Effects of cannabinoids on prolactin and gonadotrophin secretion: Involvement of changes in hypothalamic γ-aminobutyric acid (GABA) inputs

Biochemical Pharmacology

Volumn 56, Issue 10, 1998, Pages 1331-1338

  De Miguel, Rosario ^a   Romero, Julián ^a   Muñoz, Raúl M ^a   García Gil, Lucía ^a   González, Sara ^a   Villanua, Maria A ^a   Makriyannis, Alexandros ^b   Ramos, José A ^a   Fernández Ruiz, J Javier ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

9 tetrahydrocannabinol; CB1 cannabinoid receptors; GABA; Gonadotrophin; Methanandamide; Prolactin

Indexed keywords

4 AMINOBUTYRIC ACID; ANANDAMIDE; CANNABINOID; CANNABINOID RECEPTOR; DOPAMINE; DRONABINOL; FOLLITROPIN; GONADOTROPIN; MESSENGER RNA; PROLACTIN; RIMONABANT;

ADENOHYPOPHYSIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; FOLLITROPIN BLOOD LEVEL; GABAERGIC SYSTEM; GONADOTROPIN RELEASE; HYPOTHALAMUS; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; PROLACTIN RELEASE; PROTEIN SYNTHESIS; RAT; RECEPTOR BINDING; RECEPTOR UPREGULATION;

ANIMALS; ARACHIDONIC ACIDS; GAMMA-AMINOBUTYRIC ACID; GONADOTROPINS; HYPOTHALAMUS; MALE; PROLACTIN; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; RNA, MESSENGER; TETRAHYDROCANNABINOL;

EID: 0031741879     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00185-3     Document Type: Article

References (46)

1. 9-tetrahydrocannabinol, cannabinol and cannabidiol, alone and in combination, on luteinizing hormone and prolactin release and on hypothalamic neurotransmitters in the male rat. Neuroendocrinology 52: 316-321, 1990.
2. Murphy LL, Steger RW and Bartke A, Psychoactive and non-psychoactive cannabinoids and their effects on reproductive neuroendocrine parameters. In: Biochemistry and Physiology of Substance Abuse, vol. 2. Ed. Watson RR, pp. 73-93. CRC Press, Boca Raton, FL, 1990.
3. 9-tetrahydrocannabinol on dopaminergic activity in several rat brain areas. Pharmacol Biochem Behav 42: 269-275, 1992.
4. Dalterio SL, Cannabinoid exposure: Effects on development. Neurobehav Toxicol Teratol 8: 345-352, 1986.
5. Rodriguez de Fonseca F, Cebeira M, Fernandez-Ruiz JJ, Navarro M and Ramos JA, Effects of pre- and perinatal exposure to hashish extracts on the ontogeny of brain dopaminergic neurons. Neuroscience 43: 713-723, 1991.
6. Fernandez-Ruiz JJ, Rodriguez de Fonseca F, Navarro M and Ramos JA, Maternal cannabinoid exposure and brain development: Changes in the ontogeny of dopaminergic neurons. In: Marihuana/Cannabinoids: Neurobiology and Neurophysiology, Eds. Murphy LL and Bartke A, pp. 119-164. CRC Press, Boca Raton, FL, 1992.
7. Romero J, GarcRa-Gil L, Ramos JA and Fernandez-Ruiz JJ, The putative cannabinoid receptor ligand, anandamide, stimulates tyrosine hydroxylase activity and inhibits prolactin release. Neuroendocrine Lett 16: 159-164, 1994.
8. 1 receptors in hypothalamic structures and their involvement in the effects of cannabimimetics. Biochem Pharmacol 53: 1919-1927, 1997.
9. Wenger T, Fragakis G, Probonas K, Toth BE and Yiannakakis N, Anandamide (endogenous cannabinoid) affects anterior pituitary hormone secretion in adult male rats. Neuroendocrine Lett 16:295-303, 1994.
10. Wenger T, Jamali KA, Juanede C, Leonardelli J and Tramu G, Arachidonyl ethanolamide (anandamide) activates the parvocellular part of hypothalamic paraventricular nucleus. Biochem Biophys Res Comm 237: 724-728, 1997.
11. Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A and Mechoulam R, Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258: 1946-1949, 1992.
12. 9-tetrahydrocannabinol suppression of prolactin secretion in the rat: Lack of direct pituitary effect. Endocrinology 109: 876-880, 1981.
13. 9-tetrahydrocannabinol action. Pharmacol Biochem Behav 40: 603-608, 1991.
14. Herkenham M, Lynn AB, Johnson MR, Melvin LS, de Costa BR and Rice KC, Characterization and localization of cannabinoid receptors in rat brain: A quantitative in vitro autoradiographic study. J Neurosci 11: 563-583, 1991.
15. Howlett AC, Bidaut-Russell M, Devane WA, Melvin LS, Johnson MR and Herkenham M, The cannabinoid receptor: biochemical, anatomical and behavioral characterization. Trends Neurosci 13: 420-423, 1990.
16. Lynn AB and Herkenham M, Localization of cannabinoid receptors and nonsaturable high-density cannabinoid binding sites in peripheral tissues of the rat: Implications for receptor-mediated immune modulation by cannabinoids. J Pharmacol Exp Ther 268: 1612-1623, 1994.
17. 9-tetrahydrocannabinol on tuberoinfundibular dopaminergic activity, anterior pituitary sensitivity to dopamine and prolactin release vary as a function of estrous cycle. Neuroendocrinology 58: 280-286, 1993.
18. 9-tetrahydrocannabinol (THC): Involvement of serotoninergic and dopaminergic pathways. Endocrinology 103: 452-458, 1978.
19. 9-tetrahydrocannabinol: changes in hypothalamic biogenic amines and anterior pituitary hormone secretion. Neuroendocrine Lett 14: 349-355, 1992.
20. 9-tetrahydrocannabinol-induced stimulation of tuberoinfundibular dopaminergic activity in female rats. Biochem Pharmacol 48: 1387-1392, 1994.
21. 9-tetrahydrocannabinol on tuberoinfundibular dopaminergic activity and prolactin release in estrogen-replaced ovariectomized rats. Neuroendocrine Lett 16: 305-314, 1994.
22. 9-Tetrahydrocannabinol inhibits luteinizing hormone secretion in the male rat: effect of intracerebroventricular norepinephrine infusion. Neuroendocrine Lett 16: 1-7, 1994.
23. Schimchowitsch S, Vuillez P, Tappaz ML, Klein MJ and Stoeckel ME, Systemic presence of GABA-immunoreactivity in the tubero-infundibular and tubero-hypophyseal dopaminergic axonal systems: An ultrastructural immunogold study on several mammals. Exp Brain Res 83: 575-586, 1991.
24. Racagni G, Apud JA, Cocchi D, Locatelli V and Muller EE, GABAergic control of anterior pituitary hormone secretion. Life Sci 31: 823-838, 1982.
25. Nicoletti F, Grandison L and Meek JL, Effects of repeated administration of estradiol benzoate on tubero-infundibular GABAergic activity in male rats. J Neurochem 44: 1217-1220, 1985.
26. B receptors originate from discrete afferent neurons. Neurosci Lett 134: 207-211, 1992.
27. Wagner EJ, Goudreau JL, Moore KE and Lookingland KJ, GABAergic regulation of tuberoinfundibular dopaminergic neurons in the male rat. Brain Res 659: 194-200, 1994.
28. Tal J, Price MT and Olney JW, Neuroactive amino acids influence gonadotrophin output by a suprapituitary mechanism in rodents or primates. Brain Res 273: 179-182, 1983.
29. Oviedo A, Glowa J and Herkenham M, Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: A quantitative autoradiographic study. Brain Res 616: 293-302, 1993.
30. 35S]γ autoradiography in rat brain. J Neurosci 15: 8057-8066, 1996.
31. 9-tetrahydrocannabinol on cannabinoid receptor binding and mRNA levels in several rat brain regions. Brain Res Mol Brain Res 46: 100-108, 1997.
32. Rinaldi-Carmona M, Barth F, Heaulme M, Shire D, Calandra B, Congy C, Martinez S, Maruani J, Neliat G, Caput D, Ferrara P, SoubriJ P, BreliPre JC and Le Fur G, SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett 350: 240-244, 1994.
33. Romero J, de Miguel R, Ramos JA and Fernandez-Ruiz JJ, The activation of cannabinoid receptors in striatonigral GABAergic neurons inhibited GABA uptake. Life Sci 62: 351-363, 1998.
34. Abadji V, Lin S, Taha G, Griffin G, Stevenson LA, Pertwee RG and Makriyannis A, (R)-Methanandamide: A chiral novel anandamide possessing higher potency and metabolic stability. J Med Chem 37: 1889-1893, 1994.
35. Paxinos G and Watson C, The rat brain in stereotaxic coordinates. Academic Press, London, 1986.
36. Jansen EM, Haycock DA, Ward SJ and Seybold US, Distribution of cannabinoid receptors in rat brain determined with aminoalkylindoles. Brain Res 575: 93-102, 1992.
37. Rubino T, Massi P, Patrini G, Venier I, Giagnoni G and Parolaro D, Chronic CP-55,940 alters cannabinoid receptor mRNA in the rat brain: An in situ hybridization study. Neuroreport 5: 2493-2496, 1994.
38. 35S]guanylyl-5′0-(thio)-triphosphate binding in the basal ganglia of aged rats. Neuroscience 84: 1075-1083, 1998.
39. Smith S and Sharp T, Measurement of GABA in rat brain microdialysates using o-phthaldialdehyde-sulphite derivatization and high-performance liquid chromatography with electrochemical detection. J Chromatography 652: 228-233, 1994.
40. Esquifino AI, Marc I and Lafuente A, Cyclosporine modifies the pulsatile secretory patterns of prolactin and luteinizing hormone in normal and pituitary-grafted female rats. Neuroendocrinology 60: 581-588, 1994.
41. Esquifino AI, Moreno ML, Agrasal C and Villanua MA, Effects of cyclosporine on ovarian function in sham-operated and pituitary-grafted young female rats. Proc Soc Exp Biol Med 208: 397-403, 1995.
42. Tuomisto J and Mannisto P, Neurotransmitter regulation of anterior pituitary hormones. Pharmacol Rev 37: 249-332, 1985.
43. 1-tetrahydrocannabinol on luteinizing hormone release in castrated and hypothalamic deafferented male rats. Exp Brain Res 59: 213-216, 1985.
44. Müller EE, Some aspects of the neurotransmitter control of anterior pituitary function. Pharmacol Res 21: 75-85, 1989.
45. Romero J, Wenger T, de Miguel R, Ramos JA and Fernandez-Ruiz JJ, Cannabinoid receptor binding did not vary in several hypothalamic nuclei after hypothalamic deafferentation. Life Sci 63: 351-356, 1998.
46. Mailleux Pand Vanderhaeghen JJ, Distribution of neuronal cannabinoid receptors in the adult rat brain: A comparative receptor binding radioautography and in situ hybridization histochemistry. Neuroscience 48: 655-668, 1992.