
    • Benoff S and Gilbert BR (2001) Varicocele and male infertility: Part I. Preface. Hum Reprod Update 7,47-54.
    • (2001) Hum Reprod Update , vol.7 , pp. 47-54
    • Benoff, S.1    Gilbert, B.R.2
  • 10
    • 1542606771 scopus 로고    scopus 로고
    • Bilateral increased apoptosis and bilateral accumulation of cadmium in infertile men with left varicocele
    • Benoff SH, Millan C, Hurley IR, Napolitano B and Marmar JL (2004) Bilateral increased apoptosis and bilateral accumulation of cadmium in infertile men with left varicocele. Hum Reprod 19,616-627.
    • (2004) Hum Reprod , vol.19 , pp. 616-627
    • Benoff, S.H.1    Millan, C.2    Hurley, I.R.3    Napolitano, B.4    Marmar, J.L.5
  • 11
    • 2442691071 scopus 로고    scopus 로고
    • The predictive value of sperm chromatin structure assay (SCSA) parameters for the outcome of intrauterine insemination, IVF and ICSI
    • Bungum M, Humaidan P, Spano M, Jepson K, Bungum L and Giwercman A (2004) The predictive value of sperm chromatin structure assay (SCSA) parameters for the outcome of intrauterine insemination, IVF and ICSI. Hum Reprod 19,1401-1408.
    • (2004) Hum Reprod , vol.19 , pp. 1401-1408
    • Bungum, M.1    Humaidan, P.2    Spano, M.3    Jepson, K.4    Bungum, L.5    Giwercman, A.6
  • 12
    • 4043134464 scopus 로고    scopus 로고
    • The role of reactive oxygen species and apoptosis in the pathogenesis of varicocele in a rat model and efficiency of vitamin E treatment
    • Cam K, Simsek F, Yuksel M, Turkeri L, Haklar G, Yalcin S and Akdas A (2004) The role of reactive oxygen species and apoptosis in the pathogenesis of varicocele in a rat model and efficiency of vitamin E treatment. Int J Androl 27,228-233.
    • (2004) Int J Androl , vol.27 , pp. 228-233
    • Cam, K.1    Simsek, F.2    Yuksel, M.3    Turkeri, L.4    Haklar, G.5    Yalcin, S.6    Akdas, A.7
  • 15
    • 0025720162 scopus 로고
    • The pathogenesis of epididymo-testicular dysfunction in varicocele: Factors other than temperature
    • Comhaire F (1991) The pathogenesis of epididymo-testicular dysfunction in varicocele: Factors other than temperature. Adv Exp Med Biol 286,281-287.
    • (1991) Adv Exp Med Biol , vol.286 , pp. 281-287
    • Comhaire, F.1
  • 16
    • 0035141934 scopus 로고    scopus 로고
    • Varicocele as a progressive lesion: Positive effect of varicocele repair
    • Cozzolino DJ and Lipshultz LI (2001) Varicocele as a progressive lesion: positive effect of varicocele repair. Hum Reprod Update 7,55-58.
    • (2001) Hum Reprod Update , vol.7 , pp. 55-58
    • Cozzolino, D.J.1    Lipshultz, L.I.2
  • 17
    • 0034469287 scopus 로고    scopus 로고
    • Sperm chromatin structure assay is useful for fertility assessment
    • Evenson DP and Jost LK (2000) Sperm chromatin structure assay is useful for fertility assessment. Methods Cell Sci 22, l69-189.
    • (2000) Methods Cell Sci , vol.22 , pp. 169-189
    • Evenson, D.P.1    Jost, L.K.2
  • 19
    • 0035665312 scopus 로고    scopus 로고
    • Sperm chromatin structure assay: Its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques
    • Evenson DP, Larson KL and Jost LK (2002) Sperm chromatin structure assay: Its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques. J Androl 23,25-43.
    • (2002) J Androl , vol.23 , pp. 25-43
    • Evenson, D.P.1    Larson, K.L.2    Jost, L.K.3
  • 20
    • 0029917272 scopus 로고    scopus 로고
    • Smoking and low antioxidant levels increase oxidative damage to sperm DNA
    • Fraga CG, Motchnik PA, Wyrobek AJ, Rempel DM and Ames BN (1996) Smoking and low antioxidant levels increase oxidative damage to sperm DNA. Mutat Res 351,199-203.
    • (1996) Mutat Res , vol.351 , pp. 199-203
    • Fraga, C.G.1    Motchnik, P.A.2    Wyrobek, A.J.3    Rempel, D.M.4    Ames, B.N.5
  • 22
    • 0028205594 scopus 로고
    • The significance of gonadotropin-releasing hormone test for predicting fertility after varicocelectomy
    • Fujisawa M, Hayashi A, Imanishi O, Tanaka H, Okada H, Matsumoto O and Kamidono S (1994) The significance of gonadotropin-releasing hormone test for predicting fertility after varicocelectomy. Fertil Steril 61,779-782.
    • (1994) Fertil Steril , vol.61 , pp. 779-782
    • Fujisawa, M.1    Hayashi, A.2    Imanishi, O.3    Tanaka, H.4    Okada, H.5    Matsumoto, O.6    Kamidono, S.7
  • 24
    • 0027217458 scopus 로고
    • Presence of DNA strand breaks and increased sensitivity of DNA in situ to denaturation in abnormal human sperm cells: Analogy to apoptosis of somatic cells
    • Gorczyca W, Traganos F, Jesionowska H and Darzynkiewicz Z (1993) Presence of DNA strand breaks and increased sensitivity of DNA in situ to denaturation in abnormal human sperm cells: Analogy to apoptosis of somatic cells. Exp Cell Res 207,202-205.
    • (1993) Exp Cell Res , vol.207 , pp. 202-205
    • Gorczyca, W.1    Traganos, F.2    Jesionowska, H.3    Darzynkiewicz, Z.4
  • 25
    • 0026027753 scopus 로고
    • Physical examination for varicocele
    • Hargreave TB and Liakatas J (1991) Physical examination for varicocele. Br J Urol 67,328.
    • (1991) Br J Urol , vol.67 , pp. 328
    • Hargreave, T.B.1    Liakatas, J.2
  • 27
    • 0032829436 scopus 로고    scopus 로고
    • Varicocele is associated with elevated spermatozoal reactive oxygen species production and diminished seminal plasma antioxidant capacity
    • Hendin BN, Kolettis PN, Sharma RK, Thomas AJ Jr and Agarwal A (1999) Varicocele is associated with elevated spermatozoal reactive oxygen species production and diminished seminal plasma antioxidant capacity. J Urol 161,1831-1834.
    • (1999) J Urol , vol.161 , pp. 1831-1834
    • Hendin, B.N.1    Kolettis, P.N.2    Sharma, R.K.3    Thomas Jr., A.J.4    Agarwal, A.5
  • 28
    • 0642375804 scopus 로고    scopus 로고
    • Chromosomal DNA fragmentation in apoptosis and necrosis induced by oxidative stress
    • Higuchi Y (2003) Chromosomal DNA fragmentation in apoptosis and necrosis induced by oxidative stress. Biochem Pharmacol 66,1527-1535.
    • (2003) Biochem Pharmacol , vol.66 , pp. 1527-1535
    • Higuchi, Y.1
  • 29
    • 0028797113 scopus 로고
    • Temporal and stage-specific effects of recombinant human follicle-stimulating hormone on the maintenance of spermatogenesis in gonadotropin-releasing hormone antagonist-treated rat
    • Hikim AP and Swerdloff RS (1995) Temporal and stage-specific effects of recombinant human follicle-stimulating hormone on the maintenance of spermatogenesis in gonadotropin-releasing hormone antagonist-treated rat. Endocrinology 136,253-261.
    • (1995) Endocrinology , vol.136 , pp. 253-261
    • Hikim, A.P.1    Swerdloff, R.S.2
  • 31
    • 0033947956 scopus 로고    scopus 로고
    • The role of DNA strand breaks in human spermatozoa used for IVF and ICSI
    • Host E, Lindenberg S and Smidt-Jensen S (2000) The role of DNA strand breaks in human spermatozoa used for IVF and ICSI. Acta Obstet Gynecol Scand 79,559-563.
    • (2000) Acta Obstet Gynecol Scand , vol.79 , pp. 559-563
    • Host, E.1    Lindenberg, S.2    Smidt-Jensen, S.3
  • 32
    • 0027753948 scopus 로고
    • Decreased blood flow and defective energy metabolism in the varicocele-bearing testicles of rats
    • Hsu HS, Chang LS, Chen MT and Wei YH (1994) Decreased blood flow and defective energy metabolism in the varicocele-bearing testicles of rats. Eur Urol 25,71-75.
    • (1994) Eur Urol , vol.25 , pp. 71-75
    • Hsu, H.S.1    Chang, L.S.2    Chen, M.T.3    Wei, Y.H.4
  • 34
    • 0032959345 scopus 로고    scopus 로고
    • Reactive oxygen intermediates as mediators of programmed cell death in plants and animals
    • Jabs T (1999) Reactive oxygen intermediates as mediators of programmed cell death in plants and animals. Biochem Pharmacol 57,231-245.
    • (1999) Biochem Pharmacol , vol.57 , pp. 231-245
    • Jabs, T.1
  • 35
    • 0035142686 scopus 로고    scopus 로고
    • Effects of varicocele on male fertility
    • Jarow JP (2001) Effects of varicocele on male fertility. Hum Reprod Update 7,59-64.
    • (2001) Hum Reprod Update , vol.7 , pp. 59-64
    • Jarow, J.P.1
  • 36
    • 0032852440 scopus 로고    scopus 로고
    • Varicocele repair improves semen parameters in azoospermic men with spermatogenic failure
    • Kim ED, Leibman BB, Grinblat DM and Lipshultz LI (1999) Varicocele repair improves semen parameters in azoospermic men with spermatogenic failure. J Urol 162,737-740.
    • (1999) J Urol , vol.162 , pp. 737-740
    • Kim, E.D.1    Leibman, B.B.2    Grinblat, D.M.3    Lipshultz, L.I.4
  • 40
    • 0033871530 scopus 로고    scopus 로고
    • Sperm chromatin structure assay parameters as predictors of failed pregnancy following assisted reproductive techniques
    • Larson KL, DeJonge CJ, Barnes AM, Jost LK and Evenson DP (2000) Sperm chromatin structure assay parameters as predictors of failed pregnancy following assisted reproductive techniques. Hum Reprod 15,1717-1722.
    • (2000) Hum Reprod , vol.15 , pp. 1717-1722
    • Larson, K.L.1    DeJonge, C.J.2    Barnes, A.M.3    Jost, L.K.4    Evenson, D.P.5
  • 41
    • 0141958097 scopus 로고    scopus 로고
    • Relationship between the outcomes of assisted reproductive techniques and sperm DNA fragmentation as measured by the sperm chromatin structure assay
    • Larson-Cook KL, Brannian JD, Hansen KA, Kasperson KM, Aamold ET and Evenson DP (2003) Relationship between the outcomes of assisted reproductive techniques and sperm DNA fragmentation as measured by the sperm chromatin structure assay. Fertil Steril 80,895-902.
    • (2003) Fertil Steril , vol.80 , pp. 895-902
    • Larson-Cook, K.L.1    Brannian, J.D.2    Hansen, K.A.3    Kasperson, K.M.4    Aamold, E.T.5    Evenson, D.P.6
  • 42
    • 0030890609 scopus 로고    scopus 로고
    • The Fas system is a key regulator of germ cell apoptosis in the testis
    • Lee J, Richburg JH, Younkin SC and Boekelheide K (1997) The Fas system is a key regulator of germ cell apoptosis in the testis. Endocrinology 138,2081-2088.
    • (1997) Endocrinology , vol.138 , pp. 2081-2088
    • Lee, J.1    Richburg, J.H.2    Younkin, S.C.3    Boekelheide, K.4
  • 43
    • 0029116225 scopus 로고
    • Total antioxidant capacity of seminal plasma is different in fertile and infertile men
    • Lewis SE, Boyle PM, McKinney KA, Young IS and Thompson W (1995) Total antioxidant capacity of seminal plasma is different in fertile and infertile men. Fertil Steril 64,868-870.
    • (1995) Fertil Steril , vol.64 , pp. 868-870
    • Lewis, S.E.1    Boyle, P.M.2    McKinney, K.A.3    Young, I.S.4    Thompson, W.5
  • 44
    • 0033153490 scopus 로고    scopus 로고
    • Effect of surgically induced varicocele on testicular blood flow and Sertoli cell function
    • Li H, Dubocq F, Jiang Y, Tiguert R, Gheiler EL and Dhabuwala CB (1999) Effect of surgically induced varicocele on testicular blood flow and Sertoli cell function. Urology 53,1258-1262.
    • (1999) Urology , vol.53 , pp. 1258-1262
    • Li, H.1    Dubocq, F.2    Jiang, Y.3    Tiguert, R.4    Gheiler, E.L.5    Dhabuwala, C.B.6
  • 45
    • 0032823381 scopus 로고    scopus 로고
    • The role of autosomal cell apoptosis regulator genes in human spermatogenesis
    • Lin WW, Lamb DJ, Lipshultz LI and Kim ED (1999) The role of autosomal cell apoptosis regulator genes in human spermatogenesis. Int Urol Nephrol 31,237-246.
    • (1999) Int Urol Nephrol , vol.31 , pp. 237-246
    • Lin, W.W.1    Lamb, D.J.2    Lipshultz, L.I.3    Kim, E.D.4
  • 47
    • 0031895751 scopus 로고    scopus 로고
    • Sperm deoxyribonucleic acid fragmentation is increased in poor-quality semen samples and correlates with failed fertilization in intracytoplasmic sperm injection
    • Lopes S, Sun JG, Jurisicova A, Meriano J and Casper RF (1998) Sperm deoxyribonucleic acid fragmentation is increased in poor-quality semen samples and correlates with failed fertilization in intracytoplasmic sperm injection. Fertil Steril 69,528-532.
    • (1998) Fertil Steril , vol.69 , pp. 528-532
    • Lopes, S.1    Sun, J.G.2    Jurisicova, A.3    Meriano, J.4    Casper, R.F.5
  • 48
    • 0028940712 scopus 로고
    • Presence of endogenous nicks in DNA of ejaculated human spermatozoa and its relationship to chromomycin A3 accessibility
    • Manicardi GC, Bianchi PG, Pantano S, Azzoni P, Bizzaro D, Bianchi U and Sakkas D (1995) Presence of endogenous nicks in DNA of ejaculated human spermatozoa and its relationship to chromomycin A3 accessibility. Biol Reprod 52,864-867.
    • (1995) Biol Reprod , vol.52 , pp. 864-867
    • Manicardi, G.C.1    Bianchi, P.G.2    Pantano, S.3    Azzoni, P.4    Bizzaro, D.5    Bianchi, U.6    Sakkas, D.7
  • 49
    • 0034839692 scopus 로고    scopus 로고
    • The pathophysiology of varicoceles in the light of current molecular and genetic information
    • Marmar JL (2001) The pathophysiology of varicoceles in the light of current molecular and genetic information. Hum Reprod Update 7,461-472.
    • (2001) Hum Reprod Update , vol.7 , pp. 461-472
    • Marmar, J.L.1
  • 50
    • 1542723120 scopus 로고    scopus 로고
    • Incidence of Fas positivity and deoxyribonucleic acid double-stranded breaks in human ejaculated sperm
    • McVicar CM, McClure N, Williamson K, Dalzell LH and Lewis SE (2004) Incidence of Fas positivity and deoxyribonucleic acid double-stranded breaks in human ejaculated sperm. Fertil Steril 81 (Suppl. 1),767-774.
    • (2004) Fertil Steril , vol.81 , Issue.SUPPL. 1 , pp. 767-774
    • McVicar, C.M.1    McClure, N.2    Williamson, K.3    Dalzell, L.H.4    Lewis, S.E.5
  • 52
    • 0029133602 scopus 로고
    • Testicular heating and its possible contributions to male infertility: A review
    • Mieusset R and Bujan L (1995) Testicular heating and its possible contributions to male infertility: A review. Int J Androl 18,169-184.
    • (1995) Int J Androl , vol.18 , pp. 169-184
    • Mieusset, R.1    Bujan, L.2
  • 53
    • 0036108498 scopus 로고    scopus 로고
    • The spectrum of DNA damage in human sperm assessed by single cell gel electrophoresis (Comet assay) its relationship to fertilization and embryo development
    • Morris ID, Ilott S, Dixon L and Brison DR (2002) The spectrum of DNA damage in human sperm assessed by single cell gel electrophoresis (Comet assay) its relationship to fertilization and embryo development. Hum Reprod 17,990-998.
    • (2002) Hum Reprod , vol.17 , pp. 990-998
    • Morris, I.D.1    Ilott, S.2    Dixon, L.3    Brison, D.R.4
  • 54
    • 0347316382 scopus 로고    scopus 로고
    • Relationship between ROS production, apoptosis and DNA denaturation in spermatozoa from patients examined for infertility
    • Moustafa MH, Sharma RK, Thornton J, Mascha E, Abdel-Hafez MA, Thomas AJ Jr and Agarwal A (2004) Relationship between ROS production, apoptosis and DNA denaturation in spermatozoa from patients examined for infertility. Hum Reprod 19,129-138.
    • (2004) Hum Reprod , vol.19 , pp. 129-138
    • Moustafa, M.H.1    Sharma, R.K.2    Thornton, J.3    Mascha, E.4    Abdel-Hafez, M.A.5    Thomas Jr., A.J.6    Agarwal, A.7
  • 55
  • 56
    • 0031669992 scopus 로고    scopus 로고
    • Update on treatment of varicocele: Counselling as effective as occlusion of the vena spermatica
    • Nieschlag E, Hertle L, Fischedick A, Abshagen K and Behre HM (1998) Update on treatment of varicocele: Counselling as effective as occlusion of the vena spermatica. Hum Reprod 13,2147-2150.
    • (1998) Hum Reprod , vol.13 , pp. 2147-2150
    • Nieschlag, E.1    Hertle, L.2    Fischedick, A.3    Abshagen, K.4    Behre, H.M.5
  • 58
    • 0033954920 scopus 로고    scopus 로고
    • Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing infertility investigation
    • Pasqualotto FF, Sharma RK, Nelson DR, Thomas AJ and Agarwal A (2000) Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing infertility investigation. Fertil Steril 73,459-464.
    • (2000) Fertil Steril , vol.73 , pp. 459-464
    • Pasqualotto, F.F.1    Sharma, R.K.2    Nelson, D.R.3    Thomas, A.J.4    Agarwal, A.5
  • 59
    • 0033030170 scopus 로고    scopus 로고
    • Fas regulates germ cell apoptosis in the human testis in vitro
    • Pentikainen V, Erkkila K and Dunkel L (1999) Fas regulates germ cell apoptosis in the human testis in vitro. Am J Physiol 276,E310-E316.
    • (1999) Am J Physiol , vol.276
    • Pentikainen, V.1    Erkkila, K.2    Dunkel, L.3
  • 60
    • 0034064385 scopus 로고    scopus 로고
    • Germ cell suicide: New insights into apoptosis during spermatogenesis
    • Print CG and Loveland KL (2000) Germ cell suicide: New insights into apoptosis during spermatogenesis. Bioessays 22,423-430.
    • (2000) Bioessays , vol.22 , pp. 423-430
    • Print, C.G.1    Loveland, K.L.2
  • 61
    • 0030975776 scopus 로고    scopus 로고
    • An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis
    • Rodriguez I, Ody C, Araki K, Garcia I and Vassalli P (1997) An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis. EMBO J 16,2262-2270.
    • (1997) EMBO J , vol.16 , pp. 2262-2270
    • Rodriguez, I.1    Ody, C.2    Araki, K.3    Garcia, I.4    Vassalli, P.5
  • 62
    • 0028913310 scopus 로고
    • Relationship between the presence of endogenous nicks and sperm chromatin packaging in maturing and fertilizing mouse spermatozoa
    • Sakkas D, Manicardi G, Bianchi PG, Bizzaro D and Bianchi U (1995) Relationship between the presence of endogenous nicks and sperm chromatin packaging in maturing and fertilizing mouse spermatozoa. Biol Reprod 52,1149-1155.
    • (1995) Biol Reprod , vol.52 , pp. 1149-1155
    • Sakkas, D.1    Manicardi, G.2    Bianchi, P.G.3    Bizzaro, D.4    Bianchi, U.5
  • 64
    • 0033567961 scopus 로고    scopus 로고
    • Abnormal sperm parameters in humans are indicative of an abortive apoptotic mechanism linked to the Fas-mediated pathway
    • Sakkas D, Mariethoz E and St John JC (1999b) Abnormal sperm parameters in humans are indicative of an abortive apoptotic mechanism linked to the Fas-mediated pathway. Exp Cell Res 251,350-355.
    • (1999) Exp Cell Res , vol.251 , pp. 350-355
    • Sakkas, D.1    Mariethoz, E.2    St John, J.C.3
  • 65
    • 0036196244 scopus 로고    scopus 로고
    • Nature of DNA damage in ejaculated human spermatozoa and the possible involvement of apoptosis
    • Sakkas D, Moffatt O, Manicardi GC, Mariethoz E, Tarozzi N and Bizzaro D (2002) Nature of DNA damage in ejaculated human spermatozoa and the possible involvement of apoptosis. Biol Reprod 66,1061-1067.
    • (2002) Biol Reprod , vol.66 , pp. 1061-1067
    • Sakkas, D.1    Moffatt, O.2    Manicardi, G.C.3    Mariethoz, E.4    Tarozzi, N.5    Bizzaro, D.6
  • 67
    • 0344012671 scopus 로고    scopus 로고
    • Abnormal spermatozoa in the ejaculate: Abortive apoptosis and faulty nuclear remodeling during spermatogenesis
    • Sakkas D, Seli E, Bizzaro D, Tarozzi N and Manicardi GC (2003b) Abnormal spermatozoa in the ejaculate: Abortive apoptosis and faulty nuclear remodeling during spermatogenesis. Reprod Biomed Online 7,428-432.
    • (2003) Reprod Biomed Online , vol.7 , pp. 428-432
    • Sakkas, D.1    Seli, E.2    Bizzaro, D.3    Tarozzi, N.4    Manicardi, G.C.5
  • 68
    • 0036868446 scopus 로고    scopus 로고
    • Oxidative stress and male infertility: From research bench to clinical practice
    • Saleh RA and Agarwal A (2002) Oxidative stress and male infertility: from research bench to clinical practice. J Androl 23,737-752.
    • (2002) J Androl , vol.23 , pp. 737-752
    • Saleh, R.A.1    Agarwal, A.2
  • 71
    • 0037834778 scopus 로고    scopus 로고
    • Negative effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertility
    • Saleh RA, Agarwal A, Nada EA, El-Tonsy MH, Sharma RK, Meyer A, Nelson DR and Thomas AJ (2003b) Negative effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertility. Fertil Steril 79 (Suppl. 3),1597-1605.
    • (2003) Fertil Steril , vol.79 , Issue.SUPPL. 3 , pp. 1597-1605
    • Saleh, R.A.1    Agarwal, A.2    Nada, E.A.3    El-Tonsy, M.H.4    Sharma, R.K.5    Meyer, A.6    Nelson, D.R.7    Thomas, A.J.8
  • 72
    • 0027935585 scopus 로고
    • Treatment outcome after varicocelectomy. A critical analysis
    • Schlesinger MH, Wilets IF and Nagler HM (1994) Treatment outcome after varicocelectomy. A critical analysis. Urol Clin North Am 21,517-529.
    • (1994) Urol Clin North Am , vol.21 , pp. 517-529
    • Schlesinger, M.H.1    Wilets, I.F.2    Nagler, H.M.3
  • 73
    • 4143065747 scopus 로고    scopus 로고
    • Extent of nuclear DNA damage in ejaculated spermatozoa impacts on blastocyst development after in vitro fertilization
    • Seli E, Gardner DK, Schoolcraft WB, Moffatt O and Sakkas D (2004) Extent of nuclear DNA damage in ejaculated spermatozoa impacts on blastocyst development after in vitro fertilization. Fertil Steril 82,378-383.
    • (2004) Fertil Steril , vol.82 , pp. 378-383
    • Seli, E.1    Gardner, D.K.2    Schoolcraft, W.B.3    Moffatt, O.4    Sakkas, D.5
  • 74
    • 0034652432 scopus 로고    scopus 로고
    • Detection of oxidative DNA damage in human sperm and its association with sperm function and male infertility
    • Shen H and Ong C (2000) Detection of oxidative DNA damage in human sperm and its association with sperm function and male infertility. Free Radic Biol Med 28,529-536.
    • (2000) Free Radic Biol Med , vol.28 , pp. 529-536
    • Shen, H.1    Ong, C.2
  • 75
    • 0036107443 scopus 로고    scopus 로고
    • Detection of apoptotic alterations in sperm in subfertile patients and their correlations with sperm quality
    • Shen HM, Dai J, Chia SE, Lim A and Ong CN (2002) Detection of apoptotic alterations in sperm in subfertile patients and their correlations with sperm quality. Hum Reprod 17,1266-1273.
    • (2002) Hum Reprod , vol.17 , pp. 1266-1273
    • Shen, H.M.1    Dai, J.2    Chia, S.E.3    Lim, A.4    Ong, C.N.5
  • 77
    • 0033973324 scopus 로고    scopus 로고
    • Sperm chromatin damage impairs human fertility
    • The Danish First Pregnancy Planner Study Team
    • Spano M, Bonde JP, Hjollund HI, Kolstad HA, Cordelli E and Leter G (2000) Sperm chromatin damage impairs human fertility. The Danish First Pregnancy Planner Study Team. Fertil Steril 73,43-50.
    • (2000) Fertil Steril , vol.73 , pp. 43-50
    • Spano, M.1    Bonde, J.P.2    Hjollund, H.I.3    Kolstad, H.A.4    Cordelli, E.5    Leter, G.6
  • 78
    • 0031045420 scopus 로고    scopus 로고
    • Detection of deoxyribonucleic acid fragmentation in human sperm: Correlation with fertilization in vitro
    • Sun JG, Jurisicova A and Casper RF (1997) Detection of deoxyribonucleic acid fragmentation in human sperm: Correlation with fertilization in vitro. Biol Reprod 56,602-607.
    • (1997) Biol Reprod , vol.56 , pp. 602-607
    • Sun, J.G.1    Jurisicova, A.2    Casper, R.F.3
  • 79
    • 0029080125 scopus 로고
    • Alteration of testicular microvascular pressures during venous pressure elevation
    • Sweeney TE, Rozum JS and Gore RW (1995) Alteration of testicular microvascular pressures during venous pressure elevation. Am J Physiol 269,H37-H45.
    • (1995) Am J Physiol , vol.269
    • Sweeney, T.E.1    Rozum, J.S.2    Gore, R.W.3
  • 80
    • 0036093615 scopus 로고    scopus 로고
    • Apoptosis-related proteins in the testes of infertile men with varicocele
    • Tanaka H, Fujisawa M, Okada H and Kamidono S (2002) Apoptosis-related proteins in the testes of infertile men with varicocele. BJU Int 89,905-909.
    • (2002) BJU Int , vol.89 , pp. 905-909
    • Tanaka, H.1    Fujisawa, M.2    Okada, H.3    Kamidono, S.4
  • 81
    • 0031822956 scopus 로고    scopus 로고
    • Germ cell apoptosis in men with complete and incomplete spermiogenesis failure
    • Tesarik J, Greco E, Cohen-Bacrie P and Mendoza C (1998) Germ cell apoptosis in men with complete and incomplete spermiogenesis failure. Mol Hum Reprod 4,757-762.
    • (1998) Mol Hum Reprod , vol.4 , pp. 757-762
    • Tesarik, J.1    Greco, E.2    Cohen-Bacrie, P.3    Mendoza, C.4
  • 82
    • 0036065438 scopus 로고    scopus 로고
    • In-vitro effects of FSH and testosterone withdrawal on caspase activation and DNA fragmentation in different cell types of human seminiferous epithelium
    • Tesarik J, Martinez F, Rienzi L, Iacobelli M, Ubaldi F, Mendoza C and Greco E (2002) In-vitro effects of FSH and testosterone withdrawal on caspase activation and DNA fragmentation in different cell types of human seminiferous epithelium. Hum Reprod 17,1811-1819.
    • (2002) Hum Reprod , vol.17 , pp. 1811-1819
    • Tesarik, J.1    Martinez, F.2    Rienzi, L.3    Iacobelli, M.4    Ubaldi, F.5    Mendoza, C.6    Greco, E.7
  • 83
    • 1242296288 scopus 로고    scopus 로고
    • Caspase-dependent and -independent DNA fragmentation in Sertoli and germ cells from men with primary testicular failure: Relationship with histological diagnosis
    • Tesarik J, Ubaldi F, Rienzi L, Martinez F, Iacobelli M, Mendoza C and Greco E (2004a) Caspase-dependent and -independent DNA fragmentation in Sertoli and germ cells from men with primary testicular failure: relationship with histological diagnosis. Hum Reprod 19,254-261.
    • (2004) Hum Reprod , vol.19 , pp. 254-261
    • Tesarik, J.1    Ubaldi, F.2    Rienzi, L.3    Martinez, F.4    Iacobelli, M.5    Mendoza, C.6    Greco, E.7
  • 84
    • 1542711820 scopus 로고    scopus 로고
    • Late, but not early, paternal effect on human embryo development is related to sperm DNA fragmentation
    • Tesarik J, Greco E and Mendoza C (2004b) Late, but not early, paternal effect on human embryo development is related to sperm DNA fragmentation. Hum Reprod 19,611-615.
    • (2004) Hum Reprod , vol.19 , pp. 611-615
    • Tesarik, J.1    Greco, E.2    Mendoza, C.3
  • 85
    • 0042836892 scopus 로고    scopus 로고
    • Falcone T and Agarwal A Oxidative stress is associated with increased apoptosis leading to spermatozoa DNA damage in patients with male factor infertility
    • Wang X, Sharma RK, Sikka SC, Thomas AJ Jr, Falcone T and Agarwal A (2003) Oxidative stress is associated with increased apoptosis leading to spermatozoa DNA damage in patients with male factor infertility. Fertil Steril 80,531-535.
    • (2003) Fertil Steril , vol.80 , pp. 531-535
    • Wang, X.1    Sharma, R.K.2    Sikka, S.C.3    Thomas Jr., A.J.4
  • 87
    • 0026642535 scopus 로고
    • The influence of varicocele on parameters of fertility in a large group of men presenting to infertility clinics
    • WHO World Health Organization
    • WHO (1992) The influence of varicocele on parameters of fertility in a large group of men presenting to infertility clinics. World Health Organization. Fertil Steril 57,1289-1293.
    • (1992) Fertil Steril , vol.57 , pp. 1289-1293
  • 88
    • 0035237634 scopus 로고    scopus 로고
    • Laboratory manual of the WHO for the examination of human semen and sperm-cervical mucus interaction
    • WHO I-XII
    • WHO (2001) [Laboratory manual of the WHO for the examination of human semen and sperm-cervical mucus interaction]. Ann Ist Super Sanita 37,I-XII, 1-123.
    • (2001) Ann Ist Super Sanita , vol.37 , pp. 1-123
  • 89
    • 0030806916 scopus 로고    scopus 로고
    • Reduction in testicular temperature after varicocelectomy in infertile men
    • Wright EJ, Young GP and Goldstein M (1997) Reduction in testicular temperature after varicocelectomy in infertile men. Urology 50,257-259.
    • (1997) Urology , vol.50 , pp. 257-259
    • Wright, E.J.1    Young, G.P.2    Goldstein, M.3
  • 90
    • 0033835737 scopus 로고    scopus 로고
    • Varicocele is associated with abnormal retention of cytoplasmic droplets by human spermatozoa
    • Zini A, Defreitas G, Freeman M, Hechter S and Jarvi K (2000) Varicocele is associated with abnormal retention of cytoplasmic droplets by human spermatozoa. Fertil Steril 74,461-464.
    • (2000) Fertil Steril , vol.74 , pp. 461-464
    • Zini, A.1    Defreitas, G.2    Freeman, M.3    Hechter, S.4    Jarvi, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.