2,6-di(ω-aminoalkyl)-2,5,6,7- tetrahydropyrazolo[3,4,5-mn]pyrimido[5,6,1-de]-acridine-5,7-diones: Novel, potent, cytotoxic, and DNA-binding agents

Journal of Medicinal Chemistry

Volumn 45, Issue 3, 2002, Pages 696-702

  Antonini, Ippolito ^a   Polucci, Paolo ^a,b   Magnano, Amelia ^a   Gatto, Barbara ^c   Palumbo, Manlio ^c   Menta, Ernesto ^d   Pescalli, Nicoletta ^d   Martellii, Sante ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b PFIZER INC   (United States)

^c UNIVERSITY OF PADOVA   (Italy)

^d Novuspharma SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2,5,6,7 TETRAHYDROPYRAZOLO[3,4,5]PYRIMIDO[5,6,1]ACRIDINE 5,7 DIONE; ACRIDINE DERIVATIVE; INTERCALATING AGENT; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ANTINEOPLASTIC ACTIVITY; ARTICLE; COLON CARCINOMA; CROSS RESISTANCE; CYCLIZATION; CYTOTOXICITY; DNA BINDING; DRUG POTENCY; FLUOROMETRY; STRUCTURE ACTIVITY RELATION;

ACRIDINES; ANTINEOPLASTIC AGENTS; CELL DIVISION; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; ELECTROPHORESIS, AGAR GEL; FLUOROMETRY; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; INTERCALATING AGENTS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0037204016     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm011004x     Document Type: Article

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