Synthesis of 7-oxo-7H-naphtho[1,2,3-de]quinoline derivatives as potential anticancer agents active on multidrug resistant cell lines

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 9, 2006, Pages 2880-2886

  Dzieduszycka, Maria ^a   Bontemps Gracz, Maria M ^a   Stefańska, Barbara ^a   Martelli, Sante ^b   Piwkowska, Agnieszka ^a   Arciemiuk, Małgorzata ^a   Borowski, Edward ^a  

^a GDANSK UNIVERSITY OF TECHNOLOGY   (Poland)

^b UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Anthracenedione analogs; Anthrapyridones; Antitumor compounds; Cytotoxic activity; Multidrug resistance

Indexed keywords

1 [2 (DIMETHYLAMINO)ETHYL] 2 HYDROXY 7 OXO 7H NAPHTHO[1,2,3 DE]QUINOLINE 1 CARBOXAMIDE; 1 [2 (DIMETHYLAMINO)ETHYL] 6 [[(2 DIETHYLAMINO)ETHYL]AMINO] 2 HYDROXY 7 OXO 7H NAPHTHO[1,2,3 DE]QUINOLINE 1 CARBOXAMIDE; 1 [2 (DIMETHYLAMINO)ETHYL] 6 [[(2 DIMETHYLAMINO)ETHYL]AMINO] 2 HYDROXY 7 OXO 7H NAPHTHO[1,2,3 DE]QUINOLINE 1 CARBOXAMIDE; 1 [2 (DIMETHYLAMINO)ETHYL] 6 [[(2 PIPERIDIN 1 YL)ETHYL]AMINO] 2 HYDROXY 7 OXO 7H NAPHTHO[1,2,3 DE]QUINOLINE 1 CARBOXAMIDE; 1 AMINO 4 CHLOROANTHRAQUINONE; 1 AMINOANTHRAQUINONE; 2 CHLORO 6 [[(2 DIMETHYLAMINO)ETHYL]AMINO] 7 OXO 7H NAPHTHO[1,2,3 DE]QUINOLINE; 2 CHLORO 6 [[(2 PIPERIDIN 1 YL)ETHYL]AMINO] 7 OXO 7H NAPHTHO[1,2,3 DE]QUINOLINE; 6 [[(2 DIMETHYLAMINO)ETHYL]AMINO] 2 HYDROXY 7 OXO 7H NAPHTHO[1,2,3 DE]QUINOLINE; 6 [[(2 PIPERIDIN 1 YL)ETHYL]AMINO] 2 HYDROXY 7 OXO 7H NAPHTHO[1,2,3 DE]QUINOLINE; 6 [[(3 DIMETHYLAMINO)PROPYL]AMINO] 2 HYDROXY 7 OXO 7H NAPHTHO[1,2,3 DE]QUINOLINE; 6 CHLORO 2 HYDROXY 7 OXO 7H NAPHTHO[1,2,3 DE]QUINOLINE 1 CARBOXYLIC ACID; 7 OXO 7H NAPHTHO[1,2,3 DE]QUINOLINE DERIVATIVE; ANTINEOPLASTIC AGENT; DIPYRONE; DOXORUBICIN; ETHYL 6 [[2 (DIMETHYLAMINO)ETHYL]AMINO] 2 HYDROXY 7 OXO 7H NAPHTHO[1,2,3 DE]QUINOLINE 1 CARBOXYLATE; ETHYL 6 CHLORO 2 HYDROXY 7 OXO 7H NAPHTHO[1,2,3 DE]QUINOLINE 1 CARBOXYLATE; MALONIC ACID DERIVATIVE; MALONIC ACID DIETHYL ESTER; MITOXANTRONE; QUINOLINE DERIVATIVE; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; DRUG EFFECT; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LEUKEMIA CELL LINE; MULTIDRUG RESISTANCE; TUMOR CELL;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; MOLECULAR STRUCTURE; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33644980761     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.008     Document Type: Article

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