A fungal multicopper oxidase restores iron homeostasis in aceruloplasminemia

Blood

Volumn 103, Issue 12, 2004, Pages 4672-4673

  Harris, Z Leah ^b   Davis Kaplan, Sandra R ^b   Gitlin, Jonathan D ^b   Kaplan, Jerry ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CERULOPLASMIN; COPPER COMPLEX; COPPER PROTEIN; IRON; PROTEIN FET3P; UNCLASSIFIED DRUG;

ACERULOPLASMINEMIA; ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CERULOPLASMIN GENE; ENZYME BLOOD LEVEL; FUNGUS; GENE; GENE DELETION; GENE MUTATION; HOMEOSTASIS; IRON BLOOD LEVEL; IRON HOMEOSTASIS; IRON KINETICS; IRON METABOLISM; IRON STORAGE; MALE; MOUSE; NONHUMAN; PHLEBOTOMY; PRIORITY JOURNAL; PROTEIN FUNCTION;

EID: 2942595705     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-11-4060     Document Type: Article

References (11)

1. Hellman NE, Gitlin JD. Ceruloplasmin metabolism and function. Annu Rev Nutr. 2002;22:439-458.
2. Attieh ZK, Mukhopadhyay CK, Seshadri V, Tripoulas NA, Fox PL. Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cation-specific transport mechanism. J Biol Chem. 1999;274:1116-1123.
3. Vulpe CD, Kuo YM, Murphy TL, et al. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet. 1999;21:195-199.
4. Van Ho A, Ward DM, Kaplan J. Transition metal transport in yeast. Annu Rev Microbiol. 2002;56:237-261.
5. Harris ZL, Takahashi Y, Miyajima H, Serizawa M, MacGillivray RT, Gitlin JD. Aceruloplasminemia: molecular characterization of this disorder of iron metabolism. Proc Natl Acad Sci U S A. 1995;92:2539-2543.
6. Hassett RF, Yuan DS, Kosman DJ. Spectral and kinetic properties of the Fet3 protein from Saccharomyces cerevisiae, a multinuclear copper ferroxidase enzyme. J Biol Chem. 1998;273:23274-23282.
7. de Silva D, Davis-Kaplan S, Fergestad J, Kaplan J. Purification and characterization of Fet3 protein, a yeast homologue of ceruloplasmin. J Biol Chem. 1997;272:14208-14213.
8. Davis-Kaplan SR, Askwith CC, Bengtzen AC, Radisky D, Kaplan J. Chloride is an allosteric effector of copper assembly for the yeast multicopper oxidase fet3p: an unexpected role for intracellular chloride channels. Proc Natl Acad Sci U S A. 1998;95:13641-13645.
9. Harris ZL, Durley AP, Man TK, Gitlin JD. Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux. Proc Natl Acad Sci U S A. 1999;96:10812-10817.
10. Patel BN, Dunn RJ, David S. Alternative RNA splicing generates a glycosylphosphatidylinositol-anchored form of ceruloplasmin in mammalian brain. J Biol Chem. 2000;275:4305-4310.
11. Jeong SY, David S. Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system. J Biol Chem. 2003;278:27144-27148.