Genetic alteration of the α2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels

Molecular Psychiatry

Volumn 4, Issue 5, 1999, Pages 443-452

  Sallinen, J ^a   Haapalinna, A ^a   MacDonald, E ^c   Viitamaa, T ^a   Lahdesmaki J ^b   Rybnikova, E ^d   Pelto Huikko, M ^e,f   Kobilka, B K ^g   Scheinin, M ^b  

^a ORION CORPORATION   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d PAVLOV INSTITUTE OF PHYSIOLOGY   (Russian Federation)

^e UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

^f TAMPERE UNIVERSITY HOSPITAL   (Finland)

^g HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Adrenergic receptors; Antidepressant; Biogenic amines; Forced swimming test; Hippocampus; Immediate early gene; Transgenic mice

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; CORTICOSTERONE; DOPAMINE; MESSENGER RNA; NORADRENALIN; SEROTONIN; 3,4 DIHYDROXYPHENYLACETIC ACID; 4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; 5 HYDROXYINDOLEACETIC ACID; HOMOVANILLIC ACID; PROTEIN C FOS; PROTEIN C JUN;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DEPRESSION; DOPAMINE BRAIN LEVEL; FORCED SWIMMING TEST; GENE EXPRESSION; MOUSE; NONHUMAN; NORADRENALIN BLOOD LEVEL; ONCOGENE C FOS; ONCOGENE C JUN; PRIORITY JOURNAL; SEROTONIN BRAIN LEVEL; STRESS; ANIMAL; ANIMAL BEHAVIOR; BLOOD; BRAIN CORTEX; CHEMISTRY; CORPUS STRIATUM; EXERCISE; GENETIC MARKER; GENETICS; HIPPOCAMPUS; IMMEDIATE EARLY GENE; IN SITU HYBRIDIZATION; PATHOPHYSIOLOGY; PHYSIOLOGY; SWIMMING; TRANSGENIC MOUSE;

3,4-DIHYDROXYPHENYLACETIC ACID; ANIMALS; BEHAVIOR, ANIMAL; CEREBRAL CORTEX; CORPUS STRIATUM; CORTICOSTERONE; DEPRESSION; DOPAMINE; GENES, IMMEDIATE-EARLY; GENETIC MARKERS; HIPPOCAMPUS; HOMOVANILLIC ACID; HYDROXYINDOLEACETIC ACID; IN SITU HYBRIDIZATION; METHOXYHYDROXYPHENYLGLYCOL; MICE; MICE, TRANSGENIC; NOREPINEPHRINE; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RECEPTORS, ADRENERGIC, ALPHA-2; RESTRAINT, PHYSICAL; RNA, MESSENGER; SEROTONIN; STRESS; SWIMMING;

EID: 0032589476     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000543     Document Type: Article

References (52)

1. 1 Ruffolo RR, Nichols AJ, Hieble JP. Functions mediated by alpha-2 adrenergic receptors. In: Limbird LE (ed). The Alpha-2 Adrenergic Receptors. Humana Press: New York, 1988, pp 187-280.
2. 2 Ruffolo RR, Nichols AJ, Stadel JM, Hieble PJ. Pharmacologic and therapeutic applications of alpha2-adrenoceptor subtypes. Annu Rev Pharmacol Toxicol 1993; 32: 243-279.
3. 3 Foote SL, Aston-Jones GS. Pharmacology and physiology of central noradrenergic systems. In: Bloom FE, Kupfer DJ (eds). Psychopharmacology: The Fourth Generation of Progress. Raven Press: New York, 1995, pp 335-345.
4. 4 Robbins TW, Everitt BJ. Central norepinephrine neurons and behavior. In: Bloom FE, Kupfer DJ (eds). Psychopharmacology. The Fourth Generation of Progress. Raven Press: New York, 1995, pp 363-372.
5. 2-adrenoceptor system under chronic psychosocial stress. Neuroscience 1996; 75: 187-196.
6. 6 Bylund DB, Eikenberg DC, Hieble JP. International union of pharmacology nomenclature of adrenoceptors. Pharmacol Rev 1994; 46: 121-136.
7. 7 Nicholas AP, Pieribone V, Hökfelt T. Distributions of mRNAs for alpha-2 adrenergic receptor subtypes in rat brain: an in situ hybridization study. J Comp Neurology 1993; 328: 575-594.
8. 8 Nicholas AP, Hökfelt T, Pieribone VA. The distribution and significance of CNS adrenoceptors examined with in situ hybridization. Trends Pharmacol Sci 1996; 17: 245-255.
9. 9 Scheinin M, Lomasney JW, Hayden-Hixson DM, Schambra UB, Caron MG, Lefkowitz RJ et al. Distribution of alpha2-adrenergic receptor subtype gene expression in rat brain. Brain Res Mol Brain Res 1994; 21: 133-149.
10. 2C-adrenergic receptor-like immunoreactivity in the rat central nervous system. J Comp Neurology 1996; 372: 135-165.
11. 2C-adrenergic receptor-like immunoreactivity in the rat central nervous system. J Comp Neurology 1996; 372: 111-134.
12. 2A-AR-receptor gene in transgenic animals. Neuroscience 1996; 74: 199-218.
13. 13 von Zastrow M, Link R, Daunt D, Barsh G, Kobilka B. Subtype-specific differences in the intracellular sorting of G protein-coupled receptors. J Biol Chem 1993; 268: 763-766.
14. 2-adrenergic receptors. Mol Pharmacol 1997; 51: 711-720.
15. 2-adrenoceptor-subtype function. Trends Pharmarol Sci 1997; 18: 211-219.
16. 2A-adrenergic receptor subtype. Science 1996; 273: 801-803.
17. 2-adrenergic receptor subtypes b and c. Science 1996; 273: 803-805.
18. 2-adrenoceptor subtypes to the antinociceptive action of dexmedetomidine and clonidine in rodent models of acute and chronic pain. Br J Pharmacol 1997; 122: 1339-1344.
19. 2a-adrenergic receptor via 'hit and run' gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo. Proc Natl Acad Sci USA 1997; 94: 9950-9955.
20. 2 agonists and is necessary for spinal adrenergic-opioid synergy. J Neurosci 1997; 17: 7157-7165.
21. 2-adrenoceptor agonist. Mol Pharmacol 1997; 51: 36-46.
22. 2C-receptors modulate the acoustic startle reflex, prepulse inhibition, and aggression in mice. J Neurosci 1998; 18: 3035-3042.
23. 2C-adrenergic receptor subtype. Neuroscience 1998; 86: 959-965.
24. 24 Porsolt RD, LePichon M, Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature 1977; 266: 730-732.
25. 2C-adrenoceptor homolog. Mol Pharmacol 1995; 48: 48-55.
26. 26 Porsolt RD. Behavioural despair. In: Enna SJ, Malick JB, Richelson E (eds). Antidepressants: Neurochemical, Behavioural and Clinical Perspectives. Raven Press: New York, 1981, pp 121-139.
27. 27 Willner P. The validity of animal models of depression. Psychopharmacology 1984; 83: 1-16.
28. 28 Borsini F, Meli A. Is the forced swimming test a suitable model for revealing antidepressant activity? Psychopharmacology 1988; 94: 147-160.
29. 29 Geyer MA, Markou A. Animal models of psychiatric disorders. In: Bloom FE, Kupfer DJ (eds). Psychopharmacology: The Fourth Generation of Progress. Raven Press: New York, 1995, pp 787-798.
30. 30 Valentino RJ, Curtis AL, Page ME, Pavcovich LA, Florin-Lechner SM. Activation of the locus ceruleus brain noradrenergic system during stress: circuitry, consequences, and regulation. In: Goldstein DS, Eisenhofer G, McCarty R (eds). Advances in Pharmacology. Academic Press: San Diego, 1998, pp 781-784.
31. 31 Nagy A, Rossant J, Nagy R, Abramow-Newerly W, Roder JC. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci USA 1993; 90: 8424-8428.
32. 32 Overbeek PA, Aguilar-Cordova E, Hanten G, Schaffner DL, Patel P, Lebovitz RM et al. Coinjection strategy for visual identification of transgenic mice. Transgenic Res 1991; 1: 31-37.
33. 33 Mefford I. Applications of high performance liquid chromatography with electrochemical detection to neurochemical analysis: measurement of catecholamines, serotonin and metabolites in rat brain. J Neurosci Meth 1981; 3: 207-224.
34. 34 MacDonald E, Scheinin H, Scheinin M. Behavioural and neurochemical effects of medetomidine, a novel veterinary sedative. Eur J Pharmacol 1988; 158: 119-127.
35. 35 Ojala-Karlsson P, Scheinin M. Improved high performance liquid chromatographic method for the routine determination of unconjungated 3-methoxy-4-hydroxyphenylethyleneglycol in human plasma using solid-phase extraction and electrochemical detection. J Chromatogr 1991; 565: 131-139.
36. 36 Curran T, Gordon MB, Rubino KL, Sambucetti LC. Isolation and characterization of the c-fos (rat) cDNA and analysis of post-translational modification in vitro. Oncogene 1987; 2: 79-84.
37. 37 Kononen J, Pelto-Huikko M. Multiple consecutive hybridizations in radioactive in situ hybridization. Trends Genetic Technical Tips Online 1997; URL: http://tto.trends.com/
38. 1 transition in mouse fibroblasts. Nature 1988; 334: 535-537.
39. 39 Detke MJ, Johnson I, Lucki I. Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression. Exp Clin Psychopharmacol 1997; 5: 107-112.
40. 40 Cervo L, Grignaschi G, Samanin R. Alpha 2-adrenoceptor blockade prevents the effect of desipramine in the forced swim test. Eur J Pharmacol 1990; 175: 301-307.
41. 41 Bourin M, Colomber M-C, Malinge M, Bradwejn J. Clonidine as a sensitizing agent in the forced swimming test for revealing antidepressant activity. J Psych Neurosci 1991; 16; 199-203.
42. 2-adrenoceptor antagonist, in open-field, plus-maze, two compartment exploratory, and forced swimming tests in the rat. Eur J Pharmacol 1991; 205: 177-182.
43. 2-adrenoceptor subtype binding, brain neurochemistry and behaviour in comparison with yohimbine. Naunyn-Schmedeberg's Arch Pharmacol 1997; 356: 570-582.
44. 44 Mongeau R, Blier P, de Montigny C. The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments. Brain Res Rev 1997; 23: 145-195.
45. 2-adrenoceptors on 5-hydroxytry ptamine terminals in the rat hippocampus. Naunyn-Schmedeberg's Arch Pharmacol 1993; 347: 266-272.
46. 46 Guhits RM, Smith TM, Fairhurst JL, Yu H. Adrenergic receptors mediate changes in c-fos mRNA levels in brain. Mol Brain Res 1989; 6: 39-45.
47. 47 Duman RS, Heninger GR, Nestler EJ. A molecular and cellular theory of depression. Arch Gen Psychiatry 1997; 54: 597-608.
48. 48 Young EA, Haskett RF, Murphy-Weinberg V, Watson SJ, Akil H. Loss of glucocorticoid last feedback in depression. Arch Gen Psychiatry 1991; 48: 693-699.
49. 49 Akil HA, Morano MI. Stress. In: Bloom RE, Kupfer DJ (eds). Psychopharmacology: The Fourth Generation of Progress. Raven Press: New York, 1995, pp 773-786.
50. 50 Baez M, Volosin M. Corticosterone influences forced swim-induced immobility. Pharmacol Biochem Behav 1994; 49: 729-736.
51. 51 Korte SM, De Kloet ER, Buwalda B, Bouman SD, Bohus B. Antisense to the glucocorticoid receptor in hippocampal dentate gyrus reduces immobility in forced swim test. Eur J Pharmacol 1996; 301: 19-25.
52. 52 De Paermentier F, Mauger JM, Lowther S, Crompton MR, Katona CLE, Horton RW. Brain α-adrenoceptors in depressed suicides. Brain Res 1997; 757: 60-68.