Calmegin is required for fertilin α/β heterodimerization and sperm fertility

Developmental Biology

Volumn 240, Issue 1, 2001, Pages 254-261

  Ikawa, Masahito ^a   Nakanishi, Tomoko ^a   Yamada, Shuichi ^a,b   Wada, Ikuo ^b   Kominami, Katsuya ^c   Tanaka, Hiromitsu ^a   Nozaki, Masami ^a   Nishimune, Yoshitake ^a   Okabe, Masaru ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Fuso Pharmaceutical Industries Ltd   (Japan)

Author keywords

ADAM; Calmegin; Calnexin; Chaperone; Cyritestin; Egg plasma membrane; Fertilin; Fertilization; Sperm; Zona pellucida

Indexed keywords

CALMEGIN; CALNEXIN; CHAPERONE; FERTILIN; FERTILIN ALPHA; FERTILIN BETA; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIMERIZATION; ENDOPLASMIC RETICULUM; FEMALE; FERTILITY; FERTILIZATION; FERTILIZATION IN VITRO; IMMUNOPRECIPITATION; MALE; NONHUMAN; OVIDUCT; PRIORITY JOURNAL; PROTEIN BINDING; SPERMATOGENESIS; SPERMATOZOON MIGRATION; TRANSGENIC MOUSE; WESTERN BLOTTING; ZONA PELLUCIDA;

EID: 0035578387     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2001.0462     Document Type: Article

References (22)

1. Folding of insulin receptor monomers is facilitated by the molecular chaperones calnexin and calreticulin and impaired by rapid dimerization
2. A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion
3. Calnexin family members as modulators of genetic diseases
4. Fertilization defects in sperm from mice lacking fertilin beta
5. Analysis of mouse fertilin in wild-type and fertilin beta(-/-) sperm: Evidence for C-terminal modification, alpha/beta dimerization, and lack of essential role of fertilin alpha in sperm-egg fusion
6. Setting the standards: Quality control in the secretory pathway
7. Calnexin and calreticulin binding to human thyroperoxidase is required for its first folding step(s) but is not sufficient to promote efficient cell surface expression
8. Angiotensin-converting enzyme and male fertility
9. The putative chaperone calmegin is required for sperm fertility
10. Physiological non-equivalence of the two isoforms of angiotensin-converting enzyme
11. Defective sperm-zona pellucida interaction: A major cause of failure of fertilization in clinical in-vitro fertilization
12. Positive effect of partial zona-pellucida dissection on the in vitro fertilizing capacity of cryopreserved C57BL/6J transgenic mouse spermatozoa of low motility
13. Analysis of loss of adhesive function in sperm lacking cyritestin or fertilin beta
14. Know your neighbors: Three phenotypes in null mutants of the myogenic bHLH gene MRF4
15. Participation of the endoplasmic reticulum chaperone calnexin (p88, IP90) in the biogenesis of the cystic fibrosis transmembrane conductance regulator
16. The ADAM gene family: Surface proteins with adhesion and protease activity
17. Male mice deficient for germ-cell cyritestin are infertile
18. Lectins as chaperones in glycoprotein folding
19. Characterization of the testis-specific gene "calmegin" promoter sequence and its activity defined by transgenic mouse experiments
20. Characterization of male meiotic germ cell-specific antigen (Meg 1) by monoclonal antibody TRA 369 in mice
21. Molecular cloning of a novel Ca(2+)-binding protein (calmegin) specifically expressed during male meiotic germ cell development
22. Molecular chaperone calmegin localization to the endoplasmic reticulum of meiotic and post-meiotic germ cells in the mouse testis