N6-Ethyl-2-alkynyl NECAs, selective human A3 adenosine receptor agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 9, 2006, Pages 2416-2418

  Zhu, Ran ^a   Frazier, Cynthia R ^a   Linden, Joel ^a   Macdonald, Timothy L ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

A3 adenosine agonist human NECA N6 ethyl

Indexed keywords

2 AMINO 1 [4 [3 (4 CYCLOPROPANECARBONYLPHENOXY)PROPYL] 1 PIPERAZINYL] 1 PROPANONE; 6 N (3 IODOBENZYL)ADENOSINE 5' N METHYLCARBOXAMIDE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE RECEPTOR; ADENOSINE RECEPTOR STIMULATING AGENT; CP 608039; ZR 1121; ADENOSINE A3 RECEPTOR; DRUG DERIVATIVE; ZR1121;

ARTICLE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG POTENTIATION; HUMAN; STRUCTURE ACTIVITY RELATION;

ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); CELL LINE; HUMANS; MOLECULAR STRUCTURE; RECEPTOR, ADENOSINE A3; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33644985973     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.110     Document Type: Article

References (17)

1. I. Feoktistov, and I. Biaggioni Biochem. Pharmacol. 55 1998 627
2. D.K.J.E. Von Lubitz, R.C.S. Lin, P. Popik, M.F. Carter, and K.A. Jacobson Eur. J. Pharmacol. 263 1994 59
3. M.P. Abbracchio, S. Ceruti, R. Brambilla, C. Franceschi, W. Malorni, K.A. Jacobson, D.K. von Lubitz, and F. Cattabeni Ann. N.Y. Acad. Sci. 825 1997 11
4. K.M. Fleming, and D. Mogul J. Neuropharmacol. 36 1997 353
5. J.A. Auchampach, A. Rizvi, Y. Qiu, X.L. Tang, C. Maldonado, S. Teschner, and R. Bolli Circ. Res. 80 1997 800
6. C.S. Carr, R.J. Hill, H. Masamune, S.P. Kennedy, D.R. Knight, W.R. Tracey, and D.M. Yellon Cardiovasc. Res. 36 1997 52
7. B.T. Liang, and K.A. Jacobson Proc. Natl. Acad. Sci. U.S.A. 95 1998 6995
8. V. Ramkumar, G.L. Stiles, M.A. Beaven, and H. Ali J. Biol. Chem. 268 1993 16887
9. Y. Kohno, Y. Sei, M. Koshiba, H.O. Kim, and K.A. Jacobson Biochem. Biophys. Res. Commun. 219 1996 904
10. P.G. Baraldi, B. Cacciari, R. Romagnoli, S. Merighi, K. Varani, P.A. Borea, and G. Spalluto Med. Res. Rev. 20 2000 103
11. K.A. Jacobson, O. Nikodijevic, D. Shi, C. Gallo-Rodriguez, M.E. Olah, G.L. Stiles, and J.W. Daly FEBS Lett. 336 1993 57
12. J. Linden Trends Pharmacol. Sci. 15 1994 298
13. M.P. DeNinno, H. Masamune, L.K. Chenard, K.J. DiRico, C. Eller, J.B. Etienne, J.E. Tickner, R.J. Hill, S.P. Kennedy, D.R. Knight, J. Kong, J.J. Oleynek, and W.R. Tracey J. Med. Chem. 46 2003 353
14. R. Volpini, S. Costanzi, C. Lambertucci, S. Taffi, S. Vittori, K.-N. Klotz, and G. Cristalli J. Med. Chem. 45 2002 3271
15. V. Nair, and S.G. Richardson Synthesis 1982 670
16. J.B. Epp, and T.S. Widlanski J. Org. Chem. 64 1999 293
17. S. Vittori, S. Costanzi, C. Lambertucci, F.R. Portino, S. Taffi, R. Volpini, K.-N. Klotz, and G. Cristalli Nucleosides Nucleotides Nucleic Acids 23 2004 471