Leptin and its receptors in the course of pregnancy in the rat

International Journal of Molecular Medicine

Volumn 17, Issue 1, 2006, Pages 95-99

  Szczepankiewicz, Dawid ^a   Wojciechowicz, Tatiana ^a   Kaczmarek, Przemyslaw ^a   Nowak, Krzysztof W ^a  

^a POZNA UNIVERSITY OF LIFE SCIENCES   (Poland)

Author keywords

Leptin; Leptin receptors; Pregnancy

Indexed keywords

CELL SURFACE RECEPTOR; ISOPROTEIN; LEPTIN; LEPTIN RECEPTOR;

ANIMAL; ARTICLE; BLOOD; BREEDING; EATING; ENERGY METABOLISM; FEMALE; GENETICS; HOMEOSTASIS; HYPOPHYSIS; HYPOTHALAMUS; METABOLISM; PLACENTA; PREGNANCY; RAT; WISTAR RAT;

ANIMALS; EATING; ENERGY METABOLISM; FEMALE; HOMEOSTASIS; HYPOTHALAMUS; LEPTIN; PITUITARY GLAND; PLACENTA; PREGNANCY; PREGNANCY, ANIMAL; PROTEIN ISOFORMS; RATS; RATS, WISTAR; RECEPTORS, CELL SURFACE;

EID: 33644877368     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.17.1.95     Document Type: Article

References (35)

1. Amico JA, Thomas A, Crowley RS and Burmeister LA: Concentration of leptin in the serum of pregnant, lactating, and cycling rats and of leptin messenger ribonucleic acid in the rat placenta tissue. Life Sci 63: 1387-1395, 1998. (Pubitemid 28470655)
2. Tartaglia LA: The leptin receptor. J Biol Chem 272: 6093-6096, 1997.
3. Ahima RS, Saper CB, Flier JS and Elmquist JK: Leptin regulation of neuroendocrine systems. Front Neuroendocrinol 21: 263-307, 2000.
4. Bjorbaek C, Elmquist JK, Michl P, Ahima RS, van Bueren A, McCall AL and Flier JS: Expression of leptin receptor isoforms in rat brain microvessels. Endocrinology 139: 3485-3491, 1998. (Pubitemid 28512305)
5. Uotani S, Bjorbaek C and Tornoe J: Functional properties of leptin receptor isoforms internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes 48: 279-286, 1999. (Pubitemid 29061099)
6. Lewandowski K, Horn R, O'Callaghan CJ, Dunlop D, Medley GF, O'Hare P and Brabant GJ: Free leptin, bound leptin, and soluble leptin receptor in normal and diabetic pregnancies. Clin Endocrinol Metab 84: 300-306, 1999. (Pubitemid 29036717)
7. Schwartz MW, Seeley RJ, Campfield LA, Burn P and Baskin DG: Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98: 1101-1106, 1996. (Pubitemid 26299921)
8. Funahashi H, Ryushi T, Mizushima H, Katoh S and Shioda S: Ultrastructural localization of the receptor for leptin in the rat hypothalamus. Horm Behav 37: 327-334, 2000. (Pubitemid 30432351)
9. Sahu A: Minireview: a hypothalamic role in energy balance with special emphasis on leptin. Endocrinology 145: 2613-2620, 2004. (Pubitemid 38686205)
10. Hollnes MJ: Current concepts concerning the role of leptin in reproductive function. Mol Cell Endocrinol 157: 11-20, 1999.
11. Chebab FF, Lim ME and Lu R: Correction of sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 12: 318-320, 1996.
12. Chebab FF, Mounzih K, Lu R and Lim ME: Early onset of reproductive function in normal mice treated with leptine. Science 275: 88-90, 1996. (Pubitemid 27020315)
13. Mounzih K, Ronghua LU and Chebab FF: Leptin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology 138: 1190-1193, 1997. (Pubitemid 27089777)
14. Cunningham MJ, Clifton DK and Steiner RA: Leptin's actions on the reproductive axis: perspectives and mechanisms. Biol Reprod 60: 216-220, 1999.
15. Morash B, Wilkinson D, Murphy P, Ur E and Wilkinson M: Developmental regulation of leptin gene expression in rat brain and pituitary. Mol Cell Endocrinol 185: 151-159, 2001. (Pubitemid 33103964)
16. Morash BA, Imran A, Wilkinson D, Ur E and Wilkinson M: Leptin receptors are developmentally regulated in rat pituitary and hypothalamus. Mol Cell Endocrinol 210: 1-8, 2003. (Pubitemid 37386312)
17. Kawai M, Murakami T, Otani S, Shima K, Yamaguchi M and Kishi K: Colocalization of leptin receptor (OB-R) mRNA and placental lactogen-II in rat trophoblast cells: gestational profile of OB-R mRNA expression in placenta. Biochem Biophys Res Commun 257: 425-430, 1999. (Pubitemid 29301462)
18. Smith JT and Waddell BJ: Leptin receptor expression in the rat placenta: changes in Ob-Ra, Ob-Rb, and Ob-Re with gestational age and suppression by glucocorticoids. Biol Reprod 67: 1204-1210, 2002.
19. Altman PL and Dittmer DS (eds): Growth. Biological Handbooks, FASEB, 1962.
20. Morash B, Johnstone J, Leopold C, Li A, Murphy P, Ur E and Wilkinson M: The regulation of leptin gene expression in the C6 glioblastoma cell line. Mol Cell Endocrinol 165: 97-105, 2000.
21. Masuzaki H, Ogawa Y, Sagawa N, et al: Non-adipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 3: 1029-1033, 1997.
22. Malik NM, Carter ND, Wilson CA, Scaramuzzi RJ, Stock MJ and Murray JF: Leptin expression in the fetus and placenta during mouse pregnancy. Placenta 26: 47-52, 2005.
23. Kawai M, Yamaguchi M, Murakami T, Shima K, Murata Y and Kishi K: The placenta is not the main source of leptin production in pregnant rat: gestational profile of leptin in plasma and adipose tissues. Biochem Biophys Res Commun 240: 798-802, 1997.
24. Hoggard N, Hunter L, Duncan JS, William LM, Trayhurn P and Mercer JG: Leptin and leptin receptor mRNA and protein expression in murine fetus and placenta. Proc Natl Acad Sci USA 94: 11073-11078, 1997.
25. Garcia MC, Casanueva FF, Dieguez C and Senaris RM: Gestational profile of leptin messenger ribonucleic acid (mRNA) content in the placenta and adipose tissue in the rat, and regulation of the mRNA levels of the leptin receptors subtypes in the hypothalamus during pregnancy and lactation. Biol Reprod 62: 698-703, 2000.
26. Terada Y, Yamakawa K, Sugaya A and Toyoda N: Serum leptin levels do not rise during pregnancy in age-matched rats. Biochem Biophys Res Commun 253: 841-844, 1998.
27. Mounzih K, Qiu J, Ewart-Toland A and Chehab FF: Leptin is not necessary for gestation and parturition but regulates maternal nutrition via a leptin resistance state. Endocrinology 139: 5259-5262, 1998.
28. Ladyman SR and Grattan DR: Suppression of leptin receptor mRNA and leptin responsiveness in the ventromedial nucleus of the hypothalamus during pregnancy in the rat. Endocrinology 146: 3868-3874, 2005.
29. Ladyman SR and Grattan DR: Region-specific reduction in leptin-induced phosphorylation of signal transducer and activator of transcription-3 (STAT3) in the rat hypothalamus is associated with leptin resistance during pregnancy. Endocrinology 145: 3704-3711, 2004.
30. Sone M, Nagata H, Takekoshi S and Osamura RY: Expression and localization of leptin receptor in the normal rat pituitary gland. Cell Tissue Res 305: 351-356, 2001.
31. Escalada J, Sanchez-Franco F, Velasco B and Cacicedo L: Regulation of growth hormone (GH) gene expression and secretion during pregnancy and lactation in the rat: role of insulin-like growth factor I, somatostatin and GH releasing hormone. Endocrinology 138: 3435-3443, 1997.
32. Shimon I, Yan X, Magoffin DA, Friedman TC and Melmed S: Intact leptin receptor is selectively expressed in human fetal pituitary and pituitary adenomas and signals human fetal pituitary growth hormone secretion. J Clin Endocrinol Metab 83: 4059-4064, 1998.
33. Yu WH, Kimura M, Walczewska A, Karanth S and McCann SM: Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci USA 94: 1023-1028, 1997.
34. Chien EK, Hara M, Rouard M, Yano H, Phillipe M, Polonsky KS and Bell GI: Increase in serum leptin and uterine leptin receptor messenger RNA levels during pregnancy in rats. Biochem Biophys Res Commun 237: 476-480, 1997.
35. Kastin AJ, Pan W, Maness LM, Koletsky RJ and Ernsberger P: Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor. Peptides 20: 1449-1453, 1999.