메뉴 건너뛰기




Volumn 3, Issue 2, 1997, Pages 91-99

Multidrug resistance: Molecular and clinical aspects

Author keywords

mdr gene family; Multidrug rresistance; P glycoprotein; Tumor aggressiveness

Indexed keywords

GENE PRODUCT; GLYCOPROTEIN GP 170; GLYCOPROTEIN P; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

EID: 0030749045     PISSN: 13684736     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (23)

References (90)
  • 1
    • 0021797892 scopus 로고
    • Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines
    • Riordan JR, Deuchars K, Kartner N et al, Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines. Nature (1985) 316: 817-19.
    • (1985) Nature , vol.316 , pp. 817-819
    • Riordan, J.R.1    Deuchars, K.2    Kartner, N.3
  • 2
    • 0022993652 scopus 로고
    • Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins
    • Gros P, Croop J, Housman D, Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell (1986) 47: 371-80.
    • (1986) Cell , vol.47 , pp. 371-380
    • Gros, P.1    Croop, J.2    Housman, D.3
  • 3
    • 0022972654 scopus 로고
    • Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
    • Chen CJ, Chin JE, Ueda K et al, Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell (1986) 47: 381-9.
    • (1986) Cell , vol.47 , pp. 381-389
    • Chen, C.J.1    Chin, J.E.2    Ueda, K.3
  • 4
    • 0000598335 scopus 로고
    • Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells
    • Roninson IB, Chin JE, Choi K et al, Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci USA (1986) 83: 4538-42.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 4538-4542
    • Roninson, I.B.1    Chin, J.E.2    Choi, K.3
  • 5
    • 0024414605 scopus 로고
    • Structure and expression of the human mdr (P-glycoprotein) gene family
    • Chin JE, Soffir R, Noonan KE et al, Structure and expression of the human mdr (P-glycoprotein) gene family. Mol Cell Biol (1989) 9: 3808-20.
    • (1989) Mol Cell Biol , vol.9 , pp. 3808-3820
    • Chin, J.E.1    Soffir, R.2    Noonan, K.E.3
  • 6
    • 0023638508 scopus 로고
    • Localization of the human multiple drug resistance gene, MDR1, to 7q21.1
    • Callen DF, Baker E, Simmers RN et al, Localization of the human multiple drug resistance gene, MDR1, to 7q21.1. Hum Genet (1987) 77: 142-4.
    • (1987) Hum Genet , vol.77 , pp. 142-144
    • Callen, D.F.1    Baker, E.2    Simmers, R.N.3
  • 7
    • 0022972654 scopus 로고
    • Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
    • Chen CJ, Chin JE, Ueda K et al, Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell (1986) 47: 381-9.
    • (1986) Cell , vol.47 , pp. 381-389
    • Chen, C.J.1    Chin, J.E.2    Ueda, K.3
  • 8
    • 0025191307 scopus 로고
    • Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins
    • Chen CJ, Clark D, Ueda K et al, Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. J Biol Chem (1990) 265: 506-14.
    • (1990) J Biol Chem , vol.265 , pp. 506-514
    • Chen, C.J.1    Clark, D.2    Ueda, K.3
  • 9
    • 0027120232 scopus 로고
    • P-glycoprotein and resistance to anticancer drugs
    • Ling V, P-glycoprotein and resistance to anticancer drugs. Cancer (1992) 69: 2603-9.
    • (1992) Cancer , vol.69 , pp. 2603-2609
    • Ling, V.1
  • 10
    • 0027263181 scopus 로고
    • Clinical significance of P-glycoprotein in multidrug resistance malignancies
    • Arecli RJ, Clinical significance of P-glycoprotein in multidrug resistance malignancies. Blood (1993) 81: 2215-22.
    • (1993) Blood , vol.81 , pp. 2215-2222
    • Arecli, R.J.1
  • 11
    • 0026009514 scopus 로고
    • Multidrug resistance from the clinical point of view
    • Van Kallen EK, Pinedo HM, Giaccone G, Multidrug resistance from the clinical point of view. Eur J Cancer (1991) 27: 1481-6.
    • (1991) Eur J Cancer , vol.27 , pp. 1481-1486
    • Van Kallen, E.K.1    Pinedo, H.M.2    Giaccone, G.3
  • 12
    • 0028269030 scopus 로고
    • Clinical relevance of P-glycoprotein expression in haematological malignancies
    • Nooter K, Sonneveld P, Clinical relevance of P-glycoprotein expression in haematological malignancies. Leuk Res (1994) 17: 233-43.
    • (1994) Leuk Res , vol.17 , pp. 233-243
    • Nooter, K.1    Sonneveld, P.2
  • 13
    • 0028861933 scopus 로고
    • P-glycoprotein: A marker of cancer cell behaviour
    • Pinedo HM, Giaccone G, P-glycoprotein: a marker of cancer cell behaviour. N Engl J Med (1995) 333: 1417-19.
    • (1995) N Engl J Med , vol.333 , pp. 1417-1419
    • Pinedo, H.M.1    Giaccone, G.2
  • 14
    • 0022981352 scopus 로고
    • Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene
    • Shen DW, Fojo A, Roninson IB et al, Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene. Mol Cell Biol (1986) 6: 4039-44.
    • (1986) Mol Cell Biol , vol.6 , pp. 4039-4044
    • Shen, D.W.1    Fojo, A.2    Roninson, I.B.3
  • 15
    • 0008632564 scopus 로고
    • Expression of a full-length cDNA for the human 'MDR1' gene confers resistance to colchicine, doxorubicin, and vinblastine
    • Ueda K, Cardarelli C, Gottesman MM, Pastan I, Expression of a full-length cDNA for the human 'MDR1' gene confers resistance to colchicine, doxorubicin, and vinblastine. Proc Natl Adac Sci USA (1987) 84: 3004-8.
    • (1987) Proc Natl Adac Sci USA , vol.84 , pp. 3004-3008
    • Ueda, K.1    Cardarelli, C.2    Gottesman, M.M.3    Pastan, I.4
  • 16
    • 0042043472 scopus 로고    scopus 로고
    • Transfer of the mdr1 gene into hematopoietic cells
    • Bauard M, Pastan I, Gottesman MM, Transfer of the mdr1 gene into hematopoietic cells. Eur J Cancer (1996) 32A: 1019-23.
    • (1996) Eur J Cancer , vol.32 A , pp. 1019-1023
    • Bauard, M.1    Pastan, I.2    Gottesman, M.M.3
  • 17
    • 0026705269 scopus 로고
    • Transfer and expression of the human multiple drug resistance gene into live mice
    • Podda S, Ward M, Himelstein A et al, Transfer and expression of the human multiple drug resistance gene into live mice. Proc Natl Acad Sci USA (1992) 89: 9676-80.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 9676-9680
    • Podda, S.1    Ward, M.2    Himelstein, A.3
  • 18
    • 0025801867 scopus 로고
    • Structure of the human mdr3 gene and physical mapping of the human mdr locus
    • Lincke CR, Smith JJM, Van der Velde-Koerts T, Borst P, Structure of the human mdr3 gene and physical mapping of the human mdr locus. J Biol Chem (1991) 266: 5303-10.
    • (1991) J Biol Chem , vol.266 , pp. 5303-5310
    • Lincke, C.R.1    Smith, J.J.M.2    Van Der Velde-Koerts, T.3    Borst, P.4
  • 19
    • 0023522193 scopus 로고
    • Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene
    • Ueda K, Pastan I, Gottesman MM, Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene. J Biol Chem (1987) 262: 17432-6.
    • (1987) J Biol Chem , vol.262 , pp. 17432-17436
    • Ueda, K.1    Pastan, I.2    Gottesman, M.M.3
  • 20
    • 0025619390 scopus 로고
    • The human multidrug resistance gene: Sequences upstream and downstream of the initiation site influence transcription
    • Cornwell MM, The human multidrug resistance gene: sequences upstream and downstream of the initiation site influence transcription. Cell Growth Diff (1990) 1: 607-15.
    • (1990) Cell Growth Diff , vol.1 , pp. 607-615
    • Cornwell, M.M.1
  • 21
    • 0027483327 scopus 로고
    • Identification of 5′ and 3′ sequences involved in the regulation of transcription of the human mdr1 gene in vivo
    • Madden MJ, Morrow CS, Nakagawa M et al, Identification of 5′ and 3′ sequences involved in the regulation of transcription of the human mdr1 gene in vivo. J Biol Chem (1993) 268: 8290-7.
    • (1993) J Biol Chem , vol.268 , pp. 8290-8297
    • Madden, M.J.1    Morrow, C.S.2    Nakagawa, M.3
  • 22
    • 0027410016 scopus 로고
    • Identification of a functional initiator sequence in the human mdr1 promoter
    • Van groenigen M, Valentijn LJ, Baas F, Identification of a functional initiator sequence in the human mdr1 promoter. Biochim Biophys Acta (1993) 1172: 138-46.
    • (1993) Biochim Biophys Acta , vol.1172 , pp. 138-146
    • Van Groenigen, M.1    Valentijn, L.J.2    Baas, F.3
  • 23
    • 0025201425 scopus 로고
    • Tissue-specific enhancer of the human multidrug-resistance (MDR1) gene
    • Kohno K, Sato SI, Uchiumi T et al, Tissue-specific enhancer of the human multidrug-resistance (MDR1) gene. J Biol Chem (1990) 265: 19690-6.
    • (1990) J Biol Chem , vol.265 , pp. 19690-19696
    • Kohno, K.1    Sato, S.I.2    Uchiumi, T.3
  • 24
    • 0029954843 scopus 로고    scopus 로고
    • P-glycoprotein - A mediator of multidrug resistance in tumor cells
    • Germann LIA, P-glycoprotein - a mediator of multidrug resistance in tumor cells. Eur J cancer (1996) 32A: 927-44.
    • (1996) Eur J Cancer , vol.32 A , pp. 927-944
    • Germann, L.I.A.1
  • 25
    • 0024292717 scopus 로고
    • An altered pattern of cross-resistance in multidrug-resiatant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene
    • Choi K, Chen CJ, Kriegler M, Roninson IB, An altered pattern of cross-resistance in multidrug-resiatant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene. Cell (1988) 53: 519-29.
    • (1988) Cell , vol.53 , pp. 519-529
    • Choi, K.1    Chen, C.J.2    Kriegler, M.3    Roninson, I.B.4
  • 26
    • 0025051429 scopus 로고
    • Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185-Val-185 substitution in P-glycoprotein
    • Safa AR, Stern RK, Choi K et al, Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185-Val-185 substitution in P-glycoprotein. Proc Natl Acad Sci USA (1990) 87: 7225-9.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 7225-7229
    • Safa, A.R.1    Stern, R.K.2    Choi, K.3
  • 27
    • 0042132423 scopus 로고
    • Expression of a multidrug-resistance gene in human tumors and tissues
    • Fojo AT, Ueda K, Slamon DJ et al, Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci USA (1987) 84: 265-9.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 265-269
    • Fojo, A.T.1    Ueda, K.2    Slamon, D.J.3
  • 28
    • 0022444431 scopus 로고
    • Amplification and expression of genes associated with multidrug resistance in mammalian cells
    • Scotto KW, Biedler JL, Melera PW, Amplification and expression of genes associated with multidrug resistance in mammalian cells. Science (1986) 232: 751-5.
    • (1986) Science , vol.232 , pp. 751-755
    • Scotto, K.W.1    Biedler, J.L.2    Melera, P.W.3
  • 29
    • 0022457103 scopus 로고
    • Human multidrug-resistant cell lines: Increased mdr1 expression can precede gene amplification
    • Shen DW, Fojo A, Chin JE et al, Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification. Science (1986) 232: 643-5.
    • (1986) Science , vol.232 , pp. 643-645
    • Shen, D.W.1    Fojo, A.2    Chin, J.E.3
  • 30
    • 0024820183 scopus 로고
    • The direct activation of human mutidrug resistance gene (mdr1) by anticancer agents
    • Kohno K, Sato S, Takano H et al. The direct activation of human mutidrug resistance gene (mdr1) by anticancer agents. Biochem Biophys Commun (1989) 165: 1415-21.
    • (1989) Biochem Biophys Commun , vol.165 , pp. 1415-1421
    • Kohno, K.1    Sato, S.2    Takano, H.3
  • 31
    • 0028109125 scopus 로고
    • Transactivation of the human multidrug resistance (mdr1) gene promoter by p53 mutants
    • Nguyen KT, Liu B, Ueda K et al, Transactivation of the human multidrug resistance (mdr1) gene promoter by p53 mutants. Oncol Res (1994) 6: 71-7.
    • (1994) Oncol Res , vol.6 , pp. 71-77
    • Nguyen, K.T.1    Liu, B.2    Ueda, K.3
  • 32
    • 0024411328 scopus 로고
    • Recent progress in understanding mechanisms of mammalian DNA amplification
    • Stark GR, Debatisse M, Giulotto E, Wahl GM, Recent progress in understanding mechanisms of mammalian DNA amplification. Cell (1989) 57: 901-8.
    • (1989) Cell , vol.57 , pp. 901-908
    • Stark, G.R.1    Debatisse, M.2    Giulotto, E.3    Wahl, G.M.4
  • 33
    • 0028853275 scopus 로고
    • The human mdr1 (multidrug resistance) gene harbours a long homopyrimidine homopurine sequence next to a cluster of Alu repeated sequences in intron 14
    • Pauly M, Kayser I, Schmitz M et al, The human mdr1 (multidrug resistance) gene harbours a long homopyrimidine homopurine sequence next to a cluster of Alu repeated sequences in intron 14. Gene (1995) 153: 299-300.
    • (1995) Gene , vol.153 , pp. 299-300
    • Pauly, M.1    Kayser, I.2    Schmitz, M.3
  • 34
    • 0029591607 scopus 로고
    • Repetitive DNA sequences located in the central region of the human mdr1 (multidrug resistance) gene may account for a gene fusion event during its evolution
    • Pauly M, Kayser I, Schmitz M et al, Repetitive DNA sequences located in the central region of the human mdr1 (multidrug resistance) gene may account for a gene fusion event during its evolution. J Mol Evol (1995) 41: 974-8.
    • (1995) J Mol Evol , vol.41 , pp. 974-978
    • Pauly, M.1    Kayser, I.2    Schmitz, M.3
  • 35
    • 0020578356 scopus 로고
    • Cell surface P-glycoprotein is associated with multidrug resistance in mammalian cells
    • Kartner N, Rierder JR, Ling V, Cell surface P-glycoprotein is associated with multidrug resistance in mammalian cells. Science (1983) 221: 1285-8.
    • (1983) Science , vol.221 , pp. 1285-1288
    • Kartner, N.1    Rierder, J.R.2    Ling, V.3
  • 36
    • 0026760289 scopus 로고
    • The genetic basis of multidrug resistance
    • Pauly M, Ries F, Dicato M, The genetic basis of multidrug resistance. Pathol Res Practice (1992) 188: 804-7.
    • (1992) Pathol Res Practice , vol.188 , pp. 804-807
    • Pauly, M.1    Ries, F.2    Dicato, M.3
  • 37
    • 0018569942 scopus 로고
    • A mathematical model for relating the drug sensitivity to the spontaneous mutation rate
    • Goldie JH, Goldman AJ, A mathematical model for relating the drug sensitivity to the spontaneous mutation rate. Cancer Treat Rep (1979) 63: 1727-33.
    • (1979) Cancer Treat Rep , vol.63 , pp. 1727-1733
    • Goldie, J.H.1    Goldman, A.J.2
  • 38
    • 0027095653 scopus 로고
    • Overexpression of a transporter gene multidrug resistant human lung cancer cell line
    • Cole SPC, Bhardwaj G, Gerlach JH, Overexpression of a transporter gene multidrug resistant human lung cancer cell line. Science (1992) 258: 1650-4.
    • (1992) Science , vol.258 , pp. 1650-1654
    • Cole, S.P.C.1    Bhardwaj, G.2    Gerlach, J.H.3
  • 39
    • 0028567035 scopus 로고
    • The human multidrug resistance associated protein MRP id a plasma membrane drug-efflux pump
    • Zaman GJR, Flens MJ, Van Leusden MR, The human multidrug resistance associated protein MRP id a plasma membrane drug-efflux pump. Proc Natl Acad Sci USA (1994) 91: 8822-6.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 8822-8826
    • Zaman, G.J.R.1    Flens, M.J.2    Van Leusden, M.R.3
  • 40
    • 0029157072 scopus 로고
    • Expression pattern of MRP in human tissues and adult solid tumor cell lines
    • Kruh GD, Caughan KT, Godwin A, Chan A, Expression pattern of MRP in human tissues and adult solid tumor cell lines. J Natl Cancer Inst (1995) 87: 1256-9.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1256-1259
    • Kruh, G.D.1    Caughan, K.T.2    Godwin, A.3    Chan, A.4
  • 41
    • 0027466646 scopus 로고
    • Overexpression of a MR 110,000 vesicle protein in non-P-glycoprotein mediated multidrug resistance
    • Scheper RJ, Broxterman HJ, Scheffer GL, Overexpression of a MR 110,000 vesicle protein in non-P-glycoprotein mediated multidrug resistance. Cancer Res (1993) 53: 1475-9.
    • (1993) Cancer Res , vol.53 , pp. 1475-1479
    • Scheper, R.J.1    Broxterman, H.J.2    Scheffer, G.L.3
  • 42
    • 0029048485 scopus 로고
    • The drug resistance-related protein LRP is the major human vaults protein
    • Scheffer GL, Wijngaard PL, Flens MJ et al. The drug resistance-related protein LRP is the major human vaults protein. Nature Med (1995) 1: 578-82.
    • (1995) Nature Med , vol.1 , pp. 578-582
    • Scheffer, G.L.1    Wijngaard, P.L.2    Flens, M.J.3
  • 43
    • 0029081126 scopus 로고
    • Drug resistance-associated marker Lrp for prediction of response to chemotherapy and prognosis in advanced ovarian carcinoma
    • Izquierdo MA, Van der Zee AGJ, Vermorken JB et al, Drug resistance-associated marker Lrp for prediction of response to chemotherapy and prognosis in advanced ovarian carcinoma. J Nad Cancer Inst (1995) 87: 1230-6.
    • (1995) J Nad Cancer Inst , vol.87 , pp. 1230-1236
    • Izquierdo, M.A.1    Van Der Zee, A.G.J.2    Vermorken, J.B.3
  • 44
    • 0028116322 scopus 로고
    • Multidrug resistance in lymphomas
    • Yuen AR, Sikic BI, Multidrug resistance in lymphomas. J Clin Oncol (1994) 12: 2453-9.
    • (1994) J Clin Oncol , vol.12 , pp. 2453-2459
    • Yuen, A.R.1    Sikic, B.I.2
  • 45
    • 0026465461 scopus 로고
    • Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes
    • Chaudhaary PM, Mechetner EB, Robinson IB, Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes. Blood (1992) 80: 2735-9.
    • (1992) Blood , vol.80 , pp. 2735-2739
    • Chaudhaary, P.M.1    Mechetner, E.B.2    Robinson, I.B.3
  • 46
    • 0025799513 scopus 로고
    • Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells
    • Chaudhary PM, Robinson IB, Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell (1991) 66: 85-94.
    • (1991) Cell , vol.66 , pp. 85-94
    • Chaudhary, P.M.1    Robinson, I.B.2
  • 47
    • 0025176743 scopus 로고
    • Expression of the multidrug resistance gene in myeloid leukemias
    • Sato H, Gottesman MM, Goldstein LJ et al, Expression of the multidrug resistance gene in myeloid leukemias. Leuk Res (1990) 14: 11-22.
    • (1990) Leuk Res , vol.14 , pp. 11-22
    • Sato, H.1    Gottesman, M.M.2    Goldstein, L.J.3
  • 48
    • 0025855920 scopus 로고
    • MDR1 gene expression and treatment outcome in acute myeloid leukemia
    • Pirker R, Wallner T, Geissler K et al, MDR1 gene expression and treatment outcome in acute myeloid leukemia. J Natl Cancer Inst (1991) 83: 708-12.
    • (1991) J Natl Cancer Inst , vol.83 , pp. 708-712
    • Pirker, R.1    Wallner, T.2    Geissler, K.3
  • 50
    • 0027314191 scopus 로고
    • Expression of the multidrug associated P-glycoprotein (P-170) in 59 cases of de novo acute lymphoblastic leukemia. Prognostic implications
    • Goasguen JE, Dossot JM, Fardel O et al, Expression of the multidrug associated P-glycoprotein (P-170) in 59 cases of de novo acute lymphoblastic leukemia. Prognostic implications. Blood (1993) 81: 2394-9.
    • (1993) Blood , vol.81 , pp. 2394-2399
    • Goasguen, J.E.1    Dossot, J.M.2    Fardel, O.3
  • 51
    • 0026553235 scopus 로고
    • Non P-glycoprotein mediated multidrug resistance in children with relapsed acute lymphoblastic leukemia
    • Pieters R, Hongo T, Loonen AH et al, Non P-glycoprotein mediated multidrug resistance in children with relapsed acute lymphoblastic leukemia. Br J Cancer (1992) 65: 691-7.
    • (1992) Br J Cancer , vol.65 , pp. 691-697
    • Pieters, R.1    Hongo, T.2    Loonen, A.H.3
  • 52
    • 0024782753 scopus 로고
    • Expression of multidrug resistance gene in blast crisis of chronic myelogenous leukemia
    • Pirker R, Goldstein LJ, Ludwig H, Expression of multidrug resistance gene in blast crisis of chronic myelogenous leukemia. Cancer Commun (1989) 1: 141-4.
    • (1989) Cancer Commun , vol.1 , pp. 141-144
    • Pirker, R.1    Goldstein, L.J.2    Ludwig, H.3
  • 53
    • 0030047552 scopus 로고    scopus 로고
    • Studies of P-glycoprotein in chronic myelogenous leukemia patients: Expression, activity and correlations with CD34 antigens
    • Turkina AG, Baryshnikov AY, Sedyakaina NP et al, Studies of P-glycoprotein in chronic myelogenous leukemia patients: expression, activity and correlations with CD34 antigens. Br J Haematol (1996) 92: 88-96.
    • (1996) Br J Haematol , vol.92 , pp. 88-96
    • Turkina, A.G.1    Baryshnikov, A.Y.2    Sedyakaina, N.P.3
  • 54
    • 0024411714 scopus 로고
    • P-glycoprotein expression in plasma cell myeloma is associated with resistance to VAD
    • Epstein J, Xoao H, Koba B, P-glycoprotein expression in plasma cell myeloma is associated with resistance to VAD. Blood (1989) 74: 913-17.
    • (1989) Blood , vol.74 , pp. 913-917
    • Epstein, J.1    Xoao, H.2    Koba, B.3
  • 55
    • 0026634681 scopus 로고
    • Modulation of multidrug resistant multiple myeloma by cyclosporin
    • The Leukemia Group of the EORTC and the HOVON
    • Sonneveld P, Durie BGM, Lokhorst HM et al, Modulation of multidrug resistant multiple myeloma by cyclosporin. The Leukemia Group of the EORTC and the HOVON. Lancet (1992) 340: 255-9.
    • (1992) Lancet , vol.340 , pp. 255-259
    • Sonneveld, P.1    Durie, B.G.M.2    Lokhorst, H.M.3
  • 56
    • 0028816350 scopus 로고
    • A phase III randomized study of oral verapamil as a chemosensitizer to reverse drug resistance in patients with refractory myeloma: A Southwest Oncology Group Study
    • Dalton WS, Crowley JJ, Salmon S et al, A phase III randomized study of oral verapamil as a chemosensitizer to reverse drug resistance in patients with refractory myeloma: a Southwest Oncology Group Study. Cancer (1995) 75: 815-20.
    • (1995) Cancer , vol.75 , pp. 815-820
    • Dalton, W.S.1    Crowley, J.J.2    Salmon, S.3
  • 58
    • 0026051296 scopus 로고
    • P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high dose varapamil
    • Miller TP, Grogan TM, Dalton WS et al, P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high dose varapamil. J Clin Oncol (1991) 9: 17-24.
    • (1991) J Clin Oncol , vol.9 , pp. 17-24
    • Miller, T.P.1    Grogan, T.M.2    Dalton, W.S.3
  • 59
    • 0027410536 scopus 로고
    • Expression of P-glycoprotein and glutathione-S-transferase in recurrent lymphomas: The possible role of Epstein-Barr virus, immunophenotypes and other predisposing factors
    • Cheng AL, Su IJ, Chen YC, Wang CH, Expression of P-glycoprotein and glutathione-S-transferase in recurrent lymphomas: the possible role of Epstein-Barr virus, immunophenotypes and other predisposing factors. J Clin Oncol (1993) 11: 109-15.
    • (1993) J Clin Oncol , vol.11 , pp. 109-115
    • Cheng, A.L.1    Su, I.J.2    Chen, Y.C.3    Wang, C.H.4
  • 60
    • 0027458768 scopus 로고
    • Expression of P-glycoprotein and anionic glutathione-S-transferase genes in non-Hodgkin's lymphoma
    • Rodriguez C, Commes T, Robert J, Rossi JF, expression of P-glycoprotein and anionic glutathione-S-transferase genes in non-Hodgkin's lymphoma. Leuk Res (1993) 17: 149-56.
    • (1993) Leuk Res , vol.17 , pp. 149-156
    • Rodriguez, C.1    Commes, T.2    Robert, J.3    Rossi, J.F.4
  • 61
    • 0025886592 scopus 로고
    • Immunohistochemical detection of the multidrug transport protein P-170 in human normal tissues and malignant lymphomas
    • Pileris S, Sabattini E, Falini B, Immunohistochemical detection of the multidrug transport protein P-170 in human normal tissues and malignant lymphomas. Histopathology (1991) 19: 131-40.
    • (1991) Histopathology , vol.19 , pp. 131-140
    • Pileris, S.1    Sabattini, E.2    Falini, B.3
  • 62
    • 0026652499 scopus 로고
    • Immunohistochemical identification of P-glycoprotein in previously untreated, diffuse large cell and immunoblastic lymphomas
    • Niehans GA, Jaszez W, brunetta V et al, Immunohistochemical identification of P-glycoprotein in previously untreated, diffuse large cell and immunoblastic lymphomas. Cancer Res (1992) 52: 3768-75.
    • (1992) Cancer Res , vol.52 , pp. 3768-3775
    • Niehans, G.A.1    Jaszez, W.2    Brunetta, V.3
  • 63
    • 9044244820 scopus 로고
    • A study of clinical and pathologic variables affecting disease specific survival (DSS) of patients with diffuse large cell lymphoma treated with MACOP-B or VACOP-B: Univariate and multyivariate analysis
    • abstr
    • Gascoyne R, Hoskins P, Connors J et al, A study of clinical and pathologic variables affecting disease specific survival (DSS) of patients with diffuse large cell lymphoma treated with MACOP-B or VACOP-B: univariate and multyivariate analysis. Proc Am Soc Clin Oncol (1994) 13: 374 (abstr).
    • (1994) Proc Am Soc Clin Oncol , vol.13 , pp. 374
    • Gascoyne, R.1    Hoskins, P.2    Connors, J.3
  • 64
    • 0027138272 scopus 로고
    • Doxorubicin and multidrug resistance
    • Kruh GD, Goldstein LJ, Doxorubicin and multidrug resistance. Curr Opin Oncol (1993) 5: 1029-34.
    • (1993) Curr Opin Oncol , vol.5 , pp. 1029-1034
    • Kruh, G.D.1    Goldstein, L.J.2
  • 65
    • 0026426196 scopus 로고
    • Clinical relevance of immunohistochemical detection of multidrug resistance P-glycoprotein in breast carcinoma
    • Verelle P, Meissonier F, Fonck Y, Clinical relevance of immunohistochemical detection of multidrug resistance P-glycoprotein in breast carcinoma. J Natl Cancer Inst (1991) 83: 111-16.
    • (1991) J Natl Cancer Inst , vol.83 , pp. 111-116
    • Verelle, P.1    Meissonier, F.2    Fonck, Y.3
  • 66
    • 0028785491 scopus 로고
    • Multidrug resistance in breast cancer: Mechanisms, strategies
    • Giaccone G, Linn SC, Pinedo HM, Multidrug resistance in breast cancer: mechanisms, strategies. Eur J Cancer (1995) 31A(S7): S15-17.
    • (1995) Eur J Cancer , vol.31 A , Issue.S7
    • Giaccone, G.1    Linn, S.C.2    Pinedo, H.M.3
  • 67
    • 16044365449 scopus 로고
    • Expression of multidrug resistance (MDR) genes in primary breast cancer and in advanced anthracycline-resistant breast cancer patients undergoing taxol treatment
    • Linn SC, Van Ark-Ott J, Kuiper K, Expression of multidrug resistance (MDR) genes in primary breast cancer and in advanced anthracycline-resistant breast cancer patients undergoing taxol treatment. Proc AACR (1994) 35: 207.
    • (1994) Proc AACR , vol.35 , pp. 207
    • Linn, S.C.1    Van Ark-Ott, J.2    Kuiper, K.3
  • 68
    • 0025231784 scopus 로고
    • Immunohistochemical detection of P-glycoprotein: Prognostic correlation in soft tissue sarcoma of childhood
    • Chan HSL, Thorner PS, Haddad G, Ling V, Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood. J Clin Oncol (1990) 8: 689-704.
    • (1990) J Clin Oncol , vol.8 , pp. 689-704
    • Chan, H.S.L.1    Thorner, P.S.2    Haddad, G.3    Ling, V.4
  • 69
    • 0027365535 scopus 로고
    • Expression of the mdr1 gene in bone and soft tissue sarcomas of adult patients
    • Stein V, Wunderlich V, Haensch W, Schmich-Peter P, Expression of the mdr1 gene in bone and soft tissue sarcomas of adult patients. Eur J Cancer (1993) 29A: 1979-81.
    • (1993) Eur J Cancer , vol.29 A , pp. 1979-1981
    • Stein, V.1    Wunderlich, V.2    Haensch, W.3    Schmich-Peter, P.4
  • 70
    • 0028809430 scopus 로고
    • Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome
    • Baldini N, Scotlandi K, Barbanti-Brodano G et al, Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome. N Engl J Med (1995) 333: 1380-5.
    • (1995) N Engl J Med , vol.333 , pp. 1380-1385
    • Baldini, N.1    Scotlandi, K.2    Barbanti-Brodano, G.3
  • 71
    • 0029126764 scopus 로고
    • MDR1/P-glycoprotein expression in colon cancer
    • Linn SC, Gaiccone G, MDR1/P-glycoprotein expression in colon cancer. Eur J Cancer (1995) 31 A: 1291-4.
    • (1995) Eur J Cancer , vol.31 A , pp. 1291-1294
    • Linn, S.C.1    Gaiccone, G.2
  • 72
    • 0025739785 scopus 로고
    • Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis
    • Weinstein RS, Jakati SM, Dominguez JM et al, Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis. Cancer Res (1991) 51: 2720-6.
    • (1991) Cancer Res , vol.51 , pp. 2720-2726
    • Weinstein, R.S.1    Jakati, S.M.2    Dominguez, J.M.3
  • 73
    • 0025169822 scopus 로고
    • Expression of the multidrug resistance mdr1 gene in neuroblastoma
    • Goldstein LJ, Fojo AAT, Nesa K, Expression of the multidrug resistance mdr1 gene in neuroblastoma. J Clin Oncol (1990) 8: 128-36.
    • (1990) J Clin Oncol , vol.8 , pp. 128-136
    • Goldstein, L.J.1    Fojo, A.A.T.2    Nesa, K.3
  • 74
    • 0025769898 scopus 로고
    • Expression of P-glycoprotein restricted to normal cells in neuroblastoma biopsies
    • Favrot M, Combaret V, Goillet E, Expression of P-glycoprotein restricted to normal cells in neuroblastoma biopsies. Br J Cancer (1991) 64: 233-8.
    • (1991) Br J Cancer , vol.64 , pp. 233-238
    • Favrot, M.1    Combaret, V.2    Goillet, E.3
  • 75
    • 0025990960 scopus 로고
    • P-glycoprotein expression as a predictor of outcome therapy for neuroblastoma
    • Chan HSL, Haddad G, Thorner RS et al, P-glycoprotein expression as a predictor of outcome therapy for neuroblastoma. N Engl J Med (1991) 325: 1608-14.
    • (1991) N Engl J Med , vol.325 , pp. 1608-1614
    • Chan, H.S.L.1    Haddad, G.2    Thorner, R.S.3
  • 76
    • 0030031845 scopus 로고    scopus 로고
    • Expression of the gene for multidrug resistance-associated protein and outcome in patients with neuroblastoma
    • Norris MD, Bordow SB, Marshall GM et al, Expression of the gene for multidrug resistance-associated protein and outcome in patients with neuroblastoma. N Engl J Med (1996) 334: 231-8.
    • (1996) N Engl J Med , vol.334 , pp. 231-238
    • Norris, M.D.1    Bordow, S.B.2    Marshall, G.M.3
  • 77
    • 0010039537 scopus 로고    scopus 로고
    • What does mutidrug resistance (MDR) expression mean in the clinic?
    • Duhem C, Ries F, Dicato M, What does mutidrug resistance (MDR) expression mean in the clinic? The Oncologist (1996) 1: 151-8.
    • (1996) The Oncologist , vol.1 , pp. 151-158
    • Duhem, C.1    Ries, F.2    Dicato, M.3
  • 78
    • 0029125017 scopus 로고
    • Chemosensitivity and chemoresistance assays: Are they clinically relevant?
    • Markman M, Chemosensitivity and chemoresistance assays: are they clinically relevant? J Cancer Res Clin Oncol (1995) 121: 441-2.
    • (1995) J Cancer Res Clin Oncol , vol.121 , pp. 441-442
    • Markman, M.1
  • 79
    • 0019430432 scopus 로고
    • Overcoming of vincristine resistance in P-388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil
    • Tsuro T, Iida M, Tsukogoshi S, Sakurai Y, Overcoming of vincristine resistance in P-388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res (1981) 41: 1967-72.
    • (1981) Cancer Res , vol.41 , pp. 1967-1972
    • Tsuro, T.1    Iida, M.2    Tsukogoshi, S.3    Sakurai, Y.4
  • 80
    • 0026030570 scopus 로고
    • Treatment of advanced breast cancer with doxorubicin, vincristine and continuous infusion of verapamil. A phase I-II clinical trial
    • Ries F, Dicato M, Treatment of advanced breast cancer with doxorubicin, vincristine and continuous infusion of verapamil. A phase I-II clinical trial. Med Oncol Tumor Pharmacother (1991) 9: 39-42.
    • (1991) Med Oncol Tumor Pharmacother , vol.9 , pp. 39-42
    • Ries, F.1    Dicato, M.2
  • 81
    • 0026017638 scopus 로고
    • Reversal of multidrug resistance
    • Chabner BA, Reversal of multidrug resistance. J Clin Oncol (1991) 9: 4-6.
    • (1991) J Clin Oncol , vol.9 , pp. 4-6
    • Chabner, B.A.1
  • 82
    • 0027136660 scopus 로고
    • Clinical trials of agents that reverse multidrug resistance. A literature review
    • Raderer M, Scheithaner W, Clinical trials of agents that reverse multidrug resistance. A literature review. Cancer (1993) 72: 3553-63.
    • (1993) Cancer , vol.72 , pp. 3553-3563
    • Raderer, M.1    Scheithaner, W.2
  • 83
    • 0029677435 scopus 로고    scopus 로고
    • Multidrug resistance modifying components in human plasma with potential clinical significance
    • Mulder HS, Pinedo HM, Timmer AT et al, Multidrug resistance modifying components in human plasma with potential clinical significance. J Exp Ther Oncol (1996) 1: 19-28.
    • (1996) J Exp Ther Oncol , vol.1 , pp. 19-28
    • Mulder, H.S.1    Pinedo, H.M.2    Timmer, A.T.3
  • 84
    • 0028923624 scopus 로고
    • Clinical studies with modulators of multidrug resistance
    • Fischer GA, Sikie BI, Clinical studies with modulators of multidrug resistance. Hematol Oncol Clin North Am (1995) 9: 363-82.
    • (1995) Hematol Oncol Clin North Am , vol.9 , pp. 363-382
    • Fischer, G.A.1    Sikie, B.I.2
  • 85
    • 0028020860 scopus 로고
    • Quinidine as a resistance modulator of epirubicin in advanced breast cancer: Mature results of a placebo-controlled randomized trial
    • Wishart GC, Bisset D, Paul J, et al, Quinidine as a resistance modulator of epirubicin in advanced breast cancer: mature results of a placebo-controlled randomized trial. J Clin Oncol (1994) 9: 1771-7.
    • (1994) J Clin Oncol , vol.9 , pp. 1771-1777
    • Wishart, G.C.1    Bisset, D.2    Paul, J.3
  • 86
    • 9844262370 scopus 로고    scopus 로고
    • Effect of MDR modulator, SDZ PSC833 on the pharmacokinetics and pharmacodynamics of 3 M paclitaxel infusion
    • Egorin M, Fracasso P, Zuhowski E et al, Effect of MDR modulator, SDZ PSC833 on the pharmacokinetics and pharmacodynamics of 3 M paclitaxel infusion. Proc Am Soc Clin Oncol (1996) 15: 473.
    • (1996) Proc Am Soc Clin Oncol , vol.15 , pp. 473
    • Egorin, M.1    Fracasso, P.2    Zuhowski, E.3
  • 87
    • 0028841512 scopus 로고
    • Decreased mutation rate for cellular resistance to doxorubicin and suppression of MDR1 gene activation by the cyclosporin PCS 833
    • Beketic-Orèskovic L, Duran GE, Chen G et al, Decreased mutation rate for cellular resistance to doxorubicin and suppression of MDR1 gene activation by the cyclosporin PCS 833. J Natl Cancer Inst (1995) 1593-602.88. Beck WT, Circumvention of multidrug resistance with anti- P-glycoprotein antibodies: clinical potential or experimental artifact. J Natl Cancer Inst (1995) 87: 73-5.
    • (1995) J Natl Cancer Inst , pp. 1593-60288
    • Beketic-Orèskovic, L.1    Duran, G.E.2    Chen, G.3
  • 88
    • 0029647132 scopus 로고
    • Circumvention of multidrug resistance with anti- P-glycoprotein antibodies: Clinical potential or experimental artifact
    • Beketic-Orèskovic L, Duran GE, Chen G et al, Decreased mutation rate for cellular resistance to doxorubicin and suppression of MDR1 gene activation by the cyclosporin PCS 833. J Natl Cancer Inst (1995) 1593-602.88. Beck WT, Circumvention of multidrug resistance with anti- P-glycoprotein antibodies: clinical potential or experimental artifact. J Natl Cancer Inst (1995) 87: 73-5.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 73-75
    • Beck, W.T.1
  • 89
    • 0029647132 scopus 로고
    • Circumvention of multidrug resistance with anti-P-glycoprotein antibodies: Clinical potential or experimental artifact
    • Beck WT, Circumvention of multidrug resistance with anti-P-glycoprotein antibodies: clinical potential or experimental artifact. J Natl Cancer Inst (1995) 87: 73-5.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 73-75
    • Beck, W.T.1
  • 90
    • 0028860372 scopus 로고
    • Chemosensitizers to overcome and prevent multidrug resistance?
    • Gersmann UA, Harding MW, Chemosensitizers to overcome and prevent multidrug resistance? J Natl Cancer Inst (1995) 87: 1573-5.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1573-1575
    • Gersmann, U.A.1    Harding, M.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.