The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells

International Journal of Cancer

Volumn 99, Issue 3, 2002, Pages 323-327

  Elder, Douglas J E ^a   Halton, Dawn E ^a   Playle, Laura C ^a   Paraskeva, Christos ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Colorectal cancer; Cyclooxygenase 2; Mitogen activated protein kinase; Nonsteroidal antiinflammatory drug

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL ADHESION; CELL PROLIFERATION; COLORECTAL CARCINOMA; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME BINDING; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; BUTADIENES; CELL DIVISION; COLORECTAL NEOPLASMS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; ISOENZYMES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASE 1; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; NITRILES; NITROBENZENES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; SULFONAMIDES; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0037140913     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10330     Document Type: Article

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