Histologic and immunohistochemical characteristics of neoplastic and nonneoplastic subgroups of atypical squamous lesions of the uterine cervix

American Journal of Clinical Pathology

Volumn 123, Issue 5, 2005, Pages 699-706

  Aoyama, Chisa ^a,b   Liu, Paul ^a,b   Ostrzega, Nora ^a,b   Holschneider, Christine H ^a,b  

^a OLIVE VIEW UCLA MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Atypical squamous lesions; High grade squamous intraepithelial lesion; HSIL; Ki 67; p16; Uterine cervix

Indexed keywords

KI 67 ANTIGEN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DIAGNOSTIC VALUE; EVALUATION; FEMALE; FOLLOW UP; GROWTH PERIOD; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; MITOSIS; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; UTERINE CERVIX BIOPSY; UTERINE CERVIX CANCER;

EID: 17844374351     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/FB900YXTF7D2HE99     Document Type: Article

References (33)

1. Geng L, Connolly DC, Isacson C, et al. Atypical immature metaplasia (AIM) of the cervix: is it related to high-grade SIL (HSIL)? Hum Pathol. 1999;30:345-351.
2. Kruse AJ, Baak JP, Helliesen T, et al. Evaluation of MIB-1-positive cell clusters as a diagnostic marker for cervical intraepithelial neoplasia. Am J Surg Pathol. 2002;26:1501-1507.
3. McCluggage WG, Buhidma M, Tang L, et al. Monoclonal antibody MIB1 in the assessment of cervical squamous intraepithelial lesions. Int J Gynecol Pathol. 1996;15:131-136.
4. Weir MM, Bell DA, Young RH. Transitional cell metaplasia of the uterine cervix and vagina: an underrecognized lesion that may be confused with high-grade dysplasia. Am J Surg Pathol. 1997;21:510-517.
5. Park J-J, Genest DR, Sun D, et al. Atypical immature metaplastic-like proliferations of the cervix: diagnostic reproducibility and viral (HPV) correlates. Hum Pathol. 1999;30:1161-1165.
6. Ng WK, Cheung LK, Li AS, et al. Transitional cell metaplasia of the uterine cervix is related to human papillomavirus: molecular analysis in seven patients with cytohistologic correlation. Cancer. 2002;96:250-258.
7. Arends MJ, Buckley CH, Wells M. Aetiology, pathogenesis, and pathology of cervical neoplasia. J Clin Pathol. 1998;51:96-103.
8. Jovanovic AS, McLachlin CM, Shen L, et al. Postmenopausal squamous atypia: a spectrum including "pseudo-koilocytosis." Mod Pathol. 1995;8:408-412.
9. von Knebel Doeberitz M. New markers for cervical dysplasia to visualise the genomic chaos created by aberrant oncogenic papillomavirus infections. Eur J Cancer. 2002;38:2229-2242.
10. Sano T, Masuda N, Oyama T, et al. Overexpression of p16 and p14ARF is associated with HPV infection in cervical squamous cell carcinoma and dysplasia. Pathol Int. 2002;52:375-383.
11. Saqi A, Pasha TL, McGrath CM, et al. Overexpression of p16INK4A in liquid-based specimens as marker of cervical dysplasia and neoplasia. Diagn Cytopathol. 2002;27;365-370.
12. von Knebel Doeberitz M. New molecular tools for efficient screening of cervical cancer. Dis Markers. 2001;17:123-128.
13. Keating JT, Cviko A, Riethdorf S, et al. Ki-67, cyclin E, and p16INK4A are complementary surrogate biomarkers for HPV-related cervical neoplasia. Am J Surg Pathol. 2001;25:884-891.
14. Keating JT, Ince T, Crum CP. Surrogate biomarkers of HPV infection in cervical neoplasia screening and diagnosis. Adv Anat Pathol. 2001;8:83-92.
15. Klaes R, Friedrich T, Spitkovsky D, et al. Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer. 2001;92:276-284.
16. Pirog EC, Baergen RN, Soslow RA, et al. Diagnostic accuracy of cervical low-grade squamous intraepithelial lesions is improved with MIB-1 immunostaining. Am J Surg Pathol. 2002;26:70-75.
17. Zeng Z, Del PG, Cohen JM, et al. MIB-1 expression in cervical Papanicolaou tests correlates with dysplasia in subsequent cervical biopsies. Appl Immunohistochem Mol Morphol. 2002;10:15-19.
18. Lee JS, Kim HS, Jung JJ, et al. Angiogenesis, cell proliferation and apoptosis in progression of cervical neoplasia. Anal Quant Cytol Histol. 2002;24:103-113.
19. Bulten J, de Wilde PC, Schijf C, et al. Decreased expression of Ki-67 in atrophic cervical epithelium of post-menopausal women. J Pathol. 2000;190:545-553.
20. Kruse AJ, Baak JP, de Bruin PC, et al. Relationship between the presence of oncogenic HPV DNA assessed by PCR and Ki-67 immunoquantitative features in CIN. J Pathol. 2001;195:557-562.
21. Maeda MY, Simoes M, Wakamatsu A, et al. Relevance of the rates of PCNA, Ki-67 and p53 expression according to the epithelial compartment in cervical lesions. Pathologica. 2001;93:189-195.
22. Kruse AJ, Baak JP, de Bruin PC, et al. Ki-67 immunoquantitation in CIN: a sensitive marker for grading. J Pathol. 2001;193:48-54.
23. Kruse AJ, Baak JP, Janssen EA, et al. Low- and high-risk CIN 1 and 2 lesions: prospective predictive value of grade, HPV, and Ki-67 immuno-quantitative variables. J Pathol. 2003;199:462-470.
24. Bulten J, de Wilde PC, Boonstra H, et al. Proliferation in "atypical" atrophic Pap smears. Gynecol Oncol. 2000;79:225-229.
25. Mittal K, Mesia A, Demopoulos RI. MIB-1 expression is useful in distinguishing dysplasia from atrophy in elderly women. Int J Gynecol Pathol. 1999;18:122-124.
26. Ejersbo D, Jensen HA, Holund B. Efficacy of Ki-67 antigen staining in Pap smears in post-menopausal women with atypia. Cytopathology. 1999;10:369-374.
27. Mittal K. Utility of proliferation-associated marker MIB-1 in evaluating lesions of the uterine cervix. Adv Anat Pathol. 1999;6:177-185.
28. Bulten J, van der Laak JA, Gemmink JH, et al. MIB1, a promising marker for the classification of cervical intraepithelial neoplasia. J Pathol. 1996;178:268-273.
29. Wright TC, Kurman RJ, Ferenczy A. Precancerous lesions of the cervix. In: Kurman RJ, ed. Blaustein's Pathology of the Female Genital Tract. 5th ed. New York, NY: Springer; 2002:253-272.
30. Duggan MA. Cytologic and histologic diagnosis and significance of controversial squamous lesions of the uterine cervix. Mod Pathol. 2000;13:252-260.
31. Grenko RT, Abendroth CS, Frauenhoffer EE, et al. Variance in the interpretation of cervical biopsy specimens obtained for atypical squamous cells of undetermined significance. Am J Clin Pathol. 2000;114:735-740.
32. Felix JC, Wright TC. Cervix. In: Weidner N, Cote RJ, Suster S, et al, eds. Modern Surgical Pathology. Philadelphia, PA: Saunders; 2003:1299-1305.
33. Sano T, Oyama T, Kashiwabara K, et al. Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol. 1998;153:1741-1748.