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Volumn 11, Issue 2, 2006, Pages 113-122

Mucosal immunization with a urease B DNA vaccine induces innate and cellular immune responses against Helicobacter pylori

Author keywords

Cytosine preceding guanosine motifs; Defensin gene expression; Helicobacter pylori; IL 10: IFN expression ratio; Interferon secretion; Murine stomach; Splenocyte proliferation; Urease B subunit

Indexed keywords

BETA DEFENSIN; CYTOKINE; CYTOSINE; DNA VACCINE; GAMMA INTERFERON; GUANOSINE; HELICOBACTER PYLORI VACCINE; INTERLEUKIN 10; RNA; UNCLASSIFIED DRUG; UREASE B DNA VACCINE;

EID: 33644844581     PISSN: 10834389     EISSN: 15235378     Source Type: Journal    
DOI: 10.1111/j.1523-5378.2006.00385.x     Document Type: Article
Times cited : (31)

References (60)
  • 1
    • 0023239538 scopus 로고
    • Campylobacter pyloridis gastritis II: Distribution of bacteria and associated inflammation in the gastroduodenal environment
    • Hazell SL Hennessy WB Borody TJ et al. Campylobacter pyloridis gastritis II: distribution of bacteria and associated inflammation in the gastroduodenal environment Am J Gastroenterol 1987 82 297 301
    • (1987) Am J Gastroenterol , vol.82 , pp. 297-301
    • Hazell, S.L.1    Hennessy, W.B.2    Borody, T.J.3
  • 2
    • 0024494239 scopus 로고
    • Campylobacter pylori and peptic ulcer disease
    • Graham D. Campylobacter pylori and peptic ulcer disease Gastroenterology 1989 96 615 25
    • (1989) Gastroenterology , vol.96 , pp. 615-25
    • Graham, D.1
  • 3
    • 0035371647 scopus 로고    scopus 로고
    • Helicobacter-induced expression of Bcl-X (L) in B lymphocytes in the mouse model: A possible step in the development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma
    • Morgner A Sutton P O'Rourke JL et al. Helicobacter-induced expression of Bcl-X (L) in B lymphocytes in the mouse model: a possible step in the development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma Int J Cancer 2001 92 634 40
    • (2001) Int J Cancer , vol.92 , pp. 634-40
    • Morgner, A.1    Sutton, P.2    O'Rourke, J.L.3
  • 4
    • 0035856021 scopus 로고    scopus 로고
    • Helicobacter pylori infection and the development of gastric cancer
    • Uemura N Okamoto S Yamamoto S et al. Helicobacter pylori infection and the development of gastric cancer N Engl J Med 2001 345 784 9
    • (2001) N Engl J Med , vol.345 , pp. 784-9
    • Uemura, N.1    Okamoto, S.2    Yamamoto, S.3
  • 7
    • 0025823864 scopus 로고
    • Essential role of urease in pathogenesis of gastritis induced by Helicobacter pylori in gnotobiotic piglets
    • Eaton KA Brooks CL Morgan DR Krakowka S. Essential role of urease in pathogenesis of gastritis induced by Helicobacter pylori in gnotobiotic piglets Infect Immun 1991 59 2470 5
    • (1991) Infect Immun , vol.59 , pp. 2470-5
    • Eaton, K.A.1    Brooks, C.L.2    Morgan, D.R.3    Krakowka, S.4
  • 8
    • 0027765268 scopus 로고
    • Helicobacter pylori and urease activity: Comparative study between urease-positive and -negative mutant strains
    • Takahashi S Igarashi H Nakamura K et al. Helicobacter pylori and urease activity: comparative study between urease-positive and -negative mutant strains Nippon Rhinso - Jpn J Clin Med 1993 51 3149 53
    • (1993) Nippon Rhinso - Jpn J Clin Med , vol.51 , pp. 3149-53
    • Takahashi, S.1    Igarashi, H.2    Nakamura, K.3
  • 9
    • 0028064605 scopus 로고
    • A urease-negative mutant of Helicobacter pylori constructed by allelic exchange lacks the ability to colonise the nude mouse stomach
    • Tsuda M Karita M Morshed G et al. A urease-negative mutant of Helicobacter pylori constructed by allelic exchange lacks the ability to colonise the nude mouse stomach Infect Immun 1994 62 3586 9
    • (1994) Infect Immun , vol.62 , pp. 3586-9
    • Tsuda, M.1    Karita, M.2    Morshed, G.3
  • 10
    • 0025247997 scopus 로고
    • Purification and amino-terminal analysis of urease from Helicobacter pylori
    • Hu LT Mobley HL. Purification and amino-terminal analysis of urease from Helicobacter pylori Infect Immun 1990 58 992 8
    • (1990) Infect Immun , vol.58 , pp. 992-8
    • Hu, L.T.1    Mobley, H.L.2
  • 11
    • 0028930318 scopus 로고
    • Helicobacter pylori nickel-transport gene nixA: Synthesis of catalytically active urease in Escherichia coli independent of growth conditions
    • Mobley H Garner R Bauerfeind P. Helicobacter pylori nickel-transport gene nixA: synthesis of catalytically active urease in Escherichia coli independent of growth conditions Mol Microbiol 1995 16 97 109
    • (1995) Mol Microbiol , vol.16 , pp. 97-109
    • Mobley, H.1    Garner, R.2    Bauerfeind, P.3
  • 12
    • 0030941212 scopus 로고    scopus 로고
    • A standardized mouse model of Helicobacter pylori infection: Introducing the Sydney strain
    • Lee A O'Rourke J De Ungria M et al. A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain Gastroenterology 1997 112 1386 97
    • (1997) Gastroenterology , vol.112 , pp. 1386-97
    • Lee, A.1    O'Rourke, J.2    De Ungria, M.3
  • 13
    • 2942597676 scopus 로고    scopus 로고
    • Immunisation against Helicobacter felis infection protects against the development of gastric MALT lymphoma
    • Sutton P O'Rourke J Wilson J et al. Immunisation against Helicobacter felis infection protects against the development of gastric MALT lymphoma Vaccine 2004 22 2541 6
    • (2004) Vaccine , vol.22 , pp. 2541-6
    • Sutton, P.1    O'Rourke, J.2    Wilson, J.3
  • 14
    • 0029069313 scopus 로고
    • Oral immunization with recombinant Helicobacter pylori urease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felis
    • Lee CK Weltzin R Thomas WD et al. Oral immunization with recombinant Helicobacter pylori urease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felis J Infect Dis 1995 172 161 72
    • (1995) J Infect Dis , vol.172 , pp. 161-72
    • Lee, C.K.1    Weltzin, R.2    Thomas, W.D.3
  • 15
    • 0034507952 scopus 로고    scopus 로고
    • Helicobacter pylori vaccine strategies: Triggering a gut reaction
    • Hatzifoti C Wren BW Morrow WJ. Helicobacter pylori vaccine strategies: triggering a gut reaction Immunol Today 2000 21 615 9
    • (2000) Immunol Today , vol.21 , pp. 615-9
    • Hatzifoti, C.1    Wren, B.W.2    Morrow, W.J.3
  • 17
    • 0037306254 scopus 로고    scopus 로고
    • Vaccine-induced reduction of Helicobacter pylori colonization in mice is interleukin 12 dependent but gamma interferon and inducible nitric oxide synthase independent
    • Garhart CA Heinzel FP Czinn SJ Nedrud JG. Vaccine-induced reduction of Helicobacter pylori colonization in mice is interleukin 12 dependent but gamma interferon and inducible nitric oxide synthase independent Infect Immun 2003 71 910 21
    • (2003) Infect Immun , vol.71 , pp. 910-21
    • Garhart, C.A.1    Heinzel, F.P.2    Czinn, S.J.3    Nedrud, J.G.4
  • 18
    • 0842347929 scopus 로고    scopus 로고
    • Systemic Th1 immunization of mice against Helicobacter pylori infection with CpG oligodeoxynucleotides as adjuvants does not protect from infection but enhances gastritis
    • Sommer F Wilken H Faller G Lohoff M. Systemic Th1 immunization of mice against Helicobacter pylori infection with CpG oligodeoxynucleotides as adjuvants does not protect from infection but enhances gastritis Infect Immun 2004 72 1029 35
    • (2004) Infect Immun , vol.72 , pp. 1029-35
    • Sommer, F.1    Wilken, H.2    Faller, G.3    Lohoff, M.4
  • 19
    • 0842324634 scopus 로고    scopus 로고
    • Clearance of Helicobacter pylori infection through immunization: The site of T-cell activation contributes to vaccine efficacy
    • Blanchard TG Eisenberg JC Matsumoto Y. Clearance of Helicobacter pylori infection through immunization: the site of T-cell activation contributes to vaccine efficacy Vaccine 2004 17 888 97
    • (2004) Vaccine , vol.17 , pp. 888-97
    • Blanchard, T.G.1    Eisenberg, J.C.2    Matsumoto, Y.3
  • 20
    • 1842477039 scopus 로고    scopus 로고
    • Helicobacter pylori-specific antibodies impair the development of gastritis, facilitate bacterial colonization, and counteract resistance against infection
    • Akhiani AA Schon K Franzen LE et al. Helicobacter pylori-specific antibodies impair the development of gastritis, facilitate bacterial colonization, and counteract resistance against infection N J Immunol 2004 15 5024 33
    • (2004) N J Immunol , vol.15 , pp. 5024-33
    • Akhiani, A.A.1    Schon, K.2    Franzen, L.E.3
  • 21
    • 85047691456 scopus 로고    scopus 로고
    • Helicobacter pylori persistence: Biology and disease
    • Blaser MJ Atherton JC. Helicobacter pylori persistence: biology and disease J Clin Invest 2004 113 321 33
    • (2004) J Clin Invest , vol.113 , pp. 321-33
    • Blaser, M.J.1    Atherton, J.C.2
  • 22
    • 0345791527 scopus 로고    scopus 로고
    • Helicobacter pylori heat-shock protein 60 mediates interleukin 6 production by macrophages via a Toll-like receptor (TLR) -2-, TLR-4-, and myeloid differentiation factor 88-independent mechanism
    • Gobert AP Bambou JC Werts C et al. Helicobacter pylori heat-shock protein 60 mediates interleukin 6 production by macrophages via a Toll-like receptor (TLR) -2-, TLR-4-, and myeloid differentiation factor 88-independent mechanism J Biol Chem 2004 279 245 50
    • (2004) J Biol Chem , vol.279 , pp. 245-50
    • Gobert, A.P.1    Bambou, J.C.2    Werts, C.3
  • 23
    • 0034649123 scopus 로고    scopus 로고
    • Suppressive effects of DNA vaccines encoding heat-shock protein on Helicobacter pylori-induced gastritis in mice
    • Todoroki I Joh T Watanabe K et al. Suppressive effects of DNA vaccines encoding heat-shock protein on Helicobacter pylori-induced gastritis in mice Biochem Biophys Res Commun 2000 277 159 63
    • (2000) Biochem Biophys Res Commun , vol.277 , pp. 159-63
    • Todoroki, I.1    Joh, T.2    Watanabe, K.3
  • 24
    • 0037157232 scopus 로고    scopus 로고
    • Immune responses in mice to intranasal and intracutaneous administration of a DNA vaccine encoding Helicobacter pylori catalase
    • Miyashita M Joh T Watanabe K et al. Immune responses in mice to intranasal and intracutaneous administration of a DNA vaccine encoding Helicobacter pylori catalase Vaccine 2002 20 2336 42
    • (2002) Vaccine , vol.20 , pp. 2336-42
    • Miyashita, M.1    Joh, T.2    Watanabe, K.3
  • 25
    • 2942679083 scopus 로고    scopus 로고
    • The immunobiology of the TLR9 subfamily
    • Wagner H. The immunobiology of the TLR9 subfamily Trends Immunol 2004 7 381 6
    • (2004) Trends Immunol , vol.7 , pp. 381-6
    • Wagner, H.1
  • 26
    • 0031867535 scopus 로고    scopus 로고
    • Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
    • Sparwasser T Koch ES Vabulas RM. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells Eur J Immunol 1998 28 2045 54
    • (1998) Eur J Immunol , vol.28 , pp. 2045-54
    • Sparwasser, T.1    Koch, E.S.2    Vabulas, R.M.3
  • 27
    • 0031569601 scopus 로고    scopus 로고
    • Contribution of CpG motifs to the immunogenicity of DNA vaccines
    • Klinman DM Yamshchikov G Ishigatsubo Y. Contribution of CpG motifs to the immunogenicity of DNA vaccines J Immunol 1997 158 3635 9
    • (1997) J Immunol , vol.158 , pp. 3635-9
    • Klinman, D.M.1    Yamshchikov, G.2    Ishigatsubo, Y.3
  • 28
    • 13944269509 scopus 로고    scopus 로고
    • Intranasal CpG-oligodeoxynucleotide is a potent adjuvant of vaccine against Helicobacter pylori, and T helper 1 type response and interferon-gamma correlate with the protection
    • Shi T Liu WZ Gao F. Intranasal CpG-oligodeoxynucleotide is a potent adjuvant of vaccine against Helicobacter pylori, and T helper 1 type response and interferon-gamma correlate with the protection Helicobacter 2005 10 71 9
    • (2005) Helicobacter , vol.10 , pp. 71-9
    • Shi, T.1    Liu, W.Z.2    Gao, F.3
  • 29
    • 11244254035 scopus 로고    scopus 로고
    • Protection of neonatal chicks against a lethal challenge of Escherichia coli using DNA containing cytosine-phosphodiester-guanine motifs
    • Gomis S Babiuk L Allan B et al. Protection of neonatal chicks against a lethal challenge of Escherichia coli using DNA containing cytosine- phosphodiester-guanine motifs Avian Dis 2004 48 813 22
    • (2004) Avian Dis , vol.48 , pp. 813-22
    • Gomis, S.1    Babiuk, L.2    Allan, B.3
  • 30
    • 0037304594 scopus 로고    scopus 로고
    • Protection of chickens against Escherichia coli infections by DNA containing CpG motifs
    • Gomis S Babiuk L Godson DL et al. Protection of chickens against Escherichia coli infections by DNA containing CpG motifs Infect Immun 2003 71 857 63
    • (2003) Infect Immun , vol.71 , pp. 857-63
    • Gomis, S.1    Babiuk, L.2    Godson, D.L.3
  • 31
    • 0033558121 scopus 로고    scopus 로고
    • Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria
    • Elkins KL Rhinehart-Jones TR Stibitz S et al. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria J Immunol 1999 1 62 2291 8
    • (1999) J Immunol , vol.162 , pp. 2291-8
    • Elkins, K.L.1    Rhinehart-Jones, T.R.2    Stibitz, S.3
  • 32
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg AM. CpG motifs in bacterial DNA and their immune effects Annu Rev Immunol 2002 20 709 60
    • (2002) Annu Rev Immunol , vol.20 , pp. 709-60
    • Krieg, A.M.1
  • 34
    • 0033527409 scopus 로고    scopus 로고
    • Induction of human beta-defensin-2 mRNA expression by Helicobacter pylori in human gastric cell line MKN45 cells on cag pathogenicity island
    • Wada A Mori N Oishi K et al. Induction of human beta-defensin-2 mRNA expression by Helicobacter pylori in human gastric cell line MKN45 cells on cag pathogenicity island Biochem Biophys Res Commun 1999 263 770 4
    • (1999) Biochem Biophys Res Commun , vol.263 , pp. 770-4
    • Wada, A.1    Mori, N.2    Oishi, K.3
  • 35
    • 0036719946 scopus 로고    scopus 로고
    • Modulation of host antimicrobial peptide ({beta}-defensins 1 and 2) expression during gastritis
    • Bajaj-Elliott M Fedeli P Smith GV et al. Modulation of host antimicrobial peptide ({beta}-defensins 1 and 2) expression during gastritis Gut 2002 51 356 61
    • (2002) Gut , vol.51 , pp. 356-61
    • Bajaj-Elliott, M.1    Fedeli, P.2    Smith, G.V.3
  • 37
    • 10744224946 scopus 로고    scopus 로고
    • Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori
    • Hase K Murakami M Iimura M et al. Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori Gastroenterology 2003 125 1613 25
    • (2003) Gastroenterology , vol.125 , pp. 1613-25
    • Hase, K.1    Murakami, M.2    Iimura, M.3
  • 38
    • 2942622043 scopus 로고    scopus 로고
    • A plasmid immunization construct encoding urease B of Helicobacter pylori induces an antigen-specific antibody response and up-regulates the expression of beta-defensins and IL-10 in the stomachs of immunized mice
    • Hatzifoti C Bajaj-Elliott M Dorrell N et al. A plasmid immunization construct encoding urease B of Helicobacter pylori induces an antigen-specific antibody response and up-regulates the expression of beta-defensins and IL-10 in the stomachs of immunized mice Vaccine 2004 22 2651 9
    • (2004) Vaccine , vol.22 , pp. 2651-9
    • Hatzifoti, C.1    Bajaj-Elliott, M.2    Dorrell, N.3
  • 39
    • 0037350476 scopus 로고    scopus 로고
    • Catalase (KatA) and KatA-associated protein (KapA) are essential for persistent colonization in the Helicobacter pylori SS1 mouse model
    • Harris AG Wilson JE Danon SG et al. Catalase (KatA) and KatA-associated protein (KapA) are essential for persistent colonization in the Helicobacter pylori SS1 mouse model Microbiology 2003 149 665 72
    • (2003) Microbiology , vol.149 , pp. 665-72
    • Harris, A.G.1    Wilson, J.E.2    Danon, S.G.3
  • 40
    • 17044425007 scopus 로고    scopus 로고
    • Evaluation of DNA extraction methods from mouse stomachs for the quantification of H. pylori by real-time PCR
    • Roussel Y Wilks M Harris A et al. Evaluation of DNA extraction methods from mouse stomachs for the quantification of H. pylori by real-time PCR J Microbiol Meth 2005 62 71 81
    • (2005) J Microbiol Meth , vol.62 , pp. 71-81
    • Roussel, Y.1    Wilks, M.2    Harris, A.3
  • 41
    • 33644843854 scopus 로고    scopus 로고
    • Cell viability, necrosis and apoptosis
    • In*McCarthy D.A.*Macey M.G. Cambridge University Press Cambridge eds
    • Allen PD Newland AC. Cell viability, necrosis and apoptosis In McCarthy DA Macey MG eds Cytometric Analysis of Cell Phenotype and Function 2001 193 6 Cambridge University Press Cambridge
    • (2001) Cytometric Analysis of Cell Phenotype and Function , pp. 193-6
    • Allen, P.D.1    Newland, A.C.2
  • 42
    • 0032444909 scopus 로고    scopus 로고
    • Immunization of mice with urease vaccine affords protection against Helicobacter pylori infection in the absence of antibodies and is mediated by MHC Class II-restricted responses
    • Ermak TH Giannasca PJ Nichols R et al. Immunization of mice with urease vaccine affords protection against Helicobacter pylori infection in the absence of antibodies and is mediated by MHC Class II-restricted responses J Exp Med 1998 188 2277 88
    • (1998) J Exp Med , vol.188 , pp. 2277-88
    • Ermak, T.H.1    Giannasca, P.J.2    Nichols, R.3
  • 43
    • 0032693595 scopus 로고    scopus 로고
    • Helicobacter pylori infection in interleukin 4-deficient and transgenic mice
    • Chen W Shu D Chadwick VC. Helicobacter pylori infection in interleukin 4-deficient and transgenic mice Scand J Gastroenterol 1999 34 987 92
    • (1999) Scand J Gastroenterol , vol.34 , pp. 987-92
    • Chen, W.1    Shu, D.2    Chadwick, V.C.3
  • 44
    • 0035158918 scopus 로고    scopus 로고
    • Immunity against Helicobacter pylori: Significance of interleukin 4 receptor chain status and gender of infected mice
    • Aebischer T Laforsch S Hurwitz R et al. Immunity against Helicobacter pylori: Significance of interleukin 4 receptor chain status and gender of infected mice Infect Immun 2001 69 556 8
    • (2001) Infect Immun , vol.69 , pp. 556-8
    • Aebischer, T.1    Laforsch, S.2    Hurwitz, R.3
  • 45
    • 0035112343 scopus 로고    scopus 로고
    • + T cells specific for subunit a of Helicobacter pylori urease reduces H. pylori stomach colonization in mice in the absence of interleukin 4 (IL-4)/IL-13 receptor signaling
    • + T cells specific for subunit A of Helicobacter pylori urease reduces H. pylori stomach colonization in mice in the absence of interleukin 4 (IL-4)/IL-13 receptor signaling Infect Immun 2001 69 1714 22
    • (2001) Infect Immun , vol.69 , pp. 1714-22
    • Lucas, B.1    Bumann, D.2    Walduck, A.3
  • 46
    • 0034661646 scopus 로고    scopus 로고
    • Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice
    • Smythies L Waites KB Lindsey JR et al. Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice J Immunol 2002 165 1022 9
    • (2002) J Immunol , vol.165 , pp. 1022-9
    • Smythies, L.1    Waites, K.B.2    Lindsey, J.R.3
  • 47
    • 0037114133 scopus 로고    scopus 로고
    • Protection against Helicobacter pylori infection following immunization is IL-12 dependent and mediated by Th1 Cells
    • Akhiani AA Pappo J Kabok Z et al. Protection against Helicobacter pylori infection following immunization is IL-12 dependent and mediated by Th1 Cells J Immunol 2002 169 6977 84
    • (2002) J Immunol , vol.169 , pp. 6977-84
    • Akhiani, A.A.1    Pappo, J.2    Kabok, Z.3
  • 48
    • 23444440849 scopus 로고    scopus 로고
    • IL-10 from regulatory T cells determines vaccine efficacy in murine Leishmania major infection
    • Stober CB Lange UG Roberts MT Alcami A Blackwell JM. IL-10 from regulatory T cells determines vaccine efficacy in murine Leishmania major infection J Immunol 2005 175 2517 24
    • (2005) J Immunol , vol.175 , pp. 2517-24
    • Stober, C.B.1    Lange, U.G.2    Roberts, M.T.3    Alcami, A.4    Blackwell, J.M.5
  • 49
    • 0141799911 scopus 로고    scopus 로고
    • Defensins: Antimicrobial peptides of innate immunity
    • Ganz T. Defensins: antimicrobial peptides of innate immunity Nat Rev Immunol 2003 3 710 20
    • (2003) Nat Rev Immunol , vol.3 , pp. 710-20
    • Ganz, T.1
  • 50
    • 0030747618 scopus 로고    scopus 로고
    • The mouse genome encodes a single homolog of the antimicrobial peptide human [beta]-defensin 1
    • Huttner K Kozak C Bevins C. The mouse genome encodes a single homolog of the antimicrobial peptide human [beta]-defensin 1 FEBS Lett 1997 413 45 9
    • (1997) FEBS Lett , vol.413 , pp. 45-9
    • Huttner, K.1    Kozak, C.2    Bevins, C.3
  • 51
    • 0033043785 scopus 로고    scopus 로고
    • Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs
    • Bals R Wang X Meegalla RL et al. Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs Infect Immun 1999 67 3542 7
    • (1999) Infect Immun , vol.67 , pp. 3542-7
    • Bals, R.1    Wang, X.2    Meegalla, R.L.3
  • 52
    • 0037083505 scopus 로고    scopus 로고
    • Impaired resistance and enhanced pathology during infection with a non-invasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-{gamma}
    • Simmons CP Goncalves NS Ghaem-Maghami M et al. Impaired resistance and enhanced pathology during infection with a non-invasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-{gamma} J Immunol 2002 168 1804 12
    • (2002) J Immunol , vol.168 , pp. 1804-12
    • Simmons, C.P.1    Goncalves, N.S.2    Ghaem-Maghami, M.3
  • 53
    • 2142653566 scopus 로고    scopus 로고
    • Differential regulation of beta-defensin gene expression during Cryptosporidium parvum infection
    • Zaalouk TK Bajaj-Elliott M George JT McDonald V. Differential regulation of beta-defensin gene expression during Cryptosporidium parvum infection Infect Immun 2004 72 2772 9
    • (2004) Infect Immun , vol.72 , pp. 2772-9
    • Zaalouk, T.K.1    Bajaj-Elliott, M.2    George, J.T.3    McDonald, V.4
  • 54
    • 0036791234 scopus 로고    scopus 로고
    • Real-time quantitative PCR for detection of Helicobacter pylori
    • He Q Wang JP Osato M Lachman LB. Real-time quantitative PCR for detection of Helicobacter pylori J Clin Microbiol 2002 40 3720 8
    • (2002) J Clin Microbiol , vol.40 , pp. 3720-8
    • He, Q.1    Wang, J.P.2    Osato, M.3    Lachman, L.B.4
  • 55
    • 0036196015 scopus 로고    scopus 로고
    • Gastric mucosal density of Helicobacter pylori estimated by real-time PCR compared with results of urea breath test and histological grading
    • Kobayashi D Eishi Y Ohkusa T et al. Gastric mucosal density of Helicobacter pylori estimated by real-time PCR compared with results of urea breath test and histological grading J Med Microbiol 2002 51 305 11
    • (2002) J Med Microbiol , vol.51 , pp. 305-11
    • Kobayashi, D.1    Eishi, Y.2    Ohkusa, T.3
  • 56
    • 0037128134 scopus 로고    scopus 로고
    • The expression of the Helicobacter pylori genes ureA and nap is higher in vivo than in vitro as measured by quantitative competitive reverse transcriptase-PCR
    • Blom K Svennerholm A Bïlin I. The expression of the Helicobacter pylori genes ureA and nap is higher in vivo than in vitro as measured by quantitative competitive reverse transcriptase-PCR FEMS Immunol Med Microbiol 2002 32 219 26
    • (2002) FEMS Immunol Med Microbiol , vol.32 , pp. 219-26
    • Blom, K.1    Svennerholm, A.2    Bïlin, I.3
  • 57
    • 0033831647 scopus 로고    scopus 로고
    • Quantitative and bioluminescent assay to measure efficacy of conventional and DNA vaccinations against Helicobacter pylori
    • Ozpolat B Rao XM Lachman LB et al. Quantitative and bioluminescent assay to measure efficacy of conventional and DNA vaccinations against Helicobacter pylori Comb Chem High Throughput Screen 2002 3 289 302
    • (2002) Comb Chem High Throughput Screen , vol.3 , pp. 289-302
    • Ozpolat, B.1    Rao, X.M.2    Lachman, L.B.3
  • 58
    • 0034235701 scopus 로고    scopus 로고
    • Repeated administration of cytosine-phosphorothiolated guanine-containing oligonucleotides together with peptide/protein immunization results in enhanced CTL responses with anti-tumor activity
    • Davila E Celis A. Repeated administration of cytosine-phosphorothiolated guanine-containing oligonucleotides together with peptide/protein immunization results in enhanced CTL responses with anti-tumor activity J Immunol 2000 165 539 47
    • (2000) J Immunol , vol.165 , pp. 539-47
    • Davila, E.1    Celis, A.2
  • 59
    • 0036077213 scopus 로고    scopus 로고
    • Molecular and immunological characterisation of recombinant Brucella abortus glyceraldehyde-3-phosphate-dehydrogenase, a T- and B-cell reactive protein that induces partial protection when co-administered with an interleukin 12-expressing plasmid in a DNA vaccine formulation
    • Rosinha GM Myioshi AN Azevedo VA et al. Molecular and immunological characterisation of recombinant Brucella abortus glyceraldehyde-3-phosphate- dehydrogenase, a T- and B-cell reactive protein that induces partial protection when co-administered with an interleukin 12-expressing plasmid in a DNA vaccine formulation J Med Microbiol 2002 51 661 71
    • (2002) J Med Microbiol , vol.51 , pp. 661-71
    • Rosinha, G.M.1    Myioshi, A.N.2    Azevedo, V.A.3
  • 60
    • 0033993515 scopus 로고    scopus 로고
    • Protective DNA immunization against Chlamydia pneumoniae
    • Svanholm C Bandholt L Castanos-Velez E et al. Protective DNA immunization against Chlamydia pneumoniae Scand J Immunol 2001 51 345 53
    • (2001) Scand J Immunol , vol.51 , pp. 345-53
    • Svanholm, C.1    Bandholt, L.2    Castanos-Velez, E.3


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