Effects of oral androstenedione on phospholipid fatty acids, ATP, caspase-3, prostaglandin E2 and C-reactive protein in serum and livers of pregnant and non-pregnant female rats

Food and Chemical Toxicology

Volumn 44, Issue 4, 2006, Pages 579-587

  Wiesenfeld, P W ^a   Sapienza, P P ^a   Flynn, T J ^a   Ford, C E ^a   Ross, I A ^a   Sahu, S ^a   Kim, C S ^a   O'Donnell Jr , M W ^a   Collins, T F X ^a   Sprando, R L ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Androstenedione; C reactive protein; Fatty acids; Liver; Pregnant; Prostaglandin E2; Rats

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANDROSTENEDIONE; C REACTIVE PROTEIN; CASPASE 3; DOCOSAHEXAENOIC ACID; FATTY ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIVER PROTEIN; PLASMA PROTEIN; PROSTAGLANDIN E2; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; LIPID BLOOD LEVEL; LIVER TOXICITY; LIVER WEIGHT; NONHUMAN; PREGNANCY;

ADENOSINE TRIPHOSPHATE; ADMINISTRATION, ORAL; ANDROSTENEDIONE; ANIMALS; C-REACTIVE PROTEIN; CASPASE 3; CASPASES; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS; FEMALE; LIVER; PREGNANCY; RATS;

ANIMALIA;

EID: 33644854132     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2005.09.005     Document Type: Article

References (55)

1. M. Alen, and P. Rahkila Reduced high-density lipoprotein-cholesterol in power athletes: use of male sex hormone derivatives, an atherogenic factor Int. J. Sports Med. 5 1984 341 342
2. D.M. Amundson, and M. Zhou Fluorometric method for the enzymatic determination of cholesterol J. Biochem. Biophy. Methods 38 1999 43 52
3. Anabolic Steroids Control Act of, 1990 (ASCA) (title XIX of Public Law 101-647). Schedule III. Controlled Substance Act (CSA) (21 U.S.C. 801 et seq.).
4. M. Banerjee, L.M. Tripathi, V.M. Srivastava, A. Puri, and R. Shukla Modulations of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat Immunopharmacol. Immunotoxicol. 25 2 2003 213 224
5. C.D. Bannon, J.D. Craske, and A.E. Hillker Analysis of fatty methyl esters with high accuracy and reliability. V. Validation of theoretical relative response factors of unsaturated esters in the flame ionization detector JAOCS 63 1 1986 105 110
6. L.D. Boada, M. Zumbado, S. Torres, A. López, B.N. DIÍaz-Chico, J.J. Cabrera, and O.P. Luzardo Evaluation of acute and chronic hepatotoxic effects exerted by anabolic-androgenic steroid stanozolol in adult male rats Arch. Toxicol. 73 1999 465 472
7. C.E. Broeder, J. Quindry, K. Brittingham, L. Panton, J. Thomson, S. Appakonud, K. Breuel, R. Byrd, J. Douglas, C. Earnest, C. Mitchell, M. Olson, T. Roy, and C. Yarlagadda The Andro Project. Physiological and hormonal influences of androstenedione supplementation on men 35 to 65 years old participating in a high-intensity resistance training program Arch. Int. Med. 160 20 2000 3093 3104
8. C.E. Broeder Oral andro-related prohormone supplementation: do the potential risks outweigh the benefits? Can. J. Appl. Physiol. 28 1 2003 102 116
9. D.H. Catlin, B.Z. Leder, B. Ahrens, B. Starvevic, C.K. Hatton, G.A. Green, and F.S. Finkelstein Trace contamination of over-the-counter androstenedione and positive urine tests for a nandrolone metabolite JAMA 284 20 2000 2618 2621
10. I.A. Cree, and P.E. Andreotti Measurement of cytotoxicity by ATP-based luminescence assay in primary cultures and cell lines Toxicol. in Vitro 11 1997 536 553
11. S.P.M. Crouch, R. Kozlowski, K.J. Slater, and J. Fletcher The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity J. Immunol. Methods 160 1993 81 88
12. C. Dilworth, G.A. Hamilton, E. George, and J.A. Timbrell The use of liver spheroids as an in vitro model for studying induction of the stress response as a marker of chemical toxicity Toxicol. in Vitro 14 2 2000 169 176
13. Y. Eguchi, A. Srinivasan, K.J. Tomaselli, S. Shimizu, and Y. Tsujimoto ATP-dependent steps in apoptotic signal transduction Cancer Res. 59 9 1999 2174 2181
14. FDA, 2004. Health Effects of Androstenedione. FDA White Paper, March 11, 2004. Available from: 〈www.fda.gov/oc/whitepapers/andro.html〉.
15. T.J. Flynn, P.P. Sapienza, P.W. Wiesenfeld, I.A. Ross, S. Sahu, C.S. Kim, M.W. O'Donnell Jr., T.F.X. Collins, and R.L. Sprando Effects of oral androstenedione on steroid metabolism in liver of pregnant and non-pregnant female rats Food Chem. Toxicol. 43 2005 537 542
16. J. Folch, M. Lees, and G.H. Sloane Stanley A simple method for the isolation and purification of total lipids from animal tissues J. Biol. Chem. 226 1957 497 509
17. A.A. Goyeneche, V. Calvo, G. Gibori, and C.M. Telleria Androstenedione interferes in luteal regression by inhibiting apoptosis and stimulating progesterone production Biol. Reprod. 66 5 2002 1540 1547
18. N.C. Haave, and S.M. Innis Hepatic cholesterol and fatty acid synthesis in pregnant and fetal rats: effect of maternal dietary fat and cholestyramine J. Nutr. 121 1 1991 1529 1535
19. F. Hartgens, H. Kuipers, J.A. Wijnen, and H.A. Keizer Body composition, cardiovascular risk factors and liver function in long-term androgenic-anabolic steroid using bodybuilders three months after drug withdrawal Int. J. Sports Med. 17 6 1996 429 433
20. M.S. Hislop, A. St Clair Gibson, M.I. Lambert, T.D. Noakes, and A.D. Marais Effects of androgen manipulation on postprandial triglycerides, low-density lipoprotein particle size and lipoproteins in men Atherosclerosis 159 2 2001 425 432
21. Y.C. Huang, Z. Li, S.D. Harder, and J.M. Soukup Apoptosis and inflammatory effects induced by different particles in human alveolar macrophages Inhal. Toxicol 16 14 2004 863 878
22. R. Hutter, C. Valdiviezo, B.V. Sauter, M. Savontaus, I. Chereshnev, F.E. Carrick, G. Bauriedel, B. Luderitz, J.T. Fallon, V. Fuster, and J.J. Badimon Caspase-3 and tissue factor expression in lipid-rich plaque macrophages: evidence for apoptosis as link between inflammation and atherothrombosis Circulation 109 16 2004 2001 2008
23. S.M. Innis, and N.C. Haave Effects of cortisol or corticotrophin administration on hepatic-3-hydroxy-3-methylglytaryl CoA reductase activity and plasma lipids in the pregnant rat and fetuses J. Dev. Physiol. 11 6 1989 346 350
24. H. Jaeschke, G.J. Gores, A.I. Cederbaum, J.A. Hinson, D. Pessayre, and J.J. Lemaste Mechanisms of hepatotoxicity Toxicol. Sci. 65 2 2002 166 176
25. B. Kadenbach, S. Arnold, I. Lee, and M. Huttemann The possible role of cytochrome c oxidase in stress-induced apoptosis and degenerative diseases Biochem. Biophys. Acta 1655 2004 400 408
26. M.A. Kantor, A. Bianchini, D. Bernier, S.P. Sady, and P.D. Thompson Androgens reduce HDL2 cholesterol and increase hepatic triglyceride lipase activity Med. Sci. Sports Exerc. 17 1985 462 465
27. A.T. Kicman, T. Bassindale, D.A. Cowan, S. Dale, A.J. Hutt, and A.R. Leeds Effect of androstenedione ingestion on plasma testosterone in young women; a dietary supplement with potential health risks Clin. Chem. 49 2003 167 169
28. D.S. King, R.L. Sharp, M.D. Vukovich, G.A. Brown, T.A. Reifenrath, N.L. Uhl, and K.A. Parsons Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men: a randomized controlled trial JAMA 281 21 1999 2043 2044
29. C.L. Kiraly Androgenic-anabolic steroid effects on serum and skin surface lipids on red cells and on liver enzymes Int. J. Sports Med. 9 1988 249 252
30. J.B. LaBorde, K.S. Wall, B. Bolon, T.S. Kumpe, R. Patton, Q. Zheng, R. Kodell, and J.F. Young Hematology and serum chemistry parameters of the pregnant rat Lab. Anim. 33 3 1999 275 287
31. S. Leoni, S. Spagnuolo, D.L. Conti, M.T. Mangiantini, and A. Trentalance Cholesterol synthesis and related enzymes in rat liver during pregnancy Experiential 40 7 1984 703 704
32. T.A. Liberati, S.R. Sansone, and M.H. Feuston Hematology and clinical chemistry values in pregnant Wistar Hannover rats compared with nonmated controls Vet. Clin. Pathol. 33 2 2004 68 73
33. D.W.L. Ma, J. Seo, K.C. Switzer, Y.Y. Fan, D.N. McMurray, J.R. Lupton, and R.S. Chapkin n-3 PUFA and membrane microdomains: a new frontier in bioactive lipid research J. Nutr. Biochem. 15 2004 700 706
34. M.F. Mariani, L. Thomas, B. DeFeo, and G.D. van Rossum Effect of monensin on ATP levels and cell functions in rat liver and lung in vitro J. Membr. Biol. 108 3 1989 235 246
35. D.R. Mottram, and A.J. George Anabolic steroids. Bailiere's Best Practice and Research Clin. Endocrinol. Metab. 14 1 2000 55 69
36. B.R. Nathan, and W.M. Scheld The potential roles of C-reactive protein and procalcitonin concentration in the serum and cerebrospinal fluid in diagnosis of bacterial meningitis Curr. Clin. Top Infect. Dis. 22 2002 155 165
37. NIDA Research report, 2000. Steroid use and addiction: NIH Publication No. 00-3721. Printed 1991, reprinted 1994, 1996. Revised April 2000.
38. K. Plaetzer, T. Kiesslich, B. Krammer, and P. Hammer Characterization of the cell death modes and the associated changes in cellular energy supply in response to AIPcS4-PDT Photochem. Photobiol. Sci. 1 3 2002 172 177
39. P.S. Ribeiro, H. Cortez-Pinto, S. Sola, R.E. Castro, R.M. Ramalho, A. Baptista, M.C. Moura, M.E. Camilo, and C.M. Rodrigues Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients Am. J. Gastroenterol. 99 9 2004 1718 1719
40. M.A. Sader, K.A. Griffiths, R.J. McCredie, D.J. Handelsman, and D.S. Celermajer Androgenic anabolic steroids and arterial structure and function in male bodybuilders J. Am. Coll. Cardiol. 37 1 2001 224 230
41. S.C. Sahu, P.P. Sapienza, R.L. Sprando, T.F.X. Collins, I.A. Ross, T.J. Flynn, P.L. Wiesenfeld, M.W. O'Donnell, and C.S. Kim Hepatotoxicity of androstenedione in pregnant rats Food Chem. Toxicol. 43 2005 341 344
42. J.L. Smith, S.R. Lear, T.M. Forte, W. Ko, M. Massimi, and S.K. Erickson Effect of pregnancy and lactation on lipoprotein and cholesterol metabolism in the rat J. Lipid Res. 39 11 1998 2237 2249
43. R.L. Sprando, T.F.X. Collins, T.N. Black, N. Olejnik, E. Grundel, and D.I. Ruggles Effects of androstenedione on in utero development in rats Food Chem. Toxicol. 42 2004 917 924
44. R.L. Sprando, T.F.X. Collins, T.N. Black, N. Olejnik, M. Ramos-Valle, P. Sapienza, J. Rorie, and D.I. Ruggles Maternal exposure to androstenedione does not induce developmental toxicity in the rat Food Chem. Toxicol. 43 2005 505 513
45. T. Takadera, Y. Shirasish, and T. Ohyashiki Prostaglandin E2 induced caspase-dependent apoptosis possibly through activation of PGE2 receptors in cultured hippocampal neurons Neurochem. Int. 45 5 2004 713 719
46. B.F. Trump, I.K. Berezesky, S.H. Chang, and P.C. Phelps The pathways of cell death: oncosis, apoptosis, and necrosis Toxicol. Pathol. 25 1 1997 82 88
47. G.V. Vahouny, R. Chanderbahan, R. Hinds, V.A. Hodges, and C.R. Treadwell ACTH-induced hydrolysis of cholesteryl esters in rat adrenal cells J. Lipid Res. 19 1978 570 577
48. C. Volbracht, M. Leist, and P. Nicotera ATP controns neuronal apoptosis triggered by microtubule breakdown or potassium deprivation Mol. Med. 5 7 1999 477 489
49. P. Wainwright Dietary essential fatty acids and brain function: a developmental perspective on mechanism Proc. Nutr. Soc. 61 2002 61 69
50. P.W. Wiesenfeld, U.S. Babu, and M.W. O'Donnell Effect of long-chain fatty acids in the culture medium on fatty acid composition of WEHI-3 and J774A.1 cells Comp. Biochem. Physiol. Biochem. Mol. Biol. 128 1 2001 123 134
51. A.A. Welder, J.W. Robertson, and R.B. Melchert Toxic effects of anabolic-androgenic steroids in primary rat hepatic cell cultures Pharmacol. Toxicol. Methods 33 1995 187 195
52. C.E. Yesalis Medical, legal and societal implications of androstenedione use JAMA 281 1999 2043 2044
53. C.E. Yesalis, and M.S. Bahrke Doping among adolescent athletes Best Pract. Res. Clin. Endocrinol. Metab. 14 2000 25 35
54. T.N. Ziegenfuss, J.M. Beradi, and L.M. Lowery Effects of prohormone supplementation in humans: a review Can. J. Appl. Physiol. 27 6 2002 628 646
55. X. Zhou, F. Li, L. Kong, H. Tomita, C. Li, and W. Cao Involvement of inflammation, degradation and apoptosis in a mouse model of glaucoma J. Biol. Chem. 280 5 2005 31240 31248