DNA nano-carriers from biodegradable cationic branched polyesters are formed by a modified solvent displacement method

Journal of Controlled Release

Volumn 111, Issue 3, 2006, Pages 371-381

  Oster, Christine G ^a   Wittmar, Matthias ^a   Bakowsky, Udo ^b   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

Biodegradable polymer; DNA vaccine; Gene delivery; Nanoparticles; Solvent displacement

Indexed keywords

AMINES; ATOMIC FORCE MICROSCOPY; BIODEGRADATION; ENZYMES; MONOMERS; MORPHOLOGY; NANOSTRUCTURED MATERIALS; POLYESTERS; POLYVINYL ALCOHOLS;

BIODEGRADABLE POLYMERS; DNA VACCINES; GENE DELIVERY; NANOPARTICLES; SOLVENT DISPLACEMENTS;

DNA;

CATION; DNA VACCINE; DRUG CARRIER; LUCIFERASE; MONOMER; NITROGEN; PHOSPHATE; POLYESTER; POLYGLACTIN; SOLVENT;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; ARTICLE; ATOMIC FORCE MICROSCOPY; BIODEGRADABILITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; ELECTRICITY; ENZYME DEGRADATION; GENE TARGETING; GENETIC TRANSFECTION; HYDRODYNAMICS; MOUSE; NANOPARTICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINES; ANIMALS; CATIONS; DEOXYRIBONUCLEASES; DNA; DRUG CARRIERS; HUMANS; LACTIC ACID; MICE; NANOPARTICLES; NIH 3T3 CELLS; POLYESTERS; POLYGLYCOLIC ACID; POLYMERS; POLYVINYL ALCOHOL; RABBITS; SOLVENTS; SURFACE PROPERTIES; TRANSFECTION;

EID: 33645281933     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.12.004     Document Type: Article

References (41)

1. D.C. Tang, M. DeVit, and S.A. Johnston Genetic immunization is a simple method for eliciting an immune response Nature 356 1992 152 154
2. M.A. Liu DNA vaccines: a review J. Int. Med. 253 2003 402 410
3. J.B. Ulmer, J.J. Donnelly, S.E. Parker, G.H. Rhodes, P.L. Felgner, V.J. Dwarki, S.H. Gromkowski, R.R. Deck, C.M. DeWitt, and A. Friedman Heterologous protection against influenza by injection of DNA encoding a viral protein Science 259 1993 1745 1749
4. J.J. Donnelly, A. Friedman, J.B. Ulmer, and M.A. Liu Further protection against antigenic drift of influenza virus in a ferret model by DNA vaccination Vaccine 15 1997 865 868
5. J.M. Timmerman, G. Singh, G. Hermanson, P. Hobart, D.K. Czerwinski, B. Taidi, R. Rajapaksa, C.B. Caspar, A. Van Beckhoven, and R. Levy Immunogenicity of a plasmid DNA vaccine encoding chimeric idiotype in patients with B-cell lymphoma Cancer Res. 62 2002 5845 5852
6. N.L. Letvin, D.C. Montefiori, Y. Yasutomi, H.C. Perry, M.E. Davies, C. Lekutis, M. Alroy, D.C. Freed, C.I. Lord, L.K. Handt, M.A. Liu, and J.W. Shiver Potent, protective anti-HIV immune responses generated by bimodal HIV envelope DNA plus protein vaccination Proc. Natl. Acad. Sci. U. S. A. 94 1997 9378 9383
7. J. Wang, P.C. Zhang, H.Q. Mao, and K.W. Leong Enhanced gene expression in mouse muscle by sustained release of plasmid DNA using PPE-EA as a carrier Gene Ther. 9 2002 1254 1261
8. E. Walter, K. Moelling, J. Pavlovic, and H.P. Merkle Microencapsulation of DNA using poly(dl-lactide-co-glycolide): stability issues and release characteristics J. Control. Release 61 1999 361 374
9. A.M. Tinsley-Bown, R. Fretwell, A.B. Dowsett, S.L. Davis, and G.H. Farrar Formulation of poly(d,l-lactic-co-glycolic acid) microparticles for rapid plasmid DNA delivery J. Control. Release 66 2000 229 241
10. R.K. Evans, Z. Xu, K.E. Bohannon, B. Wang, M.W. Bruner, and D.B. Volkin Evaluation of degradation pathways for plasmid DNA in pharmaceutical formulations via accelerated stability studies J. Pharm. Sci. 89 2000 76 87
11. S. Ando, D. Putnam, D.W. Pack, and R. Langer PLGA microspheres containing plasmid DNA: preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization J. Pharm. Sci. 88 1999 126 130
12. Y. Capan, B.H. Woo, S. Gebrekidan, S. Ahmed, and P.P. DeLuca Influence of formulation parameters on the characteristics of poly(d,l-lactide-co-glycolide) microspheres containing poly(l-lysine) complexed plasmid DNA J. Control. Release 60 1999 279 286
13. N. Csaba, P. Caamano, A. Sanchez, F. Dominguez, and M. Alonso PLGA:poloxamer and PLGA:poloxamine blend nanoparticles: new carriers for gene delivery Biomacromolecules 6 2005 271 278
14. N. Csaba, L. Gonzalez, A. Sanchez, and M. Alonso Design and characterisation of new nanoparticulate polymer blends for drug delivery J. Biomater. Sci., Polym. Ed. 15 2004 1137 1151
15. A. Potineni, D. Lynn, R. Langer, and M. Amiji Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery J. Control. Release 17 2003 223 234
16. D. Anderson, A. Akinc, N. Hossain, and R. Langer Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters) Mol. Ther. 11 2005 426 434
17. M. Neu, D. Fischer, and T. Kissel Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives J. Gene Med. 2005
18. C.V. Sterling, and L.E. Scriven Interfacial Turbulences: hydrodynamic instability and the Marangoni effect A.I.Ch.E. J. 5 1959 514 523
19. B. Dimitrova, I.B. Ivanov, and E. Nakache Mass transport effects on the stability of emulsion: emulsion films with acetic acid and acetone diffusing across the interface J. Dispers. Sci. Technol. 9 1988 321 341
20. C. Oster, M. Wittmar, F. Unger, L. Barbu-Tudoran, A. Schaper, and T. Kissel Effective biodegradable DNA nanocarrier systems of newly synthesized amphiphilic, amine-modified graft polyesters Pharm. Res. 21 2004 927 931
21. M. Wittmar, Charge modified, comb-like graft polyesters for drug delivery and DNA vaccination: synthesis and characterization of Poly[vinyl-dialkylamino- carbamate-co-vinyl acetate-graft-poly(d,-lactide-co-glycolide)]s, PhD Thesis, Philipps-Universität Marburg, 2004.
22. T. Jung, A. Breitenbach, and T. Kissel Sulfobutylated poly(vinyl alcohol)-graft-poly(lactide-co-glycolide)s facilitate the preparation of small negatively charged biodegradable nanospheres J. Control. Release 67 2000 157 169
23. V. Oberle, U. Bakowsky, I.S. Zuhorn, and D. Hoekstra Lipoplex formation under equilibrium conditions reveals a three-step mechanism Biophys. J. 79 2000 1447 1454
24. D.I. Axel, B.R. Brehm, K. Wolburg-Buchholz, E.L. Betz, G. Koveker, and K.R. Karsch Induction of cell-rich and lipid-rich plaques in a transfilter coculture system with human vascular cells J. Vasc. Res. 33 1996 327 339
25. K. Kunath, A. von Harpe, D. Fischer, H. Petersen, U. Bickel, K. Voigt, and T. Kissel Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine J. Control. Release 89 2003 113 125
26. M.T. Peracchia, R. Gref, Y. Minamitake, A. Domb, V. Trubetskoy, V. Torchilin, and R. Langer Poly(ethylene glycol)-coated nanospheres: potential carriers for intravenous drug administration J. Control. Release 46 1997 223 231
27. T. Niwa, H. Takeuchi, T. Hino, N. Kunou, and Y. Kawashima Preparations of biodegradable nanospheres of water-soluble and insoluble drugs with d,l-lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behavior J. Control. Release 25 1993 89 98
28. D. Quintanar-Guerrero, E. Allemann, H. Fessi, and E. Doelker Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers Drug Dev. Ind. Pharm. 24 1998 1113 1128
29. D. Quintanar-Guerrero, H. Fessi, E. Allemann, and E. Doelker Influence of stabilizing agents and preparative variables on the formation of poly(d,l-lactic acid) nanoparticles by an emulsification-diffusion technique Int. J. Pharm. 143 1996 133.141
30. M. Jobmann, and G. Rafler Submicronparticles from biodegradable polymers Int. J. Pharm. 242 2002 213 217
31. H. Petersen, P.M. Fechner, A.L. Martin, K. Kunath, S. Stolnik, C.J. Roberts, D. Fischer, M.C. Davies, and T. Kissel Polyethylenimine-graft- poly(ethylene glycol) copolymers: influence of copolymer block structure on DNA complexation and biological activities as gene delivery system Bioconjug. Chem. 13 2002 845 854
32. S. Choksakulnimitr, S. Masuda, H. Tokuda, Y. Takakura, and H.M. In vitro cytotoxicity of macromolecules in different cell culture systems J. Control. Release 34 1995 233 241
33. A. Prokop, E. Kozlov, W. Moore, and J.M. Davidson Maximizing the in vivo efficiency of gene transfer by means of nonviral polymeric gene delivery vehicles J. Pharm. Sci. 91 2002 67 76
34. O. Boussif, F. Lezoualc'h, M.A. Zanta, M.D. Mergny, D. Scherman, B. Demeneix, and J.P. Behr A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine Proc. Natl. Acad. Sci. U. S. A. 92 1995 7297 7301
35. M. Wittmar, F. Unger, A.K. Schaper, T. Kissel, Fast degrading, high-molecular weight, brush-like branched, amine-modified poly(vinyl alcohol)-graft-poly(d,l-lactide-co-glycolide)s as platform for parenteral drug delivery systems: Synthesis, characterization and degradation behavior, Macromolecules (submitted for publication).
36. Y.W. Cho, J.D. Kim, and K. Park Polycation gene delivery systems: escape from endosomes to cytosol J. Pharm. Pharmacol. 55 2003 721 734
37. D.W. Lim, Y.I. Yeom, and T.G. Park Poly(DMAEMA-NVP)-b-PEG-galactose as gene delivery vector for hepatocytes Bioconjug. Chem. 11 2000 688 695
38. N.D. Sonawane, F.C. Szoka Jr., and A.S. Verkman Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes J. Biol. Chem. 2003
39. M. Koping-Hoggard, I. Tubulekas, H. Guan, K. Edwards, M. Nilsson, K.M. Varum, and P. Artursson Chitosan as a nonviral gene delivery system. Structure-property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo Gene Ther. 8 2001 1108 1121
40. N. Murthy, J.R. Robichaud, D.A. Tirrell, P.S. Stayton, and A.S. Hoffman The design and synthesis of polymers for eukaryotic membrane disruption J. Control. Release 61 1999 137 143
41. T. Ishii, Y. Okahata, and T. Sato Mechanism of cell transfection with plasmid/chitosan complexes Biochim. Biophys. Acta 1514 2001 51 64