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Volumn 23, Issue 1, 2006, Pages 151-160

Blockade of mGluR5 glutamate receptors in the subthalamic nucleus ameliorates motor asymmetry in an animal model of Parkinson's disease

Author keywords

Basal ganglia; Motor behavior; MPEP; Rat; STN

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; DOPAMINE; GLUTAMATE RECEPTOR; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; OXIDOPAMINE; 6 METHYL 2 (PHENYLETHYNYL)PYRIDINE; 6-METHYL-2-(PHENYLETHYNYL)PYRIDINE; ADRENERGIC RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR BLOCKING AGENT; METABOTROPIC RECEPTOR; PYRIDINE DERIVATIVE;

EID: 33644955961     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2005.04550.x     Document Type: Article
Times cited : (46)

References (49)
  • 1
    • 0030886785 scopus 로고    scopus 로고
    • Excitation of rat subthalamic nucleus neurons in vitro by activation of a group 1 metabotropic glutamate receptor
    • Abbott A. Wigmore MA. Lacey MG. 1997 Excitation of rat subthalamic nucleus neurons in vitro by activation of a group 1 metabotropic glutamate receptor BrainRes 766 162 167
    • (1997) BrainRes , vol.766 , pp. 162-167
    • Abbott, A.1    Wigmore, M.A.2    Lacey, M.G.3
  • 2
    • 0029166745 scopus 로고
    • Does the blockade of excitatory amino acid transmission in the basal ganglia simply reverse reaction time deficits induced by dopamine inactivation?
    • Amalric M. Baunez C. Nieoullon A. 1995 Does the blockade of excitatory amino acid transmission in the basal ganglia simply reverse reaction time deficits induced by dopamine inactivation? BehavPharmacol 6 508 519
    • (1995) BehavPharmacol , vol.6 , pp. 508-519
    • Amalric, M.1    Baunez, C.2    Nieoullon, A.3
  • 3
    • 0034332480 scopus 로고    scopus 로고
    • Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus
    • Awad H. Hubert GW. Smith Y. Levey AI. Conn PJ. 2000 Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus JNeurosci 20 7871 7879
    • (2000) JNeurosci , vol.20 , pp. 7871-7879
    • Awad, H.1    Hubert, G.W.2    Smith, Y.3    Levey, A.I.4    Conn, P.J.5
  • 4
    • 0027479766 scopus 로고
    • Reversal of rigidity and improvement in motor performance by subthalamic high frequency stimulation in MPTP-treated monkeys
    • Benazzouz A. Gross C. Feger J. Boraud T. Bioulac B. 1993 Reversal of rigidity and improvement in motor performance by subthalamic high frequency stimulation in MPTP-treated monkeys EurJNeurosci 5 382 389
    • (1993) EurJNeurosci , vol.5 , pp. 382-389
    • Benazzouz, A.1    Gross, C.2    Feger, J.3    Boraud, T.4    Bioulac, B.5
  • 5
    • 0028021805 scopus 로고
    • The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism
    • Bergman H. Wichmann T. Karmon B. DeLong MR. 1994 The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism JNeurophysiol 72 507 520
    • (1994) JNeurophysiol , vol.72 , pp. 507-520
    • Bergman, H.1    Wichmann, T.2    Karmon, B.3    Delong, M.R.4
  • 6
    • 0033555825 scopus 로고    scopus 로고
    • Subthalamic nucleus neurons switch from single-spike activity to burst-firing mode
    • Beurrier C. Congar P. Bioulac B. Hammond C. 1999 Subthalamic nucleus neurons switch from single-spike activity to burst-firing mode JNeurosci 19 599 609
    • (1999) JNeurosci , vol.19 , pp. 599-609
    • Beurrier, C.1    Congar, P.2    Bioulac, B.3    Hammond, C.4
  • 7
    • 0033611972 scopus 로고    scopus 로고
    • Immunohistochemical localization of subtype 4a metabotropic glutamate receptors in the rat and mouse basal ganglia
    • Bradley SR. Standaert DG. Rhodes KJ. Rees HD. Testa CM. Levey AI. Conn PJ. 1999 Immunohistochemical localization of subtype 4a metabotropic glutamate receptors in the rat and mouse basal ganglia JCompNeurol 407 33 46
    • (1999) JCompNeurol , vol.407 , pp. 33-46
    • Bradley, S.R.1    Standaert, D.G.2    Rhodes, K.J.3    Rees, H.D.4    Testa, C.M.5    Levey, A.I.6    Conn, P.J.7
  • 8
    • 0141856474 scopus 로고    scopus 로고
    • Metabotropic glutamate 5 receptor blockade alleviates akinesia by normalizing activity of selective basal-ganglia structures in parkinsonian rats
    • Breysse N. Amalric M. Salin P. 2003 Metabotropic glutamate 5 receptor blockade alleviates akinesia by normalizing activity of selective basal-ganglia structures in parkinsonian rats JNeurosci 23 8302 8309
    • (2003) JNeurosci , vol.23 , pp. 8302-8309
    • Breysse, N.1    Amalric, M.2    Salin, P.3
  • 9
    • 0036662945 scopus 로고    scopus 로고
    • Chronic but not acute treatment with a metabotropic glutamate 5 receptor antagonist reverses the akinetic deficits in a rat model of parkinsonism
    • Breysse N. Baunez C. Spooren W. Gasparini F. Amalric M. 2002 Chronic but not acute treatment with a metabotropic glutamate 5 receptor antagonist reverses the akinetic deficits in a rat model of parkinsonism JNeurosci 22 5669 5678
    • (2002) JNeurosci , vol.22 , pp. 5669-5678
    • Breysse, N.1    Baunez, C.2    Spooren, W.3    Gasparini, F.4    Amalric, M.5
  • 10
    • 3242765264 scopus 로고    scopus 로고
    • 5 receptors increase their efficacy in reversing Parkinsonian deficits in rats
    • 5 receptors increase their efficacy in reversing Parkinsonian deficits in rats Neuropsychopharm 29 1451 1461
    • (2004) Neuropsychopharm , vol.29 , pp. 1451-1461
    • Coccurello, R.1    Breysse, N.2    Amalric, M.3
  • 11
    • 0030995878 scopus 로고    scopus 로고
    • Pharmacology and functions of metabotropic glutamate receptors
    • Conn PJ. Pin J-P. 1997 Pharmacology and functions of metabotropic glutamate receptors AnnRevPharmacolToxicol 37 205 237
    • (1997) AnnRevPharmacolToxicol , vol.37 , pp. 205-237
    • Conn, P.J.1    Pin, J.-P.2
  • 13
    • 0026005169 scopus 로고
    • M-methyl-D-aspartate antagonists in the treatment of Parkinson's disease
    • Greenamyre JT. O'Brien CF. 1991 M-methyl-D-aspartate antagonists in the treatment of Parkinson's disease ArchNeurol 48 977 981
    • (1991) ArchNeurol , vol.48 , pp. 977-981
    • Greenamyre, J.T.1    O'Brien, C.F.2
  • 14
    • 0030009705 scopus 로고    scopus 로고
    • Increased subthalamic neuronal activity after nigral dopaminergic lesion independent of disinhibition via the globus pallidus
    • Hassani OK. Mouroux M. Feger J. 1996 Increased subthalamic neuronal activity after nigral dopaminergic lesion independent of disinhibition via the globus pallidus Neuroscience 72 105 115
    • (1996) Neuroscience , vol.72 , pp. 105-115
    • Hassani, O.K.1    Mouroux, M.2    Feger, J.3
  • 15
    • 0031660613 scopus 로고    scopus 로고
    • Targeting the subthalamic nucleus in the treatment of parkinson's disease
    • Henderson JM. Dunnett SB. 1998 Targeting the subthalamic nucleus in the treatment of parkinson's disease Brain ResBull 46 467 474
    • (1998) Brain ResBull , vol.46 , pp. 467-474
    • Henderson, J.M.1    Dunnett, S.B.2
  • 16
    • 0035869454 scopus 로고    scopus 로고
    • Differential subcellular localization of mGluR1a and mGluR5 in the rat and monkey substantia nigra
    • Hubert GW. Paquet M. Smith Y. 2001 Differential subcellular localization of mGluR1a and mGluR5 in the rat and monkey substantia nigra JNeurosci 21 1838 1847
    • (2001) JNeurosci , vol.21 , pp. 1838-1847
    • Hubert, G.W.1    Paquet, M.2    Smith, Y.3
  • 17
    • 0032876499 scopus 로고    scopus 로고
    • Akinesia and postural abnormality after unilateral dopamine depletion
    • q2
    • Johnston RE. Schallert T. Becker JB. 1999 Akinesia and postural abnormality after unilateral dopamine depletion BehavBrRes 104 189 196 q2
    • (1999) BehavBrRes , vol.104 , pp. 189-196
    • Johnston, R.E.1    Schallert, T.2    Becker, J.B.3
  • 18
    • 0026536547 scopus 로고
    • Leksell's posteroventral pallidotomy in the treatment of Parkinson's disease
    • Laitinen LV. Bergenheim AT. Hariz MI. 1992 Leksell's posteroventral pallidotomy in the treatment of Parkinson's disease JNeurosurg 76 53 61
    • (1992) JNeurosurg , vol.76 , pp. 53-61
    • Laitinen, L.V.1    Bergenheim, A.T.2    Hariz, M.I.3
  • 19
    • 0034667626 scopus 로고    scopus 로고
    • High frequency synchronization of neuronal activity in the subthalamic nucleus of parkinsonian patients with limb tremor
    • Levy R. Hutchison WD. Lozano AM. Dostrovsky JO. 2000 High frequency synchronization of neuronal activity in the subthalamic nucleus of parkinsonian patients with limb tremor JNeurosci 20 7766 7775
    • (2000) JNeurosci , vol.20 , pp. 7766-7775
    • Levy, R.1    Hutchison, W.D.2    Lozano, A.M.3    Dostrovsky, J.O.4
  • 21
    • 1242341372 scopus 로고    scopus 로고
    • Activation of group III metabotropic glutamate receptors in selected regions of the basal ganglia alleviates akinesia in the reserpine-treated rat
    • MacInnes N. Messenger MJ. Duty S. 2004 Activation of group III metabotropic glutamate receptors in selected regions of the basal ganglia alleviates akinesia in the reserpine-treated rat BrJPharmacol 141 15 22
    • (2004) BrJPharmacol , vol.141 , pp. 15-22
    • MacInnes, N.1    Messenger, M.J.2    Duty, S.3
  • 23
    • 0036389444 scopus 로고    scopus 로고
    • Localization and physiological roles of metabotropic glutamate receptors in the direct and indirect pathways of the basal ganglia
    • Marino MJ. Awad H. Poisik O. Wittmann M. Conn PJ. 2002b Localization and physiological roles of metabotropic glutamate receptors in the direct and indirect pathways of the basal ganglia Amino Acids 23 185 191
    • (2002) Amino Acids , vol.23 , pp. 185-191
    • Marino, M.J.1    Awad, H.2    Poisik, O.3    Wittmann, M.4    Conn, P.J.5
  • 24
    • 0036669760 scopus 로고    scopus 로고
    • Haloperidol-induced alteration in the physiological actions of group I mGluRs in the subthalamic nucleus and the substantia nigra pars reticulate
    • Marino MJ. Awad-Granko H. Ciombor KJ. Conn PJ. 2002a Haloperidol-induced alteration in the physiological actions of group I mGluRs in the subthalamic nucleus and the substantia nigra pars reticulate Neuropharmacol 43 147 159
    • (2002) Neuropharmacol , vol.43 , pp. 147-159
    • Marino, M.J.1    Awad-Granko, H.2    Ciombor, K.J.3    Conn, P.J.4
  • 26
    • 0035884943 scopus 로고    scopus 로고
    • Activation of Group I metabotropic glutamate receptors produces a direct excitation and disinhibition of GABAergic projection neurons in the substantia nigra pars reticulate
    • Marino MJ. Wittman M. Bradley SR. Hubert GW. Smith Y. Conn PJ. 2001 Activation of Group I metabotropic glutamate receptors produces a direct excitation and disinhibition of GABAergic projection neurons in the substantia nigra pars reticulate JNeurosci 21 7001 7012
    • (2001) JNeurosci , vol.21 , pp. 7001-7012
    • Marino, M.J.1    Wittman, M.2    Bradley, S.R.3    Hubert, G.W.4    Smith, Y.5    Conn, P.J.6
  • 27
    • 0037363728 scopus 로고    scopus 로고
    • Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP
    • Mathiesen JM. Svendsen N. Brauner-Osborne H. Thomsen C. Ramirez MT. 2003 Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP BrJPharmacol 138 1026 1030
    • (2003) BrJPharmacol , vol.138 , pp. 1026-1030
    • Mathiesen, J.M.1    Svendsen, N.2    Brauner-Osborne, H.3    Thomsen, C.4    Ramirez, M.T.5
  • 28
    • 0036669625 scopus 로고    scopus 로고
    • Changes in metabotropic glutamate receptor 1-8 gene expression in the rodent basal ganglia motor loop following lesion of the nigrostriatal tract
    • Messenger MJ. Dawson LG. Duty S. 2002 Changes in metabotropic glutamate receptor 1-8 gene expression in the rodent basal ganglia motor loop following lesion of the nigrostriatal tract Neuropharmacol 43 261 271
    • (2002) Neuropharmacol , vol.43 , pp. 261-271
    • Messenger, M.J.1    Dawson, L.G.2    Duty, S.3
  • 29
    • 0033000841 scopus 로고    scopus 로고
    • Orphanin FF/nociceptin modulation of mesolimbic dopamine transmission determined by microdialysis
    • Murphy NP. Maidment NT. 1999 Orphanin FF/nociceptin modulation of mesolimbic dopamine transmission determined by microdialysis JNeurochem 73 179 186
    • (1999) JNeurochem , vol.73 , pp. 179-186
    • Murphy, N.P.1    Maidment, N.T.2
  • 30
    • 0034868541 scopus 로고    scopus 로고
    • Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rat
    • Ossowska K. Konieczny J. Wolfarth S. Wieronska J. Pilc A. 2001 Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rat Neuropharmacol 41 413 420
    • (2001) Neuropharmacol , vol.41 , pp. 413-420
    • Ossowska, K.1    Konieczny, J.2    Wolfarth, S.3    Wieronska, J.4    Pilc, A.5
  • 32
    • 0028174502 scopus 로고
    • Antiparkinsonian action of MK-801 on the reserpine-induced rigidity: A mechanomyographic analysis
    • Ossowska K. Lorenc-Koci E. Wolfarth S. 1994 Antiparkinsonian action of MK-801 on the reserpine-induced rigidity: a mechanomyographic analysis JNeural TransmParkDisDementSect 7 143 152
    • (1994) JNeural TransmParkDisDementSect , vol.7 , pp. 143-152
    • Ossowska, K.1    Lorenc-Koci, E.2    Wolfarth, S.3
  • 34
    • 0032967965 scopus 로고    scopus 로고
    • Reaction time performance following unilateral striatal dopamine depletion and lesions of the subthalamic nucleus in the rat
    • Phillips JM. Brown VJ. 1999 Reaction time performance following unilateral striatal dopamine depletion and lesions of the subthalamic nucleus in the rat EurJNeurosci 11 1003 1010
    • (1999) EurJNeurosci , vol.11 , pp. 1003-1010
    • Phillips, J.M.1    Brown, V.J.2
  • 35
    • 33644949768 scopus 로고    scopus 로고
    • The subthalamic nucleus (STN) mediates the anti-Parkinsonian effect of MPEP in an animal model of Parkinson's disease
    • Phillips JM. Maidment NT. 2002 The subthalamic nucleus (STN) mediates the anti-Parkinsonian effect of MPEP in an animal model of Parkinson's disease SocNeurosciAbstr 885.7q3
    • (2002) SocNeurosciAbstr
    • Phillips, J.M.1    Maidment, N.T.2
  • 38
    • 0034451725 scopus 로고    scopus 로고
    • Distribution and roles of metabotropic glutamate receptors in the basal ganglia motor circuit: Implications for treatment of Parkinson's disease and related disorders
    • Rouse ST. Marino MJ. Bradley SR. Awad H. Wittman M. Conn JP. 2000 Distribution and roles of metabotropic glutamate receptors in the basal ganglia motor circuit: implications for treatment of Parkinson's disease and related disorders PharmacolTherapeut 88 427 435
    • (2000) PharmacolTherapeut , vol.88 , pp. 427-435
    • Rouse, S.T.1    Marino, M.J.2    Bradley, S.R.3    Awad, H.4    Wittman, M.5    Conn, J.P.6
  • 39
    • 0033950675 scopus 로고    scopus 로고
    • CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
    • Schallert T. Fleming SM. Leasure JL. Tillerson JL. Bland ST. 2000 CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury Neuropharmacol 39 777 787
    • (2000) Neuropharmacol , vol.39 , pp. 777-787
    • Schallert, T.1    Fleming, S.M.2    Leasure, J.L.3    Tillerson, J.L.4    Bland, S.T.5
  • 40
    • 0000431473 scopus 로고    scopus 로고
    • Intervention strategies for degeneration of dopamine neurons in Parkinsonism
    • . In *Emerich D.F.*Dean R.L.*Sanberg P.R.*Totowa N.J. (Eds). Humana Press New York, USA , pp.
    • Schallert T. Tillerson JL. 1999 Intervention strategies for degeneration of dopamine neurons in Parkinsonism. In Emerich DF. Dean RL. Sanberg PR. Totowa NJ. (Eds) Central Nervous System Diseases Humana Press New York, USA, pp. 131 151
    • (1999) Central Nervous System Diseases , pp. 131-151
    • Schallert, T.1    Tillerson, J.L.2
  • 41
    • 0032834028 scopus 로고    scopus 로고
    • Pharmacological agents acting at subtypes of metabotropic glutamate receptors
    • Schoepp DD. Jane DE. Monn AJ. 1999 Pharmacological agents acting at subtypes of metabotropic glutamate receptors Neuropharmacol 38 1431 1476
    • (1999) Neuropharmacol , vol.38 , pp. 1431-1476
    • Schoepp, D.D.1    Jane, D.E.2    Monn, A.J.3
  • 42
    • 0042868860 scopus 로고    scopus 로고
    • Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: Behavioural characterization and implications for the treatment of CNS disorders
    • Spooren W. Ballard T. Gasparini F. Amalric M. Mutel V. Schreiber R. 2003 Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: behavioural characterization and implications for the treatment of CNS disorders BehavPharmacol 14 257 277
    • (2003) BehavPharmacol , vol.14 , pp. 257-277
    • Spooren, W.1    Ballard, T.2    Gasparini, F.3    Amalric, M.4    Mutel, V.5    Schreiber, R.6
  • 43
    • 0034693328 scopus 로고    scopus 로고
    • Effects of the prototypical mGlu5 receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats
    • Spooren WPJM. Gasparini F. Bergmann R. Kuhn R. 2000 Effects of the prototypical mGlu5 receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats EurJPharmacol 406 403 410
    • (2000) EurJPharmacol , vol.406 , pp. 403-410
    • Spooren, W.P.J.M.1    Gasparini, F.2    Bergmann, R.3    Kuhn, R.4
  • 44
    • 0028987683 scopus 로고
    • Glutamate/dopamine D1/D2 balance in the basal ganglia and its relevance to Parkinson's disease
    • Starr MS. 1995 Glutamate/dopamine D1/D2 balance in the basal ganglia and its relevance to Parkinson's disease Synapse 19 264 293
    • (1995) Synapse , vol.19 , pp. 264-293
    • Starr, M.S.1
  • 45
    • 0028270378 scopus 로고
    • Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat
    • Testa CM. Standaert DG. Young AB. Penney JB. 1994 Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat JNeurosci 14 3005 3018
    • (1994) JNeurosci , vol.14 , pp. 3005-3018
    • Testa, C.M.1    Standaert, D.G.2    Young, A.B.3    Penney, J.B.4
  • 46
    • 19444377720 scopus 로고    scopus 로고
    • Group III metabotropic-glutamate-receptor-mediated modulation of excitatory transmission in rodent substantia nigra pars compacta dopamine neurons
    • Valenti O. Mannaioni G. Seabrook GR. Conn J. Marino MJ. 2005 Group III metabotropic-glutamate-receptor-mediated modulation of excitatory transmission in rodent substantia nigra pars compacta dopamine neurons JPharmacolExpTher 313 1296 1304
    • (2005) JPharmacolExpTher , vol.313 , pp. 1296-1304
    • Valenti, O.1    Mannaioni, G.2    Seabrook, G.R.3    Conn, J.4    Marino, M.J.5
  • 48
    • 0001829399 scopus 로고    scopus 로고
    • Physiology of the basal ganglia and pathophysiology of movement disorders of basal ganglia origin
    • . In *Watts R.L. McGraw-Hill (Ed.)
    • Wichmann T. DeLong MR. 1997 Physiology of the basal ganglia and pathophysiology of movement disorders of basal ganglia origin. In Watts RL. (Ed.) Movement Disorders: Neurological Principles and Practice McGraw-Hill
    • (1997) Movement Disorders: Neurological Principles and Practice
    • Wichmann, T.1    Delong, M.R.2
  • 49
    • 0036076705 scopus 로고    scopus 로고
    • Dopamine modulates the function of group II and group III metabotropic glutamate receptors in the substantia nigra pars reticulata
    • Wittmann M. Marino MJ. Conn PJ. 2002 Dopamine modulates the function of group II and group III metabotropic glutamate receptors in the substantia nigra pars reticulata JPharmacolExpTher 302 433 441
    • (2002) JPharmacolExpTher , vol.302 , pp. 433-441
    • Wittmann, M.1    Marino, M.J.2    Conn, P.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.