Sperm from mice genetically deficient for the PCSK4 proteinase exhibit accelerated capacitation, precocious acrosome reaction, reduced binding to egg zona pellucida, and impaired fertilizing ability

Biology of Reproduction

Volumn 74, Issue 4, 2006, Pages 666-673

  Gyamera Acheampong, Charles ^a   Tantibhedhyangkul, Julierut ^a   Weerachatyanukul, Wattana ^a   Tadros, Haidy ^a   Xu, Hongbin ^a   Van De Loo, Jan W ^b   Pelletier, R Marc ^c   Tanphaichitr, Nongnuj ^a   Mbikay, Majambu ^a  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b EUROPEAN COMMISSION   (Belgium)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Acrosome reaction; Fertilization; Sperm; Sperm capacitation; Sperm maturation

Indexed keywords

GENE PRODUCT; KEXIN; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASE SUBTILISIN KEXIN LIKE 4; SERINE PROTEINASE; SUBTILISIN; UNCLASSIFIED DRUG;

ACROSOME; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; FERTILIZATION; GENE INACTIVATION; GENETIC TRANSCRIPTION; IMMUNOELECTRON MICROSCOPY; IMMUNOFLUORESCENCE; MALE; MALE INFERTILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SPERMATOZOON CAPACITATION; SUBFERTILITY; ZONA PELLUCIDA;

ACROSOME REACTION; ANIMALS; FEMALE; FERTILIZATION; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; RABBITS; SERINE ENDOPEPTIDASES; SPERM CAPACITATION; SPERMATOZOA; TESTIS; TIME FACTORS;

ANIMALIA;

EID: 33645046617     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.105.046821     Document Type: Article

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