The ability to overcome multidrug resistance of tumor cell lines by novel acridine cytostatics with condensed heterocyclic rings

Acta Biochimica Polonica

Volumn 49, Issue 1, 2002, Pages 87-92

  Bontemps Gracz, Maria M ^a   Kupiec, Agnieszka ^a   Antonini, Ippolito ^b   Borowski, Edward ^a  

^a GDANSK UNIVERSITY OF TECHNOLOGY   (Poland)

^b UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Acridine cytostatics; Antitumor compounds; Cytotoxic activity; Multidrug resistance

Indexed keywords

2 (2 DIMETHYLAMINOETHYL) 9 METHOXY 5 NITROPYRAZOLO[3,4,5 KL]ACRIDINE; ACRIDINE DERIVATIVE; PYRAZOLE DERIVATIVE;

ARTICLE; CELL CULTURE; DRUG EFFECT; HUMAN; IN VITRO STUDY; MULTIDRUG RESISTANCE;

ACRIDINES; DRUG RESISTANCE, MULTIPLE; HUMANS; PYRAZOLES; TUMOR CELLS, CULTURED;

EID: 0036050988     PISSN: 0001527X     EISSN: None     Source Type: Journal    
DOI: 10.18388/abp.2002_3824     Document Type: Article

References (9)

1. Dicato, M., Duhem, C., Pauly, M. & Ries, F. (1997) Multidrug resistance: Molecular and clinical aspects. Cytokines Cell. Mol. Ther. 3, 91-99.
2. Ling, V. (1997) Multidrug resistance: Molecular mechanisms and clinical relevance. Cancer Chemother. Pharmacol. 40 (Suppl), S3-S8.
3. van den Heuvel-Eibrink, M.M., Sonneveld, P. & Pieters, R. (2000) The prognostic significance of membrane-transport-associated multidrug resistance (MDR) proteins in leukemia. Int. J. Clin. Pharmacol. Therapeut. 38, 94-110.
4. Stefańska, B., Dzieduszycka, M., Bontemps-Gracz, M.M., Borowski, E., Martelli, S., Supino, R., Pratesi, G., De Cesare, M.A., Zunino, F., Kuśnierczyk, H. & Radzikowski, C. (1999) 8,11-Dihydroxy-6-[(aminoalkyl)amino]-7H-benzo[e]perimidin-7-ones with activity in multidrug resistant cell lines; synthesis and antitumor evaluation. J. Med. Chem. 42, 3494-3501.
5. Tkaczyk-Gobis, K., Tarasiuk, J., Seksek, O., Stefańska, B., Borowski, E. & Garnier-Suillerot, A. (2000) Transport of new non-cross-resistant antitumor compounds of the benzoperimidine family in multidrug resistant cells. Eur. J. Pharmacol. 413, 131-141.
6. Bontemps-Gracz, M.M. (2000) Aktywność cytotoksyczna nowych pochodnych i analogów antrachinonu oraz zwia̧zków pokrewnych z grupy akrydyny ze szczególnym uwzglçdnieniem koniórek nowotworowych z indukowaņ krzyżowa̧ opornościa̧ wielolekowa̧. (The cytotoxic activity of novel derivatives and analogues of anthraquinone and related acridine compounds with particular emphasis on tumor cell lines with induced multidrug cross-resistance.) Ph.D. Thesis, Gdańsk, 2000 (in Polish).
7. Antonini, I., Polucci, P. & Martelli, S. (1999) Preparation of pyrazoloacridines and pyrazolopyrimidoacridines as antitumor agents. PCT Int. Appl. WO 9906405, Chem. Abstr. 130, 153666.
8. Antonini, I., Polucci, P., Magnano, A. & Martelli, S. (2001) Synthesis, antitumor cytotoxicity, and DNA-binding of novel N-5,2-di-(ω-aminoalkyl)-2,6-dihyclropyrazolo-[3,4,5-/kl/]-acridine-5- carboxamides. J. Med. Chem. 44, 3329-3333.
9. Antonini, I., Polucci, P., Magnano, A., Gatto, B., Palumbo, M., Menta, E., Pescalli, N. & Martelli, S. (2002) 2,6-Di(ω-aminoalkyl)-2,5,6,7-tetrahydropyrazolo[3,4,5-mn]pyrimido-[5,6,1- de]acridine-5,7-diones: Novel, potent, cytotoxic, and DNA-binding agents. J. Med. Chem. (in press).