Acrylamide and glycidamide: Approach towards risk assessment based on biomarker guided dosimetry of genotoxic/mutagenic effects in human blood

Advances in Experimental Medicine and Biology

Volumn 561, Issue , 2005, Pages 77-88

  Baum, Matthias ^a   Fauth, Evelyne ^a   Fritzen, Silke ^a   Herrmann, Armin ^a   Mertes, Peter ^a   Rudolphi, Melanie ^a   Spormann, Thomas ^a   Zankl, Heinrich ^a   Eisenbrand, Gerhard ^a   Bertow, Daniel ^a  

^a Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

Author keywords

Acrylamide; Genotoxicity; Glycidamide; Mutagenicity; Protein adducts

Indexed keywords

ACRYLAMIDE; AMINO ACID; BIOLOGICAL MARKER; CARCINOGEN; GLYCIDAMIDE; HEMOGLOBIN; THIOL DERIVATIVE; EPOXIDE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MUTAGENIC AGENT;

ANIMAL CELL; ARTICLE; BLOOD COMPONENT; CHEMICAL REACTION; CHEMICAL STRUCTURE; COMET ASSAY; DNA ADDUCT; DNA DAMAGE; DOSIMETRY; FOOD INTAKE; GENE MUTATION; GENOTOXICITY; IN VIVO STUDY; LYMPHOCYTE; MICRONUCLEUS; MUTAGENIC ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INDUCTION; RISK ASSESSMENT; ANIMAL; CELL LINE; CHEMICAL MODEL; CHEMISTRY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; GENETICS; HAMSTER; HUMAN; METABOLISM; METHODOLOGY; MICRONUCLEUS TEST; TIME;

ANIMALIA;

ACRYLAMIDE; ANIMALS; BIOLOGICAL MARKERS; CELL LINE; CRICETINAE; DISEASE MODELS, ANIMAL; DNA ADDUCTS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOXY COMPOUNDS; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LYMPHOCYTES; MICRONUCLEUS TESTS; MODELS, CHEMICAL; MUTAGENS; RISK ASSESSMENT; TIME FACTORS;

EID: 33644857719     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/0-387-24980-X_6     Document Type: Article

References (31)

1. Adler, I. D., Schmid, T. E., and Baumgartner, A., 2002, Induction of aneuploidy in male mouse germ cells detected by the sperm-FISH assay: a review of the present data base, Mutat. Res. 504:173-182.
2. Bergmark, E., Calleman, C. J., He, F., and Costa, L. G., 1993, Determination of hemoglobin adducts in humans occupationally exposed to acrylamide, Toxicol. Appl. Pharmacol. 120:45-54.
3. Bergmark, E., 1997, Hemoglobin adducts of acrylamide and acetonitrile in laboratory workers, smokers and nonsmokers, Chem. Res. Toxicol. 10(1):78-84.
4. Bradley, M. O., Bhuyan, B., Francis, M. C., Langenbach, R., Peterson, A., and Huberman E., 1981, Mutagenisis by chemical agents in V79 Chinese hamster cells: A review and analysis of the literature; A report of the Gene-Tox Program, Mutat. Res. 87:81-142.
5. Calleman, C. J., Bergmark, E., and Costa, L. G., 1990, Acrylamide is metabolized to glycidamide in the rat: evidence from hemoglobin adduct formation, Chem. Res. Toxicol. 3:406-412.
6. Calleman, C. J., Wu, J., He, F., Tian, G., Bergmark, E., Zhang, S., Deng, H., Wang, Y., Crofton, K. M., Fennell, T., and Costa, L. G., 1994, Relationship between biomarkers of exposure and neurological effects in a group of workers exposed to acrylamide, Toxicol. Appl. Pharmacol. 126:197-201.
7. Da Costa, G., Churchwell, M. I., Hamilton, P., von Tungeln, L. S., Beland, F. A., Marques, M. M., and Doerge, D. R., 2003, DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice, Chem. Res. Toxicol. 16:1328-1337.
8. Dearfield, K. L., Douglas, G. R., Ehling, U. H., Moore, M. M., Sega, G. A., and Brusick, D. J., 1995, Acrylamide: a review of its genotoxicity and assessment of heritable genetic risk, Mutat. Res. 330:71-99.
9. Fenech, M., 2000, The in vitro micronucleus technique; Mutat. Res. 455: 81-95
10. Friedman, M. A., Dulak, L. H., and Stedham, M. A., 1995, A lifetime oncogenicity study in rats with acrylamide, Fundam. Appl. Toxicol. 27:95-105.
11. Glatt, H.-R., 1993, HPRT-Genmutationstest in V79-Zellen des Chinesischen Hamsters, in: Mutationsforschung und genetische Toxikologie, R. Fahrig, ed., Wissenschaftliche Buchgesellschaft, Darmstadt, pp. 243-262.
12. Granvogl, M., Jezussek, M., Koehler, P., and Schieberle, P., 2004, Quantitation of 3-aminopropionamide in potatoes - A minor but potent precursor in acrylamide formation; J. Agric. Food Chem, 52:4751-4757.
13. Hagmar, L., Törnqvist, M., Nordander, C., Rosén, I., Bruze, M., Kautiainen, A., Magnusson, A.-L., Malmberg, B., Aprea, P., Granath, F., and Axmon, A., 2001, Health effects of occupational exposure to acrylamide using hemoglobin adducts as biomarkers of internal dose, Scand. J. Work Environ. Health 27(4):219-226.
14. Hartmann, A., Plappert, U., Poetter, F., and Suter, W., 2003, Comparative study with the alkaline Comet assay and the chromosome aberration test, Mutat. Res. 536(1-2):27-38.
15. Hashimoto, K., and Tanii, H., 1985, Mutagenicity of acrylamide and its analogues in Salmonella typhimurium, Mutat. Res. 158:129-133.
16. Johnson, K. A., Gorzinski, S. J., Bodner, K. M., Campbell, R. A., Wolf, C. H., Friedman, M. A., and Mast, R. W., 1986, Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 Rats, Toxicol. Appl. Pharmacol. 85:154-168.
17. Knaap, A., Kramers P., Voogd C., Bergkamp, W., Langebroek, P., Mout, H., van der Stel, J., and Verharen, H., 1988, Mutagenic Activity of Acrylamide in Eucaryotic Systems but not in Bacteria, Mutagenesis 3:263-268.
18. Madle, S., Broschinski, L., Mosbach-Schulz, O., Schönig, G., and Schulte, A., 2003, Zur aktuellen Risikobewertung von Acrylamid in Lebensmitteln, Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz 46:405-415.
19. Paulsson, B., Grawe, J., and Törnqvist, M., 2002, Hemoglobin adducts and micronucleus frequencies in mouse and rat after acrylamide or N-methyloacrylamide treatment, Mutat. Res. 516(1-2):101-111.
20. Paulsson, B., Athanassiadis, I., Rydberg, P., and Tornqvist, M., 2003, Hemoglobin adducts from glycidamide: acetonization of hydrophilic groups for reproducible gas chromatography/ tandem mass spectrometric analysis, Rapid Commun. Mass Spectrom. 17(16):1859-1865.
21. Schettgen, T., Broding, H. C., Angerer, J., and Drexler, H., 2002, Hemoglobin adducts of ethylene oxide, propylene oxide, acrylonitrile and acrylamide-biomarkers in occupational and environmental medicine, Toxicol. Lett. 134(1-3):65-70.
22. Singh, N. P., McCoy, M. T., Tice, R. R., and Schneider, E. L., 1988, A simple technique for quantitation of low levels of DNA damage in individual cells., Exp. Cell Res. 175:184-191.
23. Solomon, J. J., Fedyk, J., Mukai, F., and Segal A., 1985, Direct alkylation of 2′-desoxynucleosides and DNA following in vitro reactions with acrylamide, Cancer Res. 45:3465-3470.
24. Stadler, R. H., Blank, I., Varga, N., Robert, F., Hau, J., Guy, P. A., Robert, M.-C., and Riediker, S., 2002, Acrylamide from Maillard reaction products, Nature 419:449.
25. Sumner, S. C. J., Fennell, T. R., Moore, T. A., Ghanas, B., Gonzalez, F., and Ghanayern, B. L, 1999, Role of cytochrom P450 2E1 in the metabolism of acrylamide and acetonitrile in mice, Chem. Res. Toxicol. 12:1110-1116.
26. Tareke, E., Rydberg, P., Karlsson, P., Eriksson, S., and Törnqvist, M., 2002, Analysis of acrylamide, a carcinogen formed in heated foodstuffs, J. Agric. Food Chem. 50:4998-5006.
27. Tice, R. R., Agurell, E., Anderson, D., Burlinson, B., Hartmann, A., Kobayashi, H., Miyamae, Y., Rojas, E., Ryu, J.-C., and Sasaki, Y. F., 2000, Single cell gel/Comet assay: guidelines for in-vitro and in-vivo genetic toxicology testing, Environ. Mol. Mutagen. 35:206-221.
28. Törnqvist, M., Mowrer, J., Jensen, S., and Ehrenberg, L., 1986, Monitoring of environmental cancer initiators through hemoglobin adducts by modified Edman degradation method, Anal. Biochem. 154:255-266.
29. Tsuda, H., Shimizu, C. S., Taketomi, M. K., Hasegawa, M. M., Hamada, A., Kawata, K. M., and Inui, N., 1993, Acrylamide: induction of DNA damage, chromosomal aberrations and cell transformation without gene mutations, Mutagenesis 8(1):23-29.
30. Tyl, R. W., and Freidman, M. A., 2003, Effects of acrylamide on rodent reproductive performance, Reprod. Toxicol., 17:1-13.
31. Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W., 1987, Salmonella mutagenicity tests. III. Results from the testing of 255 chemicals, Envrion. Mutagen., 9(Suppl. 9):1-110.