Meloxicam inhibits osteosarcoma growth, invasiveness and metastasis by COX-2-dependent and independent routes

Carcinogenesis

Volumn 27, Issue 3, 2006, Pages 584-592

  Naruse, Takahiro ^a   Nishida, Yoshihiro ^a   Hosono, Kozo ^a   Ishiguro, Naoki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CYCLOOXYGENASE 2; MATRIGEL; MELOXICAM; MESSENGER RNA; PROSTAGLANDIN E2; PROTEIN BAX; PROTEIN BCL 2; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOASSAY; CANCER GROWTH; CANCER INVASION; CELL CULTURE; CELL PROLIFERATION; CELL STRAIN; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME IMMUNOASSAY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LUNG METASTASIS; METASTASIS POTENTIAL; MOUSE; NICK END LABELING; NONHUMAN; OSTEOSARCOMA; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; BONE NEOPLASMS; CELL PROLIFERATION; CELL SURVIVAL; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; GENE EXPRESSION PROFILING; HUMANS; OSTEOSARCOMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THIAZINES; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 33644905567     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgi240     Document Type: Article

References (34)

1. Smith,W.L., DeWitt,D.L. and Garavito,R.M. (2000) Cyclooxygenases: structural, cellular, and molecular biology. Annu. Rev. Biochem., 69, 145-182.
2. Williams,C.S., Mann,M. and DuBois,R.N. (1999) The role of cyclooxygenases in inflammation, cancer, and development. Oncogene, 18, 7908-7916.
3. Eberhart,C.E., Coffey,R.J., Radhika,A., Giardiello,F.M., Ferrenbach,S. and DuBois,R.N. (1994) Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology, 107, 1183-1188.
4. Gupta,S., Srivastava,M., Ahmad,N., Bostwick,D.G. and Mukhtar,H. (2000) Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma. The Prostate, 42, 73-78.
5. Hwang,D., Scollard,D., Byrne,J. and Levine,E. (1998) Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. J. Natl Cancer Inst., 90, 455-460.
6. Watkins,D.N., Lenzo,J.C., Segal,A., Garlepp,M.J. and Thompson,P.J. (1999) Expression and localization of cyclo-oxygenase isoforms in non-small cell lung cancer. Eur. Respir. J., 14, 412-418.
7. Sheng,H., Shao,J., Kirkland,S.C., Isakson,P., Coffey,R.J., Morrow,J., Beauchamp,R.D. and DuBois,R.N. (1997) Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J. Clin. Investig., 99, 2254-2259.
8. Yao,M., Kargman,S., Lam,E.C., Kelly,C.R., Zheng,Y., Luk,P., Kwong,E., Evans,J.F. and Wolfe,M.M. (2003) Inhibition of cyclooxygenase-2 by rofecoxib attenuates the growth and metastatic potential of colorectal carcinoma in mice. Cancer Res., 63, 586-592.
9. Liu,C.H., Chang,S.H., Narko,K., Trifan,O., Wu,M.T., Smith,E., Haudenschild,C., Lane,T.F. and Hla,T. (2001) Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. J. Biol. Chem., 276, 18563-18569.
10. Thun,M.J., Henley,S.J. and Patrono,C. (2002) Nonsteroidal antiinflammatory drugs as anticancer agents: Mechanics, pharmacologic, and clonical issues. J. Natl Cancer Inst., 94, 252-266.
11. Fosslien,E. (2000) Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia. Crit. Rev. Clin. Lab. Sci., 37, 431-502.
12. Link,M.P., Goorin,A.M., Miser,A.W., Green,A.A., Pratt,C.B., Belasco,J.B., Pritchard,J., Malpas, J.S., Baker,A.R. and Kirkpatrick,J.A. (1986) The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. N. Engl. J. Med., 19, 1600-1606.
13. Goldman,A.P., Williams,C.S., Sheng,H., Lamps,L.W., Williams,V.P., Pairet,M., Morrow,J.D. and DuBois,R.N. (1998) Meloxicam inhibits the growth of colorectal cancer cells. Carcinogenesis, 19, 2195-2199.
14. Tsubouchi,Y., Mukai,S., Kawahito,Y., Yamada,R., Kohno,M., Inoue,K. and Sano,H. (2000) Meloxicam inhibits the growth of non-small cell lung cancer. Anticancer Res., 20, 2867-2872.
15. Dickens,D.S., Kozielski,P., Khan,J., Forus,A. and Cripe,T.P. (2002) Cyclooxygenase-2 expression in pediatric sarcomas. Pediatr. Dev. Pathol., 5, 356-364.
16. Dickens,D.S., Kozielski,R., Leavey,P.J., Timmons,C. and Cripe,T,P. (2003) Cyclooxygenase-2 expression does not correlate with outcome in osteosarcoma or rhabdomyosarcoma. J. Pediatr. Hematol. Oncol., 25, 282-285.
17. Asai,T., Ueda,T., Itoh,K., Yoshikawa,K., Aoki,Y., Mori,S. and Yoshikawa,H. (1998) Establishment and characterization of a murine osteosarcoma cell line (LM8) with high metastatic potential to the lung. Int. J. Cancer, 76, 418-422.
18. Maier,T.J., Schilling,K., Schmidt,R. and Geisslinger,G., Grosch,S. (2004) Cyclooxygenase-2 (COX-2)-dependent and -independent anticarcinogenic effects of celecoxib in human colon carcinoma cells. Biochem. Phamacol., 67, 1469-1478.
19. Hsu,A.L., Ching,T.T., Wang,D.S., Song,X., Rangnekar,V.M. and Chen,C.S. (2000) The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. J. Biol. Chem., 275, 11397-11403.
20. 2 pathway in human cholangiocarcinoma cell lines. World J. Gastroenterol., 9, 1302-1306.
21. Dohadwala,M., Barta,R.K., Luo,J., Lin,Y., Krysan,K., Pold,M., Sharma,S. and Dubinett,S.M. (2002) Autocrine/paracrine PGE2 production by non-small cell lung cancer cells regulates MMP-2 and CD44 in COX-2 dependent invasion. J. Biol. Chem., 277, 50828-50833.
22. Ito,H., Duxbury,M., Benoit,E., Farivar,R.S., Gardner-Thorpe,J., Zinner,M.I., Ashley,S.W. and Whang,E.E. (2004) Fibronectin-induced COX-2 mediates MMP-2 expression and invasiveness of rhabdomyosarcoma. Biochem. Biophy. Res. Com., 318, 594-600.
23. Agarwal,B., Swaroop,P., Protiva,P., Raj,S.V., Shirin,H. and Holt,P.R. (2003) Cox-2 is needed but not sufficient for apoptosis induced by COX-2 selective inhibitors in colon cancer cells. Apoptosis, 8, 649-654.
24. Elder,D.J.E., Halton,D.E., Playle,L.C. and Paraskeva,C. (2002) The MEK/ ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells. Int. J. Cancer, 99, 323-327.
25. Zhang,L., Yu,J., Park,B.H., Kinzler,K.W. and Vogelstein,B. (2000) Role of BAX in the apoptotic response to anticancer agents. Science, 290, 989-992.
26. He,T.C., Chan,T.A., Volgelstein,B. and Kinzler,K.W. (1999) PPAR-delta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell, 99, 335-345.
27. Liu,X.H., Yao,S., Kirschenbaum,A. and Levin,A.C. (1998) NS-398, a selective cyclooxygenase-2 inhibitor, induces apoptosis and down-regulates bcl-2 expression in LNCaP cells. Cancer Res., 58, 4245-4249.
28. Palayoor,S.T., Youmell,M.Y., Calderwood,S.K., Coleman,C.N. and Price,B.D. (1999) Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene, 18, 7389-7394.
29. Yip-Schneider,M.T., Sweeny,C.J., Jung,S.H., Crowell,P.L. and Marshall,M.S. (2001) Cell cycle effects of nonsteroidal antiinflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. J. Pharmacol. Exp. Ther., 298, 976-985.
30. Tseng,W.W., Deganutti,A., Chen,M.N., Saxton,R.E. and Liu,C.D. (2002) Selective cyclooxygenase-2 inhibitor rofecoxib (Vioxx) induces expression of cell cycle arrest genes and slows tumor growth in human pancreatic cancer. J. Gastrointest. Surg., 6, 838-844.
31. Masferrer,J.L., Leahy,K.M., Koki,A.T., Zweifel,B.S., Settle,S.L., Woerner,B.M., Edwards,D.A., Flickinger,A.G., Moore,R.J. and Seibert,K. (2000) Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors. Cancer Res., 60, 1306-1311.
32. Sawaoka,H., Tsuji,S., Tsuji,M., Gunawan,E.S., Sasaki,Y., Kawano,S. and Hori,M. (1999) Cyclooxygenase inhibitors suppress angiogenesis and reduce tumor growth in vivo. Lab. Invest., 79(12), 1469-1477.
33. Liu,X.H., Kirschenbaum,A., Yao,S., Lee,R., Holland,J.F. and Levine,A.C. (2000) Inhibition of cyclooxygenase-2 suppresses angiogenesis and the growth of prostate cancer in vivo. J. Urol., 164(3), 820-825.
34. Williams,C.S., Tsuji,M., Reese,J., Dey,S.K. and Dubois,R.N. (2000) Host cyclooxygenase-2 modulates carcinoma growth. J. Clin. Invest., 105, 1589-1594.