-
1
-
-
2342667387
-
The development of proteasome inhibitors as anticancer drugs
-
Adams J. The development of proteasome inhibitors as anticancer drugs. Cancer Cell 2004; 5: 417-421.
-
(2004)
Cancer Cell
, vol.5
, pp. 417-421
-
-
Adams, J.1
-
2
-
-
2342613652
-
The proteasome: A suitable antineoplastic target
-
Adams J. The proteasome: a suitable antineoplastic target. Nat Rev Cancer 2004; 4: 349-360.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 349-360
-
-
Adams, J.1
-
3
-
-
0036023407
-
A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies
-
Aghajanian C, Soignet S, Dizon DS, Pien CS, Adams J, Elliott PJ, Sabbatini P, Miller V, Hensley ML, Pezzulli S, Canales C, Daud A, Spriggs DR. A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies. Clin Cancer Res 2002; 8: 2505-2511.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2505-2511
-
-
Aghajanian, C.1
Soignet, S.2
Dizon, D.S.3
Pien, C.S.4
Adams, J.5
Elliott, P.J.6
Sabbatini, P.7
Miller, V.8
Hensley, M.L.9
Pezzulli, S.10
Canales, C.11
Daud, A.12
Spriggs, D.R.13
-
4
-
-
0842281433
-
Therapeutic implications of cancer stem cells
-
Al Hajj M, Becker MW, Wicha M, Weissman I, Clarke MF. Therapeutic implications of cancer stem cells. Curr Opin Genet Dev 2004; 14: 43-47.
-
(2004)
Curr Opin Genet Dev
, vol.14
, pp. 43-47
-
-
Al Hajj, M.1
Becker, M.W.2
Wicha, M.3
Weissman, I.4
Clarke, M.F.5
-
5
-
-
0033558192
-
Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers
-
Bachman KE, Herman JG, Corn PG, Merlo A, Costello JF, Cavenee WK, Baylin SB, Graff JR. Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers. Cancer Res 1999; 59: 798-802.
-
(1999)
Cancer Res
, vol.59
, pp. 798-802
-
-
Bachman, K.E.1
Herman, J.G.2
Corn, P.G.3
Merlo, A.4
Costello, J.F.5
Cavenee, W.K.6
Baylin, S.B.7
Graff, J.R.8
-
6
-
-
21744434825
-
UV-induced skin cancer: Similarities-variations
-
Boukamp P. UV-induced skin cancer: similarities-variations. J Dtsch Dermatol Ges 2005; 3: 493-503.
-
(2005)
J Dtsch Dermatol Ges
, vol.3
, pp. 493-503
-
-
Boukamp, P.1
-
7
-
-
16844385347
-
Melanoma genetics and the development of rational therapeutics
-
Chudnovsky Y, Khavari PA, Adams AE. Melanoma genetics and the development of rational therapeutics. J Clin Invest 2005; 115: 813-824.
-
(2005)
J Clin Invest
, vol.115
, pp. 813-824
-
-
Chudnovsky, Y.1
Khavari, P.A.2
Adams, A.E.3
-
8
-
-
7644234360
-
Issues regarding study design for initial clinical trials using decitabine
-
DeBaun MR. Issues regarding study design for initial clinical trials using decitabine. Semin Hematol 2004; 41: 23-27.
-
(2004)
Semin Hematol
, vol.41
, pp. 23-27
-
-
DeBaun, M.R.1
-
9
-
-
6344229760
-
Proteasome inhibition sensitizes non-small cell lung cancer to histone deacetylase inhibitor-induced apoptosis through the generation of reactive oxygen species
-
Denlinger CE, Rundall BK, Jones DR. Proteasome inhibition sensitizes non-small cell lung cancer to histone deacetylase inhibitor-induced apoptosis through the generation of reactive oxygen species. J Thorac Cardiovasc Surg 2004; 128: 740-748.
-
(2004)
J Thorac Cardiovasc Surg
, vol.128
, pp. 740-748
-
-
Denlinger, C.E.1
Rundall, B.K.2
Jones, D.R.3
-
10
-
-
5144223978
-
Cell cycle checkpoints and their impact on anticancer therapeutic strategies
-
Eastman A. Cell cycle checkpoints and their impact on anticancer therapeutic strategies. J Cell Biochem 2004; 91: 223-231.
-
(2004)
J Cell Biochem
, vol.91
, pp. 223-231
-
-
Eastman, A.1
-
11
-
-
0037068312
-
CpG island hypermethylation and tumor suppressor genes: A booming present, a brighter future
-
Esteller M. CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene 2002; 21: 5427-5440.
-
(2002)
Oncogene
, vol.21
, pp. 5427-5440
-
-
Esteller, M.1
-
12
-
-
0036145156
-
Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours
-
Esteller M, Herman JG. Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. J Pathol 2002; 196: 1-7.
-
(2002)
J Pathol
, vol.196
, pp. 1-7
-
-
Esteller, M.1
Herman, J.G.2
-
13
-
-
1642569629
-
New molecular targets in melanoma
-
Flaherty KT. New molecular targets in melanoma. Curr Opin Oncol 2004; 16: 150-154.
-
(2004)
Curr Opin Oncol
, vol.16
, pp. 150-154
-
-
Flaherty, K.T.1
-
14
-
-
3042576479
-
Valproic acid: An old drug newly discovered as inhibitor of histone deacetylases
-
Gottlicher M. Valproic acid: an old drug newly discovered as inhibitor of histone deacetylases. Ann Hematol 2004; 83: S91-S92.
-
(2004)
Ann Hematol
, vol.83
-
-
Gottlicher, M.1
-
15
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
16
-
-
13444274622
-
Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
-
Insinga A, Monestiroli S, Ronzoni S, Gelmetti V, Marchesi F, Viale A, Altucci L, Nervi C, Minucci S, Pelicci PG. Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway. Nat Med 2005; 11: 71-76.
-
(2005)
Nat Med
, vol.11
, pp. 71-76
-
-
Insinga, A.1
Monestiroli, S.2
Ronzoni, S.3
Gelmetti, V.4
Marchesi, F.5
Viale, A.6
Altucci, L.7
Nervi, C.8
Minucci, S.9
Pelicci, P.G.10
-
17
-
-
21244431605
-
Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate
-
Issa JP, Gharibyan V, Cortes J, Jelinek J, Morris G, Verstovsek S, Talpaz M, Garcia-Manero G, Kantarjian HM. Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate. J Clin Oncol 2005; 23: 3948-3956.
-
(2005)
J Clin Oncol
, vol.23
, pp. 3948-3956
-
-
Issa, J.P.1
Gharibyan, V.2
Cortes, J.3
Jelinek, J.4
Morris, G.5
Verstovsek, S.6
Talpaz, M.7
Garcia-Manero, G.8
Kantarjian, H.M.9
-
18
-
-
0033052844
-
DNA hypermethylation at the D17S5 locus and reduced HIC-1 mRNA expression are associated with hepatocarcinogenesis
-
Kanai Y, Hui AM, Sun L, Ushijima S, Sakamoto M, Tsuda H, Hirohashi S. DNA hypermethylation at the D17S5 locus and reduced HIC-1 mRNA expression are associated with hepatocarcinogenesis. Hepatology 1999; 29: 703-709.
-
(1999)
Hepatology
, vol.29
, pp. 703-709
-
-
Kanai, Y.1
Hui, A.M.2
Sun, L.3
Ushijima, S.4
Sakamoto, M.5
Tsuda, H.6
Hirohashi, S.7
-
19
-
-
0037068358
-
Reactivating the expression of methylation silenced genes in human cancer
-
Karpf AR, Jones DA. Reactivating the expression of methylation silenced genes in human cancer. Oncogene 2002; 21: 5496-5503.
-
(2002)
Oncogene
, vol.21
, pp. 5496-5503
-
-
Karpf, A.R.1
Jones, D.A.2
-
20
-
-
0034446542
-
DNA methylation, nuclear structure, gene expression and cancer
-
Leonhardt H, Cardoso MC. DNA methylation, nuclear structure, gene expression and cancer. J Cell Biochem 2000; 35: 78-83.
-
(2000)
J Cell Biochem
, vol.35
, pp. 78-83
-
-
Leonhardt, H.1
Cardoso, M.C.2
-
21
-
-
2942724589
-
Histone deacetylase inhibitors: Development as cancer therapy
-
Marks PA, Richon VM, Kelly WK, Chiao JH, Miller T. Histone deacetylase inhibitors: development as cancer therapy. Novartis Found Symp 2004; 259: 269-281.
-
(2004)
Novartis Found Symp
, vol.259
, pp. 269-281
-
-
Marks, P.A.1
Richon, V.M.2
Kelly, W.K.3
Chiao, J.H.4
Miller, T.5
-
22
-
-
4143140016
-
Histone deacetylase inhibitors open new doors in cancer therapy
-
McLaughlin F, La Thangue NB. Histone deacetylase inhibitors open new doors in cancer therapy. Biochem Pharmacol 2004; 68: 1139-1144.
-
(2004)
Biochem Pharmacol
, vol.68
, pp. 1139-1144
-
-
McLaughlin, F.1
La Thangue, N.B.2
-
23
-
-
3042785975
-
A review of depsipeptide and other histone deacetylase inhibitors in clinical trials
-
Piekarz R, Bates S. A review of depsipeptide and other histone deacetylase inhibitors in clinical trials. Curr Pharm Des 2004; 10: 2289-2298.
-
(2004)
Curr Pharm des
, vol.10
, pp. 2289-2298
-
-
Piekarz, R.1
Bates, S.2
-
24
-
-
0035499267
-
Stem cells, cancer, and cancer stem cells
-
Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001; 414: 105-111.
-
(2001)
Nature
, vol.414
, pp. 105-111
-
-
Reya, T.1
Morrison, S.J.2
Clarke, M.F.3
Weissman, I.L.4
-
25
-
-
21244449980
-
Evaluation of a 7-day continuous intravenous infusion of decitabine: Inhibition of promoter-specific and global genomic DNA methylation
-
Samlowski WE, Leachman SA, Wade M, Cassidy P, Porter-Gill P, Busby L, Wheeler R, Boucher K, Fitzpatrick F, Jones DA, Karpf AR. Evaluation of a 7-day continuous intravenous infusion of decitabine: inhibition of promoter-specific and global genomic DNA methylation. J Clin Oncol 2005; 23: 3897-3905.
-
(2005)
J Clin Oncol
, vol.23
, pp. 3897-3905
-
-
Samlowski, W.E.1
Leachman, S.A.2
Wade, M.3
Cassidy, P.4
Porter-Gill, P.5
Busby, L.6
Wheeler, R.7
Boucher, K.8
Fitzpatrick, F.9
Jones, D.A.10
Karpf, A.R.11
-
26
-
-
0034161905
-
Loss of pRb expression in pituitary adenomas is associated with methylation of the RB1 CpG island
-
200
-
Simpson DJ, Hibberts NA, McNicol AM, Clayton RN, Farrell WE. Loss of pRb expression in pituitary adenomas is associated with methylation of the RB1 CpG island. Cancer Res 200; 60: 1211-1216.
-
Cancer Res
, vol.60
, pp. 1211-1216
-
-
Simpson, D.J.1
Hibberts, N.A.2
McNicol, A.M.3
Clayton, R.N.4
Farrell, W.E.5
-
27
-
-
20144388727
-
Sequential 5-Aza 2′-deoxycytidine/depsipeptide FK228 treatment induces tissue factor pathway inhibitor 2 (TFPI-2) expression in cancer cells
-
Steiner FA, Hong JA, Fischette MR, Beer DG, Guo ZS, Chen GA, Weiser TS, Kassis ES, Nguyen DM, Lee S, Trepel JB, Schrump DS. Sequential 5-Aza 2′-deoxycytidine/depsipeptide FK228 treatment induces tissue factor pathway inhibitor 2 (TFPI-2) expression in cancer cells. Oncogene 2005; 24: 2386-2397.
-
(2005)
Oncogene
, vol.24
, pp. 2386-2397
-
-
Steiner, F.A.1
Hong, J.A.2
Fischette, M.R.3
Beer, D.G.4
Guo, Z.S.5
Chen, G.A.6
Weiser, T.S.7
Kassis, E.S.8
Nguyen, D.M.9
Lee, S.10
Trepel, J.B.11
Schrump, D.S.12
-
28
-
-
0030038229
-
Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis
-
Stromblad S, Becker JC, Yebra M, Brooks PC, Cheresh DA. Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis. J Clin Invest 1996; 98: 426-433.
-
(1996)
J Clin Invest
, vol.98
, pp. 426-433
-
-
Stromblad, S.1
Becker, J.C.2
Yebra, M.3
Brooks, P.C.4
Cheresh, D.A.5
-
29
-
-
4544323749
-
Histone deacetylase inhibitors: Understanding a new wave of anticancer agents
-
Villar-Garea A, Esteller M. Histone deacetylase inhibitors: understanding a new wave of anticancer agents. Int J Cancer 2004; 112: 171-178.
-
(2004)
Int J Cancer
, vol.112
, pp. 171-178
-
-
Villar-Garea, A.1
Esteller, M.2
-
30
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004; 10: 789-799.
-
(2004)
Nat Med
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
31
-
-
0029014425
-
p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3
-
Wales MM, Biel MA, el Deiry W, Nelkin BD, Issa JP, Cavenee WK, Kuerbitz SJ, Baylin SB. p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. Nat Med 1995; 1: 570-577.
-
(1995)
Nat Med
, vol.1
, pp. 570-577
-
-
Wales, M.M.1
Biel, M.A.2
El Deiry, W.3
Nelkin, B.D.4
Issa, J.P.5
Cavenee, W.K.6
Kuerbitz, S.J.7
Baylin, S.B.8
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