Oxidative stress is associated with increased apoptosis leading to spermatozoa DNA damage in patients with male factor infertility

Fertility and Sterility

Volumn 80, Issue 3, 2003, Pages 531-535

  Wang, Xia ^a   Sharma, Rakesh K ^a   Sikka, Suresh C ^a   Thomas Jr , Anthony J ^a,b   Falcone, Tommaso ^a,b   Agarwal, Ashok ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Apoptosis; Caspases; Cytochrome c; Human spermatozoa; Reactive oxygen species

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; DNA; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA DAMAGE; EJACULATION; HEALTH CENTER; HUMAN; IDIOPATHIC DISEASE; MALE; MALE INFERTILITY; OUTCOMES RESEARCH; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEMEN ANALYSIS; SPERM DONOR; SPERMATOZOON; SPERMATOZOON MOTILITY; STATISTICAL SIGNIFICANCE;

EID: 0042836892     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(03)00756-8     Document Type: Article

References (35)

1. Sharma R.K., Agarwal A. Role of reactive oxygen species in male infertility. Urology. 48:1996;835-850.
2. Agarwal A., Saleh R. Role of oxidants in male infertility rationale, significance, and treatment . Urol Clin N Am. 29:2002;817-827.
3. Saleh R, Agarwal A. Oxidative stress and male infertility: from research bench to clinical practice. J Androl, 2002;23:737-52.
4. Twigg J.P., Irvine D.S., Aitken R.J. Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at intracytoplasmic sperm injection. Hum Reprod. 13:1998;1864-1871.
5. Sikka S.C. Relative impact of oxidative stress on male reproductive function. Current Medicinal Chemistry. 8:2001;851-862.
6. Sun J.G., Jurisicova A., Casper R.F. Detection of deoxyribonucleic acid fragmentation in human sperm correlation with fertilization in vitro . Biol Reprod. 56:1997;602-607.
7. Evenson D.P., Larson K.L., Jost L.K. Sperm chromatin structure assay its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques . J Androl. 23:2002;25-43.
8. Wyllie A.H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature. 284:1980;555-556.
9. Print C.G., Loveland K.L. Germ cell suicide new insights into apoptosis during spermatogenesis . Bioessays. 22:2000;423-430.
10. Kierszenbaum A.L. Apoptosis during spermatogenesis the thrill of being alive . Mol Reprod Dev. 58:2001;1-3.
11. Sinha Hikim A.P., Wang C., Lue Y. Spontaneous germ cell apoptosis in human Evidence for ethnic difference in the susceptibility of germ cells to programmed cell death . J Clin Endocrinol Metab. 83:1998;152-156.
12. Juriscova A., Lopes S., Merrano J. DNA damage in round spermatids of mice with targeted disruption of the Pp1c 75 gene and in testicular biopsies of patients with non-obstructive azoospermia. Mol Hum Reprod. 5:1999;323-330.
13. Lin W.W., Lamb D.J., Wheeler T.M., Lipshultz L.I., Kim E.D. In situ end-labeling of human testicular tissue demonstrates increased apoptosis in conditions of abnormal spermatogenesis. Fertil Steril. 68:1997;1065-1069.
14. Gorczyca W., Traganos F., Jesionowska H., Darzynkiewicz Z. Presence of DNA strand breaks and increased sensitivity of DNA in situ to denaturation in abnormal human sperm cells analogy to apoptosis of somatic cells . Exp Cell Res. 207:1993;202-205.
15. Irvine D.S., Twigg J.P., Gordon E.L., Fulton N., Milne P.A., Aitken R.J. DNA integrity in human spermatozoa relationships with semen quality . J Androl. 21:2000;33-44.
16. Oosterhuis G.J., Mulder A.B., Kalsbeek-Batenburg E., Lambalk C.B., Schoemaker J., Vermes I. Measuring apoptosis in human spermatozoa a biological assay for semen quality? Fertil Steril. 74:2000;245-250.
17. Salvesen GS, Dixit VM. Caspases: intracellular signaling by proteolysis. Cell 1997;91:443-6.
18. Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4th ed :1999;Cambridge University Press, New York.
19. Kruger T.F., Menkveld R., Stander F.S., Lombard C.J., Van der Merwe J.P., van Zyl J.A., et al. Sperm morphologic features as a prognosis factor of in vitro fertilization. Fertil Steril. 46:1986;1118-1123.
20. Shekarriz M., Sharma R.K., Thromas A.J., Agarwal A. Positive myeloperoxidase staining (Endtz test) as an indicator of excessive reactive oxygen species formation in semen. J Assist Reprod Genetics. 12:1995;70-74.
21. Vermes I., Haanen C., Steffens-Nakken H., Reutenlingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosaphatidyl serine expression on early apoptotic ells using fluorescein labelled annexin V. J Immunol Methods. 184:1995;39-51.
22. Reed J.C. Cytochrome c can't live with it - can't live without it . Cell. 91:1997;559-562.
23. Yang J., Liu X., Bhalla K., Kim C.N., Ibardo A.M., Cai J., et al. Prevention of apoptosis by Bcl-2; release of cytochrome c from mitochondria blocked. Science. 275:1997;1129-1132.
24. Wang S, Sharma RK, Ranganathan P, Thomas AJ, Jr, Falcone T, Agarwal A. Oxidative stress and increased levels of apoptosis (cytochrome C, Caspase 3 and 9) in patients with male-factor infertility. 57th Annual Meeting of the American Society for Reproductive Medicine, 2001, October 20-25, Orlando, FL. Fertil Steril 76:S195.
25. Paasch, U, Grunewald S, Wündrich K, Glander H-J. Caspases are associated with human spermatogenesis and apoptosis in ejaculated spermatozoa. VII International Congress of Andrology, June 15-19, 2001, Montreal, Canada. J Androl (suppl) P-037.
26. Barroso G., Morshedi M., Oehninger S. Analysis of DNA fragmentation, plasma membrane translocation of phosphatidylserine and oxidative stress in human spermatozoa. Hum Reprod. 15:2000;1338-1344.
27. Host E., Lindenberg S., Smidt-Jensen S. DNA strand breaks in human spermatozoa correlation with fertilization in vitro in oligozoospermic men and in men with unexplained infertility . Acta Obstet Gynecol Scand. 79:2000;189-193.
28. Host E., Lindenberg S., Smidt-Jensen S. The role of DNA strand breaks in human spermatozoa used for IVF and ICSI. Acta Obstet Gynecol Scand. 79:2000;559-563.
29. Shen H.M., Dai J., Chia S.E., Lim A., Ong C.N. Detection of apoptotic alterations in sperm in subfertile patients and their correlations with sperm quality. Hum Reprod. 17:2002;1266-1273.
30. Muratori M., Piombi P., Baldi E., Filimberti E., Pecchioli P., Moretti E., et al. Functional and ultrastructural features of DNA-fragmented human sperm. J Androl. 21:2000;903-912.
31. Sinha Hikim A.P., Swerdloff R.S. Hormonal and genetic control of germ cell apoptosis in the testis. Rev Reprod. 4:1999;38-47.
32. Weng SL, Taylor SL, Morshedi M, Schuffner A, Duran EH, Beebe S, et al. Caspase activity and apoptotic markers in ejaculated human sperm Mol Hum Reprod 2002;8:984-91.
33. Weil M., Jacobson M.D., Raff M.C. Are caspases involved in the death of cells with a transcriptionally inactive nucleus? Sperm and chicken erythrocytes. J Cell Sci. 111:1998;2707-2715.
34. Sakkas D., Mariethoz E., Manicardi G. Origin of DNA damage in ejaculated human spermatozoa. Rev Reprod. 4:1999;31-37.
35. Sakkas D., Moffatt O., Manicardi G.C., Mariethoz E., Tarozzi N., Bizzaro D. Nature of DNA damage in ejaculated spermatozoa and the possible involvement of apoptosis. Biol Reprod. 66:2002;1061-1067.