Mutational analysis of K-ras segregates ovarian serous carcinomas into two types: Invasive MPSC (low-grade tumor) and conventional serous carcinoma (high-grade tumor)

International Journal of Gynecological Pathology

Volumn 22, Issue 1, 2003, Pages 37-41

  Singer, Gad ^a   Shih, Ie Ming ^a   Truskinovsky, Alexander ^a   Umudum, Haldun ^a,b   Kurman, Robert J ^a,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Hava Hastanesi Patoloji Lab   (Turkey)

^c DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Genetics; K ras; Morphology; Ovary; Serous carcinoma

Indexed keywords

ARTICLE; CANCER CLASSIFICATION; CANCER CYTODIAGNOSIS; CANCER GRADING; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; EPITHELIUM CELL; GENE MUTATION; GENE SEGREGATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MICROPAPILLARY SEROUS CARCINOMA; MOLECULAR BIOLOGY; ONCOGENE K RAS; OVARY CARCINOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEROUS CARCINOMA; WILD TYPE;

CYSTADENOCARCINOMA, SEROUS; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; GENES, RAS; HUMANS; MUTATION; OVARIAN NEOPLASMS; RETROSPECTIVE STUDIES;

EID: 0037216291     PISSN: 02771691     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004347-200301000-00009     Document Type: Article

References (7)

1. Burks RT, Sherman ME, Kurman RJ. Micropapillary serous carcinoma of the ovary. A distinctive low-grade carcinoma related to serous borderline tumors. Am J Surg Pathol 1996;20:1319-30.
2. Seidman JD, Kurman RJ. Subclassification of serous borderline tumors of the ovary into benign and malignant types. A clinico-pathologic study of 65 advanced stage cases. Am J Surg Pathol 1996;20:1331-45.
3. Bell KA, Smith Sehdev AE, Kurman RJ. Refined diagnostic criteria for implants associated with ovarian atypical proliferative serous tumors (borderline) and micropapillary serous carcinomas. Am J Surg Pathol 2001;25:419-32.
4. Bell DA, Scully RE. Early de novo ovarian carcinoma. A study of fourteen cases. Cancer 1994;73:1859-64.
5. Singer G, Kurman RJ, Chang H-W, Cho SKR, Shih I-M. Diverse tumorigenic pathways in ovarian serous carcinoma. Am J Pathol 2002;160:1223-8.
6. Vogelstein B, Kinzler KW. Digital PCR. Proc Natl Acad Sci USA 1999;96:9236-41.
7. Shih IM, Yan H, Speyrer D, Shmookler BM, Sugarbaker PH, Ronnett BM. Molecular genetic analysis of appendiceal mucinous adenomas in identical twins, including one with pseudomyxoma peritonei. Am J Surg Pathol 2001;25:1095-9.