P16INK4a expression and progression risk of low-grade intraepithelial neoplasia of the cervix uteri

Virchows Archiv

Volumn 445, Issue 6, 2004, Pages 616-620

  Negri, Giovanni ^a   Vittadello, Fabio ^a   Romano, Fabio ^a   Kasal, Armin ^a   Rivasi, Francesco ^b   Girlando, Salvatore ^c   Mian, Christine ^a   Egarter Vigl, Eduard ^a  

^a CENTRAL HOSPITAL OF BOLZANO   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c SANTA CHIARA HOSPITAL   (Italy)

Author keywords

Cervical intraepithelial neoplasia; Human papilloma virus; Immunohistochemistry; p16; Progression; Regression

Indexed keywords

BIOLOGICAL MARKER; PROTEIN P16INK4A;

ARTICLE; CANCER CYTODIAGNOSIS; CANCER GRADING; CANCER GROWTH; CANCER REGRESSION; CANCER RISK; CONTROLLED STUDY; DISEASE MARKER; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RISK ASSESSMENT; SCORING SYSTEM; STAINING; UTERINE CERVIX CARCINOMA IN SITU; DISEASE COURSE; PATHOLOGY; UTERINE CERVIX TUMOR;

CERVICAL INTRAEPITHELIAL NEOPLASIA; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE PROGRESSION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; UTERINE CERVICAL NEOPLASMS;

EID: 12144254382     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-004-1127-9     Document Type: Article

References (25)

1. INK4a expression correlates with degree of cervical neoplasia: a comparison with Ki-67 expression and detection of high-risk HPV types. Mod Pathol 16:665-673
2. Chan JK, Monk BJ, Brewer C Keefe KA, Osann K, McMeekin S, Rose GS, Youssef M, Wilczynski SP, Meyskens FL, Berman ML (2003) HPV infection and number of lifetime sexual partners are strong predictors for "natural" regression of CIN2 and 3. Br J Cancer 15:1062-1066
3. Dalstein V, Riethmuller D, Pretet JL Le Bail Carval K, Sautiere JL, Carbillet JP, Kantelip B, Schaal JP, Mougin C (2003) Persistence and load of high-risk HPV are predictors for development of cervical lesions: a longitudinal French cohort study. Int J Cancer 106:396-403
4. El Hamidi A, Kocjan G, Du M-Q (2003) Clonality analysis of archival cervical smears. Correlation of monoclonality with grade and clinical behaviour of cervical intraepithelial neoplasia. Acta Cytol 47:117-123
5. Gallo G, Bibbo M, Bagella L Zamparelli A, Sanseverino F, Giovagnoli MR, Vecchione A, Giordano A (2003) Study of viral integration of HPV-16 in young patients with LSIL. J Clin Pathol 56:532-536
6. Giarre M, Caldeira S, Malanchi I Ciccolini F, Leao MJ, Tommasino M (2001) Induction of pRb degradation by the human papillomavirus type 16 E7 protein is essential to efficiently overcome p16INK4a-imposed G1 cell cycle arrest. J Virol 75:4705-4712
7. Ho GYF, Bierman R, Beardsley L, Chang CJ, Burk RD (1998) Natural history of cervicovaginal papillomavirus infection in young women. N Engl J Med 338:423-428
8. Huang LW, Chao SL, Chen TJ (2003) Reduced Fhit expression in cervical carcinoma: correlation with tumor progression and poor prognosis. Gynecol Oncol 90:331-337
9. Kjaer SK, van den Brule AJ, Paull G Svare EI, Sherman ME, Thomsen BL, Suntum M, Bock JE, Poll PA, Meijer CJ (2002) Type specific persistence of high risk human papillomavirus (HPV) as indicator of high grade cervical squamous intraepithelial lesions in young women: population based prospective follow up study. BMJ 325:572
10. Klaes R, Woerner SM, Ridder R Wentzensen N, Duerst M, Schneider A, Lotz B, Melsheimer P, von Knebel Doeberitz M (1999) Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes. Cancer Res 59:6132-6136
11. Klaes R, Friedrich T, Spitkowsky D, Ridder R, Rudy W, Petry U, Dallenbach-Hellweg G, Schmidt D, von Knebel Doeberitz M (2001) Overexpression of p16INK4a as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer 92:276-284
12. Klaes R, Benner A, Friedrich T, Ridder R, Herrington S, Jenkins D, Kurman RJ, Schmidt D, Stoler M, von Knebel Doeberitz M (2002) p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol 26:1389-1399
13. Kruse AJ, Baak JP, Janssen EA Bol MG, Kjellevold KH, Fianne B, Lovslett K, Bergh J (2003) Low- and high-risk CIN 1 and 2 lesions: prospective predictive value of grade, HPV, and Ki-67 immuno-quantitative variables. J Pathol 199:462-470
14. INK4a is a useful marker for the diagnosis of adenocarcinoma of the cervix uteri and its precursors. An immunohistochemical study with immunocytochemical correlations. Am J Surg Pathol 27:187-193
15. Ostor AG (1993) Natural history of cervical intraepithelial neoplasia: a critical review. Int J Gynecol Pathol 12:186-192
16. Ozalp SS, Yalcin OT, Tanir HM Dundar E, Yildirim S (2002) Bcl-2 expression in preinvasive and invasive cervical lesions. Eur J Gynaecol Oncol 23:419-422
17. Sano T, Oyama T, Kashiwabara K, Fukuda T, Nakajima T (1998) Expression status of p16 protein is associated with human papilloma virus oncogenic potential in cervical and genital lesions. Am J Pathol 153:1741-1748
18. Sano T, Oyama T, Kashiwabara K, Fukuda T, Nakajima T (1998) Immunohistochemical overexpression of p16 protein associated with intact retinoblastoma protein expression in cervical cancer and cervical intraepithelial neoplasia. Pathol Int 48:580-585
19. Schlecht NF, Platt RW, Duarte-Franco E Costa MC, Sobrinho JP, Prado JC, Ferenczy A, Rohan TE, Villa LL, Franco EL (2003) Human papillomavirus infection and time to progression and regression of cervical intraepithelial neoplasia. J Natl Cancer Inst 95:1336-1343
20. Schneider V (2003) CIN prognostication: will molecular techniques do the trick? Acta Cytol 47:115-116
21. The Atypical Squamous Cells of Undetermined Significance/ Low-Grade Squamous Intraepithelial Lesions Triage Study (ALTS) Group (2000) Human papillomavirus testing for triage of women with cytologic evidence of low-grade squamous intraepithelial lesions: baseline data from a randomized trial. J Natl Cancer Inst 92:397-402
22. Tringler B, Gup CJ, Singh M, Groshong S, Shroyer AL, Heinz DE, Shroyer KR (2004) Evaluation of p16INK4a and pRb expression in cervical squamous and glandular neoplasia. Hum Pathol 35:689-696
23. Ueda J, Enomoto T, Miyatake T Ozaki K, Yoshizaki T, Kanao H, Ueno Y, Nakashima R, Shroyer KR, Murata Y (2003) Monoclonal expansion with integration of high-risk human papillomavirus is an initial step for cervical carcinogenesis: association of clonal status and human papillomavirus infection with clinical outcome in cervical intraepithelial neoplasia. Lab Invest 83:1517-1527
24. von Knebel Doeberitz M (2002) New markers for cervical dysplasia to visualise the genomic chaos created by aberrant oncogenic papillomavirus infections. Eur J Cancer 38:2229-2242
25. Wollscheid V, Kuhne-Heid R, Stein I Jansen L, Kollner S, Schneider A, Durst M (2002) Identification of a new proliferation-associated protein NET-1C4.8 characteristic for a subset of high-grade cervical intraepithelial neoplasia and cervical carcinomas. Int J Cancer 99:771-775